ES2688796T3 - Análisis dimensional de conjugados de sacáridos con GPC y SEC-MALS - Google Patents
Análisis dimensional de conjugados de sacáridos con GPC y SEC-MALS Download PDFInfo
- Publication number
- ES2688796T3 ES2688796T3 ES11163751.8T ES11163751T ES2688796T3 ES 2688796 T3 ES2688796 T3 ES 2688796T3 ES 11163751 T ES11163751 T ES 11163751T ES 2688796 T3 ES2688796 T3 ES 2688796T3
- Authority
- ES
- Spain
- Prior art keywords
- conjugate
- conjugates
- molar mass
- serogroup
- mals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Spectrometry And Color Measurement (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0413868 | 2004-06-21 | ||
| GBGB0413868.1A GB0413868D0 (en) | 2004-06-21 | 2004-06-21 | Dimensional anlaysis of saccharide conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2688796T3 true ES2688796T3 (es) | 2018-11-07 |
Family
ID=32750313
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11163751.8T Expired - Lifetime ES2688796T3 (es) | 2004-06-21 | 2005-06-21 | Análisis dimensional de conjugados de sacáridos con GPC y SEC-MALS |
| ES05770612.9T Expired - Lifetime ES2443465T3 (es) | 2004-06-21 | 2005-06-21 | Análisis dimensional de conjugados de sacáridos con GPC y SEC-MALS |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05770612.9T Expired - Lifetime ES2443465T3 (es) | 2004-06-21 | 2005-06-21 | Análisis dimensional de conjugados de sacáridos con GPC y SEC-MALS |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8163296B2 (https=) |
| EP (2) | EP2374473B1 (https=) |
| JP (5) | JP2008503716A (https=) |
| CN (1) | CN1976725B (https=) |
| AU (1) | AU2005256961B2 (https=) |
| BR (1) | BRPI0512281A (https=) |
| CA (1) | CA2571565C (https=) |
| ES (2) | ES2688796T3 (https=) |
| GB (1) | GB0413868D0 (https=) |
| MX (2) | MXPA06015188A (https=) |
| NZ (1) | NZ552449A (https=) |
| RU (1) | RU2422156C2 (https=) |
| WO (1) | WO2006000920A2 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| GB0413868D0 (en) * | 2004-06-21 | 2004-07-21 | Chiron Srl | Dimensional anlaysis of saccharide conjugates |
| US8398983B2 (en) | 2005-06-27 | 2013-03-19 | Glaxosmithkline Biologicals, S.A. | Immunogenic composition |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| TW201009337A (en) * | 2008-05-30 | 2010-03-01 | Intervet Int Bv | Analytical method to monitor vaccine potency and stability |
| JP6151021B2 (ja) | 2009-06-01 | 2017-06-21 | ウオーターズ・テクノロジーズ・コーポレイシヨン | クロマトグラフ分離用ハイブリッド材料 |
| US8195405B2 (en) * | 2009-06-30 | 2012-06-05 | Wyatt Technology Corporation | Method for characterizing reversible association of macromolecules at high concentration |
| BR112012010223A2 (pt) | 2009-10-30 | 2016-12-06 | Novartis Ag | purificação de staphylococcus aureus tipo 5 e tipo 8 sacarídeos capsulares |
| CN109078626A (zh) * | 2009-12-15 | 2018-12-25 | 沃特世科技公司 | 实施体积排阻色谱的设备和方法 |
| AU2011258165B2 (en) * | 2010-05-26 | 2016-11-17 | Selecta Biosciences, Inc. | Dose selection of adjuvanted synthetic nanocarriers |
| JP5856162B2 (ja) | 2010-07-26 | 2016-02-09 | ウオーターズ・テクノロジーズ・コーポレイシヨン | 粒度分布の狭い実質的に非多孔質のハイブリッドコアを含む表面多孔質材料 |
| KR101594228B1 (ko) | 2010-08-23 | 2016-02-15 | 와이어쓰 엘엘씨 | 네이세리아 메닌기티디스 ｒＬＰ２０８６ 항원의 안정한 제제 |
| NZ607224A (en) | 2010-09-10 | 2014-11-28 | Wyeth Llc | Non-lipidated variants of neisseria meningitidis orf2086 antigens |
| MX359256B (es) | 2012-03-09 | 2018-09-19 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas. |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| US10481164B2 (en) | 2012-03-26 | 2019-11-19 | Amgen Inc. | Method for using light scattering in real time to directly monitor and control impurity removal in purification processes |
| US9802987B2 (en) | 2013-03-08 | 2017-10-31 | Pfizer Inc. | Immunogenic fusion polypeptides |
| RU2662968C2 (ru) | 2013-09-08 | 2018-07-31 | Пфайзер Инк. | Иммуногенная композиция против neisseria meningitidis (варианты) |
