JP2008504301A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008504301A5 JP2008504301A5 JP2007518379A JP2007518379A JP2008504301A5 JP 2008504301 A5 JP2008504301 A5 JP 2008504301A5 JP 2007518379 A JP2007518379 A JP 2007518379A JP 2007518379 A JP2007518379 A JP 2007518379A JP 2008504301 A5 JP2008504301 A5 JP 2008504301A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- aryl
- heteroalkyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 54
- 125000004404 heteroalkyl group Chemical group 0.000 claims 32
- 125000003118 aryl group Chemical group 0.000 claims 26
- 125000001072 heteroaryl group Chemical group 0.000 claims 21
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 19
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- 229910052736 halogen Inorganic materials 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 239000000651 prodrug Substances 0.000 claims 5
- 229940002612 prodrug Drugs 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 claims 4
- 102100028990 C-X-C chemokine receptor type 3 Human genes 0.000 claims 4
- 201000004624 Dermatitis Diseases 0.000 claims 4
- 101000916050 Homo sapiens C-X-C chemokine receptor type 3 Proteins 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000004474 heteroalkylene group Chemical group 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 230000002757 inflammatory effect Effects 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 208000006673 asthma Diseases 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 210000000056 organ Anatomy 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 208000027496 Behcet disease Diseases 0.000 claims 2
- 208000009137 Behcet syndrome Diseases 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 206010010741 Conjunctivitis Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 201000005569 Gout Diseases 0.000 claims 2
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 2
- 201000009906 Meningitis Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000005141 Otitis Diseases 0.000 claims 2
- 206010039085 Rhinitis allergic Diseases 0.000 claims 2
- 206010040047 Sepsis Diseases 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 208000024780 Urticaria Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 201000010105 allergic rhinitis Diseases 0.000 claims 2
- 208000010668 atopic eczema Diseases 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 208000019258 ear infection Diseases 0.000 claims 2
- 206010014599 encephalitis Diseases 0.000 claims 2
- 208000024908 graft versus host disease Diseases 0.000 claims 2
- 208000006454 hepatitis Diseases 0.000 claims 2
- 231100000283 hepatitis Toxicity 0.000 claims 2
- 125000005114 heteroarylalkoxy group Chemical group 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 201000008383 nephritis Diseases 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 201000000306 sarcoidosis Diseases 0.000 claims 2
- 201000009890 sinusitis Diseases 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
- 125000006833 (C1-C5) alkylene group Chemical group 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- -1 NH 2 Inorganic materials 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004802 cyanophenyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 0 C*[C@](C)C*(*(C)C)=*(C)c1c(*)*cc*1C Chemical compound C*[C@](C)C*(*(C)C)=*(C)c1c(*)*cc*1C 0.000 description 4
- LNSGIYHTBZBJHU-UHFFFAOYSA-N CC(Cc(cc1)ccc1OC(F)(F)F)=O Chemical compound CC(Cc(cc1)ccc1OC(F)(F)F)=O LNSGIYHTBZBJHU-UHFFFAOYSA-N 0.000 description 2
