ATE441116T1 - Verfahren zur selektiven bestimmung von procalcitonin 1-116 für diagnostische zwecke sowie antikírper und kits zur ausführung dieses verfahrens - Google Patents

Verfahren zur selektiven bestimmung von procalcitonin 1-116 für diagnostische zwecke sowie antikírper und kits zur ausführung dieses verfahrens

Info

Publication number
ATE441116T1
ATE441116T1 AT08715933T AT08715933T ATE441116T1 AT E441116 T1 ATE441116 T1 AT E441116T1 AT 08715933 T AT08715933 T AT 08715933T AT 08715933 T AT08715933 T AT 08715933T AT E441116 T1 ATE441116 T1 AT E441116T1
Authority
AT
Austria
Prior art keywords
procalcitonin
kits
antibodies
carrying
diagnostic purposes
Prior art date
Application number
AT08715933T
Other languages
English (en)
Inventor
Andreas Bergmann
Joachim Struck
Original Assignee
Brahms Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brahms Ag filed Critical Brahms Ag
Application granted granted Critical
Publication of ATE441116T1 publication Critical patent/ATE441116T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/585—Calcitonins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
AT08715933T 2007-02-28 2008-02-21 Verfahren zur selektiven bestimmung von procalcitonin 1-116 für diagnostische zwecke sowie antikírper und kits zur ausführung dieses verfahrens ATE441116T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007009751A DE102007009751A1 (de) 2007-02-28 2007-02-28 Verfahren zur selektiven Bestimmung von Procalcitonin 1-116 für diagnostische Zwecke sowie Antikörper und Kits zur Durchführung eines solchen Verfahrens
PCT/EP2008/001373 WO2008104321A1 (en) 2007-02-28 2008-02-21 Method for the selective determination of procalcitonin 1-116 for diagnostic purposes and antibodies and kits for carrying out such a method

Publications (1)

Publication Number Publication Date
ATE441116T1 true ATE441116T1 (de) 2009-09-15

Family

ID=39327375

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08715933T ATE441116T1 (de) 2007-02-28 2008-02-21 Verfahren zur selektiven bestimmung von procalcitonin 1-116 für diagnostische zwecke sowie antikírper und kits zur ausführung dieses verfahrens

Country Status (8)