| AU2016221318B2 (en) | 2015-02-19 | 2020-06-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| KR102906912B1 (ko) | 2016-09-02 | 2026-01-05 | 사노피 파스퇴르 인크 | 네이세리아 메닌기티디스 백신 |
| ES3024474T3 (en) | 2016-12-30 | 2025-06-04 | Vaxcyte Inc | Polypeptide-antigen conjugates with non-natural amino acids |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| AU2018215585B2 (en) | 2017-01-31 | 2022-03-17 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| CN109459523B (zh) * | 2017-09-06 | 2022-11-08 | 上海绿谷制药有限公司 | 一种测定酸性糖可溶性盐重均分子量和含量的方法 |
| CN109459504B (zh) * | 2017-09-06 | 2022-05-27 | 绿谷(上海)医药科技有限公司 | 一种测定聚古罗糖醛酸硫酸酯盐重均分子量和含量的方法 |
| EP4034157A1 (en) | 2019-09-27 | 2022-08-03 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| JP7409055B2 (ja) * | 2019-12-05 | 2024-01-09 | 株式会社島津製作所 | 検出器の出力を補正する方法、および多角度光散乱検出器 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4057685A (en) | 1972-02-02 | 1977-11-08 | Abbott Laboratories | Chemically modified endotoxin immunizing agent |
| US4356170A (en) | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| US4673574A (en) | 1981-08-31 | 1987-06-16 | Anderson Porter W | Immunogenic conjugates |
| US4459286A (en) | 1983-01-31 | 1984-07-10 | Merck & Co., Inc. | Coupled H. influenzae type B vaccine |
| US4663160A (en) | 1983-03-14 | 1987-05-05 | Miles Laboratories, Inc. | Vaccines for gram-negative bacteria |
| US4761283A (en) | 1983-07-05 | 1988-08-02 | The University Of Rochester | Immunogenic conjugates |
| US4808700A (en) | 1984-07-09 | 1989-02-28 | Praxis Biologics, Inc. | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
| JPH01125328A (ja) | 1987-07-30 | 1989-05-17 | Centro Natl De Biopreparados | 髄膜炎菌ワクチン |
| NL8802046A (nl) | 1988-08-18 | 1990-03-16 | Gen Electric | Polymeermengsel met polyester en alkaansulfonaat, daaruit gevormde voorwerpen. |
| DE3841091A1 (de) | 1988-12-07 | 1990-06-13 | Behringwerke Ag | Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung |
| EP0378881B1 (en) | 1989-01-17 | 1993-06-09 | ENIRICERCHE S.p.A. | Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines |
| WO1991001146A1 (en) | 1989-07-14 | 1991-02-07 | Praxis Biologics, Inc. | Cytokine and hormone carriers for conjugate vaccines |
| IT1237764B (it) | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
| SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
| IL98715A0 (en) | 1990-08-13 | 1992-07-15 | American Cyanamid Co | Filamentous hemaglutinin of bodetella pertussis as a carrier molecule for conjugate vaccines |
| US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
| IT1262896B (it) | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
| IL102687A (en) | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
| TR199701547T1 (xx) | 1995-06-07 | 1998-03-21 | Smithkline Beecham Biologicals S.A. | Polisakarit antijen protein e�leni�i i�eren a��. |
| US6299881B1 (en) | 1997-03-24 | 2001-10-09 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts |
| GB9713156D0 (en) | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
| US7018637B2 (en) * | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
| JP2004505885A (ja) | 1998-08-19 | 2004-02-26 | ノース アメリカン ワクチン， インコーポレイテッド | Ｎ−アクリロイル化ポリサッカリドを用いて産生されたワクチンとして有用な免疫原性β−プロピオンアミド連結ポリサッカリド−タンパク質結合体 |
| ES2275499T3 (es) | 1999-03-19 | 2007-06-16 | Glaxosmithkline Biologicals S.A. | Vacuna contra streptococcus pneumoniae. |
| WO2000061761A2 (en) | 1999-04-09 | 2000-10-19 | Techlab, Inc. | Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines |
| PT2289545T (pt) | 2000-01-17 | 2016-09-06 | Glaxosmithkline Biologicals Sa | Vacina de omv suplementada contra meningococos |
| GB0007432D0 (en) | 2000-03-27 | 2000-05-17 | Microbiological Res Authority | Proteins for use as carriers in conjugate vaccines |
| US6936261B2 (en) | 2000-07-27 | 2005-08-30 | Children's Hospital & Research Center At Oakland | Vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis |
