JP2016530323A5 - - Google Patents
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- JP2016530323A5 JP2016530323A5 JP2016542315A JP2016542315A JP2016530323A5 JP 2016530323 A5 JP2016530323 A5 JP 2016530323A5 JP 2016542315 A JP2016542315 A JP 2016542315A JP 2016542315 A JP2016542315 A JP 2016542315A JP 2016530323 A5 JP2016530323 A5 JP 2016530323A5
- Authority
- JP
- Japan
- Prior art keywords
- item
- tumor
- antigen
- administered
- binding fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361876509P | 2013-09-11 | 2013-09-11 | |
| US61/876,509 | 2013-09-11 | ||
| US201461971212P | 2014-03-27 | 2014-03-27 | |
| US61/971,212 | 2014-03-27 | ||
| US201461978401P | 2014-04-11 | 2014-04-11 | |
| US61/978,401 | 2014-04-11 | ||
| US201462003349P | 2014-05-27 | 2014-05-27 | |
| US62/003,349 | 2014-05-27 | ||
| PCT/EP2014/069425 WO2015036499A1 (en) | 2013-09-11 | 2014-09-11 | Anti-b7-h1 antibodies for treating tumors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019081639A Division JP2019163269A (ja) | 2013-09-11 | 2019-04-23 | 腫瘍を治療するための抗ｂ７−ｈ１抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016530323A JP2016530323A (ja) | 2016-09-29 |
| JP2016530323A5 true JP2016530323A5 (enExample) | 2017-10-12 |
| JP6550053B2 JP6550053B2 (ja) | 2019-07-24 |
Family
ID=51570487
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016542315A Active JP6550053B2 (ja) | 2013-09-11 | 2014-09-11 | 腫瘍を治療するための抗ｂ７−ｈ１抗体 |
| JP2019081639A Pending JP2019163269A (ja) | 2013-09-11 | 2019-04-23 | 腫瘍を治療するための抗ｂ７−ｈ１抗体 |
| JP2020152079A Active JP7119037B2 (ja) | 2013-09-11 | 2020-09-10 | 腫瘍を治療するための抗ｂ７－ｈ１抗体 |
| JP2022021883A Active JP7342167B2 (ja) | 2013-09-11 | 2022-02-16 | 腫瘍を治療するための抗ｂ７－ｈ１抗体 |
| JP2023139429A Pending JP2023166474A (ja) | 2013-09-11 | 2023-08-30 | 腫瘍を治療するための抗ｂ７－ｈ１抗体 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019081639A Pending JP2019163269A (ja) | 2013-09-11 | 2019-04-23 | 腫瘍を治療するための抗ｂ７−ｈ１抗体 |
| JP2020152079A Active JP7119037B2 (ja) | 2013-09-11 | 2020-09-10 | 腫瘍を治療するための抗ｂ７－ｈ１抗体 |
| JP2022021883A Active JP7342167B2 (ja) | 2013-09-11 | 2022-02-16 | 腫瘍を治療するための抗ｂ７－ｈ１抗体 |
| JP2023139429A Pending JP2023166474A (ja) | 2013-09-11 | 2023-08-30 | 腫瘍を治療するための抗ｂ７－ｈ１抗体 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US10336823B2 (enExample) |
| EP (2) | EP3043816B1 (enExample) |
| JP (5) | JP6550053B2 (enExample) |
| KR (5) | KR20240056664A (enExample) |
| CN (2) | CN112546217B (enExample) |
| AU (3) | AU2014320343B2 (enExample) |
| BR (1) | BR112016005303A2 (enExample) |
| CA (1) | CA2923499A1 (enExample) |
| DK (1) | DK3043816T3 (enExample) |
| ES (1) | ES2749744T3 (enExample) |
| HU (1) | HUE046674T2 (enExample) |
| IL (5) | IL321966A (enExample) |
| MX (1) | MX370818B (enExample) |
| NZ (2) | NZ718821A (enExample) |
| PL (1) | PL3043816T3 (enExample) |
| RU (1) | RU2701327C2 (enExample) |
| SA (1) | SA516370713B1 (enExample) |
| TW (1) | TWI643633B (enExample) |