Country Link
US (2) US8354506B2 (de)
EP (1) EP2032992B1 (de)
JP (1) JP5520609B2 (de)
CN (2) CN107422133A (de)
AT (1) ATE441116T1 (de)
DE (2) DE102007009751A1 (de)
ES (1) ES2331936T3 (de)
WO (1) WO2008104321A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8283131B2 (en) 2008-10-28 2012-10-09 Assistance Publique-Hopitaux De Paris Methods and kits for the rapid determination of patients at high risk of death during severe sepsis and septic shock
JP5619016B2 (ja) * 2008-10-28 2014-11-05 アシスタンスピュブリック−オピトド パリＡｓｓｉｓｔａｎｃｅ Ｐｕｂｌｉｑｕｅ−Ｈｏｐｉｔａｕｘ Ｄｅ Ｐａｒｉｓ 重症敗血症及び敗血症性ショック中の死亡の危険性が高い患者を迅速に決定するための方法及びキット
TR201806292T4 (tr) * 2009-04-28 2018-06-21 Brahms Gmbh Prokalsi̇toni̇ni̇n saptanmasi i̇çi̇n i̇mmünoloji̇k test
ES2617982T3 (es) * 2009-08-28 2017-06-20 B.R.A.H.M.S Gmbh Procalcitonina para la prognosis de eventos adversos
US8383332B2 (en) * 2009-10-13 2013-02-26 B.R.A.H.M.S. Gmbh Procalcitonin for the diagnosis of bacterial infections and guidance of antibiotic treatment in patients with acute stroke or transient ischemic attack
WO2011110565A1 (en) * 2010-03-08 2011-09-15 B.R.A.H.M.S Gmbh Procalcitonin for the diagnosis of bacterial infections and guidance of antibiotic treatment in patients with non-specific complaints
ITRM20100121A1 (it) * 2010-03-18 2011-09-19 Univ Pisa Marcatori molecolari per infezioni delle vie urinarie.
JP5956434B2 (ja) 2011-05-19 2016-07-27 持田製薬株式会社 血液検体を用いた呼吸器感染症の診断
CN103635805B (zh) 2011-05-19 2016-03-02 持田制药株式会社 使用尿样本的呼吸道传染病的诊断
CN102702323B (zh) * 2011-09-15 2015-04-22 重庆业为基生物科技有限公司 降钙素原b细胞表位肽段及其单克隆抗体的应用
CN102643332B (zh) * 2011-09-15 2014-12-31 重庆业为基生物科技有限公司 人pct的b细胞表位肽段及其单克隆抗体的应用
IN2014MN01780A (de) 2012-02-09 2015-07-03 Memed Diagnostics Ltd
US9488659B2 (en) * 2012-04-12 2016-11-08 B.R.A.H.M.S. Gmbh Prognosis of adverse events in patients with suspected chronic heart failure
CN103018456B (zh) * 2012-11-29 2014-10-01 深圳市伯劳特生物制品有限公司 降钙素原检测试纸条及其制备方法
US10260111B1 (en) 2014-01-20 2019-04-16 Brett Eric Etchebarne Method of detecting sepsis-related microorganisms and detecting antibiotic-resistant sepsis-related microorganisms in a fluid sample
CN104792997B (zh) * 2014-01-22 2017-07-11 天津汇滨生物科技有限公司 一种人降钙素原免疫检测试剂盒及其制备方法与应用
CN103913579B (zh) * 2014-03-24 2016-05-25 北京普恩光德生物科技开发有限公司 一种降钙素原检测试剂盒
EP3699930B1 (de) 2014-08-14 2024-02-07 MeMed Diagnostics Ltd. Rechnerische analyse biologischer daten mit verteiler und hyperebene
WO2016059636A1 (en) 2014-10-14 2016-04-21 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof
US9375478B1 (en) 2015-01-30 2016-06-28 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9750785B2 (en) 2015-01-30 2017-09-05 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9937223B2 (en) 2015-01-30 2018-04-10 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9687526B2 (en) 2015-01-30 2017-06-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744209B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
CN104714017A (zh) * 2015-02-06 2015-06-17 北京豪迈生物工程有限公司 一种定量检测降钙素原的方法
CN105801697A (zh) * 2015-07-09 2016-07-27 南京诺尔曼生物技术有限公司 人源降钙素原的单克隆抗体其制备方法和用途
CN106399294B (zh) * 2015-12-07 2019-07-09 湖南师范大学 一种抗人降钙素原蛋白n末端抗原表位的单克隆抗体7h8的制备
EP3423590A4 (de) 2016-03-03 2020-02-26 Memed Diagnostics Ltd. Rna-determinanten zur unterscheidung zwischen bakteriellen und viralen infektionen
CN105758832A (zh) * 2016-04-06 2016-07-13 上海奥普生物医药有限公司 一种基于微球的杯式时间分辨荧光降钙素原分析试剂盒及其制备方法和应用
EP4141448A1 (de) 2016-07-10 2023-03-01 MeMed Diagnostics Ltd. Proteinsignaturen zur unterscheidung zwischen bakteriellen und viralen infektionen
WO2018011796A1 (en) 2016-07-10 2018-01-18 Memed Diagnostics Ltd. Early diagnosis of infections
US11385241B2 (en) 2016-09-29 2022-07-12 Memed Diagnostics Ltd. Methods of prognosis and treatment
US11353456B2 (en) 2016-09-29 2022-06-07 Memed Diagnostics Ltd. Methods of risk assessment and disease classification for appendicitis
CN107817347A (zh) * 2017-09-25 2018-03-20 南京航思生物科技有限公司 一种均相发光法检测动物降钙素原的试剂盒
JP7051096B2 (ja) * 2018-05-30 2022-04-11 国立大学法人山口大学 ウシプロカルシトニンを特異的に認識する抗体、その抗原結合断片、および、その使用
CN116559471A (zh) * 2018-07-18 2023-08-08 科美博阳诊断技术(上海)有限公司 一种降钙素原均相化学发光检测试剂盒、检测方法与装置
CN109633163B (zh) * 2018-11-28 2022-03-04 浙江聚康生物工程有限公司 降钙素原/c反应蛋白二合一检测试剂盒
CN115136009A (zh) 2020-04-09 2022-09-30 B.R.A.H.M.S有限公司 用于呼吸道感染诊断的生物标志物
CN115980341A (zh) * 2022-12-26 2023-04-18 南京珀尔泰生物技术有限公司 一种新型胶体金法定量检测降钙素原pct免疫层析试纸条及其制备方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2570703B1 (fr) 1984-09-26 1988-07-08 Commissariat Energie Atomique Complexes macropolycycliques de terres rares et application a titre de marqueurs fluorescents
US4822733A (en) 1985-05-28 1989-04-18 Amoco Corporation Lifetime-resolved assay procedures
