ATE517124T1 - Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 42- 46 bindet - Google Patents
Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 42- 46 bindetInfo
- Publication number
- ATE517124T1 ATE517124T1 AT04732282T AT04732282T ATE517124T1 AT E517124 T1 ATE517124 T1 AT E517124T1 AT 04732282 T AT04732282 T AT 04732282T AT 04732282 T AT04732282 T AT 04732282T AT E517124 T1 ATE517124 T1 AT E517124T1
- Authority
- AT
- Austria
- Prior art keywords
- amino acid
- monoclonal antibodies
- probnp
- native probnp
- binds amino
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000001413 amino acids Chemical class 0.000 title 1
- 102100036836 Natriuretic peptides B Human genes 0.000 abstract 5
- 101710187802 Natriuretic peptides B Proteins 0.000 abstract 5
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 210000004408 hybridoma Anatomy 0.000 abstract 1
- 238000011895 specific detection Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pathology (AREA)
- Cardiology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03010591 | 2003-05-12 | ||
| PCT/EP2004/005092 WO2004099253A1 (en) | 2003-05-12 | 2004-05-12 | Method of detecting probnp with a monoclonal antibody binding to the amino acid 41-46 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE517124T1 true ATE517124T1 (de) | 2011-08-15 |
Family
ID=33427054
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04732278T ATE522546T1 (de) | 2003-05-12 | 2004-05-12 | Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 38- 43 bindet |
| AT04732282T ATE517124T1 (de) | 2003-05-12 | 2004-05-12 | Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 42- 46 bindet |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04732278T ATE522546T1 (de) | 2003-05-12 | 2004-05-12 | Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 38- 43 bindet |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US7264939B2 (de) |
| EP (4) | EP2949669A1 (de) |
| JP (4) | JP4430066B2 (de) |
| KR (2) | KR20080011467A (de) |
| CN (3) | CN1784425A (de) |
| AT (2) | ATE522546T1 (de) |
| AU (1) | AU2004235974B2 (de) |
| BR (1) | BRPI0410261B8 (de) |
| CA (2) | CA2522378C (de) |
| DK (3) | DK1625163T3 (de) |
| ES (3) | ES2369008T3 (de) |
| HK (1) | HK1097855A1 (de) |
| HU (1) | HUE025169T2 (de) |
| MX (1) | MXPA05011826A (de) |
| PL (3) | PL1625164T3 (de) |
| WO (2) | WO2004099253A1 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2843396B1 (fr) * | 2002-08-07 | 2005-04-15 | Bio Rad Pasteur | Anticorps specifiques pour le diagnostic de l'insuffisance cardiaque |
| DK1625163T3 (da) * | 2003-05-12 | 2011-12-05 | Hoffmann La Roche | Fremgangsmåde til at påvise proBNP med en monoklonal antistofbinding til aminosyrerne 38-43 |
| WO2004105575A2 (en) * | 2003-05-29 | 2004-12-09 | Trustee Of Darmouth College | A method for detecting cardiac ischemia via changes in b-natriuretic peptide levels |
| DE10355731A1 (de) | 2003-11-28 | 2005-06-30 | Roche Diagnostics Gmbh | Analytischer Sandwichtest zur Bestimmung von NT-proBNP |
| ES2288718T3 (es) * | 2004-07-07 | 2008-01-16 | F. Hoffmann-La Roche Ag | Panel de multiples marcadores para la diabetes de tipo 1 y de tipo 2. |
| AT500800B1 (de) * | 2004-09-08 | 2008-07-15 | Biomedica Medizinprodukte Gmbh | Verfahren zur bestimmung von probnp |
| WO2008089994A1 (en) | 2007-01-25 | 2008-07-31 | Roche Diagnostics Gmbh | Use of igfbp-7 in the assessment of heart failure |
| KR100836322B1 (ko) * | 2007-08-31 | 2008-06-09 | 현대자동차주식회사 | 차량용 흡음재 제작장치 및 방법 |
| US9482677B2 (en) | 2008-02-27 | 2016-11-01 | Scios Inc. | Method, composition and device for sampling natriuretic peptides in a biological fluid |
