ES2369008T3 - Método para detectar probnp con un anticuerpo monoclonal que fija los aminoácidos 42-46. - Google Patents

Método para detectar probnp con un anticuerpo monoclonal que fija los aminoácidos 42-46. Download PDF

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Publication number
ES2369008T3
ES2369008T3 ES04732282T ES04732282T ES2369008T3 ES 2369008 T3 ES2369008 T3 ES 2369008T3 ES 04732282 T ES04732282 T ES 04732282T ES 04732282 T ES04732282 T ES 04732282T ES 2369008 T3 ES2369008 T3 ES 2369008T3
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ES
Spain
Prior art keywords
probnp
antibody
native
mab
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES04732282T
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English (en)
Spanish (es)
Inventor
Volker Klemt
Anneliese Borgya
Andreas Gallusser
Michael Grol
Klaus Hallermayer
Christoph Seidel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Original Assignee
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33427054&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2369008(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG, Roche Diagnostics GmbH filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2369008T3 publication Critical patent/ES2369008T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/58Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • C12N5/12Fused cells, e.g. hybridomas
    • C12N5/16Animal cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/975Kit
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/811Test for named disease, body condition or organ function

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ES04732282T 2003-05-12 2004-05-12 Método para detectar probnp con un anticuerpo monoclonal que fija los aminoácidos 42-46. Expired - Lifetime ES2369008T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03010591 2003-05-12
EP03010591 2003-05-12

Publications (1)

Publication Number Publication Date
ES2369008T3 true ES2369008T3 (es) 2011-11-24

Family

ID=33427054

Family Applications (3)

Application Number Title Priority Date Filing Date
ES04732282T Expired - Lifetime ES2369008T3 (es) 2003-05-12 2004-05-12 Método para detectar probnp con un anticuerpo monoclonal que fija los aminoácidos 42-46.
ES04732278T Expired - Lifetime ES2372282T3 (es) 2003-05-12 2004-05-12 Método para detectar probnp con un anticuerpo monoclonal que fija los aminoácidos 38-43.
ES10172014.2T Expired - Lifetime ES2548327T3 (es) 2003-05-12 2004-05-12 Método para detectar proBNP con un anticuerpo monoclonal

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES04732278T Expired - Lifetime ES2372282T3 (es) 2003-05-12 2004-05-12 Método para detectar probnp con un anticuerpo monoclonal que fija los aminoácidos 38-43.
ES10172014.2T Expired - Lifetime ES2548327T3 (es) 2003-05-12 2004-05-12 Método para detectar proBNP con un anticuerpo monoclonal

Country Status (15)

Country Link
US (4) US7264939B2 (enExample)
EP (4) EP1625164B1 (enExample)
JP (4) JP4430066B2 (enExample)
KR (2) KR20080011467A (enExample)
CN (3) CN1784425A (enExample)
AT (2) ATE522546T1 (enExample)
AU (1) AU2004235974B2 (enExample)
BR (1) BRPI0410261B8 (enExample)
CA (2) CA2522747C (enExample)
DK (3) DK2256132T3 (enExample)
ES (3) ES2369008T3 (enExample)
HU (1) HUE025169T2 (enExample)
MX (1) MXPA05011826A (enExample)
PL (3) PL2256132T3 (enExample)
WO (2) WO2004099253A1 (enExample)

