|
US3225539A
(en)
|
1962-06-20 |
1965-12-28 |
George C Coverston |
Explosion inertia turbine engine
|
|
NL154598B
(nl)
|
1970-11-10 |
1977-09-15 |
Organon Nv |
Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
|
|
US3901654A
(en)
|
1971-06-21 |
1975-08-26 |
Biological Developments |
Receptor assays of biologically active compounds employing biologically specific receptors
|
|
US3817827A
(en)
|
1972-03-30 |
1974-06-18 |
Scott Paper Co |
Soft absorbent fibrous webs containing elastomeric bonding material and formed by creping and embossing
|
|
US4098876A
(en)
|
1976-10-26 |
1978-07-04 |
Corning Glass Works |
Reverse sandwich immunoassay
|
|
US4172124A
(en)
|
1978-04-28 |
1979-10-23 |
The Wistar Institute |
Method of producing tumor antibodies
|
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
US4699880A
(en)
|
1984-09-25 |
1987-10-13 |
Immunomedics, Inc. |
Method of producing monoclonal anti-idiotype antibody
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5092885A
(en)
|
1987-02-12 |
1992-03-03 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Peptides with laminin activity
|
|
JPH02500329A
(ja)
|
1987-05-21 |
1990-02-08 |
クリエイテイブ・バイオマリキユールズ・インコーポレーテツド |
ターゲット化多機能蛋白質
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
IL162181A
(en)
|
1988-12-28 |
2006-04-10 |
Pdl Biopharma Inc |
A method of producing humanized immunoglubulin, and polynucleotides encoding the same
|
|
US5530101A
(en)
*
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5112946A
(en)
|
1989-07-06 |
1992-05-12 |
Repligen Corporation |
Modified pf4 compositions and methods of use
|
|
US5192744A
(en)
|
1990-01-12 |
1993-03-09 |
Northwestern University |
Method of inhibiting angiogenesis of tumors
|
|
JPH04218000A
(ja)
|
1990-02-13 |
1992-08-07 |
Kirin Amgen Inc |
修飾ポリペプチド
|
|
GB9014932D0
(en)
|
1990-07-05 |
1990-08-22 |
Celltech Ltd |
Recombinant dna product and method
|
|
ATE130517T1
(de)
|
1990-08-08 |
1995-12-15 |
Takeda Chemical Industries Ltd |
Intravaskulär embolisierendes mittel mit gehalt an einem die angiogenesis hemmenden stoff.
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
ES2246502T3
(es)
|
1990-08-29 |
2006-02-16 |
Genpharm International, Inc. |
Animales no humanos transgenicos capaces de producir anticuerpos heterologos.
|
|
AU1411992A
(en)
|
1991-01-15 |
1992-08-27 |
Robert A Bok |
A composition containing a tetracycline and use for inhibiting angiogenesis
|
|
DE69233482T2
(de)
|
1991-05-17 |
2006-01-12 |
Merck & Co., Inc. |
Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
ATE278019T1
(de)
|
1991-06-21 |
2004-10-15 |
Inst Medical W & E Hall |
Neuartige rezeptor-typ tyrosinkinase und deren verwendung
|
|
JP3540315B2
(ja)
|
1991-09-23 |
2004-07-07 |
メディカル リサーチ カウンシル |
キメラ抗体の製造−組合せアプローチ
|
|
JPH05244982A
(ja)
|
1991-12-06 |
1993-09-24 |
Sumitomo Chem Co Ltd |
擬人化ｂ−ｂ１０
|
|
JPH07504813A
(ja)
|
1992-01-22 |
1995-06-01 |
ニユー・イングランド・デイーコネス・ホスピタル |
新規蛋白質チロシンキナーゼ類
|
|
US5635177A
(en)
*
|
1992-01-22 |
1997-06-03 |
Genentech, Inc. |
Protein tyrosine kinase agonist antibodies
|
|
US6331302B1
(en)
*
|
1992-01-22 |
2001-12-18 |
Genentech, Inc. |
Protein tyrosine kinase agonist antibodies
|
|
KR100335584B1
(ko)
|
1992-10-28 |
2002-11-29 |
제넨테크, 인코포레이티드 |
혈관내피세포성장인자에대한길항제
|
|
US5824303A
(en)
*
|
1992-11-13 |
1998-10-20 |
Amgen Inc. |
Eck receptor ligands
|
|
FI952328A7
(fi)
|
1992-11-13 |
1995-07-10 |
Amgen Inc |
eck-respetorin lignandeja
|
|
DE614989T1
(de)
|
1993-02-17 |
1995-09-28 |
Morphosys Proteinoptimierung |
Verfahren für in vivo Selektion von Ligandenbindende Proteine.
