BRPI0509331B8 - uso de uma composição de ligação de sódio - Google Patents

uso de uma composição de ligação de sódio

Info

Publication number
BRPI0509331B8
BRPI0509331B8 BRPI0509331A BRPI0509331A BRPI0509331B8 BR PI0509331 B8 BRPI0509331 B8 BR PI0509331B8 BR PI0509331 A BRPI0509331 A BR PI0509331A BR PI0509331 A BRPI0509331 A BR PI0509331A BR PI0509331 B8 BRPI0509331 B8 BR PI0509331B8
Authority
BR
Brazil
Prior art keywords
compositions
pharmaceutical compositions
binding composition
sodium binding
sodium
Prior art date
Application number
BRPI0509331A
Other languages
English (en)
Inventor
Charmot Dominique
Klaerner Gerrit
Ting Chang Han
M Buysse Jerry
Fordtran John
James Cope Michael
Alpern Robert
Original Assignee
Ilypsa Inc
Relypsa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35054544&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0509331(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US10/814,527 external-priority patent/US7854924B2/en
Priority claimed from US10/813,872 external-priority patent/US8282960B2/en
Priority claimed from US10/814,749 external-priority patent/US8192758B2/en
Application filed by Ilypsa Inc, Relypsa Inc filed Critical Ilypsa Inc
Publication of BRPI0509331A publication Critical patent/BRPI0509331A/pt
Publication of BRPI0509331B1 publication Critical patent/BRPI0509331B1/pt
Publication of BRPI0509331B8 publication Critical patent/BRPI0509331B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/795—Polymers containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F120/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
    • C08F120/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F120/04—Acids; Metal salts or ammonium salts thereof
    • C08F120/06—Acrylic acid; Methacrylic acid; Metal salts or ammonium salts thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F128/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a bond to sulfur or by a heterocyclic ring containing sulfur
    • C08F128/02—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a bond to sulfur or by a heterocyclic ring containing sulfur by a bond to sulfur

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Polymers & Plastics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

método para remover sódio e para remover sal de um indivíduo animal. a presente invenção provê métodos e composições para o tratamento de desequilíbrios iônicos. em particular, a invenção provê composições, que compreendem polímeros de ligação de sódio e composições farmacêuticas dos mesmos. métodos de uso de composições poliméricas e farmacêuticas para benefícios terapêuticos e/ ou profiláticos são aqui expostos. exemplos destes usos incluem o preparo de medicamentos para o tratamento de hipertensão, falha cardíaca crônica, doença renal em estágio terminal, cirrose hepática, insuficiência renal crônica.
BRPI0509331A 2004-03-30 2005-03-30 uso de uma composição de ligação de sódio BRPI0509331B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10/814,527 US7854924B2 (en) 2004-03-30 2004-03-30 Methods and compositions for treatment of ion imbalances
US10/813,872 US8282960B2 (en) 2004-03-30 2004-03-30 Ion binding compositions
US10/814,749 US8192758B2 (en) 2004-03-30 2004-03-30 Ion binding compositions
US10/965,274 US7488495B2 (en) 2004-03-30 2004-10-13 Ion binding polymers and uses thereof
PCT/US2005/011010 WO2005094384A2 (en) 2004-03-30 2005-03-30 Methods and compositions for treatment of ion imbalances

Publications (3)

Publication Number Publication Date
BRPI0509331A BRPI0509331A (pt) 2007-09-04
BRPI0509331B1 BRPI0509331B1 (pt) 2018-11-27
BRPI0509331B8 true BRPI0509331B8 (pt) 2021-05-25

Family

ID=35054544

Family Applications (3)

Application Number Title Priority Date Filing Date
BRPI0509366A BRPI0509366B8 (pt) 2004-03-30 2005-03-30 composição farmacêutica, kit farmacêutico, e, uso de uma composição farmacêutica
BRPI0509365A BRPI0509365B8 (pt) 2004-03-30 2005-03-30 composição farmacêutica, kit farmacêutico, e, uso da referida composição
BRPI0509331A BRPI0509331B8 (pt) 2004-03-30 2005-03-30 uso de uma composição de ligação de sódio

