ES2341560T3 - Aminas n-arilsulfonilheterociclicas sustituidas como inhibidores de gamma-secretasa. - Google Patents
Aminas n-arilsulfonilheterociclicas sustituidas como inhibidores de gamma-secretasa. Download PDFInfo
- Publication number
- ES2341560T3 ES2341560T3 ES05790194T ES05790194T ES2341560T3 ES 2341560 T3 ES2341560 T3 ES 2341560T3 ES 05790194 T ES05790194 T ES 05790194T ES 05790194 T ES05790194 T ES 05790194T ES 2341560 T3 ES2341560 T3 ES 2341560T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- aryl
- alkylene
- substituted
- substituents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 0 *c(cc1)ccc1S1(=C(C2)C2(*C([C@@]2C3[C@](CO)CCCC23)=O)[C@@](C*C2)N1[C@@]2c1cc(F)cc(F)c1)=O Chemical compound *c(cc1)ccc1S1(=C(C2)C2(*C([C@@]2C3[C@](CO)CCCC23)=O)[C@@](C*C2)N1[C@@]2c1cc(F)cc(F)c1)=O 0.000 description 4
- OFCMYNWDYZNDOA-RBUKOAKNSA-N O=C(N1CCCC1)OC1(CC1)[C@@H](COC[C@H]1C2CC2)N1S(c(cc1)ccc1Cl)(=O)=O Chemical compound O=C(N1CCCC1)OC1(CC1)[C@@H](COC[C@H]1C2CC2)N1S(c(cc1)ccc1Cl)(=O)=O OFCMYNWDYZNDOA-RBUKOAKNSA-N 0.000 description 1
- FCTGNWPRBOLOKW-KSBZDLFUSA-N OCCN(C(CC1)C2)C1N2C(OC1(CC1)[C@@H](COC[C@H]1C2CC2)N1S(c(cc1)ccc1Cl)(=O)=O)=O Chemical compound OCCN(C(CC1)C2)C1N2C(OC1(CC1)[C@@H](COC[C@H]1C2CC2)N1S(c(cc1)ccc1Cl)(=O)=O)=O FCTGNWPRBOLOKW-KSBZDLFUSA-N 0.000 description 1
- VCWWBXZMZHRONX-YSIASYRMSA-N OC[C@H](CCC1)N1C(OC1(CC1)[C@@H](COC[C@H]1C2CC2)N1S(c(cc1)ccc1Cl)(=O)=O)=O Chemical compound OC[C@H](CCC1)N1C(OC1(CC1)[C@@H](COC[C@H]1C2CC2)N1S(c(cc1)ccc1Cl)(=O)=O)=O VCWWBXZMZHRONX-YSIASYRMSA-N 0.000 description 1
- BXNFKVQCLLJFJZ-LOSJGSFVSA-N OS(c(cc1)ccc1Cl)(N([C@@H](COC1)C2CC2)[C@H]1C1(CC1)OC(N(CC1)CCC1N1CCCCC1)=O)=O Chemical compound OS(c(cc1)ccc1Cl)(N([C@@H](COC1)C2CC2)[C@H]1C1(CC1)OC(N(CC1)CCC1N1CCCCC1)=O)=O BXNFKVQCLLJFJZ-LOSJGSFVSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58401004P | 2004-06-30 | 2004-06-30 | |
| US584010P | 2004-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2341560T3 true ES2341560T3 (es) | 2010-06-22 |
Family
ID=35783342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05790194T Expired - Lifetime ES2341560T3 (es) | 2004-06-30 | 2005-06-28 | Aminas n-arilsulfonilheterociclicas sustituidas como inhibidores de gamma-secretasa. |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US7763613B2 (enExample) |
| EP (1) | EP1789404B1 (enExample) |
| JP (1) | JP2008505100A (enExample) |
| CN (2) | CN101602741A (enExample) |
| AR (1) | AR050994A1 (enExample) |
| AT (1) | ATE461926T1 (enExample) |
| CA (1) | CA2570183A1 (enExample) |
| DE (1) | DE602005020156D1 (enExample) |
| ES (1) | ES2341560T3 (enExample) |
| MX (1) | MX2007000040A (enExample) |
| PE (1) | PE20060481A1 (enExample) |
| TW (1) | TWI297270B (enExample) |
| WO (1) | WO2006004880A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2008009414A (es) | 2006-01-20 | 2008-10-01 | Schering Corp | Arilsulfonas carbociclicas y heterociclicas como inhibidores de gamma secretasa. |
| JP2009526059A (ja) * | 2006-02-07 | 2009-07-16 | ワイス | １１−ベータｈｓｄ１阻害剤 |
