BRPI0410261B8 - anticorpo monoclonal que se liga especificamente ao probnp, métodos para detecção específica de probnp in vitro e para diagnóstico de insuficiência cardíaca in vitro, kit para medição de probnp, e linhagem celular de hibridoma mab 1.21.3 - Google Patents
anticorpo monoclonal que se liga especificamente ao probnp, métodos para detecção específica de probnp in vitro e para diagnóstico de insuficiência cardíaca in vitro, kit para medição de probnp, e linhagem celular de hibridoma mab 1.21.3Info
- Publication number
- BRPI0410261B8 BRPI0410261B8 BRPI0410261A BRPI0410261A BRPI0410261B8 BR PI0410261 B8 BRPI0410261 B8 BR PI0410261B8 BR PI0410261 A BRPI0410261 A BR PI0410261A BR PI0410261 A BRPI0410261 A BR PI0410261A BR PI0410261 B8 BRPI0410261 B8 BR PI0410261B8
- Authority
- BR
- Brazil
- Prior art keywords
- probnp
- vitro
- cell line
- heart failure
- hybridoma cell
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03010591 | 2003-05-12 | ||
| EP03010591.0 | 2003-05-12 | ||
| PCT/EP2004/005092 WO2004099253A1 (en) | 2003-05-12 | 2004-05-12 | Method of detecting probnp with a monoclonal antibody binding to the amino acid 41-46 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0410261A BRPI0410261A (pt) | 2006-05-16 |
| BRPI0410261B1 BRPI0410261B1 (pt) | 2020-03-10 |
| BRPI0410261B8 true BRPI0410261B8 (pt) | 2021-07-27 |
Family
ID=33427054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0410261A BRPI0410261B8 (pt) | 2003-05-12 | 2004-05-12 | anticorpo monoclonal que se liga especificamente ao probnp, métodos para detecção específica de probnp in vitro e para diagnóstico de insuficiência cardíaca in vitro, kit para medição de probnp, e linhagem celular de hibridoma mab 1.21.3 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US7264939B2 (enExample) |
| EP (4) | EP1625164B1 (enExample) |
| JP (4) | JP4430066B2 (enExample) |
| KR (2) | KR20080011467A (enExample) |
| CN (3) | CN1784425A (enExample) |
| AT (2) | ATE522546T1 (enExample) |
| AU (1) | AU2004235974B2 (enExample) |
| BR (1) | BRPI0410261B8 (enExample) |
| CA (2) | CA2522747C (enExample) |
| DK (3) | DK2256132T3 (enExample) |
| ES (3) | ES2369008T3 (enExample) |
| HU (1) | HUE025169T2 (enExample) |
| MX (1) | MXPA05011826A (enExample) |
| PL (3) | PL2256132T3 (enExample) |
| WO (2) | WO2004099253A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2843396B1 (fr) * | 2002-08-07 | 2005-04-15 | Bio Rad Pasteur | Anticorps specifiques pour le diagnostic de l'insuffisance cardiaque |
| ATE522546T1 (de) * | 2003-05-12 | 2011-09-15 | Hoffmann La Roche | Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 38- 43 bindet |
| US20070037208A1 (en) * | 2003-05-29 | 2007-02-15 | Foote Robert S | Method for detecting cardiac ischemia via changes in b-natriuretic peptide levels |
| DE10355731A1 (de) | 2003-11-28 | 2005-06-30 | Roche Diagnostics Gmbh | Analytischer Sandwichtest zur Bestimmung von NT-proBNP |
| DE602005001299T2 (de) * | 2004-07-07 | 2008-02-07 | Roche Diagnostics Gmbh | Kombinationen von Markern zum Nachweis von typ 1 und 2 Diabetes |
| AT500800B1 (de) * | 2004-09-08 | 2008-07-15 | Biomedica Medizinprodukte Gmbh | Verfahren zur bestimmung von probnp |
| WO2008089994A1 (en) | 2007-01-25 | 2008-07-31 | Roche Diagnostics Gmbh | Use of igfbp-7 in the assessment of heart failure |
| KR100836322B1 (ko) * | 2007-08-31 | 2008-06-09 | 현대자동차주식회사 | 차량용 흡음재 제작장치 및 방법 |
| US9482677B2 (en) | 2008-02-27 | 2016-11-01 | Scios Inc. | Method, composition and device for sampling natriuretic peptides in a biological fluid |