Family Applications Before (2)

Application Number Title Priority Date Filing Date
BRPI0509366A BRPI0509366B8 (pt) 2004-03-30 2005-03-30 composição farmacêutica, kit farmacêutico, e, uso de uma composição farmacêutica
BRPI0509365A BRPI0509365B8 (pt) 2004-03-30 2005-03-30 composição farmacêutica, kit farmacêutico, e, uso da referida composição

Country Status (12)

Country Link
US (14) US7776319B2 (pt)
EP (3) EP1732516B1 (pt)
JP (3) JP4964122B2 (pt)
KR (3) KR101153035B1 (pt)
AU (3) AU2005228696B2 (pt)
BR (3) BRPI0509366B8 (pt)
CA (3) CA2557848C (pt)
DE (1) DE112005000730B4 (pt)
GB (3) GB2430624B (pt)
MX (1) MXPA06011270A (pt)
PL (1) PL1732523T3 (pt)
WO (3) WO2005094384A2 (pt)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7381428B2 (en) 2003-08-26 2008-06-03 Shire International Licensing B.V. Stabilized lanthanum carbonate compositions
CZ17621U1 (cs) 2003-08-26 2007-06-25 Shire Holdings Ag Farmaceutický prostredek zahrnující slouceniny lanthanu
DE112005000708B4 (de) * 2004-03-30 2017-12-21 Relypsa, Inc. (n.d.Ges.d. Staates Delaware) Ionen bindende Zusammensetzung
CA2557848C (en) * 2004-03-30 2013-12-10 Ilypsa, Inc. Ion binding compositions
BRPI0616604A2 (pt) 2005-09-30 2012-12-25 Ilypsa Inc mÉtodo para remover e composiÇço para seletivamente remover Íon de potÁssio do trato gastrintestinal de um mamÍfero, mÉtodo para seletivamente remover Íon de potÁssio de um meio-ambiente, composiÇço farmacÊutica, partÍcula de nécleo-envoltàrio, e, usos de uma partÍcula de nécleo-envoltàrio e de uma composiÇço farmacÊutica
WO2007038801A2 (en) * 2005-09-30 2007-04-05 Ilypsa, Inc. Monovalent cation-binding compositions comprising core-shell particles having crosslinked poly-vinylic shells, and methods of use thereof
CA2624112A1 (en) * 2005-09-30 2007-04-05 Ilypsa, Inc. Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom
CN100398112C (zh) * 2006-03-24 2008-07-02 辽宁诺康生物制药有限责任公司 一种治疗血磷酸盐过多症的药物及其制备方法
ES2708851T3 (es) * 2006-10-06 2019-04-11 Bionet Pharma Gmbh Un implante del núcleo pulposo espinal
WO2008078797A1 (ja) * 2006-12-26 2008-07-03 Otsuka Pharmaceutical Factory, Inc. ナトリウム吸収阻害剤、カリウム吸収阻害剤およびリン吸収阻害剤、並びにそれを含む予防剤、治療剤および食品
EP2108661A1 (en) * 2006-12-26 2009-10-14 Chisso Corporation Metal salt of crosslinked cellulose derivative
MX2009011898A (es) * 2007-05-04 2009-11-18 Ironwood Pharmaceuticals Inc Composiciones y metodos para tratar trastornos asociados con retencion de sal o fluido.
CA2697803A1 (en) * 2007-08-29 2009-03-05 Sorbent Therapeutics, Inc. Absorbent polymeric compositions with varying counterion content and their methods of preparation and use
JP5294681B2 (ja) * 2008-04-28 2013-09-18 東京エレクトロン株式会社 基板処理装置及びその基板搬送方法
WO2010022381A1 (en) * 2008-08-22 2010-02-25 Relypsa, Inc. Treating hyperkalemia with crosslinked cation exchange polymers of improved physical properties
AU2013204879B2 (en) * 2008-08-22 2015-10-29 Vifor (International) Ltd. Crosslinked cation exchange polymers, compositions and use in treating hyperkalemia
WO2010022383A2 (en) 2008-08-22 2010-02-25 Relypsa, Inc. Crosslinked cation exchange polymers, compositions and use in treating hyperkalemia