| WO (1) | WO2015036499A1 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250091304A (ko) | 2013-03-15 | 2025-06-20 | 제넨테크, 인크. | Pd-1 및 pd-l1 관련 상태를 치료하기 위한 바이오마커 및 방법 |
| PL3043816T3 (pl) * | 2013-09-11 | 2020-03-31 | Medimmune Limited | Przeciwciała anty-b7-h1 do leczenia nowotworów |
| US10570204B2 (en) | 2013-09-26 | 2020-02-25 | The Medical College Of Wisconsin, Inc. | Methods for treating hematologic cancers |
| ES2716685T3 (es) | 2014-01-24 | 2019-06-14 | Dana Farber Cancer Inst Inc | Moléculas de anticuerpo para PD-1 y usos de las mismas |
| DK3099717T3 (da) | 2014-01-31 | 2019-07-01 | Novartis Ag | Antistofmolekyler med tim-3 og anvendelser deraf |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| TWI777174B (zh) | 2014-03-14 | 2022-09-11 | 瑞士商諾華公司 | 針對lag-3之抗體分子及其用途 |
| WO2015181331A1 (en) * | 2014-05-29 | 2015-12-03 | Medimmune Limited | Antagonists of pdl-1 and pd-1 for the treatment of hpv-negative cancers |
| ES2753360T3 (es) | 2014-05-29 | 2020-04-08 | Spring Bioscience Corp | Anticuerpos contra PD-L1 y usos de los mismos |
| BR112017000497B1 (pt) | 2014-07-11 | 2023-12-26 | Ventana Medical Systems, Inc | Anticorpo isolado, célula hospedeira procariótica, imunoconjugado e método de detecção da presença ou do nível de expressão de pd-l1 |
| TW201614237A (en) * | 2014-09-05 | 2016-04-16 | Medimmune Ltd | Markers for identifying patients responsive to anti-PD-L1 antibody therapy |
| EP3191126B1 (en) | 2014-09-13 | 2020-05-13 | Novartis AG | Combination therapies of alk inhibitors |
| UY36351A (es) | 2014-10-14 | 2016-06-01 | Novartis Ag | Moléculas de anticuerpo que se unen a pd-l1 y usos de las mismas |
| EP3254110B1 (en) | 2015-02-03 | 2020-03-18 | Ventana Medical Systems, Inc. | Histochemical assay for evaluating expression of programmed death ligand 1 (pd-l1) |
| CN112263677A (zh) | 2015-02-26 | 2021-01-26 | 默克专利股份公司 | 用于治疗癌症的pd-1/pd-l1抑制剂 |
| AU2016233495B2 (en) | 2015-03-13 | 2022-02-24 | Cytomx Therapeutics, Inc | Anti-PDL1 antibodies, activatable anti-PDL1 antibodies, and methods of use thereof |
| CN107530434A (zh) * | 2015-04-23 | 2018-01-02 | 免疫医疗有限公司 | 非小细胞肺癌egfr突变阳性的联合疗法 |
| EP3294770B2 (en) | 2015-05-12 | 2024-03-20 | F. Hoffmann-La Roche AG | Therapeutic and diagnostic methods for cancer |
| US10696745B2 (en) | 2015-06-11 | 2020-06-30 | Wuxi Biologics (Shanghai) Co. Ltd. | Anti-PD-L1 antibodies |
| MY193229A (en) | 2015-06-16 | 2022-09-26 | Merck Patent GmbH | Pd-l1 antagonist combination treatments |
| EP3316902A1 (en) | 2015-07-29 | 2018-05-09 | Novartis AG | Combination therapies comprising antibody molecules to tim-3 |
| LT3317301T (lt) | 2015-07-29 | 2021-07-26 | Novartis Ag | Kombinuotos terapijos, apimančios antikūno molekules prieš lag-3 |
| CN108025051B (zh) | 2015-07-29 | 2021-12-24 | 诺华股份有限公司 | 包含抗pd-1抗体分子的联合疗法 |
| WO2017020291A1 (en) | 2015-08-06 | 2017-02-09 | Wuxi Biologics (Shanghai) Co. Ltd. | Novel anti-pd-l1 antibodies |
| ES2986067T3 (es) | 2015-12-17 | 2024-11-08 | Novartis Ag | Moléculas de anticuerpos frente a PD-1 y usos de las mismas |
