BRPI0410261B8 - anticorpo monoclonal que se liga especificamente ao probnp, métodos para detecção específica de probnp in vitro e para diagnóstico de insuficiência cardíaca in vitro, kit para medição de probnp, e linhagem celular de hibridoma mab 1.21.3 - Google Patents

anticorpo monoclonal que se liga especificamente ao probnp, métodos para detecção específica de probnp in vitro e para diagnóstico de insuficiência cardíaca in vitro, kit para medição de probnp, e linhagem celular de hibridoma mab 1.21.3

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Publication number
BRPI0410261B8
BRPI0410261B8 BRPI0410261A BRPI0410261A BRPI0410261B8 BR PI0410261 B8 BRPI0410261 B8 BR PI0410261B8 BR PI0410261 A BRPI0410261 A BR PI0410261A BR PI0410261 A BRPI0410261 A BR PI0410261A BR PI0410261 B8 BRPI0410261 B8 BR PI0410261B8
Authority
BR
Brazil
Prior art keywords
probnp
vitro
cell line
heart failure
hybridoma cell
Prior art date
Application number
BRPI0410261A
Other languages
English (en)
Inventor
Gallusser Andreas
Borgya Anneliese
Seidel Christoph
Hallermayer Klaus
Grol Michael
Klemt Volker
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33427054&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0410261(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0410261A publication Critical patent/BRPI0410261A/pt
Publication of BRPI0410261B1 publication Critical patent/BRPI0410261B1/pt
Publication of BRPI0410261B8 publication Critical patent/BRPI0410261B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Cardiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"método de detecção de probnp natural". a presente invenção refere-se a anticorpos que especificamente se ligam ao probnp natural, a um método para detecção específica de probnp natural, um método de correlacionar o nível de probnp natural ao diagnóstico de colapso cardíaco, um kit para detecção de probnp natural e a uma linha celular de hibridoma que produz um anticorpo para o probnp natural.
BRPI0410261A 2003-05-12 2004-05-12 anticorpo monoclonal que se liga especificamente ao probnp, métodos para detecção específica de probnp in vitro e para diagnóstico de insuficiência cardíaca in vitro, kit para medição de probnp, e linhagem celular de hibridoma mab 1.21.3 BRPI0410261B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03010591 2003-05-12
EP03010591.0 2003-05-12
PCT/EP2004/005092 WO2004099253A1 (en) 2003-05-12 2004-05-12 Method of detecting probnp with a monoclonal antibody binding to the amino acid 41-46

Publications (3)

Publication Number Publication Date
BRPI0410261A BRPI0410261A (pt) 2006-05-16
BRPI0410261B1 BRPI0410261B1 (pt) 2020-03-10
BRPI0410261B8 true BRPI0410261B8 (pt) 2021-07-27

Family

ID=33427054

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410261A BRPI0410261B8 (pt) 2003-05-12 2004-05-12 anticorpo monoclonal que se liga especificamente ao probnp, métodos para detecção específica de probnp in vitro e para diagnóstico de insuficiência cardíaca in vitro, kit para medição de probnp, e linhagem celular de hibridoma mab 1.21.3

Country Status (16)

Country Link
US (4) US7264938B2 (pt)
EP (4) EP1625163B8 (pt)
JP (4) JP5128125B2 (pt)
KR (2) KR100857752B1 (pt)
CN (3) CN1784425A (pt)
AT (2) ATE517124T1 (pt)
AU (1) AU2004235974B2 (pt)
BR (1) BRPI0410261B8 (pt)
CA (2) CA2522378C (pt)
DK (3) DK1625164T3 (pt)
ES (3) ES2372282T3 (pt)
HK (1) HK1097855A1 (pt)
HU (1) HUE025169T2 (pt)
MX (1) MXPA05011826A (pt)
PL (3) PL1625164T3 (pt)
WO (2) WO2004099252A1 (pt)