| CA2649996A1 (en) | 2006-04-26 | 2007-11-08 | Merck Sharp & Dohme Limited | Piperidines and related compounds for treatment of alzheimer's disease |
| DK2041181T3 (da) * | 2006-06-08 | 2011-08-29 | Helmholtz Zentrum Muenchen | Specifikke proteaseinhibitorer og deres anvendelse i cancerterapi |
| WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| EP2091948B1 (en) | 2006-11-30 | 2012-04-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| CN101668525A (zh) | 2007-03-01 | 2010-03-10 | 前体生物药物股份公司 | 谷氨酰胺酰环化酶抑制剂的新用途 |
| US9656991B2 (en) | 2007-04-18 | 2017-05-23 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| BRPI0817433A2 (pt) * | 2007-10-19 | 2015-06-16 | Janssen Pharmaceutica Nv | Moduladores de gama-secretase piperidinila e piperazinila |
| ES2548913T3 (es) | 2009-09-11 | 2015-10-21 | Probiodrug Ag | Derivados heterocíclicos como inhibidores de glutaminil ciclasa |
| US20110190269A1 (en) * | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
| WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
| CA2789440C (en) | 2010-03-10 | 2020-03-24 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| JP5945532B2 (ja) | 2010-04-21 | 2016-07-05 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
| US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
| AR091279A1 (es) | 2012-06-08 | 2015-01-21 | Gilead Sciences Inc | Inhibidores macrociclicos de virus flaviviridae |
| EP3461819B1 (en) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| CN109705052B (zh) * | 2019-01-25 | 2020-12-08 | 苏州大学 | 一种制备1,4-二氢噁嗪的方法 |
| CN119060034A (zh) * | 2024-09-02 | 2024-12-03 | 上海信诺维生物医药有限公司 | 一种含吡喃取代的吗啉类化合物的制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04247081A (ja) | 1991-02-01 | 1992-09-03 | Takeda Chem Ind Ltd | ５員複素環酸アミド類 |
| US5646167A (en) | 1993-01-06 | 1997-07-08 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamix acids |
| WO1997028130A1 (en) * | 1996-02-02 | 1997-08-07 | Nippon Shinyaku Co., Ltd. | Isoquinoline derivatives and drugs |
| EA200001144A1 (ru) * | 1998-06-03 | 2001-10-22 | Джи-Пи-Ай Эн-Ай-Эл Холдингз, Инк. | Аза-гетероциклические соединения, применяемые для лечения неврологических расстройств и выпадения волос |
| IL144781A0 (en) | 1999-02-26 | 2002-06-30 | Merck & Co Inc | Novel sulfonamide compounds and uses thereof |
| FR2802206B1 (fr) | 1999-12-14 | 2005-04-22 | Sod Conseils Rech Applic | Derives de 4-aminopiperidine et leur utilisation en tant que medicament |
| SE9904738D0 (sv) * | 1999-12-22 | 1999-12-22 | Astra Pharma Prod | Novel compounds |
| JP2001261657A (ja) * | 2000-03-17 | 2001-09-26 | Yamanouchi Pharmaceut Co Ltd | シアノフェニル誘導体 |
| AU2001254546A1 (en) | 2000-04-20 | 2001-11-07 | Nps Allelix Corp. | Aminopiperidines |
| US6589978B2 (en) | 2000-06-30 | 2003-07-08 | Hoffman-La Roche Inc. | 1-sulfonyl pyrrolidine derivatives |
| IL154363A0 (en) | 2000-09-25 | 2003-09-17 | Actelion Pharmaceuticals Ltd | Substituted amino-aza-cycloalkanes useful against malaria |
| EP1411944A1 (en) | 2001-08-03 | 2004-04-28 | Schering Corporation | Sulfonamide derivatives as gamma secretase inhibitors |