- UIPDPUXNQIWJLF-UHFFFAOYSA-N CC(Cc1ccc(C(F)(F)F)cc1)=O Chemical compound CC(Cc1ccc(C(F)(F)F)cc1)=O UIPDPUXNQIWJLF-UHFFFAOYSA-N 0.000 description 2
- AUDJPOKCCLAMKC-XGOROQTFSA-N CC(CC/C=C\C(\C(F)(F)F)=C(/C#C)\F)=O Chemical compound CC(CC/C=C\C(\C(F)(F)F)=C(/C#C)\F)=O AUDJPOKCCLAMKC-XGOROQTFSA-N 0.000 description 1
- FKQYECMKLWYTCQ-UHFFFAOYSA-N CC(Cc1cc(F)c(C(F)(F)F)cc1)=O Chemical compound CC(Cc1cc(F)c(C(F)(F)F)cc1)=O FKQYECMKLWYTCQ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58390104P | 2004-06-28 | 2004-06-28 | |
| PCT/US2005/023251 WO2006004915A1 (en) | 2004-06-28 | 2005-06-28 | Fused pyrimidine derivatives and compositions thereof as cxcr3 receptor modulators, useful in prevention and treatment of inflammatory and immunoregulatory disorders and diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008504301A JP2008504301A (ja) | 2008-02-14 |
| JP2008504301A5 true JP2008504301A5 (https=) | 2008-08-14 |
Family
ID=35197976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007518379A Pending JP2008504301A (ja) | 2004-06-28 | 2005-06-28 | 炎症性及び免疫調節性の障害及び疾患の予防及び治療に有用である、ｃｘｃｒ３受容体モジュレーターとしての縮合ピリミジン誘導体及びその組成物 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7939538B2 (https=) |
| EP (1) | EP1771447A1 (https=) |
| JP (1) | JP2008504301A (https=) |
| KR (1) | KR20070045203A (https=) |
| CN (1) | CN101006088A (https=) |
| AR (1) | AR049558A1 (https=) |
| AU (1) | AU2005260620A1 (https=) |
| BR (1) | BRPI0512703A (https=) |
| CA (1) | CA2572083A1 (https=) |
| EA (1) | EA011439B1 (https=) |
| EC (1) | ECSP077212A (https=) |
| IL (1) | IL180327A0 (https=) |
| MA (1) | MA28755B1 (https=) |
| MX (1) | MX2007000051A (https=) |
| NO (1) | NO20070484L (https=) |
| TN (1) | TNSN06430A1 (https=) |
| TW (1) | TW200611699A (https=) |
| WO (1) | WO2006004915A1 (https=) |
| ZA (1) | ZA200700752B (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
| JP2003007697A (ja) * | 2001-06-21 | 2003-01-10 | Hitachi Kokusai Electric Inc | 半導体装置の製造方法、基板処理方法および基板処理装置 |
| US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
| US7939538B2 (en) | 2004-06-28 | 2011-05-10 | Amgen Inc. | Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases |
| TW200714610A (en) * | 2005-02-16 | 2007-04-16 | Univ Maryland | CXCR3 is a gliadin receptor |
| CA2612585A1 (en) | 2005-06-27 | 2007-01-04 | Amgen Inc. | Anti-inflammatory aryl nitrile compounds |
| AU2006276246B2 (en) * | 2005-07-25 | 2012-09-27 | Intermune, Inc. | Novel macrocyclic inhibitors of hepatitis C virus replication |
| ES2356776T3 (es) * | 2005-10-11 | 2011-04-13 | Intermune, Inc. | Compuestos y métodos para inhibir la replicación del virus de la hepatitis. |
| RU2008152171A (ru) * | 2006-07-05 | 2010-08-10 | Интермьюн, Инк. (Us) | Новые ингибиторы вирусной репликации гепатита с |
| WO2008041118A2 (en) * | 2006-10-04 | 2008-04-10 | Pfizer Products Inc. | Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists |
| SG174809A1 (en) * | 2007-05-03 | 2011-10-28 | Intermune Inc | Macrocyclic compounds useful as inhibitors of hepatitis c virus |
| JP2010526834A (ja) | 2007-05-10 | 2010-08-05 | インターミューン・インコーポレーテッド | Ｃ型肝炎ウイルス複製の新規ペプチド阻害剤 |
| US20110034487A1 (en) * | 2008-01-22 | 2011-02-10 | Amgen Inc. | Cxcr3 antagonists |
| WO2009142842A2 (en) * | 2008-04-15 | 2009-11-26 | Intermune, Inc. | Novel macrocyclic inhibitors of hepatitis c virus replication |
| AR075584A1 (es) * | 2009-02-27 | 2011-04-20 | Intermune Inc | COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. |