WO2010022380A2 (en) * 2008-08-22 2010-02-25 Relypsa, Inc. Linear polyol stabilized polyfluoroacrylate compositions
US20100111892A1 (en) * 2008-08-22 2010-05-06 Relypsa, Inc. Crosslinked polyfluoroacrylic acid and processes for the preparation thereof
US20120107381A1 (en) * 2009-05-13 2012-05-03 Relypsa, Inc. Powder formulations of potassium-binding active agents
PT2550305T (pt) 2010-03-20 2018-04-20 Relypsa Inc Processo contínuo para preparar partículas de polifluoroacrilato
US9314523B2 (en) 2010-09-21 2016-04-19 Elwha Llc Ingestible salt grabber
EP3246287A1 (en) 2011-02-11 2017-11-22 ZS Pharma, Inc Microporous zirconium silicate for the treatment of hyperkalemia
CN108658768A (zh) 2011-06-27 2018-10-16 瑞立普萨公司 丙烯酸酯及衍生物的氟化
CN110028603A (zh) 2011-06-27 2019-07-19 瑞立普萨公司 用于将聚合酯转化为聚合酸的方法
US9943637B2 (en) 2012-06-11 2018-04-17 ZS Pharma, Inc. Microporous zirconium silicate and its method of production
CN104968336A (zh) * 2012-07-11 2015-10-07 Zs制药公司 用于治疗高钙血症患者高钾血症的微孔硅酸锆以及用于治疗高钾血症的改进的含钙组合物
IN2015DN01369A (pt) * 2012-07-19 2015-07-03 Relypsa Inc
CA2879493C (en) 2012-08-09 2018-08-28 Dpx Fine Chemicals Austria Gmbh & Co Kg Process for drying polymeric materials
KR20150088243A (ko) * 2012-10-08 2015-07-31 리립사, 인크. 고혈압 및 고칼륨혈증을 치료하기 위한 칼륨-결합제
US10695365B2 (en) 2012-10-22 2020-06-30 ZS Pharma, Inc. Microporous zirconium silicate for the treatment of hyperkalemia
JP6423795B2 (ja) 2012-10-22 2018-11-14 ズィーエス・ファーマ，インコーポレーテッド 高カリウム血症を治療するための微多孔性ケイ酸ジルコニウム
EP3578185B1 (en) 2013-06-05 2020-08-05 Tricida Inc. Proton-binding polymers for oral administration
EP3842806A1 (en) * 2013-12-11 2021-06-30 Kagami Inc. Marker for early diagnosis of kidney failure
US9675636B2 (en) * 2014-01-31 2017-06-13 University Of Kansas Micelle sequestering polymers
JP6468780B2 (ja) * 2014-09-30 2019-02-13 積水化成品工業株式会社 中空樹脂粒子及びその製造方法
BR122021001914B1 (pt) 2014-12-10 2024-02-27 Tricida, Inc Processo para preparação de um polímero de amina reticulada
AR103250A1 (es) * 2014-12-23 2017-04-26 Ardelyx Inc Composiciones y métodos para tratar la hipercalemia
US9592253B1 (en) 2015-10-14 2017-03-14 ZS Pharma, Inc. Extended use zirconium silicate compositions and methods of use thereof
ITUB20159278A1 (it) 2015-12-23 2017-06-23 Rjw Pharma Llc Procedimento per la sintesi di patiromer
US11406661B2 (en) 2016-05-06 2022-08-09 Tricida, Inc. HCl-binding compositions for and methods of treating acid-base disorders
JP2018125951A (ja) * 2017-01-31 2018-08-09 日本電産株式会社 モータ及びそれを備えた送風装置
EP3703706A4 (en) 2017-11-03 2022-04-27 Tricida Inc. COMPOSITIONS AND METHOD FOR TREATING ACID-BASE DISORDERS
JP7365631B2 (ja) * 2019-09-02 2023-10-20 国立大学法人福井大学 ホスホン酸又はホスホン酸エステル構造を有するコア－シェル型高分子微粒子、粒子分散液、成形体及び前記微粒子の製造方法
CN113244339B (zh) * 2021-06-04 2021-09-24 南京厚生药业有限公司 一种用于高脂血症的考来烯胺散及其制备方法
US20240139234A1 (en) * 2021-11-17 2024-05-02 Waterstone Pharmaceuticals (Wuhan) Co., Ltd. Pharmaceutical polymer for treating hyperkalemia and preparation method thereof
WO2024035944A1 (en) * 2022-08-12 2024-02-15 University Of Kansas Extraction of critical minerals using polyanions