FR2664699B1 (fr) 1990-07-13 1995-08-18 Cis Bio Int Procede d'amplification du signal d'emission d'un compose luminescent.
DE4227454C1 (de) * 1992-08-19 1994-02-03 Henning Berlin Gmbh Verfahren zur Früherkennung, zur Erkennung des Schweregrads sowie zur therapiebegleitenden Verlaufsbeurteilung einer Sepsis sowie Mittel zur Durchführung des Verfahrens
DE19600875C1 (de) 1996-01-12 1997-06-26 Brahms Diagnostica Gmbh Diagnostisches Verfahren zur Bestimmung der Ätiologie entzündlicher Prozesse
US5993811A (en) * 1997-02-03 1999-11-30 Biology Associates, Llc Method and compositions for preventing and treating the systemic inflammatory response syndrome including sepsis
DE19847690A1 (de) 1998-10-15 2000-04-20 Brahms Diagnostica Gmbh Verfahren und Substanzen für die Diagnose und Therapie von Sepsis und sepsisähnlichen systemischen Infektionen
DE19903336C2 (de) * 1999-01-28 2000-12-14 Brahms Diagnostica Gmbh Gebrauchsfertige Kalibratoren für die Bestimmung von Procalcitonin
DE10041215A1 (de) * 1999-12-22 2001-10-04 Dade Behring Marburg Gmbh Gegen Procalcitonin gerichtete Antikörper, ihre Herstellung und Verwendung
DE50014159D1 (de) * 1999-12-22 2007-04-26 Dade Behring Marburg Gmbh Lösungen von humanem Procalcitonin
DE50015156D1 (de) 1999-12-22 2008-06-26 Dade Behring Marburg Gmbh Gegen Procalcitonin gerichtete Antikörper, ihre Herstellung und Verwendung
EP1270740A1 (de) * 2001-06-29 2003-01-02 SIRS-Lab GmbH Biochip und dessen Verwendung zur Bestimmung von Entzündungen
EP1355158A1 (de) 2002-04-19 2003-10-22 B.R.A.H.M.S Aktiengesellschaft Verfahren zur Diagnose von Entzündungserkrankungen und Infektionen unter Bestimmung des Phosphoproteins LASP-1 als Inflammationsmarker
EP1355159A1 (de) 2002-04-19 2003-10-22 B.R.A.H.M.S Aktiengesellschaft Verwendungen von Fragmenten der Carbamoylphosphat Synthetase 1 (CPS 1) für die Diagnose von Entzündungserkrankungen und Sepsis
EP1369693A1 (de) * 2002-06-04 2003-12-10 B.R.A.H.M.S Aktiengesellschaft Verfahren zur Sepsisdiagnose und zur Kontrolle von Spenderblut durch Bestimmung von anti-Asialo-Gangliosid-Antikörpern
EP1369118A1 (de) 2002-06-04 2003-12-10 B.R.A.H.M.S Aktiengesellschaft Verfahren und Mittel zur Prävention, Hemmung und Therapie von Sepsis
DE10316583A1 (de) 2003-04-10 2004-10-28 B.R.A.H.M.S Aktiengesellschaft Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung
EP1562046A1 (de) 2004-02-03 2005-08-10 B.R.A.H.M.S Aktiengesellschaft Diagnose von Sepsis durch selektive Bestimmung der Konzentration der Cu/Zn Superoxiddismutase (Cu/Zn SOD) in Patientenproben
ES2255003T3 (es) 2004-02-13 2006-06-16 B.R.A.H.M.S Aktiengesellschaft Procedimiento para determinar la formacion de endotelinas con fines diagnostico medico, y anticuerpos y kits para realizar un procedimiento de este tipo.
DE102004047968A1 (de) * 2004-10-01 2006-04-06 B.R.A.H.M.S Ag Bestimmung von Gastrokine 1 (GKN1) als Biomarker für Entzündungen und Infektionen
DE102005011421A1 (de) 2005-03-11 2006-09-14 Brahms Aktiengesellschaft Bestimmung von kurzkettiger SRL-Alkoholdehydrogenase (DHRS4) als Biomarker für Entzündungen und Infektionen
DE102005034174A1 (de) 2005-07-21 2007-02-08 B.R.A.H.M.S Ag Liquordiagnostisches in vitro Verfahren zur Diagnose von Demenz-Erkrankungen und neuroinflammatorischen Erkrankungen
DE102005036094A1 (de) 2005-08-01 2007-02-08 B.R.A.H.M.S Ag In vitro Verfahren zur Diagnose von neurodegenerativen Erkrankungen
US8906857B2 (en) 2005-12-01 2014-12-09 B.R.A.H.M.S. Gmbh Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists
DE102006046996A1 (de) 2006-10-01 2008-04-03 Brahms Aktiengesellschaft Diagnose von Infektionen oder Entzündungserkrankungen der Atemwege und Lunge assoziiert mit Herzinsuffizienz
EP2084543B1 (de) 2006-10-26 2017-10-18 B.R.A.H.M.S GmbH Risikostratifizierung des akuten koronarsyndroms mittels fragmenten / teilpeptiden des provasopressins, insbesondere copeptin oder neurophysin ii
DE102006052916A1 (de) 2006-11-08 2008-05-15 Brahms Aktiengesellschaft Diagnose und Risikostratifizierung von Diabetes mellitus mittels MR-proADM
US9012151B2 (en) 2006-11-09 2015-04-21 B.R.A.H.M.S. Gmbh Methods of diagnosis and risk stratification of adverse events in post myocardial infarction patients using pro-adrenomedullin
DE102006053442A1 (de) 2006-11-12 2008-05-15 Brahms Aktiengesellschaft Diagnose und Risikostratifizierung von Infektionen und chronischen Erkrankungen der Atemwege und Lunge mittels proVasopressin, insbesondere Copeptin oder Neurophysin II
DE102006060112A1 (de) 2006-12-20 2008-06-26 Brahms Aktiengesellschaft Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM

