JP2007531758A5 - - Google Patents
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- Publication number
- JP2007531758A5 JP2007531758A5 JP2007506518A JP2007506518A JP2007531758A5 JP 2007531758 A5 JP2007531758 A5 JP 2007531758A5 JP 2007506518 A JP2007506518 A JP 2007506518A JP 2007506518 A JP2007506518 A JP 2007506518A JP 2007531758 A5 JP2007531758 A5 JP 2007531758A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- group
- shell
- alkylating agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229920002873 Polyethylenimine Polymers 0.000 claims description 8
- 229920000642 polymer Polymers 0.000 claims description 8
- 229940100198 alkylating agent Drugs 0.000 claims description 7
- 239000002168 alkylating agent Substances 0.000 claims description 7
- 150000001412 amines Chemical class 0.000 claims description 6
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 5
- 229920001467 poly(styrenesulfonates) Polymers 0.000 claims description 5
- 239000011591 potassium Substances 0.000 claims description 5
- 229910052700 potassium Inorganic materials 0.000 claims description 5
- -1 quaternary ammonium ions Chemical class 0.000 claims description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 230000029936 alkylation Effects 0.000 claims description 4
- 238000005804 alkylation reaction Methods 0.000 claims description 4
- 229920001002 functional polymer Polymers 0.000 claims description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 4
- 238000005341 cation exchange Methods 0.000 claims description 3
- TYCFGHUTYSLISP-UHFFFAOYSA-N 2-fluoroprop-2-enoic acid Chemical compound OC(=O)C(F)=C TYCFGHUTYSLISP-UHFFFAOYSA-N 0.000 claims description 2
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 2
- 125000002843 carboxylic acid group Chemical group 0.000 claims description 2
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid group Chemical group S(N)(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 claims description 2
- 125000000542 sulfonic acid group Chemical group 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical group S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 239000003814 drug Substances 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims 1
- 206010016803 Fluid overload Diseases 0.000 claims 1
- 208000002682 Hyperkalemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 125000005210 alkyl ammonium group Chemical group 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 230000001195 anabolic effect Effects 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 claims 1
- 229960005084 calcitriol Drugs 0.000 claims 1
- 235000020964 calcitriol Nutrition 0.000 claims 1
- 239000011612 calcitriol Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000028208 end stage renal disease Diseases 0.000 claims 1
- 201000000523 end stage renal failure Diseases 0.000 claims 1
- 150000002334 glycols Chemical class 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000011970 polystyrene sulfonate Substances 0.000 claims 1
- 229960002796 polystyrene sulfonate Drugs 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 239000011324 bead Substances 0.000 description 5
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 4
- 239000011777 magnesium Substances 0.000 description 4
- 229910052749 magnesium Inorganic materials 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000035699 permeability Effects 0.000 description 3
