AU2005256961B2 - Dimensional analysis of saccharide conjugates with GPC & SEC-MALS - Google Patents

Dimensional analysis of saccharide conjugates with GPC & SEC-MALS Download PDF

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Publication number
AU2005256961B2
AU2005256961B2 AU2005256961A AU2005256961A AU2005256961B2 AU 2005256961 B2 AU2005256961 B2 AU 2005256961B2 AU 2005256961 A AU2005256961 A AU 2005256961A AU 2005256961 A AU2005256961 A AU 2005256961A AU 2005256961 B2 AU2005256961 B2 AU 2005256961B2
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AU
Australia
Prior art keywords
conjugate
serogroup
capsular saccharide
meningitidis
molecular size
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Expired
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AU2005256961A
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English (en)
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AU2005256961A1 (en
Inventor
Giorgio Capannoli
Valeria Carinci
Sandro D'ascenzi
Claudia Magagnoli
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GlaxoSmithKline Biologicals SA
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GlaxoSmithKline Biologicals SA
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Publication of AU2005256961A1 publication Critical patent/AU2005256961A1/en
Assigned to NOVARTIS VACCINES AND DIAGNOSTICS SRL reassignment NOVARTIS VACCINES AND DIAGNOSTICS SRL Alteration of Name(s) of Applicant(s) under S113 Assignors: CHIRON SRL
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Publication of AU2005256961B2 publication Critical patent/AU2005256961B2/en
Assigned to GLAXOSMITHKLINE BIOLOGICALS S.A. reassignment GLAXOSMITHKLINE BIOLOGICALS S.A. Request for Assignment Assignors: NOVARTIS VACCINES AND DIAGNOSTICS SRL
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Spectrometry And Color Measurement (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
AU2005256961A 2004-06-21 2005-06-21 Dimensional analysis of saccharide conjugates with GPC & SEC-MALS Expired AU2005256961B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0413868.1 2004-06-21
GBGB0413868.1A GB0413868D0 (en) 2004-06-21 2004-06-21 Dimensional anlaysis of saccharide conjugates
PCT/IB2005/002532 WO2006000920A2 (en) 2004-06-21 2005-06-21 Dimensional analysis of saccharide conjugates with gpc & sec-mals

Publications (2)

Publication Number Publication Date
AU2005256961A1 AU2005256961A1 (en) 2006-01-05
AU2005256961B2 true AU2005256961B2 (en) 2011-06-23

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005256961A Expired AU2005256961B2 (en) 2004-06-21 2005-06-21 Dimensional analysis of saccharide conjugates with GPC & SEC-MALS

Country Status (13)

Country Link
US (2) US8163296B2 (https=)
EP (2) EP2374473B1 (https=)
JP (5) JP2008503716A (https=)
CN (1) CN1976725B (https=)
AU (1) AU2005256961B2 (https=)
BR (1) BRPI0512281A (https=)
CA (1) CA2571565C (https=)
ES (2) ES2688796T3 (https=)
GB (1) GB0413868D0 (https=)
MX (2) MXPA06015188A (https=)
NZ (1) NZ552449A (https=)
RU (1) RU2422156C2 (https=)
WO (1) WO2006000920A2 (https=)

