JP2008503716A - Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析 - Google Patents

Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析 Download PDF

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JP2008503716A
JP2008503716A JP2007516078A JP2007516078A JP2008503716A JP 2008503716 A JP2008503716 A JP 2008503716A JP 2007516078 A JP2007516078 A JP 2007516078A JP 2007516078 A JP2007516078 A JP 2007516078A JP 2008503716 A JP2008503716 A JP 2008503716A
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serotype
conjugate
sugar
molecular weight
batch
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ジョルジオ カパンノリ，
バレリア カリンチ，
サンドロ ダセンツィ，
クラウディア マガノーリ，
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カイロン ソチエタ ア レスポンサビリタ リミタータ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Spectrometry And Color Measurement (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
JP2007516078A 2004-06-21 2005-06-21 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析 Withdrawn JP2008503716A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0413868.1A GB0413868D0 (en) 2004-06-21 2004-06-21 Dimensional anlaysis of saccharide conjugates
PCT/IB2005/002532 WO2006000920A2 (en) 2004-06-21 2005-06-21 Dimensional analysis of saccharide conjugates with gpc & sec-mals

Related Child Applications (1)

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JP2011192126A Division JP2011246490A (ja) 2004-06-21 2011-09-02 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析

Publications (2)

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JP2008503716A true JP2008503716A (ja) 2008-02-07
JP2008503716A5 JP2008503716A5 (https=) 2008-07-17

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JP2007516078A Withdrawn JP2008503716A (ja) 2004-06-21 2005-06-21 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析
JP2011192126A Withdrawn JP2011246490A (ja) 2004-06-21 2011-09-02 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析
JP2014047555A Expired - Lifetime JP6218327B2 (ja) 2004-06-21 2014-03-11 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析
JP2015143718A Pending JP2015180707A (ja) 2004-06-21 2015-07-21 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析
JP2017084454A Expired - Lifetime JP6661568B2 (ja) 2004-06-21 2017-04-21 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析

Family Applications After (4)

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JP2011192126A Withdrawn JP2011246490A (ja) 2004-06-21 2011-09-02 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析
JP2014047555A Expired - Lifetime JP6218327B2 (ja) 2004-06-21 2014-03-11 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析
JP2015143718A Pending JP2015180707A (ja) 2004-06-21 2015-07-21 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析
JP2017084454A Expired - Lifetime JP6661568B2 (ja) 2004-06-21 2017-04-21 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析

Country Status (13)

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US (2) US8163296B2 (https=)
EP (2) EP2374473B1 (https=)
JP (5) JP2008503716A (https=)
CN (1) CN1976725B (https=)
AU (1) AU2005256961B2 (https=)
BR (1) BRPI0512281A (https=)
CA (1) CA2571565C (https=)
ES (2) ES2688796T3 (https=)
GB (1) GB0413868D0 (https=)
MX (2) MXPA06015188A (https=)
NZ (1) NZ552449A (https=)
RU (1) RU2422156C2 (https=)
WO (1) WO2006000920A2 (https=)

Cited By (7)

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JP2011522252A (ja) * 2008-05-30 2011-07-28 インターベツト・インターナシヨナル・ベー・ベー ワクチンの効力および安定性を監視するための分析方法
JP2013514538A (ja) * 2009-12-15 2013-04-25 ウオーターズ・テクノロジーズ・コーポレイシヨン サイズ排除クロマトグラフィーを行うための装置および方法
JP2017014217A (ja) * 2010-05-26 2017-01-19 セレクタ バイオサイエンシーズ インコーポレーテッドＳｅｌｅｃｔａ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． 合成ナノキャリア混合ワクチン
US10092893B2 (en) 2010-07-26 2018-10-09 Waters Technologies Corporation Superficially porous materials comprising a substantially nonporous hybrid core having narrow particle size distribution; process for the preparation thereof; and use thereof for chromatographic separations
KR20200097239A (ko) * 2017-09-06 2020-08-18 상하이 그린벨리 파머수티컬 주식회사 중량평균 분자량 및 산성 당의 가용성 염의 함량 측정방법
JP2021089234A (ja) * 2019-12-05 2021-06-10 株式会社島津製作所 検出器の出力を補正する方法、および多角度光散乱検出器
US11291974B2 (en) 2009-06-01 2022-04-05 Waters Technologies Corporation Hybrid inorganic/organic materials having novel surface modification; process for the preparation of inorganic/organic hybrid materials; and use of said particles for chromatographic separations

