MX2007000040A - N-arilsulfonilaminas heterociclicas sustituidas como inhibidores de gamma-secretasas. - Google Patents

N-arilsulfonilaminas heterociclicas sustituidas como inhibidores de gamma-secretasas.

Info

Publication number
MX2007000040A
MX2007000040A MX2007000040A MX2007000040A MX2007000040A MX 2007000040 A MX2007000040 A MX 2007000040A MX 2007000040 A MX2007000040 A MX 2007000040A MX 2007000040 A MX2007000040 A MX 2007000040A MX 2007000040 A MX2007000040 A MX 2007000040A
Authority
MX
Mexico
Prior art keywords
alkyl
aryl
alkylene
substituents
substituted
Prior art date
Application number
MX2007000040A
Other languages
English (en)
Spanish (es)
Inventor
Ruo Xu
John W Clader
Thomas A Bara
Hubert B Josien
Zhiqiang Zhao
Hongmei Li
Dmitri Pissarnitski
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX2007000040A publication Critical patent/MX2007000040A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
MX2007000040A 2004-06-30 2005-06-28 N-arilsulfonilaminas heterociclicas sustituidas como inhibidores de gamma-secretasas. MX2007000040A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58401004P 2004-06-30 2004-06-30
PCT/US2005/023187 WO2006004880A2 (en) 2004-06-30 2005-06-28 Substituted n-arylsulfonylheterocyclic amines as gamma-secretase inhibitors

Publications (1)

Publication Number Publication Date
MX2007000040A true MX2007000040A (es) 2007-03-07

Family

ID=35783342

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007000040A MX2007000040A (es) 2004-06-30 2005-06-28 N-arilsulfonilaminas heterociclicas sustituidas como inhibidores de gamma-secretasas.

Country Status (13)

Country Link
US (3) US7763613B2 (enExample)
EP (1) EP1789404B1 (enExample)
JP (1) JP2008505100A (enExample)
CN (2) CN101602741A (enExample)
AR (1) AR050994A1 (enExample)
AT (1) ATE461926T1 (enExample)
CA (1) CA2570183A1 (enExample)
DE (1) DE602005020156D1 (enExample)
ES (1) ES2341560T3 (enExample)
MX (1) MX2007000040A (enExample)
PE (1) PE20060481A1 (enExample)
TW (1) TWI297270B (enExample)
WO (1) WO2006004880A2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR059075A1 (es) 2006-01-20 2008-03-12 Schering Corp Bencesulfonil - cromano , tiocromano tetrahidronaftaleno e inhibidores de gamma secretasa relacionados
AR059355A1 (es) 2006-02-07 2008-03-26 Wyeth Corp Inhibidores de 11-beta hsd1
CA2649996A1 (en) 2006-04-26 2007-11-08 Merck Sharp & Dohme Limited Piperidines and related compounds for treatment of alzheimer's disease
DK2041181T3 (da) * 2006-06-08 2011-08-29 Helmholtz Zentrum Muenchen Specifikke proteaseinhibitorer og deres anvendelse i cancerterapi
US8278345B2 (en) 2006-11-09 2012-10-02 Probiodrug Ag Inhibitors of glutaminyl cyclase
ATE554085T1 (de) 2006-11-30 2012-05-15 Probiodrug Ag Neue inhibitoren von glutaminylcyclase
JP5930573B2 (ja) 2007-03-01 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤の新規使用
WO2008128985A1 (en) 2007-04-18 2008-10-30 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
ATE543799T1 (de) * 2007-10-19 2012-02-15 Janssen Pharmaceutica Nv Piperidinyl- und piperazinylmodulatoren von g- sekretase
PL2475428T3 (pl) 2009-09-11 2015-12-31 Probiodrug Ag Pochodne heterocykliczne jako inhibitory cyklazy glutaminowej
US20110190269A1 (en) * 2010-02-01 2011-08-04 Karlheinz Baumann Gamma secretase modulators
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
MX2012010470A (es) 2010-03-10 2012-10-09 Probiodrug Ag Inhibidores heterociclicos d ciclasa de glutaminilo (qc, ec .3 2. 5).
US8541596B2 (en) 2010-04-21 2013-09-24 Probiodrug Ag Inhibitors
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
AR091279A1 (es) 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
CN109705052B (zh) * 2019-01-25 2020-12-08 苏州大学 一种制备1,4-二氢噁嗪的方法
CN119060034B (zh) * 2024-09-02 2026-03-24 上海信诺维生物医药有限公司 一种含吡喃取代的吗啉类化合物的制备方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04247081A (ja) 1991-02-01 1992-09-03 Takeda Chem Ind Ltd ５員複素環酸アミド類
US5646167A (en) * 1993-01-06 1997-07-08 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamix acids
PT885888E (pt) * 1996-02-02 2003-12-31 Western Therapeutics Inst D Derivados e farmacos de isoquinolina
HUP0102532A3 (en) * 1998-06-03 2002-06-28 Gpi Nil Holdings Inc Wilmingto Aza-heterocyclic compounds used to treat neurological disorders and hair loss and process for their preparation and pharmaceutical compositions containing them
CN1348442A (zh) 1999-02-26 2002-05-08 默克公司 新的磺胺化合物及其应用
FR2802206B1 (fr) 1999-12-14 2005-04-22 Sod Conseils Rech Applic Derives de 4-aminopiperidine et leur utilisation en tant que medicament
SE9904738D0 (sv) * 1999-12-22 1999-12-22 Astra Pharma Prod Novel compounds
JP2001261657A (ja) * 2000-03-17 2001-09-26 Yamanouchi Pharmaceut Co Ltd シアノフェニル誘導体
EP1296950A2 (en) 2000-04-20 2003-04-02 NPS Allelix Corp. Aminopiperidines for use as glyt-1 inhibitors
US6589978B2 (en) 2000-06-30 2003-07-08 Hoffman-La Roche Inc. 1-sulfonyl pyrrolidine derivatives
HUP0303360A2 (hu) 2000-09-25 2004-01-28 Actelion Pharmaceuticals Ltd. Maláriaellenes hatású szubsztituált amino-aza-cikloalkánok és ezeket tartalmazó gyógyszerkészítmények
MXPA04001014A (es) * 2001-08-03 2004-05-27 Schering Corp Novedosos inhibidores de la gama secretasa.
US7122675B2 (en) * 2001-08-03 2006-10-17 Schering Corporation Gamma secretase inhibitors
US7256186B2 (en) * 2002-02-06 2007-08-14 Schering Corporation Gamma secretase inhibitors
US20040171614A1 (en) 2002-02-06 2004-09-02 Schering-Plough Corporation Novel gamma secretase inhibitors
TW200302717A (en) 2002-02-06 2003-08-16 Schering Corp Novel gamma secretase inhibitors
TW200510405A (en) 2003-05-13 2005-03-16 Schering Corp Bridged n-arylsulfonylpiperidines as gamma-secretase inhibitors
JP4247081B2 (ja) 2003-09-24 2009-04-02 三菱電機株式会社 レーザアニール装置のレーザビーム強度モニタ方法とレーザアニール装置
US20060004004A1 (en) * 2004-04-05 2006-01-05 Schering Corporation Novel gamma secretase inhibitors
WO2005113542A2 (en) * 2004-05-20 2005-12-01 Elan Pharmaceuticals, Inc. N-cyclic sulfonamido inhibitors of gamma secretase
AR059075A1 (es) * 2006-01-20 2008-03-12 Schering Corp Bencesulfonil - cromano , tiocromano tetrahidronaftaleno e inhibidores de gamma secretasa relacionados