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2340111A (en) * 1942-07-03 1944-01-25 Gen Electric Process for removing cations from liquid media
US2611730A (en) 1950-09-02 1952-09-23 Simth Kline & French Lab Medical preparation for reducing the body level of sodium
US2798053A (en) * 1952-09-03 1957-07-02 Goodrich Co B F Carboxylic polymers
US2909462A (en) 1955-12-08 1959-10-20 Bristol Myers Co Acrylic acid polymer laxative compositions
US3499960A (en) 1965-01-25 1970-03-10 Merck & Co Inc Palatable coated particles of an anion exchange resin
FR2171934B1 (pt) * 1972-02-16 1974-09-13 Rhone Poulenc Sa
US3974272A (en) 1972-09-01 1976-08-10 Merck & Co., Inc. Palatable cholestyramine coacervate compositions
US4143130A (en) 1977-08-29 1979-03-06 Warren-Teed Laboratories, Inc. Method for treating kidney stones
US4470975A (en) 1977-10-21 1984-09-11 The Johns Hopkins University Method and composition for the elimination of water from an animal body
US4380590A (en) 1978-09-19 1983-04-19 Rohm And Haas Company Emulsion copolymer cation exchange resins
US4191812A (en) * 1978-09-19 1980-03-04 Rohm And Haas Company Ion exchange process involving emulsion ion exchange resins
SE8003805L (sv) 1980-05-21 1981-11-22 Haessle Ab En farmaceutisk beredning med forbettrade utlosningsegenskap
US4362711A (en) 1980-07-11 1982-12-07 Evreka Inc. Blood cholesterol level reducing agent and method
DE3031737A1 (de) 1980-08-22 1982-04-01 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von perlpolymerisaten einheitlicher teilchengroesse
DE3149136A1 (de) 1981-12-11 1983-06-23 Robert Bosch Gmbh, 7000 Stuttgart Einrichtung zur regelung des kraftstoff-luftverhaeltnisses bei brennkraftmaschinen
JPS6090243A (ja) 1983-10-25 1985-05-21 Nitto Boseki Co Ltd 小球状モノアリルアミン橋かけ重合体の製造方法
US5238924A (en) 1984-05-03 1993-08-24 Merck & Co., Inc. Treatment of renal diseases with ace inhibitors
KR920006865B1 (ko) 1984-05-18 1992-08-21 워싱톤 유니버시티 테크놀러지 어소우시에이츠 인코오퍼레이티드 입자나 액적을 피복하는 방법과 장치
US4747881A (en) 1985-02-05 1988-05-31 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US5186937A (en) 1985-06-07 1993-02-16 A.E.C. Societe De Chimie Organique Et Biologique Composition for feeding ruminants
IT1190349B (it) 1986-06-16 1988-02-16 Prodotti Formenti Srl Composizioni farmaceutiche ad attivita' sequestrante degli acidi biliari contenenti colestiramina quale principio attivo,e procedimento per prepararle
JPS63218713A (ja) 1987-02-17 1988-09-12 Daikin Ind Ltd α−フルオロアクリル酸系重合体ならびに用途
US4837015A (en) 1987-03-05 1989-06-06 Carolina Medical Products Company, Inc. Alkali metal ion-charged, cation exchanger and use thereof to adjust sodium, potassium and calcium body fluid levels
US5210079A (en) * 1988-01-07 1993-05-11 E. I. Du Pont De Nemours And Company Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists
FR2634377B1 (fr) 1988-06-30 1991-09-27 Cortial Nouvelle forme pharmaceutique a liberation prolongee a base d'un complexe resine-principe actif
GB8817015D0 (en) 1988-07-16 1988-08-17 Reckitt & Colmann Prod Ltd Method of treatment
GB8829088D0 (en) 1988-12-13 1989-01-25 Smith Kline French Lab Compounds
US5236701A (en) 1989-07-19 1993-08-17 Lowchol Scientific Inc. Ingestible hydrophilic polymeric amines useful for lowering blood cholesterol