| CN102741270B (zh) * | 2009-09-28 | 2015-07-22 | 英特穆恩公司 | C型肝炎病毒复制的环肽抑制剂 |
| BR112013001634A2 (pt) * | 2010-07-23 | 2016-05-24 | Takeda Pharmaceutical | composto ou sal, medicamento, métodos para a profilaxia ou tratamento da arteriosclerose, da diabete ou obesidade em um mamífero, e, uso do composto ou sal |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| JP6207100B2 (ja) | 2012-12-21 | 2017-10-04 | ギリアード カリストガ エルエルシー | イソキノリノンまたはキナゾリノンホスファチジルイノシトール３−キナーゼ阻害剤 |
| NZ708864A (en) | 2012-12-21 | 2016-09-30 | Gilead Calistoga Llc | Substituted pyrimidine aminoalkyl-quinazolones as phosphatidylinositol 3-kinase inhibitors |
| ES2667173T3 (es) | 2013-06-14 | 2018-05-09 | Gilead Calistoga Llc | Inhibidores de fosfatidilinositol 3-quinasa |
| UY35675A (es) | 2013-07-24 | 2015-02-27 | Novartis Ag | Derivados sustituidos de quinazolin-4-ona |
| MX2021012208A (es) | 2013-10-04 | 2023-01-19 | Infinity Pharmaceuticals Inc | Compuestos heterocíclicos y usos de los mismos. |
| WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| NZ724368A (en) | 2014-03-19 | 2023-07-28 | Infinity Pharmaceuticals Inc | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| EP4585268A3 (en) | 2015-09-14 | 2025-10-15 | Twelve Therapeutics, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
| US10759806B2 (en) | 2016-03-17 | 2020-09-01 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0481614A1 (en) | 1990-10-01 | 1992-04-22 | Merck & Co. Inc. | Substituted pyridopyrimidinones and related heterocycles as angiotensin II antagonists |
| US5256667A (en) | 1991-09-25 | 1993-10-26 | Merck & Co., Inc. | Quinazolinones and pyridopyrimidinones |
| US5202322A (en) | 1991-09-25 | 1993-04-13 | Merck & Co., Inc. | Quinazolinone and pyridopyrimidine a-II antagonists |
| US5756502A (en) | 1994-08-08 | 1998-05-26 | Warner-Lambert Company | Quinazolinone derivatives as cholyecystokinin (CCK) ligands |
| US5719144A (en) | 1995-02-22 | 1998-02-17 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| WO1996028444A1 (en) | 1995-03-15 | 1996-09-19 | Pfizer Inc. | 5,10-DIHYDROPYRIMIDO[4,5-b]QUINOLIN-4(1H)-ONE TYROSINE KINASE INHIBITORS |
| US6140064A (en) | 1996-09-10 | 2000-10-31 | Theodor-Kocher Institute | Method of detecting or identifying ligands, inhibitors or promoters of CXC chemokine receptor 3 |
| BR9714222A (pt) | 1996-12-17 | 2000-04-18 | Du Pont | Método para o controle de doenças de plantas |
| FR2778662B1 (fr) | 1998-05-12 | 2000-06-16 | Adir | Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP4831906B2 (ja) | 1999-08-27 | 2011-12-07 | ケモセントリックス， インコーポレイテッド | Ｃｘｃｒ３機能を調節するための複素環式化合物および方法 |
| AU780846B2 (en) * | 1999-09-16 | 2005-04-21 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| US6545004B1 (en) | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| ATE327224T1 (de) | 1999-10-27 | 2006-06-15 | Cytokinetics Inc | Chinazolinone benutzende verfahren und zusammenstellungen |
| GB2359551A (en) | 2000-02-23 | 2001-08-29 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
| MXPA03005152A (es) | 2000-12-11 | 2004-10-14 | Tularik Inc | Antogonista de cxcr3. |
| ITMI20010808A1 (it) | 2001-04-13 | 2002-10-13 | Ilpea Ind Spa | Procedimento per ottenere una pelle sintetica adatta in particolare arivestire plance portastrumenti in autoveicoli e pelle cosi' ottenuta |
| US6794379B2 (en) | 2001-06-06 | 2004-09-21 | Tularik Inc. | CXCR3 antagonists |
| ES2361403T3 (es) | 2002-03-07 | 2011-06-16 | X-Ceptor Therapeutics, Inc. | Moduladores de quinazolinona de receptores nucleares. |