Also Published As

Publication number Publication date
CN101617230A (zh) 2009-12-30
WO2008104321A1 (en) 2008-09-04
CN107422133A (zh) 2017-12-01
DE102007009751A1 (de) 2008-09-04
EP2032992B1 (de) 2009-08-26
US9664689B2 (en) 2017-05-30
ES2331936T3 (es) 2010-01-20
US20100056763A1 (en) 2010-03-04
EP2032992A1 (de) 2009-03-11
JP2010519322A (ja) 2010-06-03
US8354506B2 (en) 2013-01-15
JP5520609B2 (ja) 2014-06-11
US20130122515A1 (en) 2013-05-16
DE602008000117D1 (de) 2009-10-08

Similar Documents

Publication Publication Date Title
ATE441116T1 (de) Verfahren zur selektiven bestimmung von procalcitonin 1-116 für diagnostische zwecke sowie antikírper und kits zur ausführung dieses verfahrens
NZ613646A (en) Elisa for vegf
BRPI0509419A (pt) método de ensaio imunossorvente ligado por enzimas, anticorpos, hibridoma e kit de imunoensaio
BRPI0410261B8 (pt) anticorpo monoclonal que se liga especificamente ao probnp, métodos para detecção específica de probnp in vitro e para diagnóstico de insuficiência cardíaca in vitro, kit para medição de probnp, e linhagem celular de hibridoma mab 1.21.3
DE502005010086D1 (de) Monoklonaler antikörper gegen humanen frizzled-4-rezeptor
JP2010520996A5 (ja) 敗血症の合併症の検査
NZ599105A (en) Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ600828A (en) Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ592552A (en) Methods and compositions for diagnosis and prognosis of renal injury and renal failure
HK1099807A1 (en) Method for detecting the formation of endothelins for medical diagnosis, and antibodies and kits for carrying out one such method
WO2005103698A3 (en) Methods and antibodies for nitrofuran detection
MX2007014815A (es) Metodos de inmunoanalisis mejorados.
CL2008003561A1 (es) Construccion de union a il - 13 que comprende a lo menos un dominio simple (dab) de anticuerpo injertado en un anticuerpo monoclonal ( mabdab); polinucleotido y celula huesped; procedimiento para preparar la construccion; composicion farmaceutica que la comprende y uso para tratar cancer o enfermedades inflamatorias.
BRPI0707645B8 (pt) métodos in vitro para detecção de câncer em um indivíduo e para avaliação de prognóstico de um indivíduo tendo, ou suspeito de ter, câncer ovariano
WO2013132347A3 (en) Improved elisa immunoassay for calprotectin
DE60130538D1 (de) Humanisierte antikörper gegen ccr2 und verfahren zur deren verwendung
EP2295465A3 (de) Menschliche monoklonale Antikörper gegen das Influenza M2 Protein sowie Methoden zu deren Herstellung und Verwendung
ATE554106T1 (de) Antikörper für onkogene stämme von hpv und verfahren zu deren verwendung
WO2010038974A3 (ko) 이뮤노글로블린 에이 신증과 티지비엠 신증의 진단용 조성물 및 키트
WO2007024735A3 (en) Method and antibodies for detecting nitrofuran
BRPI0820885B8 (pt) "anticorpo ou fraguimento do mesmo, célula de hibridoma, polinucleotídeo, polipeptídeo compreendendoum domínio de cadeia pesada ou leve de anticorpo, método para detecção de gravidez em um animal bovino, kit e método de purificação de um antígeno principal associado à gravidez (pag)".
DE602006014581D1 (de) Turbidimetrischer immunoassay zur beurteilung von humanem cystatin c
DK2054443T3 (da) Antistoffer mod en epitop fra AGR2, assays og hybridomer
WO2005106494A3 (en) Monoclonal antibodies, hybridomas, improved method for determining the protein ptx3 and kit for said determination
ATE553127T1 (de) Oligoklonale anti-clusterin-antikörper zur diagnose und vorhersage der aggressivität von tumoren, diagnostisches verfahren und damit in zusammenhang stehende kits

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 2032992

Country of ref document: EP