JP2007537288A5 - - Google Patents

Info

Publication number

JP2007537288A5

JP2007537288A5 JP2007513370A JP2007513370A JP2007537288A5 JP 2007537288 A5 JP2007537288 A5 JP 2007537288A5 JP 2007513370 A JP2007513370 A JP 2007513370A JP 2007513370 A JP2007513370 A JP 2007513370A JP 2007537288 A5 JP2007537288 A5 JP 2007537288A5

Authority

JP

Japan

Prior art keywords

composition

microsphere

microspheres

antisense oligonucleotide

seq

Prior art date

2005-05-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 63
• 239000004005 microsphere Substances 0.000 claims 51
• 108091034117 Oligonucleotide Proteins 0.000 claims 35
• 239000000074 antisense oligonucleotide Substances 0.000 claims 27
• 238000012230 antisense oligonucleotides Methods 0.000 claims 27
• 210000002237 B-cell of pancreatic islet Anatomy 0.000 claims 14
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 12
• 230000001363 autoimmune Effects 0.000 claims 11
• 230000006378 damage Effects 0.000 claims 11
• 239000002245 particle Substances 0.000 claims 11
• 101150013553 CD40 gene Proteins 0.000 claims 10
• 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 10
• 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 10
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 10
• 238000000034 method Methods 0.000 claims 10
• 230000008685 targeting Effects 0.000 claims 8
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
• 210000004443 dendritic cell Anatomy 0.000 claims 4
• 239000007972 injectable composition Substances 0.000 claims 4
• 238000007920 subcutaneous administration Methods 0.000 claims 4
• 230000000692 anti-sense effect Effects 0.000 claims 3
• 230000005784 autoimmunity Effects 0.000 claims 3
• 238000001727 in vivo Methods 0.000 claims 3
• 241000699670 Mus sp. Species 0.000 claims 2
• 206010012601 diabetes mellitus Diseases 0.000 claims 2
• 238000007918 intramuscular administration Methods 0.000 claims 2
• 238000001990 intravenous administration Methods 0.000 claims 2
• 210000004072 lung Anatomy 0.000 claims 2
• 230000000699 topical effect Effects 0.000 claims 2
• 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 1
• 238000007912 intraperitoneal administration Methods 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 210000003200 peritoneal cavity Anatomy 0.000 claims 1
• 208000014001 urinary system disease Diseases 0.000 claims 1