| PL372212A1 (en) | 2001-08-03 | 2005-07-11 | Schering Corporation | Novel gamma secretase inhibitors |
| US7256186B2 (en) | 2002-02-06 | 2007-08-14 | Schering Corporation | Gamma secretase inhibitors |
| US20040171614A1 (en) | 2002-02-06 | 2004-09-02 | Schering-Plough Corporation | Novel gamma secretase inhibitors |
| TW200302717A (en) | 2002-02-06 | 2003-08-16 | Schering Corp | Novel gamma secretase inhibitors |
| TW200510405A (en) | 2003-05-13 | 2005-03-16 | Schering Corp | Bridged n-arylsulfonylpiperidines as gamma-secretase inhibitors |
| JP4247081B2 (ja) | 2003-09-24 | 2009-04-02 | 三菱電機株式会社 | レーザアニール装置のレーザビーム強度モニタ方法とレーザアニール装置 |
| KR20070010144A (ko) | 2004-04-05 | 2007-01-22 | 쉐링 코포레이션 | 신규한 감마 세크레타제 억제제 |
| EP1758884A2 (en) * | 2004-05-20 | 2007-03-07 | Elan Pharmaceuticals, Inc. | N-cyclic sulfonamido inhibitors of gamma secretase |
| MX2008009414A (es) | 2006-01-20 | 2008-10-01 | Schering Corp | Arilsulfonas carbociclicas y heterociclicas como inhibidores de gamma secretasa. |
-
2005
- 2005-06-28 CN CNA200910152119XA patent/CN101602741A/zh active Pending
- 2005-06-28 CA CA002570183A patent/CA2570183A1/en not_active Abandoned
- 2005-06-28 WO PCT/US2005/023187 patent/WO2006004880A2/en not_active Ceased
- 2005-06-28 US US11/168,797 patent/US7763613B2/en not_active Expired - Fee Related
- 2005-06-28 AT AT05790194T patent/ATE461926T1/de not_active IP Right Cessation
- 2005-06-28 PE PE2005000751A patent/PE20060481A1/es not_active Application Discontinuation
- 2005-06-28 CN CNA2005800284229A patent/CN101048393A/zh active Pending
- 2005-06-28 DE DE602005020156T patent/DE602005020156D1/de not_active Expired - Lifetime
- 2005-06-28 MX MX2007000040A patent/MX2007000040A/es active IP Right Grant
- 2005-06-28 JP JP2007519415A patent/JP2008505100A/ja active Pending
- 2005-06-28 EP EP05790194A patent/EP1789404B1/en not_active Expired - Lifetime
- 2005-06-28 ES ES05790194T patent/ES2341560T3/es not_active Expired - Lifetime
- 2005-06-28 AR ARP050102662A patent/AR050994A1/es not_active Application Discontinuation
- 2005-06-29 TW TW094121770A patent/TWI297270B/zh not_active IP Right Cessation
-
2009
- 2009-12-08 US US12/633,311 patent/US7998958B2/en not_active Expired - Fee Related
- 2009-12-08 US US12/633,286 patent/US20100087425A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20060040936A1 (en) | 2006-02-23 |
| CN101048393A (zh) | 2007-10-03 |
| TWI297270B (en) | 2008-06-01 |
| AR050994A1 (es) | 2006-12-13 |
| JP2008505100A (ja) | 2008-02-21 |
| EP1789404A2 (en) | 2007-05-30 |
| CA2570183A1 (en) | 2006-01-12 |
| WO2006004880A3 (en) | 2007-03-08 |
| WO2006004880A2 (en) | 2006-01-12 |
| HK1099300A1 (en) | 2007-08-10 |
| US20100087425A1 (en) | 2010-04-08 |
| TW200612928A (en) | 2006-05-01 |
| MX2007000040A (es) | 2007-03-07 |
| US7998958B2 (en) | 2011-08-16 |
| DE602005020156D1 (de) | 2010-05-06 |
| US20100093695A1 (en) | 2010-04-15 |
| CN101602741A (zh) | 2009-12-16 |
| US7763613B2 (en) | 2010-07-27 |
| EP1789404B1 (en) | 2010-03-24 |
| PE20060481A1 (es) | 2006-06-19 |
| ATE461926T1 (de) | 2010-04-15 |
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