JP2007535470A5 - - Google Patents
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- Publication number
- JP2007535470A5 JP2007535470A5 JP2006505418A JP2006505418A JP2007535470A5 JP 2007535470 A5 JP2007535470 A5 JP 2007535470A5 JP 2006505418 A JP2006505418 A JP 2006505418A JP 2006505418 A JP2006505418 A JP 2006505418A JP 2007535470 A5 JP2007535470 A5 JP 2007535470A5
- Authority
- JP
- Japan
- Prior art keywords
- probnp
- antibody
- unmodified
- detection
- acc2654
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100036836 Natriuretic peptides B Human genes 0.000 claims description 20
- 101710187802 Natriuretic peptides B Proteins 0.000 claims description 20
- 238000001514 detection method Methods 0.000 claims 4
- 210000004408 hybridoma Anatomy 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 206010019280 Heart failures Diseases 0.000 claims 2
- 238000011895 specific detection Methods 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000002967 competitive immunoassay Methods 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 238000012417 linear regression Methods 0.000 claims 1
- 239000013610 patient sample Substances 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000009918 complex formation Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03010591 | 2003-05-12 | ||
| PCT/EP2004/005091 WO2004099252A1 (en) | 2003-05-12 | 2004-05-12 | Method of detecting native probnp with amonoclonal antibody binding to the amino acids 38-44 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007535470A JP2007535470A (ja) | 2007-12-06 |
| JP2007535470A5 true JP2007535470A5 (enExample) | 2009-09-10 |
| JP4430066B2 JP4430066B2 (ja) | 2010-03-10 |
Family
ID=33427054
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006505418A Expired - Lifetime JP4430066B2 (ja) | 2003-05-12 | 2004-05-12 | アミノ酸３８〜４４に結合するモノクローナル抗体を用いたｐｒｏＢＮＰの検出方法 |
| JP2006505419A Expired - Lifetime JP5128125B2 (ja) | 2003-05-12 | 2004-05-12 | アミノ酸４１〜４６に結合するモノクローナル抗体を用いたｐｒｏＢＮＰの検出方法 |
| JP2009204610A Expired - Lifetime JP4834136B2 (ja) | 2003-05-12 | 2009-09-04 | アミノ酸４１〜４６に結合するモノクローナル抗体を用いたｐｒｏＢＮＰの検出方法 |
| JP2012222436A Expired - Lifetime JP5649631B2 (ja) | 2003-05-12 | 2012-10-04 | アミノ酸４１〜４６に結合するモノクローナル抗体を用いたｐｒｏＢＮＰの検出方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006505419A Expired - Lifetime JP5128125B2 (ja) | 2003-05-12 | 2004-05-12 | アミノ酸４１〜４６に結合するモノクローナル抗体を用いたｐｒｏＢＮＰの検出方法 |
| JP2009204610A Expired - Lifetime JP4834136B2 (ja) | 2003-05-12 | 2009-09-04 | アミノ酸４１〜４６に結合するモノクローナル抗体を用いたｐｒｏＢＮＰの検出方法 |
| JP2012222436A Expired - Lifetime JP5649631B2 (ja) | 2003-05-12 | 2012-10-04 | アミノ酸４１〜４６に結合するモノクローナル抗体を用いたｐｒｏＢＮＰの検出方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US7264939B2 (enExample) |
| EP (4) | EP1625164B1 (enExample) |
| JP (4) | JP4430066B2 (enExample) |
| KR (2) | KR20080011467A (enExample) |
| CN (3) | CN101967190A (enExample) |