| GB0103170D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| OA12590A (en) * | 2001-01-23 | 2006-06-08 | Aventis Pasteur | Multivalent meningococcal polysaccharide-protein conjugate vaccine. |
| AU2002309706A1 (en) | 2001-05-11 | 2002-11-25 | Aventis Pasteur, Inc. | Novel meningitis conjugate vaccine |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| HUE031886T2 (en) * | 2002-10-11 | 2017-08-28 | Glaxosmithkline Biologicals Sa | Polypeptide vaccines for extensive protection against hypervirulent meningococcal lines |
| ES2461350T3 (es) * | 2003-01-30 | 2014-05-19 | Novartis Ag | Vacunas inyectables contra múltiples serogrupos de meningococos |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| CN103357002A (zh) * | 2003-10-02 | 2013-10-23 | 诺华疫苗和诊断有限公司 | 多种脑膜炎球菌血清群的液体疫苗 |
| GB0408978D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Meningococcal fermentation for preparing conjugate vaccines |
| GB0413868D0 (en) * | 2004-06-21 | 2004-07-21 | Chiron Srl | Dimensional anlaysis of saccharide conjugates |
-
2004
- 2004-06-21 GB GBGB0413868.1A patent/GB0413868D0/en not_active Ceased
-
2005
- 2005-06-21 JP JP2007516078A patent/JP2008503716A/ja not_active Withdrawn
- 2005-06-21 EP EP11163751.8A patent/EP2374473B1/en not_active Expired - Lifetime
- 2005-06-21 AU AU2005256961A patent/AU2005256961B2/en not_active Expired
- 2005-06-21 ES ES11163751.8T patent/ES2688796T3/es not_active Expired - Lifetime
- 2005-06-21 NZ NZ552449A patent/NZ552449A/en not_active IP Right Cessation
- 2005-06-21 WO PCT/IB2005/002532 patent/WO2006000920A2/en not_active Ceased
- 2005-06-21 US US11/630,545 patent/US8163296B2/en active Active
- 2005-06-21 BR BRPI0512281-3A patent/BRPI0512281A/pt not_active Application Discontinuation
- 2005-06-21 ES ES05770612.9T patent/ES2443465T3/es not_active Expired - Lifetime
- 2005-06-21 CN CN2005800204436A patent/CN1976725B/zh not_active Expired - Lifetime
- 2005-06-21 RU RU2007102016/15A patent/RU2422156C2/ru active IP Right Revival
- 2005-06-21 CA CA2571565A patent/CA2571565C/en not_active Expired - Lifetime
- 2005-06-21 EP EP05770612.9A patent/EP1778291B1/en not_active Expired - Lifetime
- 2005-06-21 MX MXPA06015188A patent/MXPA06015188A/es active IP Right Grant
-
2006
- 2006-12-20 MX MX2011011568A patent/MX344621B/es unknown
-
2011
- 2011-09-02 JP JP2011192126A patent/JP2011246490A/ja not_active Withdrawn
-
2012
- 2012-04-24 US US13/454,658 patent/US20120207781A1/en not_active Abandoned
-
2014
- 2014-03-11 JP JP2014047555A patent/JP6218327B2/ja not_active Expired - Lifetime
-
2015
- 2015-07-21 JP JP2015143718A patent/JP2015180707A/ja active Pending
-
2017
- 2017-04-21 JP JP2017084454A patent/JP6661568B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015180707A (ja) | 2015-10-15 |
| ES2443465T3 (es) | 2014-02-19 |
| JP2008503716A (ja) | 2008-02-07 |
| EP1778291A2 (en) | 2007-05-02 |
| RU2422156C2 (ru) | 2011-06-27 |
| JP2014111654A (ja) | 2014-06-19 |
| EP1778291B1 (en) | 2013-10-30 |
| US20120207781A1 (en) | 2012-08-16 |
| JP6661568B2 (ja) | 2020-03-11 |
| CN1976725B (zh) | 2012-08-29 |
| JP6218327B2 (ja) | 2017-10-25 |
| US8163296B2 (en) | 2012-04-24 |
| RU2007102016A (ru) | 2008-07-27 |
| EP2374473A1 (en) | 2011-10-12 |
| WO2006000920A3 (en) | 2006-03-30 |
| AU2005256961A1 (en) | 2006-01-05 |
| NZ552449A (en) | 2010-05-28 |
| BRPI0512281A (pt) | 2008-02-26 |
| AU2005256961B2 (en) | 2011-06-23 |
| EP2374473B1 (en) | 2018-07-18 |
| CA2571565C (en) | 2014-08-12 |
| JP2017134084A (ja) | 2017-08-03 |
| GB0413868D0 (en) | 2004-07-21 |
| US20080248059A1 (en) | 2008-10-09 |
| JP2011246490A (ja) | 2011-12-08 |
| CA2571565A1 (en) | 2006-01-05 |
| CN1976725A (zh) | 2007-06-06 |
| MX344621B (es) | 2017-01-03 |
| WO2006000920A2 (en) | 2006-01-05 |
| MXPA06015188A (es) | 2007-03-27 |
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