JP2009533466A5 - - Google Patents

Info

Publication number

JP2009533466A5

JP2009533466A5 JP2009505565A JP2009505565A JP2009533466A5 JP 2009533466 A5 JP2009533466 A5 JP 2009533466A5 JP 2009505565 A JP2009505565 A JP 2009505565A JP 2009505565 A JP2009505565 A JP 2009505565A JP 2009533466 A5 JP2009533466 A5 JP 2009533466A5

Authority

JP

Japan

Prior art keywords

nucleotides

seq

interfering rna

mrna

strand

Prior art date

2007-04-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000002773 nucleotide Substances 0.000 claims 37
• 125000003729 nucleotide group Chemical group 0.000 claims 37
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 19
• 108020004999 messenger RNA Proteins 0.000 claims 19
• 230000002452 interceptive effect Effects 0.000 claims 18
• 239000003795 chemical substances by application Substances 0.000 claims 12
• 108020004459 Small interfering RNA Proteins 0.000 claims 11
• 102100032509 Histamine H1 receptor Human genes 0.000 claims 9
• 101001016841 Homo sapiens Histamine H1 receptor Proteins 0.000 claims 9
• 230000000692 anti-sense effect Effects 0.000 claims 7
• 239000003814 drug Substances 0.000 claims 7
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
• 101000864666 Homo sapiens ATP-dependent RNA helicase DHX8 Proteins 0.000 claims 5
• 229940079593 drug Drugs 0.000 claims 5
• 101150091137 HRH1 gene Proteins 0.000 claims 4
• 238000012228 RNA interference-mediated gene silencing Methods 0.000 claims 4
• 230000000295 complement effect Effects 0.000 claims 4
• 239000003937 drug carrier Substances 0.000 claims 4
• 230000009368 gene silencing by RNA Effects 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 4
• 239000000443 aerosol Substances 0.000 claims 2
• 230000002238 attenuated effect Effects 0.000 claims 2
• 238000003776 cleavage reaction Methods 0.000 claims 2
• 239000013604 expression vector Substances 0.000 claims 2
• 238000001727 in vivo Methods 0.000 claims 2
• 238000007918 intramuscular administration Methods 0.000 claims 2
• 238000007912 intraperitoneal administration Methods 0.000 claims 2
• 238000001990 intravenous administration Methods 0.000 claims 2
• 108091070501 miRNA Proteins 0.000 claims 2
• 239000002679 microRNA Substances 0.000 claims 2
• 230000004962 physiological condition Effects 0.000 claims 2
• 230000007017 scission Effects 0.000 claims 2
• 238000007920 subcutaneous administration Methods 0.000 claims 2
• 230000000699 topical effect Effects 0.000 claims 2
• 238000000034 method Methods 0.000 claims 1