| AT (2) | ATE517124T1 (enExample) |
| AU (1) | AU2004235974B2 (enExample) |
| BR (1) | BRPI0410261B8 (enExample) |
| CA (2) | CA2522378C (enExample) |
| DK (3) | DK2256132T3 (enExample) |
| ES (3) | ES2369008T3 (enExample) |
| HU (1) | HUE025169T2 (enExample) |
| MX (1) | MXPA05011826A (enExample) |
| PL (3) | PL1625164T3 (enExample) |
| WO (2) | WO2004099252A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2843396B1 (fr) * | 2002-08-07 | 2005-04-15 | Bio Rad Pasteur | Anticorps specifiques pour le diagnostic de l'insuffisance cardiaque |
| ATE517124T1 (de) * | 2003-05-12 | 2011-08-15 | Hoffmann La Roche | Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 42- 46 bindet |
| US20070037208A1 (en) * | 2003-05-29 | 2007-02-15 | Foote Robert S | Method for detecting cardiac ischemia via changes in b-natriuretic peptide levels |
| DE10355731A1 (de) * | 2003-11-28 | 2005-06-30 | Roche Diagnostics Gmbh | Analytischer Sandwichtest zur Bestimmung von NT-proBNP |
| DE602005001299T2 (de) * | 2004-07-07 | 2008-02-07 | Roche Diagnostics Gmbh | Kombinationen von Markern zum Nachweis von typ 1 und 2 Diabetes |
| AT500800B1 (de) * | 2004-09-08 | 2008-07-15 | Biomedica Medizinprodukte Gmbh | Verfahren zur bestimmung von probnp |
| DK2115477T3 (en) | 2007-01-25 | 2015-08-10 | Hoffmann La Roche | USE OF IGFBP-7 IN THE EVIDENCE OF HEART FAILURE |
| KR100836322B1 (ko) * | 2007-08-31 | 2008-06-09 | 현대자동차주식회사 | 차량용 흡음재 제작장치 및 방법 |
| US9482677B2 (en) | 2008-02-27 | 2016-11-01 | Scios Inc. | Method, composition and device for sampling natriuretic peptides in a biological fluid |
| CN102027374A (zh) | 2008-04-30 | 2011-04-20 | 霍夫曼-拉罗奇有限公司 | Sfrp-3在评价心力衰竭中的用途 |
| ES2512018T3 (es) | 2009-07-27 | 2014-10-23 | F. Hoffmann-La Roche Ag | Utilización de mimecán en la evaluación de la insuficiencia cardiaca |
| EP2499489B1 (en) * | 2009-11-13 | 2015-01-07 | BG Medicine, Inc. | Risk factors and prediction of myocardial infarction |
| US8778699B2 (en) | 2010-08-04 | 2014-07-15 | Idexx Laboratories, Inc. | Detection of degradation products of canine NT-proBNP |
| AU2012262154B2 (en) | 2011-05-31 | 2016-08-04 | Idexx Laboratories, Inc. | Detection of degradation products of feline NT-proBNP |
| JP6119607B2 (ja) * | 2011-09-20 | 2017-04-26 | コニカミノルタ株式会社 | 検体希釈用液、それを用いたキットおよび蛍光測定方法 |
| US20140273273A1 (en) | 2012-11-01 | 2014-09-18 | Christie Mitchell Ballantyne | Biomarkers to improve prediction of heart failure risk |
| CN103304665A (zh) * | 2013-05-21 | 2013-09-18 | 上海贝西生物科技有限公司 | 一种抗氨基末端脑利钠肽前体单克隆抗体及其应用 |
| JP6682445B2 (ja) | 2014-10-10 | 2020-04-15 | 松森 昭 | 心不全患者の検出方法、心疾患の識別方法、心不全の検査試薬、心不全の検査キット、心不全を検出するための装置及び心不全を検出するためのプログラム |
| EP3360570A1 (en) | 2017-02-13 | 2018-08-15 | Roche Diagnostics GmbH | Antibodies recognizing genetic variants |
| US11549940B2 (en) | 2017-10-02 | 2023-01-10 | Otsuka Pharmaceutical Co., Ltd. | Method for detecting analyte |