| CN106939047B (zh) * | 2016-01-04 | 2021-08-31 | 江苏怀瑜药业有限公司 | 一种pd-l1抗体及其制备方法 |
| WO2017176565A1 (en) | 2016-04-07 | 2017-10-12 | Eli Lilly And Company | Combinations of an anti-b7-h1 antibody and a cxcr4 peptide antagonist for treating a solid tumor |
| BR112018073920A2 (pt) * | 2016-05-26 | 2019-02-26 | Merck Patent Gmbh | inibidores de pd-1/pd-l1 para tratamento de câncer". |
| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
| TWI640536B (zh) | 2016-06-20 | 2018-11-11 | 克馬伯有限公司 | 抗體 |
| US11359017B2 (en) | 2016-07-01 | 2022-06-14 | Tohoku University | Method of altering an antibody-related adverse event based on SCD163 and/or CXCL5 levels |
| AU2017339856B2 (en) | 2016-10-06 | 2024-09-05 | Merck Patent Gmbh | Dosing regimen of avelumab for the treatment of cancer |
| US11779604B2 (en) | 2016-11-03 | 2023-10-10 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses and methods |
| WO2018098352A2 (en) | 2016-11-22 | 2018-05-31 | Jun Oishi | Targeting kras induced immune checkpoint expression |
| MX393780B (es) | 2017-01-17 | 2025-03-24 | Heparegenix Gmbh | Inhibidores de proteina cinasa para promover la regeneracion hepatica o reducir o prevenir la muerte de hepatocitos |
| BR112019025188A2 (pt) | 2017-06-01 | 2020-06-23 | Cytomx Therapeutics, Inc. | Anticorpos anti-pdl1 ativáveis e métodos de uso dos mesmos |
| KR102758037B1 (ko) | 2017-08-18 | 2025-01-22 | 코테라 바이오사이언스 인코포레이티드 | Tg02의 다형성 형태 |
| KR20200128014A (ko) * | 2018-01-31 | 2020-11-11 | 셀진 코포레이션 | 입양 세포 요법 및 체크포인트 억제제를 이용한 병용 요법 |
| KR20200135447A (ko) * | 2018-03-22 | 2020-12-02 | 카이레스 아게 | 길항성 pd-1, pd-l1 및 lag-3 결합 단백질 |
| MX2021008546A (es) | 2019-01-18 | 2021-11-12 | Dracen Pharmaceuticals Inc | Terapia combinada con un profarmaco de 6-diazo-5-oxo-l-norleucina (don) y un inhibidor de puntos de control inmunologicos. |
| CN113347996B (zh) * | 2019-01-25 | 2024-04-02 | 正大天晴药业集团股份有限公司 | 治疗肿瘤的联用药物组合物 |
| US20230083015A1 (en) | 2019-03-26 | 2023-03-16 | The Regents Of The University Of Michigan | Small molecule degraders of stat3 |
| WO2020205467A1 (en) | 2019-03-29 | 2020-10-08 | The Regents Of The University Of Michigan | Stat3 protein degraders |
| WO2020252336A1 (en) | 2019-06-12 | 2020-12-17 | Vanderbilt University | Dibenzylamines as amino acid transport inhibitors |
| CA3141405A1 (en) | 2019-06-12 | 2020-12-17 | H. Charles Manning | Amino acid transport inhibitors and the uses thereof |
| CN114173794A (zh) * | 2019-06-25 | 2022-03-11 | 希望之城 | Pdl1阳性nk细胞癌症治疗 |
| JP2022538284A (ja) | 2019-06-27 | 2022-09-01 | ザ ジョージ ワシントン ユニバーシティ， ア コングレッショナリー チャータード ノット－フォー－プロフィット コーポレイション | Ｈｄａｃ６活性化マクロファージ、その組成物および使用 |
| EP3999510A1 (en) | 2019-07-16 | 2022-05-25 | The Regents Of The University Of Michigan | Imidazopyrimidines as eed inhibitors and the use thereof |
| AU2020336381A1 (en) | 2019-08-27 | 2022-03-03 | The Regents Of The University Of Michigan | Cereblon E3 ligase inhibitors |
| JP2022548775A (ja) | 2019-09-19 | 2022-11-21 | ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン | スピロ環式アンドロゲン受容体タンパク質分解剤 |
