WO2009044561A1 - 抗proNT/NMNモノクローナル抗体 - Google Patents
抗proNT/NMNモノクローナル抗体 Download PDFInfo
- Publication number
- WO2009044561A1 WO2009044561A1 PCT/JP2008/002794 JP2008002794W WO2009044561A1 WO 2009044561 A1 WO2009044561 A1 WO 2009044561A1 JP 2008002794 W JP2008002794 W JP 2008002794W WO 2009044561 A1 WO2009044561 A1 WO 2009044561A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pront
- nmn
- monoclonal antibody
- protein
- amino acid
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57423—Specifically defined cancers of lung
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3023—Lung
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
proNeurotensin/Neuromedin N(proNT/NMN)タンパクに対する特異的モノクローナル抗体と、それを用いた高感度のproNT/NMNタンパクの検出/測定法を確立することにより、小細胞肺癌の早期診断法等を提供するものである。proNT/NMNタンパクのアミノ酸配列-1~38番、又は8~87番のペプチド断片を含む抗原を、マウスに免疫することにより7種類の抗proNT/NMNモノクローナル抗体を作製し、さらにそれらの抗体を用いたproNT/NMN測定法を確立した。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009535987A JPWO2009044561A1 (ja) | 2007-10-03 | 2008-10-03 | 抗proNT/NMNモノクローナル抗体 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007259644 | 2007-10-03 | ||
JP2007-259644 | 2007-10-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009044561A1 true WO2009044561A1 (ja) | 2009-04-09 |
Family
ID=40525993
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/002794 WO2009044561A1 (ja) | 2007-10-03 | 2008-10-03 | 抗proNT/NMNモノクローナル抗体 |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPWO2009044561A1 (ja) |
WO (1) | WO2009044561A1 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103308689A (zh) * | 2012-03-08 | 2013-09-18 | 思芬构技术有限公司 | 用于预测雌性对象中患上癌症的风险或诊断癌症的方法 |
JP2015532423A (ja) * | 2012-10-02 | 2015-11-09 | シュピーンゴテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | 女性対象において癌になるリスクを予測し又は癌を診断するための方法 |
WO2015185478A1 (en) * | 2014-06-02 | 2015-12-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-neurotensin long fragment antibodies and uses thereof |
CN109116025A (zh) * | 2013-01-08 | 2019-01-01 | 斯弗因高泰克有限公司 | 预测受试者患癌症的风险或诊断癌症的方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007292745A (ja) * | 2006-03-31 | 2007-11-08 | Shizuoka Prefecture | 小細胞肺癌の判定方法 |
-
2008
- 2008-10-03 WO PCT/JP2008/002794 patent/WO2009044561A1/ja active Application Filing
- 2008-10-03 JP JP2009535987A patent/JPWO2009044561A1/ja active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007292745A (ja) * | 2006-03-31 | 2007-11-08 | Shizuoka Prefecture | 小細胞肺癌の判定方法 |
Non-Patent Citations (3)
Title |
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"Annual Meeting of the Japan Cancer Association Kiji", vol. 65, 2006, article SHUN'ICHIRO OGURA ET AL.: "Hai Shosaibo Gan Baiyo Saibo o Mochiita Proteomics Kaiseki ni yoru Shinki Shuyo Marker no Tansaku", pages: 389, 992 * |
ERNST A. ET AL.: "Proneurotensin 1-117, a stable neurotensin precursor fragment identified in human circulation.", PEPTIDES, vol. 27, no. 7, 2006, pages 1787 - 1793 * |
YUKIO SUGINO: "Biotechnology Series Monoclonal Kotai", 1986, KODANSHA LTD., pages: 1 - 16 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103308689A (zh) * | 2012-03-08 | 2013-09-18 | 思芬构技术有限公司 | 用于预测雌性对象中患上癌症的风险或诊断癌症的方法 |
WO2013132089A3 (en) * | 2012-03-08 | 2014-02-20 | Sphingotec Gmbh | A method for predicting the risk of getting cancer or diagnosing cancer in a female subject |
JP2015512047A (ja) * | 2012-03-08 | 2015-04-23 | シュピーンゴテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | 女性の対象が癌に罹患するリスクを予測する方法、あるいは対象の癌を診断する方法 |
JP2015532423A (ja) * | 2012-10-02 | 2015-11-09 | シュピーンゴテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | 女性対象において癌になるリスクを予測し又は癌を診断するための方法 |
CN109116025A (zh) * | 2013-01-08 | 2019-01-01 | 斯弗因高泰克有限公司 | 预测受试者患癌症的风险或诊断癌症的方法 |
WO2015185478A1 (en) * | 2014-06-02 | 2015-12-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-neurotensin long fragment antibodies and uses thereof |
US10174106B2 (en) | 2014-06-02 | 2019-01-08 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Anti-neurotensin long fragment antibodies and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
JPWO2009044561A1 (ja) | 2011-02-03 |
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