DE3928990A1 (de) 1989-09-01 1991-03-07 Bayer Ag Verfahren zur herstellung von (alpha)-fluoroacrylsaeurederivaten
US5112993A (en) 1989-11-14 1992-05-12 E. I. Du Pont De Nemours And Company Process for the preparation of difluoromaleic anhydride
US5091175A (en) 1990-05-14 1992-02-25 Erbamont Inc. Pharmaceutical composition containing bile acid sequestrant enclosed in a size-exclusion membrane
ES2070307T3 (es) 1990-07-04 1995-06-01 Marcin Krotkiewski Una preparacion para el tratamiento de la hipertension.
IE914179A1 (en) 1990-12-07 1992-06-17 Ici Plc Nitrogen derivatives
US5162110A (en) * 1990-12-19 1992-11-10 Rhone-Poulenc Rorer Pharmaceuticals Inc. Binding theophylline to ion exchange resins
US5281631A (en) 1991-12-20 1994-01-25 Arch Development Corp. Phosphonic acid based ion exchange resins
DK0563731T3 (da) * 1992-03-28 1996-03-18 Hoechst Ag Lægemidler indeholdende polyhydromethylenderivater, fremgangsmåde til deres fremstilling og deres anvendelse
ATE168707T1 (de) 1992-08-20 1998-08-15 Du Pont Vernetzte polymerische ammoniumsalze
AU6818894A (en) 1993-05-20 1994-12-20 Geltex Pharmaceuticals, Inc. Process for adjusting ion concentration in a patient and compositions therefor
US5487888A (en) 1993-05-20 1996-01-30 Geltex, Inc. Iron-binding polymers for oral administration
US5618530A (en) 1994-06-10 1997-04-08 Geltex Pharmaceuticals, Inc. Hydrophobic amine polymer sequestrant and method of cholesterol depletion
US5607669A (en) 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
US5667775A (en) 1993-08-11 1997-09-16 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
ATE162958T1 (de) 1993-11-25 1998-02-15 Salternate B V Teilchen zum binden monovalenten kationen und ihre verwendung
TW474813B (en) 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
US5846990A (en) * 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
US5824339A (en) 1995-09-08 1998-10-20 Takeda Chemical Industries, Ltd Effervescent composition and its production
US6498142B1 (en) * 1996-05-06 2002-12-24 Curis, Inc. Morphogen treatment for chronic renal failure
JP3885130B2 (ja) 1996-06-11 2007-02-21 株式会社大塚製薬工場 グアニジノ化合物低下剤並びに水分及びカリウムイオン吸着剤
ES2325046T3 (es) 1996-06-26 2009-08-24 The Board Of Regents, The University Of Texas System Formulacion farmaceutica extruible por fusion en caliente.
US6491903B1 (en) * 1996-06-27 2002-12-10 Washington University Particles comprising amphiphilic copolymers
US6623759B2 (en) 1996-06-28 2003-09-23 Astrazeneca Ab Stable drug form for oral administration with benzimidazole derivatives as active ingredient and process for the preparation thereof
US5935599A (en) 1996-10-28 1999-08-10 The Board Of Trustees Of The University Of Illinois Polymer-associated liposomes for drug delivery and method of manufacturing the same
JPH10130154A (ja) 1996-10-29 1998-05-19 Otsuka Pharmaceut Factory Inc 腎疾患患者用延命率改善薬
BR9813808A (pt) 1997-12-19 2002-05-28 Smithkline Beecham Corp Processo para produção de comprimidos para dispersão na mordida
US6280717B1 (en) 1998-07-31 2001-08-28 Nikken Chemicals Co., Ltd. Cation exchange resin preparation
US6294163B1 (en) 1998-10-02 2001-09-25 Geltex Pharmaceuticals, Inc. Polymers containing guanidinium groups as bile acid sequestrants