| WO2021057836A1 (en) * | 2019-09-25 | 2021-04-01 | Wuxi Biologics (Shanghai) Co. Ltd. | Novel anti-pd-l1 antibodies |
| WO2021195481A1 (en) | 2020-03-26 | 2021-09-30 | The Regents Of The University Of Michigan | Small molecule stat protein degraders |
| US20230233690A1 (en) | 2020-07-10 | 2023-07-27 | The Regents Of The University Of Michigan | Androgen receptor protein degraders |
| WO2022011204A1 (en) | 2020-07-10 | 2022-01-13 | The Regents Of The University Of Michigan | Small molecule androgen receptor protein degraders |
| CN116601140A (zh) | 2020-10-02 | 2023-08-15 | 羿尊生物医药股份有限公司 | 用于皮下施用的包含(s)-2-((s)-2-乙酰氨基-3-(1h-吲哚-3-基)丙酰氨基)-6-重氮基-5-氧代己酸异丙酯的冻干组合物及其用途 |
| WO2022187419A1 (en) | 2021-03-03 | 2022-09-09 | The Regents Of The University Of Michigan | Small molecule degraders of androgen receptor |
| US20240166647A1 (en) | 2021-03-03 | 2024-05-23 | The Regents Of The University Of Michigan | Cereblon Ligands |
| AU2022245277B8 (en) * | 2021-03-26 | 2025-08-07 | Astrazeneca Ab | Combination treatments for melanoma |
| JP2026504180A (ja) | 2023-01-30 | 2026-02-03 | カイマブ・リミテッド | 抗体 |
| WO2025151487A2 (en) | 2024-01-08 | 2025-07-17 | Regents Of The University Of Michigan | Small-molecule inhibitors of adar1 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2192884C2 (ru) * | 2000-11-09 | 2002-11-20 | Государственное учреждение Научно-исследовательский институт клинической иммунологии СО РАМН | Вакцина для стимуляции противоопухолевого иммунитета |
| AU2002258941A1 (en) * | 2001-04-20 | 2002-11-05 | Mayo Foundation For Medical Education And Research | Methods of enhancing cell responsiveness |
| US20100285039A1 (en) * | 2008-01-03 | 2010-11-11 | The Johns Hopkins University | B7-H1 (CD274) Antagonists Induce Apoptosis of Tumor Cells |
| KR101050829B1 (ko) * | 2008-10-02 | 2011-07-20 | 서울대학교산학협력단 | 항 ｐｄ-1 항체 또는 항 ｐｄ-ｌ1 항체를 포함하는 항암제 |
| CN101693562A (zh) * | 2009-10-21 | 2010-04-14 | 山东大学 | 一种聚合氯化铁-聚环氧氯丙烷-二甲胺复合混凝剂 |
| PT2504364T (pt) * | 2009-11-24 | 2017-11-14 | Medimmune Ltd | Agentes de ligação direcionados contra b7-h1 |
| KR101981873B1 (ko) | 2011-11-28 | 2019-05-23 | 메르크 파텐트 게엠베하 | 항-ｐｄ-ｌ1 항체 및 그의 용도 |
| US9212224B2 (en) * | 2012-05-15 | 2015-12-15 | Bristol-Myers Squibb Company | Antibodies that bind PD-L1 and uses thereof |
| PL3043816T3 (pl) * | 2013-09-11 | 2020-03-31 | Medimmune Limited | Przeciwciała anty-b7-h1 do leczenia nowotworów |
| ES2749098T3 (es) * | 2014-05-13 | 2020-03-19 | Medimmune Ltd | Anticuerpos ANTI-B7-H1 y ANTI-CTLA-4 para tratar el cáncer de pulmón no microcítico |
| US10092645B2 (en) * | 2014-06-17 | 2018-10-09 | Medimmune Limited | Methods of treatment with antagonists against PD-1 and PD-L1 in combination with radiation therapy |
| TW201614237A (en) * | 2014-09-05 | 2016-04-16 | Medimmune Ltd | Markers for identifying patients responsive to anti-PD-L1 antibody therapy |
| EP3220951A1 (en) * | 2014-11-17 | 2017-09-27 | MedImmune Limited | Therapeutic combinations and methods for treating neoplasia |