| EP3779438A4 (en) * | 2018-04-13 | 2022-01-26 | Kyoritsu Seiyaku Corporation | HEART FAILURE DETECTION METHOD, HEART FAILURE DETECTION INSTRUMENT, SANDWICH IMMUNOASSAY METHOD AND ANTIBODY COMBINATION |
| CN108752480B (zh) * | 2018-05-30 | 2022-03-29 | 中元汇吉生物技术股份有限公司 | 一种免疫原组合物、其制备方法及其用途 |
| US11446009B2 (en) | 2018-12-11 | 2022-09-20 | Eko.Ai Pte. Ltd. | Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images |
| US11931207B2 (en) | 2018-12-11 | 2024-03-19 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device |
| US12400762B2 (en) | 2018-12-11 | 2025-08-26 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy |
| US12001939B2 (en) | 2018-12-11 | 2024-06-04 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views |
| US12322100B2 (en) | 2018-12-11 | 2025-06-03 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity |
| CN111487222B (zh) * | 2019-01-28 | 2023-11-14 | 上海乐合生物科技有限公司 | 一种检测bnp的spr芯片的制备方法 |
| EP4014041A1 (en) | 2019-08-13 | 2022-06-22 | Gentian AS | Highly sensitive particle enhanced assay for the quantification of nt-probnp |
| JP7650966B2 (ja) * | 2020-09-30 | 2025-03-25 | エフ． ホフマン－ラ ロシュ アーゲー | 心房細動の評価における、循環中の総ＮＴ－ｐｒｏＢＮＰ（グリコシル化および非グリコシル化ＮＴ－ｐｒｏＢＮＰ）ならびにそのＮＴ－ｐｒｏＢＮＰ（非グリコシル化ＮＴ－ｐｒｏＢＮＰ）との比率 |
| CN112964885B (zh) * | 2021-02-20 | 2022-11-11 | 广东菲鹏生物有限公司 | 一种氨基末端脑尿钠肽检测方法和试剂盒 |
| CN112986586A (zh) * | 2021-02-20 | 2021-06-18 | 广东菲鹏生物有限公司 | 一种氨基末端脑尿钠肽检测方法和试剂盒 |
| JP2024538607A (ja) | 2021-10-01 | 2024-10-23 | ゲンティアン アクティーゼルスカブ | サンプル中のｎ末端プロホルモンｂｎｐ（ｎｔ－プロｂｎｐ）の濃度を測定するための新規方法 |
| US20250362308A1 (en) | 2022-03-18 | 2025-11-27 | Roche Diagnostics Operations, Inc. | Tropnin marker combinations for early discrimination of type 2 versus type 1 acute myocardial infarction |
| JP2025509739A (ja) | 2022-03-18 | 2025-04-11 | エフ． ホフマン－ラ ロシュ アーゲー | ２型対１型の急性心筋梗塞の早期識別のためのｃＭｙＢＰＣマーカーの組み合わせ |
| WO2024219421A1 (ja) * | 2023-04-19 | 2024-10-24 | 栄研化学株式会社 | ＮＴ－ｐｒｏＢＮＰに対する抗体、これを用いたＮＴ－ｐｒｏＢＮＰ検出方法、並びに、ＮＴ－ｐｒｏＢＮＰ検出に用いるための組成物及びキット |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3445816C1 (de) | 1984-12-15 | 1986-06-12 | Behringwerke Ag, 3550 Marburg | Flaechenfoermiges diagnostisches Mittel |
| JP2665850B2 (ja) | 1991-11-14 | 1997-10-22 | 塩野義製薬株式会社 | ｈＢＮＰのＣ端を認識するモノクロ−ナル抗体 |
| GB9211686D0 (en) | 1992-06-03 | 1992-07-15 | Medisinsk Innovation A S | Chemical compounds |
| ATE315228T1 (de) * | 1997-09-11 | 2006-02-15 | Shionogi & Co | Immunoassay zum bestimmen von bnp |
| GB9827348D0 (en) | 1998-12-12 | 1999-02-03 | Univ Leicester | Natriuretic peptide |
| IL144062A0 (en) | 1999-01-29 | 2002-04-21 | Roche Diagnostics Gmbh | METHOD OF IDENTIFYING N-TERMINAL proBNP |
| US20030219734A1 (en) | 2001-04-13 | 2003-11-27 | Biosite Incorporated | Polypeptides related to natriuretic peptides and methods of their identification and use |
| US20040096919A1 (en) * | 2002-11-18 | 2004-05-20 | Michelle Davey | Polyclonal-monoclonal ELISA assay for detecting N-terminus proBNP |