|
|
US5512591A
(en)
*
|
1993-02-18 |
1996-04-30 |
President And Fellows Of Harvard College |
Treatments for diseases characterized by neovascularization
|
|
ES2152753B1
(es)
|
1993-03-29 |
2001-09-01 |
Ct Investig Energeticas Ciemat |
Animales transgenicos para la determinacion de agentes que estimulan o reprimen la hiperproliferacion epidermica y el crecimiento del pelo
|
|
US6303769B1
(en)
|
1994-07-08 |
2001-10-16 |
Immunex Corporation |
Lerk-5 dna
|
|
US5864020A
(en)
*
|
1994-07-20 |
1999-01-26 |
Genentech, Inc. |
HTK ligand
|
|
AU3144195A
(en)
|
1994-07-26 |
1996-02-22 |
Rutgers, The State University Of New Jersey |
Human brain specific kinase
|
|
US5795734A
(en)
|
1994-09-19 |
1998-08-18 |
President And Fellows Of Harvard College |
EPH receptor ligands, and uses related thereto
|
|
WO1996013518A1
(en)
|
1994-10-27 |
1996-05-09 |
Genentech, Inc. |
Al-1 neurotrophic factor, a ligand for an eph-related tyrosine kinase receptor
|
|
US6057124A
(en)
|
1995-01-27 |
2000-05-02 |
Amgen Inc. |
Nucleic acids encoding ligands for HEK4 receptors
|
|
WO1996026958A2
(en)
|
1995-02-27 |
1996-09-06 |
President And Fellows Of Harvard College |
Eph RECEPTOR LIGAND ELF-2
|
|
GB9508538D0
(en)
*
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
|
PT848755E
(pt)
|
1995-09-08 |
2003-12-31 |
Genentech Inc |
Proteina relacionada com o vegf
|
|
EP0857210B1
(en)
|
1995-10-23 |
2003-09-03 |
The Children's Medical Center Corporation |
Therapeutic antiangiogenic compositions and methods
|
|
US5837534A
(en)
*
|
1995-11-14 |
1998-11-17 |
The Board Of Regents Of The University Of Texas System |
Smooth muscle 22α promoter, gene transfer vectors containing the same, and method of use of the same to target gene expression in arterial smooth muscle cells
|
|
AUPN727795A0
(en)
|
1995-12-22 |
1996-01-18 |
Walter And Eliza Hall Institute Of Medical Research, The |
A novel receptor-type tyrosine kinase and use thereof
|
|
NZ331104A
(en)
|
1995-12-29 |
2000-03-27 |
Boehringer Ingelheim Ca Ltd |
Phenyl thiazole derivatives that inhibit herpes replication by inhibiting the herpes helicase primase enzyme complex
|
|
US6465431B1
(en)
|
1999-11-17 |
2002-10-15 |
Boston Life Sciences, Inc. |
Pharmaceutical compositions comprising troponin subunits, fragments and homologs thereof and methods of their use to inhibit angiogenesis
|
|
US6100071A
(en)
|
1996-05-07 |
2000-08-08 |
Genentech, Inc. |
Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
|
|
SK163598A3
(en)
|
1996-05-31 |
1999-06-11 |
Scripps Research Inst |
Methods and compositions useful for inhibition of angiogenesis
|
|
CA2259157A1
(en)
*
|
1996-07-05 |
1998-01-15 |
Mount Sinai Hospital Corporation |
Oligomerized receptors which affect pathways regulated by transmembrane ligands for elk-related receptor tyrosine kinases
|
|
US6321439B1
(en)
|
1997-01-21 |
2001-11-27 |
Siemens Westinghouse Power Corporation |
Method for assembly of a stator in the field
|
|
UA73073C2
(uk)
|
1997-04-03 |
2005-06-15 |
Уайт Холдінгз Корпорейшн |
Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
|
|
DE69829891T2
(de)
|
1997-04-07 |
2005-10-06 |
Genentech, Inc., South San Francisco |
Anti-VEGF Antikörper
|
|
AU6887698A
(en)
|
1997-04-08 |
1998-10-30 |
Sugen, Inc. |
Study and treatment of diseases related to specific cellular functions of receptor protein tyrosine kinases
|
|
US6440954B1
(en)
*
|
1997-04-18 |
2002-08-27 |
President And Fellows Of Harvard College |
