JP2008260733A - アミノ酸類高配合防腐水溶液 - Google Patents
アミノ酸類高配合防腐水溶液 Download PDFInfo
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- JP2008260733A JP2008260733A JP2007106161A JP2007106161A JP2008260733A JP 2008260733 A JP2008260733 A JP 2008260733A JP 2007106161 A JP2007106161 A JP 2007106161A JP 2007106161 A JP2007106161 A JP 2007106161A JP 2008260733 A JP2008260733 A JP 2008260733A
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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Abstract
【解決手段】(成分A)ピロリドンカルボン酸及び/またはその塩と、(成分B)塩基性アミノ酸及び/またはその塩と、(成分C)酸性アミノ酸及び/またはその塩と、(成分D)中性アミノ酸及び/またはその塩と、(成分E)乳酸及び/またはその塩を、特定の配合比かつpHで含有する。
【選択図】なし
Description
香粧品医薬品 防腐・殺菌剤の科学 防菌防黴ハンドブック p.3 技報堂出版 1986年 Antimicrobial Effects of Lactates: A Review、Journal of Food Protection、第57巻、第5号、p.445-450 1994年
[1] (成分A)ピロリドンカルボン酸及び/またはその塩と、(成分B)塩基性アミノ酸及び/またはその塩と、(成分C)酸性アミノ酸及び/またはその塩と、(成分D)中性アミノ酸及び/又はその塩と、(成分E)乳酸及び/またはその塩と(成分F)水とを含有し、[(成分A)+(成分E)の合計重量]/[(成分A))+(成分B)+(成分C)+(成分D)+(成分E)+(成分F)の合計重量](重量%)が25〜40重量%であり、(成分A)重量/[(成分A)+(成分E)の合計重量](重量%)=5〜95重量%であり、pHが3.5〜6.0であることを特徴とする、アミノ酸類高配合防腐水溶液。
[2] (成分B)がアルギニン及び/またはその塩であり、(成分B)重量/[(成分A)+(成分B)+(成分C)+(成分D)+(成分E)の合計重量](重量%)が4〜25重量%であることを特徴とする、請求項1に記載のアミノ酸類高配合防腐水溶液。
[3] (成分C)がアスパラギン酸及び/またはその塩であり、(成分C)重量/[(成分A)+(成分B)+(成分C)+(成分D)+(成分E)の合計重量](重量%)が5〜15重量%であることを特徴とする、請求項1または2のいずれかに記載のアミノ酸類高配合防腐水溶液。
[4](成分D)がグリシンおよび/又はその塩、アラニンおよび/又はその塩から選ばれる1種又は2種以上であり、(成分D)重量/[(成分A)+(成分B)+(成分C)+(成分D)+(成分E)の合計重量](重量%)が5〜20重量%であることを特徴とする、請求項1〜3のいずれかに記載のアミノ酸類高配合防腐水溶液。
[5] [1]〜[4]のいずれかに記載のアミノ酸類高配合防腐水溶液を含有する化粧料。
“高配合”とは、「本構成要素である(成分A)ピロリドンカルボン酸及び/またはその塩と、(成分B)塩基性アミノ酸及び/またはその塩と、(成分C)酸性アミノ酸及び/またはその塩と、(成分D)中性アミノ酸及び/またはその塩と、(成分E)乳酸及び/またはその塩と(成分F)水の総重量に対して、(成分A)ピロリドンカルボン酸及び/またはその塩と、(成分B)塩基性アミノ酸及び/またはその塩と、(成分C)酸性アミノ酸及び/またはその塩と、(成分D)中性アミノ酸及び/またはその塩の総重量が、15重量%以上、好ましくは18重量%以上、より好ましくは20重量%以上、更に好ましくは23重量%以上、更に一層好ましくは25重量%以上、殊更好ましくは28重量%以上、特に好ましくは30重量%以上のもの」を意味する。