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FR2843396B1 (fr) * 2002-08-07 2005-04-15 Bio Rad Pasteur Anticorps specifiques pour le diagnostic de l'insuffisance cardiaque
ATE522546T1 (de) * 2003-05-12 2011-09-15 Hoffmann La Roche Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 38- 43 bindet
US20070037208A1 (en) * 2003-05-29 2007-02-15 Foote Robert S Method for detecting cardiac ischemia via changes in b-natriuretic peptide levels
DE10355731A1 (de) 2003-11-28 2005-06-30 Roche Diagnostics Gmbh Analytischer Sandwichtest zur Bestimmung von NT-proBNP
DE602005001299T2 (de) * 2004-07-07 2008-02-07 Roche Diagnostics Gmbh Kombinationen von Markern zum Nachweis von typ 1 und 2 Diabetes
AT500800B1 (de) * 2004-09-08 2008-07-15 Biomedica Medizinprodukte Gmbh Verfahren zur bestimmung von probnp
WO2008089994A1 (en) 2007-01-25 2008-07-31 Roche Diagnostics Gmbh Use of igfbp-7 in the assessment of heart failure
KR100836322B1 (ko) * 2007-08-31 2008-06-09 현대자동차주식회사 차량용 흡음재 제작장치 및 방법
US9482677B2 (en) 2008-02-27 2016-11-01 Scios Inc. Method, composition and device for sampling natriuretic peptides in a biological fluid
CA2722485C (en) 2008-04-30 2018-02-13 F. Hoffmann-La Roche Ag Use of sfrp-3 in the assessment of heart failure
WO2011012268A1 (en) 2009-07-27 2011-02-03 Roche Diagnostics Gmbh Use of mimecan in the assessment of heart failure
KR20120101064A (ko) * 2009-11-13 2012-09-12 비쥐 메디신, 인코포레이티드 심근 경색의 위험 인자 및 예측
US8778699B2 (en) 2010-08-04 2014-07-15 Idexx Laboratories, Inc. Detection of degradation products of canine NT-proBNP
CA2856798A1 (en) 2011-05-31 2012-12-06 Idexx Laboratories, Inc. Detection of degradation products of feline nt-probnp
WO2013042603A1 (ja) * 2011-09-20 2013-03-28 コニカミノルタホールディングス株式会社 検体希釈用液、それを用いたキットおよび蛍光測定方法
US20140273273A1 (en) 2012-11-01 2014-09-18 Christie Mitchell Ballantyne Biomarkers to improve prediction of heart failure risk
CN103304665A (zh) * 2013-05-21 2013-09-18 上海贝西生物科技有限公司 一种抗氨基末端脑利钠肽前体单克隆抗体及其应用
JP6682445B2 (ja) * 2014-10-10 2020-04-15 松森 昭 心不全患者の検出方法、心疾患の識別方法、心不全の検査試薬、心不全の検査キット、心不全を検出するための装置及び心不全を検出するためのプログラム
EP3360570A1 (en) 2017-02-13 2018-08-15 Roche Diagnostics GmbH Antibodies recognizing genetic variants
JP7203034B2 (ja) * 2017-10-02 2023-01-12 大塚製薬株式会社 アナライトの検出方法
US12352764B2 (en) * 2018-04-13 2025-07-08 Kyoritsu Seiyaku Corporation Method of detecting heart failure, device for detecting heart failure, sandwich immunoassay method, and combination of antibodies
CN108752480B (zh) * 2018-05-30 2022-03-29 中元汇吉生物技术股份有限公司 一种免疫原组合物、其制备方法及其用途
US12400762B2 (en) 2018-12-11 2025-08-26 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy
US12001939B2 (en) 2018-12-11 2024-06-04 Eko.Ai Pte. Ltd. Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views
US11931207B2 (en) 2018-12-11 2024-03-19 Eko.Ai Pte. Ltd. Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device
US11446009B2 (en) 2018-12-11 2022-09-20 Eko.Ai Pte. Ltd. Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images
US12322100B2 (en) 2018-12-11 2025-06-03 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity
CN111487222B (zh) * 2019-01-28 2023-11-14 上海乐合生物科技有限公司 一种检测bnp的spr芯片的制备方法
JP7664226B2 (ja) 2019-08-13 2025-04-17 ゲンティアン アクティーゼルスカブ Nt-プロbnpの定量のための高感度粒子増感アッセイ
WO2022069658A1 (en) 2020-09-30 2022-04-07 F. Hoffmann-La Roche Ag Circulating total-nt-probnp (glycosylated and unglycosylated nt-probnp) and its ratio with nt-probnp (unglycosylated nt-probnp) in the assessment of atrial fibrillation
CN112964885B (zh) * 2021-02-20 2022-11-11 广东菲鹏生物有限公司 一种氨基末端脑尿钠肽检测方法和试剂盒
CN112986586A (zh) * 2021-02-20 2021-06-18 广东菲鹏生物有限公司 一种氨基末端脑尿钠肽检测方法和试剂盒
WO2023052642A1 (en) 2021-10-01 2023-04-06 Gentian As Novel method for determining a concentration of n-terminal pro-hormone bnp (nt-probnp) in a sample
CN118922721A (zh) 2022-03-18 2024-11-08 豪夫迈·罗氏有限公司 用于2型与1型急性心肌梗死的早期辨别的cMyBPC标志物组合
WO2023175152A1 (en) 2022-03-18 2023-09-21 Roche Diagnostics Gmbh Troponin marker combinations for early discrimination of type 2 versus type 1 acute myocardial infarction
WO2024219421A1 (ja) * 2023-04-19 2024-10-24 栄研化学株式会社 NT-proBNPに対する抗体、これを用いたNT-proBNP検出方法、並びに、NT-proBNP検出に用いるための組成物及びキット

