JP2006502249A5 - - Google Patents

Info

Publication number

JP2006502249A5

JP2006502249A5 JP2004523573A JP2004523573A JP2006502249A5 JP 2006502249 A5 JP2006502249 A5 JP 2006502249A5 JP 2004523573 A JP2004523573 A JP 2004523573A JP 2004523573 A JP2004523573 A JP 2004523573A JP 2006502249 A5 JP2006502249 A5 JP 2006502249A5

Authority

JP

Japan

Prior art keywords

sodium

potassium

polystyrene sulfonate

ions

sulfonate

Prior art date

2003-07-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 229920001467 poly(styrenesulfonates) Polymers 0.000 claims 41
• 229960002796 polystyrene sulfonate Drugs 0.000 claims 31
• 239000011970 polystyrene sulfonate Substances 0.000 claims 31
• 238000000034 method Methods 0.000 claims 27
• 229910001415 sodium ion Inorganic materials 0.000 claims 17
• 229910001414 potassium ion Inorganic materials 0.000 claims 16
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 11
• 229910052700 potassium Inorganic materials 0.000 claims 11
• 239000011591 potassium Substances 0.000 claims 11
• 229920001577 copolymer Polymers 0.000 claims 10
• 229940006186 sodium polystyrene sulfonate Drugs 0.000 claims 10
• QIFCIFLDTQJGHQ-UHFFFAOYSA-M potassium;2-phenylethenesulfonate Chemical compound [K+].[O-]S(=O)(=O)C=CC1=CC=CC=C1 QIFCIFLDTQJGHQ-UHFFFAOYSA-M 0.000 claims 8
• 238000000108 ultra-filtration Methods 0.000 claims 8
• 239000004793 Polystyrene Substances 0.000 claims 6
• 238000000909 electrodialysis Methods 0.000 claims 6
• 229920002223 polystyrene Polymers 0.000 claims 6
• MNCGMVDMOKPCSQ-UHFFFAOYSA-M sodium;2-phenylethenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C=CC1=CC=CC=C1 MNCGMVDMOKPCSQ-UHFFFAOYSA-M 0.000 claims 6
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 5
• 159000000000 sodium salts Chemical class 0.000 claims 5
• NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims 4
• 206010012735 Diarrhoea Diseases 0.000 claims 4
• 230000003115 biocidal effect Effects 0.000 claims 4
• 239000003729 cation exchange resin Substances 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 3
• 159000000001 potassium salts Chemical class 0.000 claims 3
• 238000002360 preparation method Methods 0.000 claims 3
• 238000000746 purification Methods 0.000 claims 3
• 229910052708 sodium Inorganic materials 0.000 claims 3
• 239000011734 sodium Substances 0.000 claims 3
• AGBXYHCHUYARJY-UHFFFAOYSA-N 2-phenylethenesulfonic acid Chemical compound OS(=O)(=O)C=CC1=CC=CC=C1 AGBXYHCHUYARJY-UHFFFAOYSA-N 0.000 claims 2
• 238000005342 ion exchange Methods 0.000 claims 2
• 230000000379 polymerizing effect Effects 0.000 claims 2
• XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 2
• 230000008929 regeneration Effects 0.000 claims 2
• 238000011069 regeneration method Methods 0.000 claims 2
• 241000193163 Clostridioides difficile Species 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• MYPYJXKWCTUITO-KIIOPKALSA-N chembl3301825 Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)C(O)[C@H](C)O1 MYPYJXKWCTUITO-KIIOPKALSA-N 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000012535 impurity Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims 1
• 229960000282 metronidazole Drugs 0.000 claims 1
• 229920000172 poly(styrenesulfonic acid) Polymers 0.000 claims 1
• 229940005642 polystyrene sulfonic acid Drugs 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1