また、“防腐水溶液”とは、「この水溶液を配合することによって配合されたものが防腐効果を呈する防腐剤としての水溶液」であることを意味するわけではなく、「この水溶液自体が特定の防腐性能を有する水溶液」であることを意味する。
以下、順次評価方法について説明する。
(保存効力試験)
第14改正日本薬局方第1追補15.保存効力試験法に基づいて試験を行った。判定は、同法記載のカテゴリーIA製剤(注射剤および点耳・点眼剤を含む非経口剤)の判定基準を参考にした。すなわち、細菌の生菌数は接種後14日の試験期間内に、接種した菌数に比べて0.1%以下に減少し、その後28日間の試験終了時まで、そのレベルと同等若しくはそれ以下の生菌数にとどまること、及び、真菌の生菌数は接種後14日と28日目まで、接種した菌数と同レベルと同等若しくはそれ以下の生菌数にとどまること、がその判定基準である。同法記載のカテゴリーIA製剤の判定基準を満たす場合は○、満たさない場合は×、同法記載のカテゴリーIA製剤の判定基準を上回る場合は◎とした。同法記載のカテゴリーIA製剤の判定基準を上回るとは、細菌に対しては、各細菌の生菌数が接種後7日の試験期間内に、接種した菌数に比べて0.1%以下に減少し、その後28日間の試験終了時まで、そのレベルと同等若しくはそれ以下の生菌数にとどまる場、真菌に対しては、その生菌数が、接種後28日目までに接種した菌数に比べて10%以下に減少する場合、である。
容量50mLの透明ガラス瓶にアミノ酸類高配合防腐水溶液をいっぱいに入れ、蓋をして-5℃に静置した。一ヶ月後、保存庫から取り出してすぐの混合物の溶状を、以下の判定基準に基づき目視で判定した。
◎ -5℃1ヶ月保存で析出、分離、凍結がなく、溶状に変化が見られない。
○ -5℃1ヶ月保存で析出、分離、凍結のいずれかが観察されるが、25℃に1時間静置することにより無色透明の均一な溶液となる。
△ -5℃1ヶ月保存で析出、分離、凍結のいずれかが観察されるが、25℃で1時間撹拌することにより無色透明の均一な溶液となる。
× -5℃1ヶ月保存で析出、分離、凍結のいずれかが観察され、25℃で1時間以上撹拌しても均一な溶液にならない。
下表1に示す組成のヘアリキッド処方2種を調製した。長さ約20cm、重さ約3gの毛束に各0.5mL塗布してくしでなじませながらドライヤーで乾燥させた。一時間後のしっとり感について
4:比較処方に比べて非常にしっとりする
3:比較処方に比べてややしっとりする
2:比較処方と同程度にしっとりする
1:比較処方の方がややしっとりする
0:比較処方の方が非常にしっとりする
という、5名のパネラーによる官能評価を行い、平均点が3.1以上の場合を◎、2.5〜3.0を○、2.0〜2.4を△、1.9以下を×とした。
(べたつき)
下表1に示すヘアリキッド処方を2種調製し、長さ約20cm、重さ約3gの毛束に各0.5mL塗布してくしでなじませながらドライヤーで乾燥させた。一時間後、比較処方に対する
試験処方のべたつき感について
4:比較処方に比べてはるかにべたつかない
3:比較処方に比べてややべたつかない
2:比較処方と同程度にべたつかない
1:比較処方の方がややべたつかない
0:比較処方の方がはるかにべたつかない
という、5名のパネラーによる官能評価を行い、平均点が3.1以上の場合を◎、2.5〜3.0を○、2.0〜2.4を△、1.9以下を×とした。
長さ約10cm、重さ約1gのハイブリーチ毛(ライトブラウン)毛束を、市販の酸化染毛料(赤)で、使用説明書の指示に従って染色した。アミノ酸類高配合防腐水溶液を20倍希釈した液50mLに染色した毛束を30分浸漬し、水道水ですすいだ。乾燥後、市販のヘアシャンプーで3回洗浄した後の色を、以下の基準に従って評価した。別に、染毛後イオン交換水に30分浸漬した毛束を用意し、コントロール0=ヘアシャンプーなし、コントロール1=市販のヘアシャンプーで1回洗浄、コントロール2=市販のヘアシャンプーで2回洗浄、コントロール3=市販のヘアシャンプーで3回洗浄 の4つの対照品を用意した。
◎:コントロール0と同程度の色みである
○:コントロール1と同程度の色みである