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ATE522546T1 (de) * 2003-05-12 2011-09-15 Hoffmann La Roche Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 38- 43 bindet

Also Published As

Publication number Publication date
EP1625164A1 (en) 2006-02-15
PL1625163T3 (pl) 2012-01-31
EP2949669A1 (en) 2015-12-02
MXPA05011826A (es) 2006-01-26
DK1625163T3 (da) 2011-12-05
US20070099241A1 (en) 2007-05-03
JP2007535470A (ja) 2007-12-06
US20060110776A1 (en) 2006-05-25
BRPI0410261B1 (pt) 2020-03-10
US20070117156A1 (en) 2007-05-24
JP2010011860A (ja) 2010-01-21
DK1625164T3 (da) 2011-10-31
PL1625164T3 (pl) 2011-12-30
CA2522378A1 (en) 2004-11-18
AU2004235974A1 (en) 2004-11-18
ATE517124T1 (de) 2011-08-15
JP4834136B2 (ja) 2011-12-14
US7811770B2 (en) 2010-10-12
CA2522378C (en) 2011-03-29
EP1625163A1 (en) 2006-02-15
CA2522747A1 (en) 2004-11-18
EP1625164B1 (en) 2011-07-20
BRPI0410261A (pt) 2006-05-16
WO2004099252A1 (en) 2004-11-18
ES2548327T3 (es) 2015-10-15
WO2004099253A1 (en) 2004-11-18
KR20080011467A (ko) 2008-02-04
JP5649631B2 (ja) 2015-01-07
CN1832964A (zh) 2006-09-13
EP1625163B8 (en) 2011-11-02
JP5128125B2 (ja) 2013-01-23
EP1625163B1 (en) 2011-08-31
US20060110775A1 (en) 2006-05-25
EP2256132A1 (en) 2010-12-01
US7264939B2 (en) 2007-09-04
JP2007525427A (ja) 2007-09-06
JP4430066B2 (ja) 2010-03-10
ATE522546T1 (de) 2011-09-15
CN1784425A (zh) 2006-06-07
CA2522747C (en) 2012-08-14
BRPI0410261B8 (pt) 2021-07-27
CN101967190A (zh) 2011-02-09
DK2256132T3 (en) 2015-07-13
AU2004235974B2 (en) 2008-02-14
KR100857752B1 (ko) 2008-09-11
PL2256132T3 (pl) 2016-08-31
HK1097855A1 (zh) 2007-07-06
KR20060003905A (ko) 2006-01-11
CN100497393C (zh) 2009-06-10
HUE025169T2 (en) 2016-02-29
EP2256132B1 (en) 2015-04-01
US7264938B2 (en) 2007-09-04
ES2372282T3 (es) 2012-01-18
JP2013018784A (ja) 2013-01-31
US7807380B2 (en) 2010-10-05

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