Inhibition of vascular smooth muscle cell proliferation
|
|
US6555321B1
(en)
|
1997-08-19 |
2003-04-29 |
Vanderbilt University |
Methods for determining cell responses through EphB receptors
|
|
EP1019080A2
(en)
|
1997-10-02 |
2000-07-19 |
Leukosite, Inc. |
Modulation of lerk-2-mediated cell adhesion
|
|
US6475784B1
(en)
|
1997-11-14 |
2002-11-05 |
Valentis, Inc. |
Inhibition of angiogenesis by delivery of nucleic acids encoding anti-angiogenic polypeptides
|
|
JP4418105B2
(ja)
|
1997-12-26 |
2010-02-17 |
持田製薬株式会社 |
ジエノゲストを有効成分とする血管新生抑制剤
|
|
DE69921102T2
(de)
*
|
1998-03-05 |
2006-02-02 |
Chiron Corp., Emeryville |
Verfahren zur verbesserung der serum-halbwertszeit von biologisch aktiven molekülen
|
|
US6864227B1
(en)
*
|
1998-04-13 |
2005-03-08 |
California Institute Of Technology |
Artery-and vein-specific proteins and uses therefor
|
|
US6887674B1
(en)
*
|
1998-04-13 |
2005-05-03 |
California Institute Of Technology |
Artery- and vein-specific proteins and uses therefor
|
|
AU3980499A
(en)
|
1998-05-11 |
1999-11-29 |
Endowment for Research in Human Biology, Inc., The |
Use of neomycin for treating angiogenesis-related diseases
|
|
US6413513B1
(en)
|
1998-05-22 |
2002-07-02 |
Entremed, Inc. |
Compositions and methods for inhibiting endothelial cell proliferation and regulating angiogenesis using cancer markers
|
|
US6395718B1
(en)
|
1998-07-06 |
2002-05-28 |
Guilford Pharmaceuticals Inc. |
Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors
|
|
US6500431B1
(en)
|
1998-07-13 |
2002-12-31 |
University Of Southern California |
Inhibitors of angiogenesis and tumor growth
|
|
WO2000003726A1
(en)
|
1998-07-14 |
2000-01-27 |
Bristol-Myers Squibb Company |
Lysine binding fragments of angiostatin
|
|
WO2000010507A2
(en)
|
1998-08-21 |
2000-03-02 |
The Children's Medical Center Corporation |
Use of melanin for inhibition of angiogenesis and macular degeneration
|
|
AU8788998A
(en)
|
1998-10-02 |
2000-04-06 |
Universite Paris 7 |
Vascular specific regulatory elements contained in the desmin 5' flanking region
|
|
AUPP674898A0
(en)
|
1998-10-27 |
1998-11-19 |
Walter And Eliza Hall Institute Of Medical Research, The |
A method of treatment
|
|
ES2242437T3
(es)
*
|
1998-11-20 |
2005-11-01 |
Genentech, Inc. |
Utilizaciones de agonistas y antagonistas del receptor eph para el tratamiento de trastornos vasculares.
|
|
US6373256B1
(en)
|
1999-01-08 |
2002-04-16 |
Fairchild Semiconductor Corporation |
Programmable low battery detector
|
|
EP1242352A2
(en)
|
1999-12-23 |
2002-09-25 |
University Of Georgia Research Foundation, Inc. |
Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states
|
|
EP1246637A2
(en)
|
2000-01-06 |
2002-10-09 |
The Hospital for Sick Children |
Methods of modulation of the immune system
|
|
JP2003528632A
(ja)
|
2000-03-31 |
2003-09-30 |
インスティティ・パスツール |
血管内皮成長因子（ｖｅｇｆ）−媒介性脈管形成を阻害するペプチド、該ペプチドをエンコードするポリヌクレオチド及びその使用方法
|
|
JP2003530871A
(ja)
|
2000-04-21 |
2003-10-21 |
アムジエン・インコーポレーテツド |
インテグリン／接着因子アンタゴニスト
|
|
US6318298B1
(en)
|
2000-05-05 |
2001-11-20 |
Dan Nonay |
Automatic, on-demand, self-adjusting brushing system for use with large animals, such as cows
|
|
CA2417982A1
(en)
|
2000-08-03 |
2002-02-14 |
The University Of Utah Research Foundation |
Manipulation of arterial-venous identity
|
|
WO2002026827A1
(en)
|
2000-09-29 |
2002-04-04 |
Novartis Ag |
Extracellular polypeptides of eph b receptors and ephrin b ligands and the corresponding nucleic acid molecules