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GB0413868D0 (en) * 2004-06-21 2004-07-21 Chiron Srl Dimensional anlaysis of saccharide conjugates
US8398983B2 (en) 2005-06-27 2013-03-19 Glaxosmithkline Biologicals, S.A. Immunogenic composition
AR064642A1 (es) 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
US8195405B2 (en) * 2009-06-30 2012-06-05 Wyatt Technology Corporation Method for characterizing reversible association of macromolecules at high concentration
BR112012010223A2 (pt) 2009-10-30 2016-12-06 Novartis Ag purificação de staphylococcus aureus tipo 5 e tipo 8 sacarídeos capsulares
KR101594228B1 (ko) 2010-08-23 2016-02-15 와이어쓰 엘엘씨 네이세리아 메닌기티디스 ｒＬＰ２０８６ 항원의 안정한 제제
NZ607224A (en) 2010-09-10 2014-11-28 Wyeth Llc Non-lipidated variants of neisseria meningitidis orf2086 antigens
MX359256B (es) 2012-03-09 2018-09-19 Pfizer Composiciones de neisseria meningitidis y metodos de las mismas.
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
US10481164B2 (en) 2012-03-26 2019-11-19 Amgen Inc. Method for using light scattering in real time to directly monitor and control impurity removal in purification processes
US9802987B2 (en) 2013-03-08 2017-10-31 Pfizer Inc. Immunogenic fusion polypeptides
RU2662968C2 (ru) 2013-09-08 2018-07-31 Пфайзер Инк. Иммуногенная композиция против neisseria meningitidis (варианты)
AU2016221318B2 (en) 2015-02-19 2020-06-25 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
KR102906912B1 (ko) 2016-09-02 2026-01-05 사노피 파스퇴르 인크 네이세리아 메닌기티디스 백신
ES3024474T3 (en) 2016-12-30 2025-06-04 Vaxcyte Inc Polypeptide-antigen conjugates with non-natural amino acids
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
AU2018215585B2 (en) 2017-01-31 2022-03-17 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
CN109459504B (zh) * 2017-09-06 2022-05-27 绿谷(上海)医药科技有限公司 一种测定聚古罗糖醛酸硫酸酯盐重均分子量和含量的方法
EP4034157A1 (en) 2019-09-27 2022-08-03 Pfizer Inc. Neisseria meningitidis compositions and methods thereof

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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011522252A (ja) * 2008-05-30 2011-07-28 インターベツト・インターナシヨナル・ベー・ベー ワクチンの効力および安定性を監視するための分析方法
US11291974B2 (en) 2009-06-01 2022-04-05 Waters Technologies Corporation Hybrid inorganic/organic materials having novel surface modification; process for the preparation of inorganic/organic hybrid materials; and use of said particles for chromatographic separations
JP2018021929A (ja) * 2009-12-15 2018-02-08 ウオーターズ・テクノロジーズ・コーポレイシヨン サイズ排除クロマトグラフィーを行うための装置および方法
JP2013514538A (ja) * 2009-12-15 2013-04-25 ウオーターズ・テクノロジーズ・コーポレイシヨン サイズ排除クロマトグラフィーを行うための装置および方法
JP2017014217A (ja) * 2010-05-26 2017-01-19 セレクタ バイオサイエンシーズ インコーポレーテッドＳｅｌｅｃｔａ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． 合成ナノキャリア混合ワクチン
JP2018052940A (ja) * 2010-05-26 2018-04-05 セレクタ バイオサイエンシーズ インコーポレーテッドＳｅｌｅｃｔａ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． 多価合成ナノキャリアワクチン
US10092893B2 (en) 2010-07-26 2018-10-09 Waters Technologies Corporation Superficially porous materials comprising a substantially nonporous hybrid core having narrow particle size distribution; process for the preparation thereof; and use thereof for chromatographic separations
US11478775B2 (en) 2010-07-26 2022-10-25 Waters Technologies Corporation Superficially porous materials comprising a substantially nonporous hybrid core having narrow particle size distribution
US12427502B2 (en) 2010-07-26 2025-09-30 Waters Technologies Corporation Superficially porous materials comprising a substantially nonporous core having narrow particle size distribution; process for the preparation thereof; and use thereof for chromatographic separations
KR20200097239A (ko) * 2017-09-06 2020-08-18 상하이 그린벨리 파머수티컬 주식회사 중량평균 분자량 및 산성 당의 가용성 염의 함량 측정방법
KR102338499B1 (ko) 2017-09-06 2021-12-14 상하이 그린벨리 파머수티컬 주식회사 중량평균 분자량 및 산성 당의 가용성 염의 함량 측정방법
US11366086B2 (en) 2017-09-06 2022-06-21 Shanghai Green Valley Pharmaceutical Co., Ltd. Method for determining weight-average molecular weight and content of soluble salt of acidic carbohydrates
JP2021089234A (ja) * 2019-12-05 2021-06-10 株式会社島津製作所 検出器の出力を補正する方法、および多角度光散乱検出器
JP7409055B2 (ja) 2019-12-05 2024-01-09 株式会社島津製作所 検出器の出力を補正する方法、および多角度光散乱検出器

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Publication number Publication date
JP2015180707A (ja) 2015-10-15
ES2443465T3 (es) 2014-02-19
EP1778291A2 (en) 2007-05-02
RU2422156C2 (ru) 2011-06-27
JP2014111654A (ja) 2014-06-19
EP1778291B1 (en) 2013-10-30
US20120207781A1 (en) 2012-08-16
JP6661568B2 (ja) 2020-03-11
ES2688796T3 (es) 2018-11-07
CN1976725B (zh) 2012-08-29
JP6218327B2 (ja) 2017-10-25
US8163296B2 (en) 2012-04-24
RU2007102016A (ru) 2008-07-27
EP2374473A1 (en) 2011-10-12
WO2006000920A3 (en) 2006-03-30
AU2005256961A1 (en) 2006-01-05
NZ552449A (en) 2010-05-28
BRPI0512281A (pt) 2008-02-26
AU2005256961B2 (en) 2011-06-23
EP2374473B1 (en) 2018-07-18
CA2571565C (en) 2014-08-12
JP2017134084A (ja) 2017-08-03
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US20080248059A1 (en) 2008-10-09
JP2011246490A (ja) 2011-12-08
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CN1976725A (zh) 2007-06-06
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