JP2007534613A - レラキシンスーパーファミリーペプチド類似体 - Google Patents

レラキシンスーパーファミリーペプチド類似体 Download PDF

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Publication number
JP2007534613A
JP2007534613A JP2006515545A JP2006515545A JP2007534613A JP 2007534613 A JP2007534613 A JP 2007534613A JP 2006515545 A JP2006515545 A JP 2006515545A JP 2006515545 A JP2006515545 A JP 2006515545A JP 2007534613 A JP2007534613 A JP 2007534613A
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JP
Japan
Prior art keywords
disease
relaxin
analog
insl3
amino acid
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Pending
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JP2006515545A
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English (en)
Japanese (ja)
Inventor
マーク・デル・ボーゴ
ジョン・ディ・ウェイド
ロス・ディ・バスゲイト
リチャード・エイ・ヒューズ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Melbourne
Florey Institute of Neuroscience and Mental Health
Original Assignee
Howard Florey Institute of Experimental Physiology and Medicine
University of Melbourne
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Application filed by Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne filed Critical Howard Florey Institute of Experimental Physiology and Medicine
Publication of JP2007534613A publication Critical patent/JP2007534613A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
JP2006515545A 2003-06-20 2004-06-18 レラキシンスーパーファミリーペプチド類似体 Pending JP2007534613A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2003903124A AU2003903124A0 (en) 2003-06-20 2003-06-20 Analogues of heteromeric proteins
PCT/AU2004/000798 WO2004113381A1 (en) 2003-06-20 2004-06-18 Relaxin superfamily peptide analogues

Publications (1)

Publication Number Publication Date
JP2007534613A true JP2007534613A (ja) 2007-11-29

Family

ID=31954163

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006515545A Pending JP2007534613A (ja) 2003-06-20 2004-06-18 レラキシンスーパーファミリーペプチド類似体

Country Status (9)

Country Link
US (1) US20070004619A1 (de)
EP (1) EP1641824B1 (de)
JP (1) JP2007534613A (de)
AT (1) ATE474850T1 (de)
AU (1) AU2003903124A0 (de)
CA (1) CA2534748C (de)
DE (1) DE602004028246D1 (de)
NZ (1) NZ544216A (de)
WO (1) WO2004113381A1 (de)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013530974A (ja) * 2010-06-23 2013-08-01 ノヴォ ノルディスク アー／エス 追加のジスルフィド結合を含有するインスリン誘導体
JP2013530702A (ja) * 2010-06-23 2013-08-01 ノヴォ ノルディスク アー／エス 追加のジスルフィド結合を含有するインスリン類似体
JP2013532970A (ja) * 2010-06-23 2013-08-22 ノヴォ ノルディスク アー／エス 追加のジスルフィド結合を含有するヒトインスリン
JP2015502971A (ja) * 2011-12-21 2015-01-29 ノヴォ ノルディスク アー／エス Ｎ末端修飾インスリン誘導体