|
|
US6548477B1
(en)
|
2000-11-01 |
2003-04-15 |
Praecis Pharmaceuticals Inc. |
Therapeutic agents and methods of use thereof for the modulation of angiogenesis
|
|
DE60127291T2
(de)
*
|
2000-11-20 |
2007-12-20 |
California Institute Of Technology, Pasadena |
Für den glatten muskel von arterien und den glatten muskel von venen spezifische proteine und deren verwendung
|
|
US6958140B2
(en)
|
2001-01-26 |
2005-10-25 |
Regeneron Pharmaceuticals, Inc. |
Methods of imaging and targeting vasculature
|
|
US20040132634A1
(en)
|
2001-01-31 |
2004-07-08 |
Frank Sicheri |
Compositions and methods for regulating the kinase domain of receptor tyrosine kinases
|
|
WO2002079382A2
(en)
|
2001-03-30 |
2002-10-10 |
President And Fellows Of Harvard College |
B-ephrin regulation of g-protein coupled chemoattraction; compositions and methods of use
|
|
EP1409549A4
(en)
|
2001-06-20 |
2007-10-24 |
Genentech Inc |
COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMORS
|
|
IL159177A0
(en)
|
2001-06-20 |
2004-06-01 |
Prochon Biotech Ltd |
Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof
|
|
US20040247592A1
(en)
*
|
2001-07-03 |
2004-12-09 |
Roifman Chaim M. |
Ephrin and eph receptor mediated immune modulation
|
|
US20060241027A1
(en)
*
|
2002-02-07 |
2006-10-26 |
Hans-Peter Hauser |
Hiv inhibiting proteins
|
|
EP1519956B1
(en)
|
2002-05-10 |
2011-09-21 |
Medimmune, Inc. |
Epha2 monoclonal antibodies and methods of use thereof
|
|
EP1575509B1
(en)
|
2002-05-10 |
2011-10-26 |
Purdue Research Foundation |
Epha2 agonistic monoclonal antibodies and methods of use thereof
|
|
US20040110150A1
(en)
*
|
2002-12-10 |
2004-06-10 |
Isis Pharmaceuticals Inc. |
Modulation of Ephrin-B2 expression
|
|
WO2004020468A2
(en)
|
2002-08-28 |
2004-03-11 |
Maxygen Aps |
Interferon beta-like molecules for treatment of cancer
|
|
AU2002951409A0
(en)
*
|
2002-09-16 |
2002-09-26 |
North Western Adelaide Health Services |
Methods for regulating cancer
|
|
AU2003260169B9
(en)
*
|
2002-09-16 |
2011-06-09 |
The Queen Elizabeth Hospital Research Foundation Inc. |
Methods for regulating cancer
|
|
EP1605961A4
(en)
*
|
2003-03-12 |
2009-11-11 |
Vasgene Therapeutics Inc |
POLYPEPTIDE COMPOUNDS FOR INHIBITING ANGIOGENESIS AND TUMOR GROWTH
|
|
NZ543122A
(en)
*
|
2003-03-24 |
2008-07-31 |
Sequoia Pharmaceuticals Inc |
An HIV fusion inhibitor peptide covalently linked to a blood protein
|
|
EP1617864A4
(en)
|
2003-04-11 |
2006-06-21 |
Medimmune Inc |
EPHA2 AND NON-NEOPLASTIC HYPERPROLIFERATIVE CELL TROUBLESHOOTING
|
|
EP1618184A4
(en)
*
|
2003-04-11 |
2006-06-21 |
Medimmune Inc |
EPHA2, HYPOPROLIFERATIVE CELL DISORDERS, AND EPITHELIAL AND ENDOTHELIAL RECONSTITUTION
|
|
WO2005048917A2
(en)
|
2003-06-06 |
2005-06-02 |
Medimmune, Inc. |
Use of epha4 and modulator or epha4 for diagnosis, treatment and prevention of cancer
|
|
DK1677735T3
(da)
*
|
2003-10-17 |
2014-10-27 |
Joslin Diabetes Center Inc |
Fremgangsmåder og sammensætninger til modulering af adipocytfunktion
|
|
KR20060135671A
(ko)
|
2003-11-20 |
2006-12-29 |
메디뮨 인코포레이티드 |
ＥｐｈＡ２ 작동성 모노클로날 항체 및 이의 사용 방법
|
|
WO2005090406A2
(en)
|
2004-03-12 |
2005-09-29 |
Vasgene Therapeutics, Inc. |
Antibodies binding to ephb4 for inhibiting angiogenesis and tumor growth
|
|
WO2006034455A2
(en)
*
|
2004-09-23 |
2006-03-30 |
Vasgene Therapeutics, Inc. |
Polipeptide compounds for inhibiting angiogenesis and tumor growth
|