| CA2722485C (en) | 2008-04-30 | 2018-02-13 | F. Hoffmann-La Roche Ag | Use of sfrp-3 in the assessment of heart failure |
| WO2011012268A1 (en) | 2009-07-27 | 2011-02-03 | Roche Diagnostics Gmbh | Use of mimecan in the assessment of heart failure |
| KR20120101064A (ko) * | 2009-11-13 | 2012-09-12 | 비쥐 메디신, 인코포레이티드 | 심근 경색의 위험 인자 및 예측 |
| US8778699B2 (en) | 2010-08-04 | 2014-07-15 | Idexx Laboratories, Inc. | Detection of degradation products of canine NT-proBNP |
| CA2856798A1 (en) | 2011-05-31 | 2012-12-06 | Idexx Laboratories, Inc. | Detection of degradation products of feline nt-probnp |
| WO2013042603A1 (ja) * | 2011-09-20 | 2013-03-28 | コニカミノルタホールディングス株式会社 | 検体希釈用液、それを用いたキットおよび蛍光測定方法 |
| US20140273273A1 (en) | 2012-11-01 | 2014-09-18 | Christie Mitchell Ballantyne | Biomarkers to improve prediction of heart failure risk |
| CN103304665A (zh) * | 2013-05-21 | 2013-09-18 | 上海贝西生物科技有限公司 | 一种抗氨基末端脑利钠肽前体单克隆抗体及其应用 |
| JP6682445B2 (ja) * | 2014-10-10 | 2020-04-15 | 松森 昭 | 心不全患者の検出方法、心疾患の識別方法、心不全の検査試薬、心不全の検査キット、心不全を検出するための装置及び心不全を検出するためのプログラム |
| EP3360570A1 (en) | 2017-02-13 | 2018-08-15 | Roche Diagnostics GmbH | Antibodies recognizing genetic variants |
| JP7203034B2 (ja) * | 2017-10-02 | 2023-01-12 | 大塚製薬株式会社 | アナライトの検出方法 |
| US12352764B2 (en) * | 2018-04-13 | 2025-07-08 | Kyoritsu Seiyaku Corporation | Method of detecting heart failure, device for detecting heart failure, sandwich immunoassay method, and combination of antibodies |
| CN108752480B (zh) * | 2018-05-30 | 2022-03-29 | 中元汇吉生物技术股份有限公司 | 一种免疫原组合物、其制备方法及其用途 |
| US12400762B2 (en) | 2018-12-11 | 2025-08-26 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy |
| US12001939B2 (en) | 2018-12-11 | 2024-06-04 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views |
| US11931207B2 (en) | 2018-12-11 | 2024-03-19 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device |
| US11446009B2 (en) | 2018-12-11 | 2022-09-20 | Eko.Ai Pte. Ltd. | Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images |
| US12322100B2 (en) | 2018-12-11 | 2025-06-03 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity |
| CN111487222B (zh) * | 2019-01-28 | 2023-11-14 | 上海乐合生物科技有限公司 | 一种检测bnp的spr芯片的制备方法 |
| JP7664226B2 (ja) | 2019-08-13 | 2025-04-17 | ゲンティアン アクティーゼルスカブ | Ｎｔ－プロｂｎｐの定量のための高感度粒子増感アッセイ |
| WO2022069658A1 (en) | 2020-09-30 | 2022-04-07 | F. Hoffmann-La Roche Ag | Circulating total-nt-probnp (glycosylated and unglycosylated nt-probnp) and its ratio with nt-probnp (unglycosylated nt-probnp) in the assessment of atrial fibrillation |
| CN112964885B (zh) * | 2021-02-20 | 2022-11-11 | 广东菲鹏生物有限公司 | 一种氨基末端脑尿钠肽检测方法和试剂盒 |
| CN112986586A (zh) * | 2021-02-20 | 2021-06-18 | 广东菲鹏生物有限公司 | 一种氨基末端脑尿钠肽检测方法和试剂盒 |
| WO2023052642A1 (en) | 2021-10-01 | 2023-04-06 | Gentian As | Novel method for determining a concentration of n-terminal pro-hormone bnp (nt-probnp) in a sample |
| CN118922721A (zh) | 2022-03-18 | 2024-11-08 | 豪夫迈·罗氏有限公司 | 用于2型与1型急性心肌梗死的早期辨别的cMyBPC标志物组合 |
| WO2023175152A1 (en) | 2022-03-18 | 2023-09-21 | Roche Diagnostics Gmbh | Troponin marker combinations for early discrimination of type 2 versus type 1 acute myocardial infarction |
| WO2024219421A1 (ja) * | 2023-04-19 | 2024-10-24 | 栄研化学株式会社 | ＮＴ－ｐｒｏＢＮＰに対する抗体、これを用いたＮＴ－ｐｒｏＢＮＰ検出方法、並びに、ＮＴ－ｐｒｏＢＮＰ検出に用いるための組成物及びキット |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3445816C1 (de) | 1984-12-15 | 1986-06-12 | Behringwerke Ag, 3550 Marburg | Flaechenfoermiges diagnostisches Mittel |
| JP2665850B2 (ja) | 1991-11-14 | 1997-10-22 | 塩野義製薬株式会社 | ｈＢＮＰのＣ端を認識するモノクロ−ナル抗体 |
| GB9211686D0 (en) | 1992-06-03 | 1992-07-15 | Medisinsk Innovation A S | Chemical compounds |