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7878978B2 (en) 2004-03-18 2011-02-01 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Use of relaxin to increase arterial compliance
CA2563433C (en) * 2004-04-30 2010-07-13 Bas Medical, Inc. Methods and compositions for control of fetal growth via modulation of relaxin
US7893197B2 (en) * 2004-08-25 2011-02-22 Janssen Pharmaceutica N.V. Relaxin-3 chimeric polypeptides and their preparation and use
US20060052304A1 (en) * 2004-09-02 2006-03-09 Bas Medical, Inc. Method for remodeling bone and related sutures
US8496446B2 (en) * 2005-08-29 2013-07-30 Carrier Corporation Compressor muffler
US20110072955A1 (en) 2005-10-06 2011-03-31 Turner William D System and method for pacing repetitive motion activities
EP2129359B1 (de) * 2007-01-30 2012-03-14 Janssen Pharmaceutica, N.V. Chimärer peptidantagonist für gpcr135 oder gpcr142
WO2009140433A1 (en) * 2008-05-16 2009-11-19 Corthera, Inc. Method of promoting wound healing
GR1006759B (el) * 2008-12-22 2010-04-20 Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras) Εξελιγμενη χημικη μεθοδος συνθεσης της ανθρωπινης ρηλαξινης
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
ES2972902T3 (es) * 2010-08-17 2024-06-17 Ambrx Inc Polipéptidos de relaxina modificados y sus usos
AU2011301146B2 (en) * 2010-09-08 2016-01-21 Howard Florey Institute Of Experimental Physiology And Medicine Single chain relaxin polypeptides
CN103456765B (zh) 2013-09-10 2015-09-16 深圳市华星光电技术有限公司 有源式有机电致发光器件背板及其制作方法
AU2018219283B2 (en) 2017-02-08 2022-05-19 Bristol-Myers Squibb Company Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
CN114075276A (zh) * 2020-08-17 2022-02-22 成都奥达生物科技有限公司 一种长效松弛素2类似物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5985292A (ja) * 1982-08-12 1984-05-17 ハワード　フローレイ　インスティテュト　オブ　イクスペリメンタル　フィジオロジー　アンド　メディシン ヒト−レラキシン遺伝子
JPS59156284A (ja) * 1982-12-13 1984-09-05 ハワ−ド・フロ−レイ・インステイテユト・オブ・イクスペリメンタル・フイジオロジ−・アンド・メデイシン ヒト−レラキシンｈ２遺伝子
JPS6366198A (ja) * 1986-06-23 1988-03-24 ジエネンテク，インコ−ポレイテツド 鎖の結合法
WO2003030930A1 (en) * 2001-10-08 2003-04-17 Howard Florey Institute Of Experimental Physiology And Medicine Human 3 relaxin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5911997A (en) * 1995-06-07 1999-06-15 Connetics Corporation Relaxin-like factor and methods and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5985292A (ja) * 1982-08-12 1984-05-17 ハワード　フローレイ　インスティテュト　オブ　イクスペリメンタル　フィジオロジー　アンド　メディシン ヒト−レラキシン遺伝子
JPS59156284A (ja) * 1982-12-13 1984-09-05 ハワ−ド・フロ−レイ・インステイテユト・オブ・イクスペリメンタル・フイジオロジ−・アンド・メデイシン ヒト−レラキシンｈ２遺伝子
JPS6366198A (ja) * 1986-06-23 1988-03-24 ジエネンテク，インコ−ポレイテツド 鎖の結合法
WO2003030930A1 (en) * 2001-10-08 2003-04-17 Howard Florey Institute Of Experimental Physiology And Medicine Human 3 relaxin

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6010018782, Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｊｏｕｒｎａｌ ｏｆ Ｐｅｐｔｉｄｅ ａｎｄ Ｐｒｏｔｅｉｎ Ｒｅｓｅａｒｃｈ, 1982, Ｖｏｌ．２０， Ｎｏ．３, ｐ．２０７−２１７ *
JPN6010018783, Ｂｉｏｌｏｇｙ ｏｆ Ｒｅｐｒｏｄｕｃｔｉｏｎ, 2002, Ｖｏｌ．６７, ｐ．６９９−７０５ *
JPN6010018784, Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｂｉｏｌｏｇｉｃａｌ Ｃｈｅｍｉｓｔｒｙ, 200303, Ｖｏｌ．２７８， Ｎｏ．１０, ｐ．７８５５−７８６２ *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013530974A (ja) * 2010-06-23 2013-08-01 ノヴォ ノルディスク アー／エス 追加のジスルフィド結合を含有するインスリン誘導体
JP2013530702A (ja) * 2010-06-23 2013-08-01 ノヴォ ノルディスク アー／エス 追加のジスルフィド結合を含有するインスリン類似体
JP2013532970A (ja) * 2010-06-23 2013-08-22 ノヴォ ノルディスク アー／エス 追加のジスルフィド結合を含有するヒトインスリン
US9512195B2 (en) 2010-06-23 2016-12-06 Novo Nordisk A/S Insulin derivatives containing additional disulfide bonds
JP2015502971A (ja) * 2011-12-21 2015-01-29 ノヴォ ノルディスク アー／エス Ｎ末端修飾インスリン誘導体

Also Published As

Publication number Publication date
US20070004619A1 (en) 2007-01-04
DE602004028246D1 (de) 2010-09-02
CA2534748C (en) 2013-09-17
WO2004113381A1 (en) 2004-12-29
ATE474850T1 (de) 2010-08-15
EP1641824B1 (de) 2010-07-21
AU2003903124A0 (en) 2003-07-10
NZ544216A (en) 2008-09-26
EP1641824A1 (de) 2006-04-05
EP1641824A4 (de) 2008-02-13
CA2534748A1 (en) 2004-12-29

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