Also Published As

Publication number Publication date
US20100087425A1 (en) 2010-04-08
EP1789404B1 (en) 2010-03-24
JP2008505100A (ja) 2008-02-21
WO2006004880A3 (en) 2007-03-08
ES2341560T3 (es) 2010-06-22
WO2006004880A2 (en) 2006-01-12
CA2570183A1 (en) 2006-01-12
TWI297270B (en) 2008-06-01
DE602005020156D1 (de) 2010-05-06
HK1099300A1 (en) 2007-08-10
US20060040936A1 (en) 2006-02-23
TW200612928A (en) 2006-05-01
AR050994A1 (es) 2006-12-13
US7763613B2 (en) 2010-07-27
US20100093695A1 (en) 2010-04-15
EP1789404A2 (en) 2007-05-30
CN101048393A (zh) 2007-10-03
ATE461926T1 (de) 2010-04-15
US7998958B2 (en) 2011-08-16
PE20060481A1 (es) 2006-06-19
CN101602741A (zh) 2009-12-16

Similar Documents

Publication Publication Date Title
US7998958B2 (en) Substituted N-arylsulfonylheterocyclic amines as gamma-secretase inhibitors
AU2016311376B2 (en) Bicyclic-fused heteroaryl or aryl compounds as IRAK4 modulators
US12162872B2 (en) Cycloalkylurea derivative
US8716312B2 (en) Inhibitors of diacylglycerol acyltransferase
AU2009314049B2 (en) Gamma secretase modulators
AU2005262330B2 (en) Piperidine derivatives as NK1 antagonists
AU2004274449A1 (en) Novel gamma secretase inhibitors
MX2011008308A (es) Derivados de azaspiranil-alquilcarbamatos de heterociclos de 5 eslabones, su preparacion y su aplicacion en terapeutica.
WO2009008980A2 (en) Tetrahydropyranochromene gamma secretase inhibitors
EP1737863A2 (en) 2-cyanopyrrolidinecarboxamides as dipeptidyl peptidase-iv inhibitors
US20140296234A1 (en) Pyrimidine derivatives as mtor inhibitors
AU2008276492A1 (en) Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors
EP3373935B1 (en) Cyanopyridine derivatives as liver x receptor beta agonists, compositions, and their use
EP4562014A2 (en) Cdk2 inhibitors and methods of using the same
WO2008100620A2 (en) Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s
AU2009314205A1 (en) Gamma secretase modulators
HK1099300B (en) Substituted n-arylsulfonylheterocyclic amines as gamma-secretase inhibitors
WO2008100635A1 (en) 1- [3- (monocyclic amino) propyl] - 4, 5, 6, 7-tetrahydro-1h-pyrazolo [4, 3-c] -pyridines as modulators of cathepsin s
JP7755874B2 (ja) 抗コリン剤
WO2005115976A1 (en) 3-amino-2-phenylpyrrolidine derivatives

Legal Events

Date Code Title Description
FG Grant or registration
HH Correction or change in general