CZ20011590A3 (cs) 1998-11-06 2003-01-15 G. D. Searle & Co. Léčivo pro léčení kardiovaskulárních poruch a kompozice s obsahem inhibitoru enzymu konvertujícího angiotensin, antagonisty aldosteronu, kličkového diuretika a digoxinu
JP2002534374A (ja) * 1999-01-07 2002-10-15 エラン コーポレーシヨン ピーエルシー 多粒子経口用量形態
US6558665B1 (en) 1999-05-18 2003-05-06 Arch Development Corporation Encapsulating particles with coatings that conform to size and shape of the particles
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
US20020054903A1 (en) * 1999-10-19 2002-05-09 Joseph Tyler Direct compression polymer tablet core
WO2001051063A1 (fr) 2000-01-14 2001-07-19 Otsuka Pharmaceutical Factory, Inc. Inhibiteurs de l'absorption de l'ion sodium, et agents prophylactiques ou therapeutiques et produits alimentaires renfermant lesdits inhibiteurs
FR2812632B1 (fr) 2000-08-07 2003-03-07 Solvay Procede pour la synthese de composes fluoroorganiques
JP2004517066A (ja) 2000-11-20 2004-06-10 ダウ グローバル テクノロジーズ インコーポレイティド 水吸収性ポリマーの生体内での使用
US20040105895A1 (en) 2001-02-06 2004-06-03 Ash Stephen R Monovalent-selective cation exchangers as oral sorbent therapy
US7033639B2 (en) 2001-05-16 2006-04-25 Rohm And Haas Company Polyaniline coating composition
US6881484B2 (en) 2001-05-30 2005-04-19 Mitsubishi Kagaku Iatron, Inc. Core-shell particle including signal-generating substance enclosed therein and process for producing the same
JP2004149525A (ja) 2002-10-09 2004-05-27 Sekisui Chem Co Ltd カリウムイオン吸着剤及びその製造方法、並びに高カリウム血症治療剤
US7060188B2 (en) * 2003-02-25 2006-06-13 Finnfeeds Finland Oy Separation system and process
EP1699442A2 (en) 2003-12-31 2006-09-13 Genzyme Corporation Enteric coated aliphatic amine polymer bile acid sequestrants
US7429394B2 (en) * 2004-03-30 2008-09-30 Relypsa, Inc. Ion binding compositions
CA2557848C (en) * 2004-03-30 2013-12-10 Ilypsa, Inc. Ion binding compositions
US7854924B2 (en) * 2004-03-30 2010-12-21 Relypsa, Inc. Methods and compositions for treatment of ion imbalances
US8192758B2 (en) 2004-03-30 2012-06-05 Relypsa, Inc. Ion binding compositions
US8282960B2 (en) * 2004-03-30 2012-10-09 Relypsa, Inc. Ion binding compositions
US7556799B2 (en) * 2004-03-30 2009-07-07 Relypsa, Inc. Ion binding polymers and uses thereof
BRPI0616604A2 (pt) * 2005-09-30 2012-12-25 Ilypsa Inc mÉtodo para remover e composiÇço para seletivamente remover Íon de potÁssio do trato gastrintestinal de um mamÍfero, mÉtodo para seletivamente remover Íon de potÁssio de um meio-ambiente, composiÇço farmacÊutica, partÍcula de nécleo-envoltàrio, e, usos de uma partÍcula de nécleo-envoltàrio e de uma composiÇço farmacÊutica
CA2624112A1 (en) * 2005-09-30 2007-04-05 Ilypsa, Inc. Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom
WO2010022380A2 (en) * 2008-08-22 2010-02-25 Relypsa, Inc. Linear polyol stabilized polyfluoroacrylate compositions
WO2010022381A1 (en) * 2008-08-22 2010-02-25 Relypsa, Inc. Treating hyperkalemia with crosslinked cation exchange polymers of improved physical properties
US20100111892A1 (en) * 2008-08-22 2010-05-06 Relypsa, Inc. Crosslinked polyfluoroacrylic acid and processes for the preparation thereof

