WO2008112891A3 - Monoclonal antibody that recognizes a seneca valley virus (svv) cellular receptor and uses thereof - Google Patents

Monoclonal antibody that recognizes a seneca valley virus (svv) cellular receptor and uses thereof Download PDF

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Publication number
WO2008112891A3
WO2008112891A3 PCT/US2008/056852 US2008056852W WO2008112891A3 WO 2008112891 A3 WO2008112891 A3 WO 2008112891A3 US 2008056852 W US2008056852 W US 2008056852W WO 2008112891 A3 WO2008112891 A3 WO 2008112891A3
Authority
WO
WIPO (PCT)
Prior art keywords
svv
monoclonal antibody
recognizes
valley virus
seneca valley
Prior art date
Application number
PCT/US2008/056852
Other languages
French (fr)
Other versions
WO2008112891A2 (en
Inventor
Paul Hallenbeck
Seshidhar Reddy Police
Laura M Hales
Kevin Burroughs
Original Assignee
Neotropix Inc
Paul Hallenbeck
Seshidhar Reddy Police
Laura M Hales
Kevin Burroughs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neotropix Inc, Paul Hallenbeck, Seshidhar Reddy Police, Laura M Hales, Kevin Burroughs filed Critical Neotropix Inc
Publication of WO2008112891A2 publication Critical patent/WO2008112891A2/en
Publication of WO2008112891A3 publication Critical patent/WO2008112891A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1009—Picornaviridae, e.g. hepatitis A virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Abstract

The invention provides a hybridoma cell and a monoclonal antibody produced therefrom, wherein the monoclonal antibody specifically binds and forms a complex with an antigen on the surface of a tumor cell and thereby inhibits Seneca Valley Virus (SVV) entry into the tumor cell. The invention further provides SVV receptors, for example, CXCR4 and the antigen recognized by the monoclonal antibody of the invention. The invention also provides methods of using the monoclonal antibody to determine whether SVV will enter a tumor cell and for determining whether a subject with a tumor will respond to SVV treatment.
PCT/US2008/056852 2007-03-13 2008-03-13 Monoclonal antibody that recognizes a seneca valley virus (svv) cellular receptor and uses thereof WO2008112891A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90673507P 2007-03-13 2007-03-13
US60/906,735 2007-03-13

Publications (2)

Publication Number Publication Date
WO2008112891A2 WO2008112891A2 (en) 2008-09-18
WO2008112891A3 true WO2008112891A3 (en) 2008-12-31

Family

ID=39760399

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/056852 WO2008112891A2 (en) 2007-03-13 2008-03-13 Monoclonal antibody that recognizes a seneca valley virus (svv) cellular receptor and uses thereof

Country Status (1)

Country Link
WO (1) WO2008112891A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL298752A (en) 2015-12-02 2023-02-01 Memorial Sloan Kettering Cancer Center Seneca valley virus (SVV) cellular receptor targeted oncotherapy
CN107253978B (en) * 2017-08-13 2020-11-20 中牧实业股份有限公司 Enzyme-linked immunoassay kit for structural protein antibody of Seneca valley virus
CN110229218B (en) * 2019-06-24 2020-12-01 中国动物疫病预防控制中心(农业农村部屠宰技术中心) Reagent for detecting Seneca virus antibody and polypeptide used by same
CN111394367B (en) * 2020-03-24 2021-05-14 中国农业科学院兰州兽医研究所 Selcarinovirus recombinant nucleic acid, recombinant vaccine strain, and preparation methods and applications thereof
CN116459355A (en) * 2020-05-15 2023-07-21 金宇保灵生物药品有限公司 Method for distinguishing Sein card virus from foot-and-mouth disease virus symptomatically by using domestic rabbits
CN117487006B (en) * 2023-12-29 2024-04-12 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） Monoclonal antibody for resisting A-type sai virus, epitope and application

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060159659A1 (en) * 2003-09-26 2006-07-20 Hallenbeck Paul L Seneca valley virus based compositions and methods for treating disease

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060159659A1 (en) * 2003-09-26 2006-07-20 Hallenbeck Paul L Seneca valley virus based compositions and methods for treating disease

Also Published As

Publication number Publication date
WO2008112891A2 (en) 2008-09-18

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