| ATE517124T1 (de) * | 2003-05-12 | 2011-08-15 | Hoffmann La Roche | Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 42- 46 bindet |
-
2004
- 2004-05-12 AT AT04732282T patent/ATE517124T1/de active
- 2004-05-12 EP EP04732282A patent/EP1625164B1/en not_active Expired - Lifetime
- 2004-05-12 WO PCT/EP2004/005091 patent/WO2004099252A1/en not_active Ceased
- 2004-05-12 EP EP04732278A patent/EP1625163B8/en not_active Expired - Lifetime
- 2004-05-12 CN CN2010101190838A patent/CN101967190A/zh active Pending
- 2004-05-12 JP JP2006505418A patent/JP4430066B2/ja not_active Expired - Lifetime
- 2004-05-12 JP JP2006505419A patent/JP5128125B2/ja not_active Expired - Lifetime
- 2004-05-12 AT AT04732278T patent/ATE522546T1/de active
- 2004-05-12 WO PCT/EP2004/005092 patent/WO2004099253A1/en not_active Ceased
- 2004-05-12 CA CA2522378A patent/CA2522378C/en not_active Expired - Lifetime
- 2004-05-12 BR BRPI0410261A patent/BRPI0410261B8/pt not_active IP Right Cessation
- 2004-05-12 ES ES04732282T patent/ES2369008T3/es not_active Expired - Lifetime
- 2004-05-12 MX MXPA05011826A patent/MXPA05011826A/es active IP Right Grant
- 2004-05-12 CN CNB200480012494XA patent/CN100497393C/zh not_active Expired - Lifetime
- 2004-05-12 PL PL04732282T patent/PL1625164T3/pl unknown
- 2004-05-12 CA CA2522747A patent/CA2522747C/en not_active Expired - Lifetime
- 2004-05-12 EP EP15161853.5A patent/EP2949669A1/en not_active Ceased
- 2004-05-12 PL PL04732278T patent/PL1625163T3/pl unknown
- 2004-05-12 KR KR1020087000782A patent/KR20080011467A/ko not_active Ceased
- 2004-05-12 ES ES04732278T patent/ES2372282T3/es not_active Expired - Lifetime
- 2004-05-12 PL PL10172014T patent/PL2256132T3/pl unknown
- 2004-05-12 DK DK10172014.2T patent/DK2256132T3/en active
- 2004-05-12 ES ES10172014.2T patent/ES2548327T3/es not_active Expired - Lifetime
- 2004-05-12 EP EP10172014.2A patent/EP2256132B1/en not_active Expired - Lifetime
- 2004-05-12 HU HUE10172014A patent/HUE025169T2/en unknown
- 2004-05-12 AU AU2004235974A patent/AU2004235974B2/en not_active Expired
- 2004-05-12 CN CNA2004800124973A patent/CN1784425A/zh active Pending
- 2004-05-12 DK DK04732282.1T patent/DK1625164T3/da active
- 2004-05-12 KR KR1020057021327A patent/KR100857752B1/ko not_active Expired - Lifetime
- 2004-05-12 DK DK04732278.9T patent/DK1625163T3/da active
-
2005
- 2005-11-10 US US11/271,651 patent/US7264939B2/en not_active Expired - Lifetime
- 2005-11-10 US US11/271,138 patent/US7264938B2/en not_active Expired - Lifetime
-
2006
- 2006-12-05 US US11/634,286 patent/US7807380B2/en not_active Expired - Lifetime
- 2006-12-22 US US11/644,565 patent/US7811770B2/en not_active Expired - Lifetime
-
2009
- 2009-09-04 JP JP2009204610A patent/JP4834136B2/ja not_active Expired - Lifetime
-
2012
- 2012-10-04 JP JP2012222436A patent/JP5649631B2/ja not_active Expired - Lifetime
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