| EP2274622B1 (de) | 2008-04-30 | 2014-10-08 | The Governing Council of the University of Toronto | Verwendung von sfrp-3 bei der beurteilung von herzversagen |
| CN102549436A (zh) | 2009-07-27 | 2012-07-04 | 霍夫曼-拉罗奇有限公司 | mimecan在评价心力衰竭中的用途 |
| BR112012011230A2 (pt) * | 2009-11-13 | 2016-04-05 | Bg Medicine Inc | fatores de risco e previsão de infarto do miocárdio |
| AU2011285694B2 (en) | 2010-08-04 | 2014-12-18 | Idexx Laboratories, Inc. | Detection of degradation products of canine NT-proBNP |
| AU2012262154B2 (en) | 2011-05-31 | 2016-08-04 | Idexx Laboratories, Inc. | Detection of degradation products of feline NT-proBNP |
| WO2013042603A1 (ja) * | 2011-09-20 | 2013-03-28 | コニカミノルタホールディングス株式会社 | 検体希釈用液、それを用いたキットおよび蛍光測定方法 |
| US20140273273A1 (en) | 2012-11-01 | 2014-09-18 | Christie Mitchell Ballantyne | Biomarkers to improve prediction of heart failure risk |
| CN103304665A (zh) * | 2013-05-21 | 2013-09-18 | 上海贝西生物科技有限公司 | 一种抗氨基末端脑利钠肽前体单克隆抗体及其应用 |
| EP3206032B1 (de) * | 2014-10-10 | 2019-02-27 | Akira Matsumori | Verfahren zur detektion eines patienten mit herzversagen, verfahren zur unterscheidung von herzkrankheiten, testreagens für herzversagen, testkit für herzversagen, vorrichtung zur detektion von herzversagen und programm zur detektion von herzversagen |
| EP3360570A1 (de) | 2017-02-13 | 2018-08-15 | Roche Diagnostics GmbH | Monoklonale antikörper für nt-probnp punktmutationen |
| JP7203034B2 (ja) * | 2017-10-02 | 2023-01-12 | 大塚製薬株式会社 | アナライトの検出方法 |
| EP3779438A4 (de) * | 2018-04-13 | 2022-01-26 | Kyoritsu Seiyaku Corporation | Verfahren zur erkennung von herzversagen, instrument zur erkennung von herzversagen, sandwich-immunoassay-verfahren und antikörperkombination |
| CN108752480B (zh) * | 2018-05-30 | 2022-03-29 | 中元汇吉生物技术股份有限公司 | 一种免疫原组合物、其制备方法及其用途 |
| US12001939B2 (en) | 2018-12-11 | 2024-06-04 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views |
| US11446009B2 (en) | 2018-12-11 | 2022-09-20 | Eko.Ai Pte. Ltd. | Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images |
| US11931207B2 (en) | 2018-12-11 | 2024-03-19 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device |
| CN111487222B (zh) * | 2019-01-28 | 2023-11-14 | 上海乐合生物科技有限公司 | 一种检测bnp的spr芯片的制备方法 |
| JP2022544394A (ja) | 2019-08-13 | 2022-10-18 | ゲンティアン アクティーゼルスカブ | Ｎｔ－プロｂｎｐの定量のための高感度粒子増感アッセイ |
| WO2022069658A1 (en) | 2020-09-30 | 2022-04-07 | F. Hoffmann-La Roche Ag | Circulating total-nt-probnp (glycosylated and unglycosylated nt-probnp) and its ratio with nt-probnp (unglycosylated nt-probnp) in the assessment of atrial fibrillation |
| CN112986586A (zh) * | 2021-02-20 | 2021-06-18 | 广东菲鹏生物有限公司 | 一种氨基末端脑尿钠肽检测方法和试剂盒 |
| CN112964885B (zh) * | 2021-02-20 | 2022-11-11 | 广东菲鹏生物有限公司 | 一种氨基末端脑尿钠肽检测方法和试剂盒 |
| IL311792A (en) | 2021-10-01 | 2024-05-01 | Gentian As | A new method for determining the concentration of N-terminal prohormone BNP (NT-PROBNP) in a sample |
| WO2023175176A1 (en) | 2022-03-18 | 2023-09-21 | Roche Diagnostics Gmbh | Cmybpc marker combinations for early discrimination of type 2 versus type 1 acute myocardial infarction |
| WO2023175152A1 (en) | 2022-03-18 | 2023-09-21 | Roche Diagnostics Gmbh | Troponin marker combinations for early discrimination of type 2 versus type 1 acute myocardial infarction |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3445816C1 (de) | 1984-12-15 | 1986-06-12 | Behringwerke Ag, 3550 Marburg | Flaechenfoermiges diagnostisches Mittel |
| JP2665850B2 (ja) | 1991-11-14 | 1997-10-22 | 塩野義製薬株式会社 | ｈＢＮＰのＣ端を認識するモノクロ−ナル抗体 |
| GB9211686D0 (en) | 1992-06-03 | 1992-07-15 | Medisinsk Innovation A S | Chemical compounds |