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TW201009337A (en) * 2008-05-30 2010-03-01 Intervet Int Bv Analytical method to monitor vaccine potency and stability
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US8195405B2 (en) * 2009-06-30 2012-06-05 Wyatt Technology Corporation Method for characterizing reversible association of macromolecules at high concentration
BR112012010223A2 (pt) 2009-10-30 2016-12-06 Novartis Ag purificação de staphylococcus aureus tipo 5 e tipo 8 sacarídeos capsulares
CN109078626A (zh) * 2009-12-15 2018-12-25 沃特世科技公司 实施体积排阻色谱的设备和方法
AU2011258165B2 (en) * 2010-05-26 2016-11-17 Selecta Biosciences, Inc. Dose selection of adjuvanted synthetic nanocarriers
JP5856162B2 (ja) 2010-07-26 2016-02-09 ウオーターズ・テクノロジーズ・コーポレイシヨン 粒度分布の狭い実質的に非多孔質のハイブリッドコアを含む表面多孔質材料
KR101594228B1 (ko) 2010-08-23 2016-02-15 와이어쓰 엘엘씨 네이세리아 메닌기티디스 ｒＬＰ２０８６ 항원의 안정한 제제
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MX359256B (es) 2012-03-09 2018-09-19 Pfizer Composiciones de neisseria meningitidis y metodos de las mismas.
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US10481164B2 (en) 2012-03-26 2019-11-19 Amgen Inc. Method for using light scattering in real time to directly monitor and control impurity removal in purification processes
US9802987B2 (en) 2013-03-08 2017-10-31 Pfizer Inc. Immunogenic fusion polypeptides
RU2662968C2 (ru) 2013-09-08 2018-07-31 Пфайзер Инк. Иммуногенная композиция против neisseria meningitidis (варианты)
AU2016221318B2 (en) 2015-02-19 2020-06-25 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
KR102906912B1 (ko) 2016-09-02 2026-01-05 사노피 파스퇴르 인크 네이세리아 메닌기티디스 백신
ES3024474T3 (en) 2016-12-30 2025-06-04 Vaxcyte Inc Polypeptide-antigen conjugates with non-natural amino acids
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
AU2018215585B2 (en) 2017-01-31 2022-03-17 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
CN109459523B (zh) * 2017-09-06 2022-11-08 上海绿谷制药有限公司 一种测定酸性糖可溶性盐重均分子量和含量的方法
CN109459504B (zh) * 2017-09-06 2022-05-27 绿谷(上海)医药科技有限公司 一种测定聚古罗糖醛酸硫酸酯盐重均分子量和含量的方法
EP4034157A1 (en) 2019-09-27 2022-08-03 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
JP7409055B2 (ja) * 2019-12-05 2024-01-09 株式会社島津製作所 検出器の出力を補正する方法、および多角度光散乱検出器

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Also Published As

Publication number Publication date
JP2015180707A (ja) 2015-10-15
ES2443465T3 (es) 2014-02-19
JP2008503716A (ja) 2008-02-07
EP1778291A2 (en) 2007-05-02
RU2422156C2 (ru) 2011-06-27
JP2014111654A (ja) 2014-06-19
EP1778291B1 (en) 2013-10-30
US20120207781A1 (en) 2012-08-16
JP6661568B2 (ja) 2020-03-11
ES2688796T3 (es) 2018-11-07
CN1976725B (zh) 2012-08-29
JP6218327B2 (ja) 2017-10-25
US8163296B2 (en) 2012-04-24
RU2007102016A (ru) 2008-07-27
EP2374473A1 (en) 2011-10-12
WO2006000920A3 (en) 2006-03-30
AU2005256961A1 (en) 2006-01-05
NZ552449A (en) 2010-05-28
BRPI0512281A (pt) 2008-02-26
EP2374473B1 (en) 2018-07-18
CA2571565C (en) 2014-08-12
JP2017134084A (ja) 2017-08-03
GB0413868D0 (en) 2004-07-21
US20080248059A1 (en) 2008-10-09
JP2011246490A (ja) 2011-12-08
CA2571565A1 (en) 2006-01-05
CN1976725A (zh) 2007-06-06
MX344621B (es) 2017-01-03
WO2006000920A2 (en) 2006-01-05
MXPA06015188A (es) 2007-03-27

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Owner name: GLAXOSMITHKLINE BIOLOGICALS S.A.

Free format text: FORMER OWNER(S): NOVARTIS VACCINES AND DIAGNOSTICS SRL

MK14 Patent ceased section 143(a) (annual fees not paid) or expired