| CA2304263C (en) * | 1997-09-11 | 2008-07-29 | Shionogi & Co., Ltd. | Immunoassay method for bnp |
| GB9827348D0 (en) * | 1998-12-12 | 1999-02-03 | Univ Leicester | Natriuretic peptide |
| CN1327228C (zh) | 1999-01-29 | 2007-07-18 | 罗赫诊断器材股份有限公司 | 鉴定样品中的n－末端前bnp的方法 |
| US20030219734A1 (en) | 2001-04-13 | 2003-11-27 | Biosite Incorporated | Polypeptides related to natriuretic peptides and methods of their identification and use |
| US20040096919A1 (en) * | 2002-11-18 | 2004-05-20 | Michelle Davey | Polyclonal-monoclonal ELISA assay for detecting N-terminus proBNP |
| ATE522546T1 (de) * | 2003-05-12 | 2011-09-15 | Hoffmann La Roche | Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 38- 43 bindet |
-
2004
- 2004-05-12 AT AT04732278T patent/ATE522546T1/de active
- 2004-05-12 HU HUE10172014A patent/HUE025169T2/en unknown
- 2004-05-12 ES ES04732282T patent/ES2369008T3/es not_active Expired - Lifetime
- 2004-05-12 CA CA2522747A patent/CA2522747C/en not_active Expired - Lifetime
- 2004-05-12 PL PL10172014T patent/PL2256132T3/pl unknown
- 2004-05-12 CA CA2522378A patent/CA2522378C/en not_active Expired - Lifetime
- 2004-05-12 AU AU2004235974A patent/AU2004235974B2/en not_active Expired
- 2004-05-12 KR KR1020087000782A patent/KR20080011467A/ko not_active Ceased
- 2004-05-12 ES ES04732278T patent/ES2372282T3/es not_active Expired - Lifetime
- 2004-05-12 DK DK10172014.2T patent/DK2256132T3/en active
- 2004-05-12 CN CNA2004800124973A patent/CN1784425A/zh active Pending
- 2004-05-12 BR BRPI0410261A patent/BRPI0410261B8/pt not_active IP Right Cessation
- 2004-05-12 KR KR1020057021327A patent/KR100857752B1/ko not_active Expired - Lifetime
- 2004-05-12 MX MXPA05011826A patent/MXPA05011826A/es active IP Right Grant
- 2004-05-12 DK DK04732278.9T patent/DK1625163T3/da active
- 2004-05-12 AT AT04732282T patent/ATE517124T1/de active
- 2004-05-12 CN CNB200480012494XA patent/CN100497393C/zh not_active Expired - Lifetime
- 2004-05-12 WO PCT/EP2004/005092 patent/WO2004099253A1/en not_active Ceased
- 2004-05-12 EP EP04732282A patent/EP1625164B1/en not_active Expired - Lifetime
- 2004-05-12 EP EP04732278A patent/EP1625163B8/en not_active Expired - Lifetime
- 2004-05-12 WO PCT/EP2004/005091 patent/WO2004099252A1/en not_active Ceased
- 2004-05-12 PL PL04732282T patent/PL1625164T3/pl unknown
- 2004-05-12 JP JP2006505418A patent/JP4430066B2/ja not_active Expired - Lifetime
- 2004-05-12 PL PL04732278T patent/PL1625163T3/pl unknown
- 2004-05-12 JP JP2006505419A patent/JP5128125B2/ja not_active Expired - Lifetime
- 2004-05-12 CN CN2010101190838A patent/CN101967190A/zh active Pending
- 2004-05-12 ES ES10172014.2T patent/ES2548327T3/es not_active Expired - Lifetime
- 2004-05-12 DK DK04732282.1T patent/DK1625164T3/da active
- 2004-05-12 EP EP15161853.5A patent/EP2949669A1/en not_active Ceased
- 2004-05-12 EP EP10172014.2A patent/EP2256132B1/en not_active Expired - Lifetime
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2005
- 2005-11-10 US US11/271,651 patent/US7264939B2/en not_active Expired - Lifetime
- 2005-11-10 US US11/271,138 patent/US7264938B2/en not_active Expired - Lifetime
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2006
- 2006-12-05 US US11/634,286 patent/US7807380B2/en not_active Expired - Lifetime
- 2006-12-22 US US11/644,565 patent/US7811770B2/en not_active Expired - Lifetime
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2009
- 2009-09-04 JP JP2009204610A patent/JP4834136B2/ja not_active Expired - Lifetime
-
2012
- 2012-10-04 JP JP2012222436A patent/JP5649631B2/ja not_active Expired - Lifetime
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