| GB9827348D0 (en) * | 1998-12-12 | 1999-02-03 | Univ Leicester | Natriuretic peptide |
| CN101046478B (zh) | 1999-01-29 | 2013-04-03 | 罗赫诊断器材股份有限公司 | 鉴定样品中的n-末端前bnp的方法 |
| US20030219734A1 (en) | 2001-04-13 | 2003-11-27 | Biosite Incorporated | Polypeptides related to natriuretic peptides and methods of their identification and use |
| US20040096919A1 (en) * | 2002-11-18 | 2004-05-20 | Michelle Davey | Polyclonal-monoclonal ELISA assay for detecting N-terminus proBNP |
| DK1625163T3 (da) * | 2003-05-12 | 2011-12-05 | Hoffmann La Roche | Fremgangsmåde til at påvise proBNP med en monoklonal antistofbinding til aminosyrerne 38-43 |
-
2004
- 2004-05-12 DK DK04732278.9T patent/DK1625163T3/da active
- 2004-05-12 EP EP15161853.5A patent/EP2949669A1/de not_active Ceased
- 2004-05-12 DK DK04732282.1T patent/DK1625164T3/da active
- 2004-05-12 CA CA2522378A patent/CA2522378C/en not_active Expired - Lifetime
- 2004-05-12 ES ES04732282T patent/ES2369008T3/es not_active Expired - Lifetime
- 2004-05-12 EP EP04732278A patent/EP1625163B8/de not_active Expired - Lifetime
- 2004-05-12 PL PL04732282T patent/PL1625164T3/pl unknown
- 2004-05-12 AU AU2004235974A patent/AU2004235974B2/en not_active Expired
- 2004-05-12 KR KR1020087000782A patent/KR20080011467A/ko not_active Application Discontinuation
- 2004-05-12 JP JP2006505418A patent/JP4430066B2/ja not_active Expired - Lifetime
- 2004-05-12 PL PL10172014T patent/PL2256132T3/pl unknown
- 2004-05-12 KR KR1020057021327A patent/KR100857752B1/ko active IP Right Grant
- 2004-05-12 HU HUE10172014A patent/HUE025169T2/en unknown
- 2004-05-12 WO PCT/EP2004/005092 patent/WO2004099253A1/en active Search and Examination
- 2004-05-12 DK DK10172014.2T patent/DK2256132T3/en active
- 2004-05-12 EP EP10172014.2A patent/EP2256132B1/de not_active Expired - Lifetime
- 2004-05-12 ES ES10172014.2T patent/ES2548327T3/es not_active Expired - Lifetime
- 2004-05-12 CN CNA2004800124973A patent/CN1784425A/zh active Pending
- 2004-05-12 AT AT04732278T patent/ATE522546T1/de active
- 2004-05-12 CA CA2522747A patent/CA2522747C/en not_active Expired - Lifetime
- 2004-05-12 AT AT04732282T patent/ATE517124T1/de active
- 2004-05-12 PL PL04732278T patent/PL1625163T3/pl unknown
- 2004-05-12 WO PCT/EP2004/005091 patent/WO2004099252A1/en active Application Filing
- 2004-05-12 CN CN2010101190838A patent/CN101967190A/zh active Pending
- 2004-05-12 EP EP04732282A patent/EP1625164B1/de not_active Expired - Lifetime
- 2004-05-12 JP JP2006505419A patent/JP5128125B2/ja not_active Expired - Lifetime
- 2004-05-12 ES ES04732278T patent/ES2372282T3/es not_active Expired - Lifetime
- 2004-05-12 CN CNB200480012494XA patent/CN100497393C/zh not_active Expired - Lifetime
- 2004-05-12 BR BRPI0410261A patent/BRPI0410261B8/pt active IP Right Grant
- 2004-05-12 MX MXPA05011826A patent/MXPA05011826A/es active IP Right Grant
-
2005
- 2005-11-10 US US11/271,651 patent/US7264939B2/en not_active Expired - Lifetime
- 2005-11-10 US US11/271,138 patent/US7264938B2/en not_active Expired - Lifetime
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2006
- 2006-12-05 US US11/634,286 patent/US7807380B2/en not_active Expired - Lifetime
- 2006-12-22 US US11/644,565 patent/US7811770B2/en not_active Expired - Lifetime
-
2007
- 2007-02-28 HK HK07102250.4A patent/HK1097855A1/xx not_active IP Right Cessation
-
2009
- 2009-09-04 JP JP2009204610A patent/JP4834136B2/ja not_active Expired - Lifetime
-
2012
- 2012-10-04 JP JP2012222436A patent/JP5649631B2/ja not_active Expired - Lifetime
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| UEP | Publication of translation of european patent specification |
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