Also Published As

Publication number Publication date
US20200085856A1 (en) 2020-03-19
US20060024265A1 (en) 2006-02-02
US20080233073A1 (en) 2008-09-25
AU2005231383A1 (en) 2005-10-20
WO2005097072A1 (en) 2005-10-20
KR101228233B1 (ko) 2013-01-31
JP4964122B2 (ja) 2012-06-27
GB2430368B (en) 2009-08-26
JP2007531758A (ja) 2007-11-08
EP1732523B9 (en) 2010-06-02
MXPA06011270A (es) 2007-03-08
EP1732523A1 (en) 2006-12-20
BRPI0509366A (pt) 2007-09-04
WO2005097081A1 (en) 2005-10-20
AU2005228696A1 (en) 2005-10-13
WO2005094384A3 (en) 2006-01-26
US8287847B2 (en) 2012-10-16
US20080241092A1 (en) 2008-10-02
US20130272992A1 (en) 2013-10-17
US8445014B2 (en) 2013-05-21
BRPI0509365A (pt) 2007-09-04
BRPI0509365B8 (pt) 2021-05-25
AU2005231424B2 (en) 2010-06-17
US7776319B2 (en) 2010-08-17
GB2430367B (en) 2009-08-05
US20160082039A1 (en) 2016-03-24
AU2005231424A1 (en) 2005-10-20
EP1732516A4 (en) 2007-06-06
EP1732524A4 (en) 2007-09-19
EP1732523A4 (en) 2007-06-06
US8475780B2 (en) 2013-07-02
EP1732524A2 (en) 2006-12-20
CA2557848C (en) 2013-12-10
BRPI0509366B8 (pt) 2021-05-25
CA2558029A1 (en) 2005-10-20
EP1732524B1 (en) 2012-08-22
AU2005228696B2 (en) 2010-06-24
JP2007531774A (ja) 2007-11-08
KR101153035B1 (ko) 2012-06-11
US8889115B2 (en) 2014-11-18
BRPI0509331B1 (pt) 2018-11-27
EP1732523B1 (en) 2010-03-17
PL1732523T3 (pl) 2010-08-31
US10485821B2 (en) 2019-11-26
US20140286891A1 (en) 2014-09-25
CA2557848A1 (en) 2005-10-20
US20090148533A1 (en) 2009-06-11
GB2430624B (en) 2009-08-05
BRPI0509331A (pt) 2007-09-04
JP4974882B2 (ja) 2012-07-11
AU2005231383B2 (en) 2010-06-10
KR20060135045A (ko) 2006-12-28
US20110033505A1 (en) 2011-02-10
CA2557999C (en) 2013-11-12
DE112005000730B4 (de) 2017-12-21
US8778324B2 (en) 2014-07-15
US20110206631A1 (en) 2011-08-25
GB0621241D0 (en) 2006-12-13
US20080241093A1 (en) 2008-10-02
GB2430368A (en) 2007-03-28
US8409561B2 (en) 2013-04-02
US20130272991A1 (en) 2013-10-17
JP5000480B2 (ja) 2012-08-15
GB0621244D0 (en) 2006-12-13
US20130272990A1 (en) 2013-10-17
GB0621242D0 (en) 2006-12-13
EP1732516A1 (en) 2006-12-20
US20160317572A1 (en) 2016-11-03
DE112005000730T5 (de) 2008-07-03
EP1732516B1 (en) 2009-12-30
US8282913B2 (en) 2012-10-09
CA2558029C (en) 2013-05-07
GB2430624A (en) 2007-04-04
KR20060135044A (ko) 2006-12-28
KR101199608B1 (ko) 2012-11-08
KR20070007168A (ko) 2007-01-12
BRPI0509365B1 (pt) 2018-06-12
US8216560B2 (en) 2012-07-10
GB2430367A (en) 2007-03-28
WO2005094384A2 (en) 2005-10-13
CA2557999A1 (en) 2005-10-13
BRPI0509366B1 (pt) 2018-07-24
JP2007531726A (ja) 2007-11-08