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FR2843396B1 (fr) * 2002-08-07 2005-04-15 Bio Rad Pasteur Anticorps specifiques pour le diagnostic de l'insuffisance cardiaque
ES2372282T3 (es) * 2003-05-12 2012-01-18 F. Hoffmann-La Roche Ag Método para detectar probnp con un anticuerpo monoclonal que fija los aminoácidos 38-43.
WO2004105575A2 (en) * 2003-05-29 2004-12-09 Trustee Of Darmouth College A method for detecting cardiac ischemia via changes in b-natriuretic peptide levels
DE10355731A1 (de) * 2003-11-28 2005-06-30 Roche Diagnostics Gmbh Analytischer Sandwichtest zur Bestimmung von NT-proBNP
ATE364177T1 (de) * 2004-07-07 2007-06-15 Hoffmann La Roche Kombinationen von markern zum nachweis von typ 1 und 2 diabetes
AT500800B1 (de) * 2004-09-08 2008-07-15 Biomedica Medizinprodukte Gmbh Verfahren zur bestimmung von probnp
DK2115477T3 (en) 2007-01-25 2015-08-10 Hoffmann La Roche USE OF IGFBP-7 IN THE EVIDENCE OF HEART FAILURE
KR100836322B1 (ko) * 2007-08-31 2008-06-09 현대자동차주식회사 차량용 흡음재 제작장치 및 방법
US9482677B2 (en) 2008-02-27 2016-11-01 Scios Inc. Method, composition and device for sampling natriuretic peptides in a biological fluid
ES2526928T3 (es) 2008-04-30 2015-01-16 The Governing Council Of The University Of Toronto Uso de SFRP-3 en la evaluación de la insuficiencia cardíaca
WO2011012268A1 (en) 2009-07-27 2011-02-03 Roche Diagnostics Gmbh Use of mimecan in the assessment of heart failure
EP2499489B1 (en) * 2009-11-13 2015-01-07 BG Medicine, Inc. Risk factors and prediction of myocardial infarction
EP2601531A1 (en) 2010-08-04 2013-06-12 IDEXX Laboratories, Inc. Detection of degradation products of canine nt-probnp
EP2715353B1 (en) 2011-05-31 2016-08-24 IDEXX Laboratories, Inc. DETECTION OF DEGRADATION PRODUCTS OF FELINE NT-proBNP
JP6119607B2 (ja) * 2011-09-20 2017-04-26 コニカミノルタ株式会社 検体希釈用液、それを用いたキットおよび蛍光測定方法
US20140273273A1 (en) 2012-11-01 2014-09-18 Christie Mitchell Ballantyne Biomarkers to improve prediction of heart failure risk
CN103304665A (zh) * 2013-05-21 2013-09-18 上海贝西生物科技有限公司 一种抗氨基末端脑利钠肽前体单克隆抗体及其应用
CN106716135B (zh) * 2014-10-10 2019-03-15 松森昭 用于检测心力衰竭的装置及储存介质
EP3360570A1 (en) 2017-02-13 2018-08-15 Roche Diagnostics GmbH Antibodies recognizing genetic variants
EP3657169B1 (en) * 2017-10-02 2023-05-03 Otsuka Pharmaceutical Co., Ltd. Method for detecting analyte
CN108752480B (zh) * 2018-05-30 2022-03-29 中元汇吉生物技术股份有限公司 一种免疫原组合物、其制备方法及其用途
US11931207B2 (en) 2018-12-11 2024-03-19 Eko.Ai Pte. Ltd. Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device
US11446009B2 (en) 2018-12-11 2022-09-20 Eko.Ai Pte. Ltd. Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images
CN111487222B (zh) * 2019-01-28 2023-11-14 上海乐合生物科技有限公司 一种检测bnp的spr芯片的制备方法
CN114207444A (zh) 2019-08-13 2022-03-18 挪威金田有限公司 用于NT-proBNP定量的高灵敏度颗粒增强测定
EP4222499A1 (en) 2020-09-30 2023-08-09 F. Hoffmann-La Roche AG Circulating total-nt-probnp (glycosylated and unglycosylated nt-probnp) and its ratio with nt-probnp (unglycosylated nt-probnp) in the assessment of atrial fibrillation
CN112964885B (zh) * 2021-02-20 2022-11-11 广东菲鹏生物有限公司 一种氨基末端脑尿钠肽检测方法和试剂盒
CN112986586A (zh) * 2021-02-20 2021-06-18 广东菲鹏生物有限公司 一种氨基末端脑尿钠肽检测方法和试剂盒
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Also Published As

Publication number Publication date
EP1625164A1 (en) 2006-02-15
HUE025169T2 (en) 2016-02-29
JP2010011860A (ja) 2010-01-21
KR20060003905A (ko) 2006-01-11
CN1784425A (zh) 2006-06-07
CA2522747A1 (en) 2004-11-18
EP1625163B1 (en) 2011-08-31
ES2369008T3 (es) 2011-11-24
EP1625163A1 (en) 2006-02-15
HK1097855A1 (en) 2007-07-06
ATE522546T1 (de) 2011-09-15
CN100497393C (zh) 2009-06-10
EP2256132B1 (en) 2015-04-01
JP5128125B2 (ja) 2013-01-23
CA2522378A1 (en) 2004-11-18
WO2004099253A1 (en) 2004-11-18
JP2007535470A (ja) 2007-12-06
BRPI0410261B1 (pt) 2020-03-10
EP2949669A1 (en) 2015-12-02
MXPA05011826A (es) 2006-01-26
DK2256132T3 (en) 2015-07-13
ATE517124T1 (de) 2011-08-15
EP1625163B8 (en) 2011-11-02
WO2004099252A1 (en) 2004-11-18
US7807380B2 (en) 2010-10-05
PL2256132T3 (pl) 2016-08-31
CA2522378C (en) 2011-03-29
DK1625164T3 (da) 2011-10-31
BRPI0410261A (pt) 2006-05-16
ES2372282T3 (es) 2012-01-18
CA2522747C (en) 2012-08-14
CN1832964A (zh) 2006-09-13
AU2004235974B2 (en) 2008-02-14
US7264939B2 (en) 2007-09-04
ES2548327T3 (es) 2015-10-15
US20060110775A1 (en) 2006-05-25
US7264938B2 (en) 2007-09-04
JP4834136B2 (ja) 2011-12-14
US20070099241A1 (en) 2007-05-03
US20070117156A1 (en) 2007-05-24
JP4430066B2 (ja) 2010-03-10
PL1625163T3 (pl) 2012-01-31
JP5649631B2 (ja) 2015-01-07
DK1625163T3 (da) 2011-12-05
KR100857752B1 (ko) 2008-09-11
KR20080011467A (ko) 2008-02-04
JP2007525427A (ja) 2007-09-06
JP2013018784A (ja) 2013-01-31
PL1625164T3 (pl) 2011-12-30
CN101967190A (zh) 2011-02-09
AU2004235974A1 (en) 2004-11-18
EP1625164B1 (en) 2011-07-20
US7811770B2 (en) 2010-10-12
US20060110776A1 (en) 2006-05-25
EP2256132A1 (en) 2010-12-01

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