- 229920003155 Eudragit® RL 100 Polymers 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229920003159 Eudragit® RS 100 Polymers 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000011162 core material Substances 0.000 description 1
- 239000011258 core-shell material Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000012039 electrophile Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000010220 ion permeability Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/814,527 US7854924B2 (en) | 2004-03-30 | 2004-03-30 | Methods and compositions for treatment of ion imbalances |
| US10/813,872 US8282960B2 (en) | 2004-03-30 | 2004-03-30 | Ion binding compositions |
| US10/814,527 | 2004-03-30 | ||
| US10/814,749 | 2004-03-30 | ||
| US10/813,872 | 2004-03-30 | ||
| US10/814,749 US8192758B2 (en) | 2004-03-30 | 2004-03-30 | Ion binding compositions |
| US10/965,274 | 2004-10-13 | ||
| US10/965,274 US7488495B2 (en) | 2004-03-30 | 2004-10-13 | Ion binding polymers and uses thereof |
| PCT/US2005/010747 WO2005097072A1 (en) | 2004-03-30 | 2005-03-30 | Ion binding compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011246755A Division JP5431439B2 (ja) | 2004-03-30 | 2011-11-10 | イオン結合組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007531758A JP2007531758A (ja) | 2007-11-08 |
| JP2007531758A5 true JP2007531758A5 (enExample) | 2012-01-26 |
| JP4964122B2 JP4964122B2 (ja) | 2012-06-27 |
Family
ID=35054544
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007506518A Expired - Fee Related JP4964122B2 (ja) | 2004-03-30 | 2005-03-30 | イオン結合組成物 |
| JP2007506580A Expired - Lifetime JP4974882B2 (ja) | 2004-03-30 | 2005-03-30 | イオン結合ポリマーとその利用 |
| JP2007506295A Expired - Fee Related JP5000480B2 (ja) | 2004-03-30 | 2005-03-30 | イオンバランス異常の治療の方法および組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007506580A Expired - Lifetime JP4974882B2 (ja) | 2004-03-30 | 2005-03-30 | イオン結合ポリマーとその利用 |
| JP2007506295A Expired - Fee Related JP5000480B2 (ja) | 2004-03-30 | 2005-03-30 | イオンバランス異常の治療の方法および組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (14) | US7776319B2 (enExample) |
| EP (3) | EP1732524B1 (enExample) |
| JP (3) | JP4964122B2 (enExample) |
| KR (3) | KR101228233B1 (enExample) |
| AU (3) | AU2005231424B2 (enExample) |
| BR (3) | BRPI0509331B8 (enExample) |
| CA (3) | CA2557848C (enExample) |
| DE (1) | DE112005000730B4 (enExample) |
| GB (3) | GB2430368B (enExample) |
| MX (1) | MXPA06011270A (enExample) |
| PL (1) | PL1732523T3 (enExample) |
| WO (3) | WO2005097081A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7381428B2 (en) | 2003-08-26 | 2008-06-03 | Shire International Licensing B.V. | Stabilized lanthanum carbonate compositions |
| CA2536959C (en) | 2003-08-26 | 2011-08-02 | Shire Holdings Ag | Pharmaceutical formulation comprising lanthanum compounds |
| KR101223335B1 (ko) * | 2004-03-30 | 2013-01-17 | 리립사, 인크. | 이온 결합 조성물 |
| CA2557848C (en) * | 2004-03-30 | 2013-12-10 | Ilypsa, Inc. | Ion binding compositions |
| WO2007038801A2 (en) * | 2005-09-30 | 2007-04-05 | Ilypsa, Inc. | Monovalent cation-binding compositions comprising core-shell particles having crosslinked poly-vinylic shells, and methods of use thereof |
| CA2624170C (en) | 2005-09-30 | 2014-02-25 | Ilypsa, Inc. | Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal |
| AU2006294455B2 (en) * | 2005-09-30 | 2013-06-20 | Relypsa, Inc. | Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom |
| CN100398112C (zh) * | 2006-03-24 | 2008-07-02 | 辽宁诺康生物制药有限责任公司 | 一种治疗血磷酸盐过多症的药物及其制备方法 |
| PL2081551T3 (pl) * | 2006-10-06 | 2013-06-28 | Scil Tech Gmbh | Wytworzenie wysuszonego rekonstytuowanego pęcherzyka do zastosowania farmaceutycznego |
| WO2008078797A1 (ja) * | 2006-12-26 | 2008-07-03 | Otsuka Pharmaceutical Factory, Inc. | ナトリウム吸収阻害剤、カリウム吸収阻害剤およびリン吸収阻害剤、並びにそれを含む予防剤、治療剤および食品 |
| TW200846071A (en) | 2006-12-26 | 2008-12-01 | Chisso Corp | Metal salt of crosslinking cellulose derivative |
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| AU2009282721B2 (en) * | 2008-08-22 | 2015-10-29 | Vifor (International) Ltd. | Crosslinked cation exchange polymers, compositions and use in treating hyperkalemia |
| AU2013204879B2 (en) * | 2008-08-22 | 2015-10-29 | Vifor (International) Ltd. | Crosslinked cation exchange polymers, compositions and use in treating hyperkalemia |
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| WO2013003495A2 (en) | 2011-06-27 | 2013-01-03 | Relypsa, Inc. | Fluorination of acrylate esters and derivatives |
| US9943637B2 (en) | 2012-06-11 | 2018-04-17 | ZS Pharma, Inc. | Microporous zirconium silicate and its method of production |
| JP2015529640A (ja) * | 2012-07-11 | 2015-10-08 | ズィーエス・ファーマ，インコーポレーテッド | 高カルシウム血症患者における高カリウム血症の治療のための微多孔性ケイ酸ジルコニウム、および高カリウム血症の治療のための改善されたカルシウム含有組成物 |
| CN110051686A (zh) * | 2012-07-19 | 2019-07-26 | 瑞立普萨公司 | 包含交联阳离子结合聚合物的组合物 |
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| CA2886788C (en) | 2012-10-08 | 2022-04-19 | Relypsa, Inc. | Potassium-binding agents for treating hypertension and hyperkalemia |
| US8877255B2 (en) | 2012-10-22 | 2014-11-04 | ZS Pharma, Inc. | Microporous zirconium silicate for the treatment of hyperkalemia |
| US10695365B2 (en) | 2012-10-22 | 2020-06-30 | ZS Pharma, Inc. | Microporous zirconium silicate for the treatment of hyperkalemia |
| DK3287133T3 (da) | 2013-06-05 | 2019-07-01 | Tricida Inc | Proton-bindende polymerer til oral indgivelse |
| CN105793712B (zh) * | 2013-12-11 | 2018-01-05 | 株式会社资生堂 | 肾衰竭的早期诊断标志物 |
| US9675636B2 (en) * | 2014-01-31 | 2017-06-13 | University Of Kansas | Micelle sequestering polymers |
| JP6468780B2 (ja) * | 2014-09-30 | 2019-02-13 | 積水化成品工業株式会社 | 中空樹脂粒子及びその製造方法 |
| KR102625115B1 (ko) | 2014-12-10 | 2024-01-12 | 트리시다, 인크. | 경구 투여용 양성자-결합 폴리머 |
| ES2800167T3 (es) * | 2014-12-23 | 2020-12-28 | Ardelyx Inc | Composiciones y métodos para tratar hiperpotasemia |
| US9592253B1 (en) | 2015-10-14 | 2017-03-14 | ZS Pharma, Inc. | Extended use zirconium silicate compositions and methods of use thereof |
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| KR102655774B1 (ko) | 2016-05-06 | 2024-04-05 | 트리시다, 인크. | 산-염기 장애의 치료를 위한 조성물 및 방법 |
| JP2018125951A (ja) * | 2017-01-31 | 2018-08-09 | 日本電産株式会社 | モータ及びそれを備えた送風装置 |
| IL319146A (en) | 2017-11-03 | 2025-04-01 | Tricida Inc | Compositions for and method of treating acid-base disorders |
| JP7365631B2 (ja) * | 2019-09-02 | 2023-10-20 | 国立大学法人福井大学 | ホスホン酸又はホスホン酸エステル構造を有するコア－シェル型高分子微粒子、粒子分散液、成形体及び前記微粒子の製造方法 |
| CN113244339B (zh) * | 2021-06-04 | 2021-09-24 | 南京厚生药业有限公司 | 一种用于高脂血症的考来烯胺散及其制备方法 |
| US20240139234A1 (en) * | 2021-11-17 | 2024-05-02 | Waterstone Pharmaceuticals (Wuhan) Co., Ltd. | Pharmaceutical polymer for treating hyperkalemia and preparation method thereof |
| WO2024035944A1 (en) * | 2022-08-12 | 2024-02-15 | University Of Kansas | Extraction of critical minerals using polyanions |
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