| CA2485148A1 (en) | 2002-05-09 | 2003-11-20 | Cytokinetics, Inc. | Pyrimidinone compounds, compositions and methods |
| EP1513820A4 (en) * | 2002-05-23 | 2006-09-13 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
| US20040242498A1 (en) | 2003-02-27 | 2004-12-02 | Collins Tassie L. | CXCR3 antagonists |
| US7375102B2 (en) * | 2004-06-28 | 2008-05-20 | Amgen Sf, Llc | Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use |
| US7939538B2 (en) | 2004-06-28 | 2011-05-10 | Amgen Inc. | Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases |
| US7271271B2 (en) | 2004-06-28 | 2007-09-18 | Amgen Sf, Llc | Imidazolo-related compounds, compositions and methods for their use |
| WO2006023381A1 (en) | 2004-08-16 | 2006-03-02 | Taigen Biotechnology | Pyrimidinone compounds |
| CA2612585A1 (en) | 2005-06-27 | 2007-01-04 | Amgen Inc. | Anti-inflammatory aryl nitrile compounds |
-
2005
- 2005-06-27 US US11/168,005 patent/US7939538B2/en not_active Expired - Fee Related
- 2005-06-28 EA EA200700169A patent/EA011439B1/ru not_active IP Right Cessation
- 2005-06-28 EP EP05789126A patent/EP1771447A1/en not_active Withdrawn
- 2005-06-28 ZA ZA200700752A patent/ZA200700752B/xx unknown
- 2005-06-28 AU AU2005260620A patent/AU2005260620A1/en not_active Abandoned
- 2005-06-28 WO PCT/US2005/023251 patent/WO2006004915A1/en not_active Ceased
- 2005-06-28 JP JP2007518379A patent/JP2008504301A/ja active Pending
- 2005-06-28 TW TW094121708A patent/TW200611699A/zh unknown
- 2005-06-28 MX MX2007000051A patent/MX2007000051A/es not_active Application Discontinuation
- 2005-06-28 CA CA002572083A patent/CA2572083A1/en not_active Abandoned
- 2005-06-28 CN CNA2005800277780A patent/CN101006088A/zh active Pending
- 2005-06-28 AR ARP050102670A patent/AR049558A1/es not_active Application Discontinuation
- 2005-06-28 BR BRPI0512703-3A patent/BRPI0512703A/pt not_active IP Right Cessation
- 2005-06-28 KR KR1020077002012A patent/KR20070045203A/ko not_active Withdrawn
-
2006
- 2006-12-25 IL IL180327A patent/IL180327A0/en unknown
- 2006-12-26 TN TNP2006000430A patent/TNSN06430A1/en unknown
-
2007
- 2007-01-25 NO NO20070484A patent/NO20070484L/no not_active Application Discontinuation
- 2007-01-29 EC EC2007007212A patent/ECSP077212A/es unknown
- 2007-01-29 MA MA29639A patent/MA28755B1/fr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008504301A5 (https=) | ||
| JP2008504304A5 (https=) | ||
| JP2017511357A5 (https=) | ||
| CN102633713B (zh) | 达比加群酯中间体及其制备方法、以及制备达比加群酯的方法 | |
| JP5324574B2 (ja) | Ｃ型肝炎の治療に有用な化合物の合成方法 | |
| JP2015503622A5 (https=) | ||
| US20050171357A1 (en) | Process for preparing indolinone derivatives | |
| WO2017202703A1 (en) | Benzazepine dicarboxamide compounds with secondary amide function | |
| JP2003525295A5 (https=) | ||
| JP2009525287A (ja) | ウイルスポリメラーゼインヒビター | |
| JP2004536796A5 (https=) | ||
| RU2124008C1 (ru) | Производные пиразина и их кислотно-аддитивные соли | |
| JP2010540504A (ja) | ニコチンアミド誘導体、これらの調製およびこれらの治療目的使用 | |
| JP2010540593A5 (https=) | ||
| JP2008504303A5 (https=) | ||
| KR20090061068A (ko) | 이매티닙의 제조 방법 | |
| US9156789B2 (en) | Process for sorafenib tosylate polymorph III | |
| HRP20151336T1 (hr) | Tetrahidroizokinolin-1-on derivat ili njegova sol | |
| JP2019510801A5 (https=) | ||
| EP2054388A1 (en) | Viral polymerase inhibitors | |
| JP2019507120A5 (https=) | ||
| JP2018065817A (ja) | 抗ウイルス活性を有するメタンチオン化合物 | |
| US20230219925A1 (en) | Benzo five-membered nitrogen heterocyclic compound and application thereof | |
| JP2008514634A5 (https=) | ||
| JP2021534084A5 (https=) |