| US20160347848A1 (en) * | 2015-05-28 | 2016-12-01 | Medimmune Limited | Therapeutic combinations and methods for treating neoplasia |
| US10421811B2 (en) * | 2016-04-25 | 2019-09-24 | Medimmune, Llc | Compositions comprising coformulation of anti-PD-L1 and anti-CTLA-4 antibodies |
| WO2017197231A1 (en) * | 2016-05-13 | 2017-11-16 | Medimmune, Llc | Cd40l-fc fusion polypeptides and methods of use thereof |
-
2014
- 2014-09-11 PL PL14766962T patent/PL3043816T3/pl unknown
- 2014-09-11 US US15/021,161 patent/US10336823B2/en active Active
- 2014-09-11 NZ NZ718821A patent/NZ718821A/en unknown
- 2014-09-11 KR KR1020247013414A patent/KR20240056664A/ko not_active Ceased
- 2014-09-11 IL IL321966A patent/IL321966A/en unknown
- 2014-09-11 DK DK14766962.6T patent/DK3043816T3/da active
- 2014-09-11 CN CN202011433007.4A patent/CN112546217B/zh active Active
- 2014-09-11 IL IL313188A patent/IL313188B2/en unknown
- 2014-09-11 TW TW103131437A patent/TWI643633B/zh active
- 2014-09-11 KR KR1020227040760A patent/KR102661249B1/ko active Active
- 2014-09-11 KR KR1020257042956A patent/KR20260008188A/ko active Pending
- 2014-09-11 CA CA2923499A patent/CA2923499A1/en active Pending
- 2014-09-11 WO PCT/EP2014/069425 patent/WO2015036499A1/en not_active Ceased
- 2014-09-11 EP EP14766962.6A patent/EP3043816B1/en active Active
- 2014-09-11 ES ES14766962T patent/ES2749744T3/es active Active
- 2014-09-11 KR KR1020167007277A patent/KR102329584B1/ko active Active
- 2014-09-11 AU AU2014320343A patent/AU2014320343B2/en active Active
- 2014-09-11 EP EP19191552.9A patent/EP3656398A1/en active Pending
- 2014-09-11 JP JP2016542315A patent/JP6550053B2/ja active Active
- 2014-09-11 MX MX2016002826A patent/MX370818B/es active IP Right Grant
- 2014-09-11 HU HUE14766962A patent/HUE046674T2/hu unknown
- 2014-09-11 IL IL292193A patent/IL292193B2/en unknown
- 2014-09-11 BR BR112016005303A patent/BR112016005303A2/pt not_active Application Discontinuation
- 2014-09-11 KR KR1020217037457A patent/KR20210143932A/ko not_active Ceased
- 2014-09-11 RU RU2016113341A patent/RU2701327C2/ru active
- 2014-09-11 NZ NZ757060A patent/NZ757060A/en unknown
- 2014-09-11 CN CN201480049982.1A patent/CN105873606B/zh active Active
-
2016
- 2016-03-03 IL IL244422A patent/IL244422B/en active IP Right Grant
- 2016-03-10 SA SA516370713A patent/SA516370713B1/ar unknown
-
2019
- 2019-04-23 JP JP2019081639A patent/JP2019163269A/ja active Pending
- 2019-05-21 US US16/418,488 patent/US10829557B2/en active Active
-
2020
- 2020-05-05 IL IL274462A patent/IL274462B/en unknown
- 2020-08-27 AU AU2020223728A patent/AU2020223728B2/en active Active
- 2020-09-10 JP JP2020152079A patent/JP7119037B2/ja active Active
- 2020-10-16 US US17/072,756 patent/US11827706B2/en active Active
-
2022
- 2022-02-16 JP JP2022021883A patent/JP7342167B2/ja active Active
-
2023
- 2023-08-30 JP JP2023139429A patent/JP2023166474A/ja active Pending
-
2024
- 2024-06-07 AU AU2024203898A patent/AU2024203898A1/en active Pending
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