△:コントロール2と同程度の色みである
×:コントロール3と同程度の色みである
下表2に示す組成のアミノ酸類高配合防腐水溶液(実施例1〜9、比較例1〜8)を調製し、保存効力、低温安定性、保湿性、べたつき、色落ちについて試験を行った。なお、表記載の各配合成分の量(表中の数値)は、組成物全体を100としたときの重量分率(%)である。
比較例3、比較例4は、処方のpHは本発明の範囲であるが、[(成分A)+(成分E)の合計重量]と(成分C)重量/[(成分A)+(成分B)+(成分C)+(成分D)+(成分E)の合計重量]が不足しており、Aspergillus niger(クロコウジカビ)に対する保存効力、および保湿効果が不十分であった。
比較例5、比較例6は、処方のpHが5.5より高く、いくつかの菌種に対する防腐効果が不十分であった。(成分A)、(成分E)をそれぞれ単独で配合した比較例7、8は、Aspergillus niger(クロコウジカビ)を中心に防腐効果が不十分であるうえ、保湿効果も低下する傾向があった。
下表3に示す組成のヘアシャンプー処方を調製した。
下表4に示す組成のヘアシャンプー処方を調製した。
下表5に示す組成のヘアコンディショナー処方を調製した。
下表6に示す組成のヘアコンディショナー処方を調製した。
下表7に示す組成のアウトバストリートメント処方を調製した。
下表8に示す組成のヘアリキッド処方を調製した。
下表9に示す組成の洗顔料処方を調製した。
下表10に示す組成のシャワージェル処方を調製した。
下表11に示す組成の洗顔ジェル処方を調製した。
下表12に示す組成のスキンケアクリーム処方を調製した。
Claims (5)
- (成分A)ピロリドンカルボン酸及び/またはその塩と、(成分B)塩基性アミノ酸及び/またはその塩と、(成分C)酸性アミノ酸及び/またはその塩と、(成分D)中性アミノ酸及び/又はその塩と、(成分E)乳酸及び/またはその塩と(成分F)水とを含有し、[(成分A)+(成分E)の合計重量]/[(成分A))+(成分B)+(成分C)+(成分D)+(成分E)+(成分F)の合計重量](重量%)が25〜40重量%であり、(成分A)重量/[(成分A)+(成分E)の合計重量](重量%)=5〜95重量%であり、pHが3.5〜6.0であることを特徴とする、アミノ酸類高配合防腐水溶液。
- (成分B)がアルギニン及び/またはその塩であり、(成分B)重量/[(成分A)+(成分B)+(成分C)+(成分D)+(成分E)の合計重量](重量%)が4〜25重量%であることを特徴とする、請求項1に記載のアミノ酸類高配合防腐水溶液。
- (成分C)がアスパラギン酸及び/またはその塩であり、(成分C)重量/[(成分A)+(成分B)+(成分C)+(成分D)+(成分E)の合計重量](重量%)が5〜15重量%であることを特徴とする、請求項1または2のいずれかに記載のアミノ酸類高配合防腐水溶液。
- (成分D)がグリシンおよび/又はその塩、アラニンおよび/又はその塩から選ばれる1種又は2種以上であり、(成分D)重量/[(成分A)+(成分B)+(成分C)+(成分D)+(成分E)の合計重量](重量%)が5〜20重量%であることを特徴とする、請求項1〜3のいずれかに記載のアミノ酸類高配合防腐水溶液。
- 請求項1〜4のいずれかに記載のアミノ酸類高配合防腐水溶液を含有する化粧料。
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WO2011102395A1 (ja) * | 2010-02-16 | 2011-08-25 | 味の素株式会社 | ピロリドンカルボン酸またはその塩の製造方法 |
JP2015134751A (ja) * | 2013-12-18 | 2015-07-27 | 御木本製薬株式会社 | アクアポリン産生促進剤 |
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CN101851869B (zh) * | 2010-06-09 | 2012-06-13 | 五邑大学 | 一种活性染料的助促染剂 |
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