Similar Documents

Publication Publication Date Title
BRPI0509331B8 (pt) uso de uma composição de ligação de sódio
EA201490822A1 (ru) Модифицированные полипептиды рецептора активина и их применение
ATE372324T1 (de) Substituierte heteroarylverbindungen als inhibitoren von proteintyrosinphosphatasen
BR112018015238A2 (pt) conjugado de anticorpo, anticorpo, kit, composição farmacêutica, e, métodos para tratar ou prevenir uma doença ou condição e para diagnosticar uma doença ou condição
WO2008043753A8 (en) Rna antagonist compounds for the modulation of pcsk9
BR112012025568A2 (pt) proteínas de ligação ao tnf-<244>.
EA200702656A1 (ru) Составы, содержащие пептиды, стимулирующие рецептор эритропоэтина, и их применение
WO2004099171A3 (en) Substituted amino carboxylic acids as inhibitors of protein tyrosine phosphatase-1b
WO2006055625A3 (en) Heterocyclylbiphenyl derivates as protein tyrosine phosphatase inhibitors
NO20054769L (no) Substituerte fenylalkansyrer
WO2009079585A3 (en) Compositions and methods for treating osteolytic disorders comprising mmp-14 binding proteins
WO2007084986A3 (en) Compositions and methods for preventing or treating feline chronic kidney disease
BRPI0914504B8 (pt) uso de um peptídeo intestinal vasoativo (piv) ou um ou mais fragmentos funcionais do piv
DE602005020501D1 (de) Vernetzte aminpolymere
WO2008113515A3 (en) huTNFR1 SELECTIVE ANTAGONISTS
EA200901249A1 (ru) Ингибиторы связывания протеинкиназ
BRPI0415781A (pt) método para o tratamento de diabetes em um paciente e kit farmacêutico
ATE453383T1 (de) Ionenbindende zusammensetzungen
WO2005079541A3 (en) Terephthalamide peptidomimetic compounds and methods
EA200701086A1 (ru) Производные изоксазола, их фармацевтические композиции и способ лечения невропатической боли
BRPI1009237A2 (pt) inibidores de ligação de proteína quinase.

Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: ILYPSA, INC. (US)

Free format text: ENDERECO ALTERADO CONFORME SOLICITADO NA PETICAO NO 020120015933/RJ DE 27/02/2012.

B25G Requested change of headquarter approved

Owner name: ILYPSA, INC. (US)

Free format text: ENDERECO ALTERADO CONFORME SOLICITADO NA PETICAO NO 020120016146/RJ DE 27/02/2012.

B25A Requested transfer of rights approved

Owner name: RELYPSA, INC. (US)

Free format text: TRANSFERIDO DE: ILYPSA, INC.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 27/11/2018, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/03/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 18A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2716 DE 24-01-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.