JP2007531758A5 - - Google Patents
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- JP2007531758A5 JP2007531758A5 JP2007506518A JP2007506518A JP2007531758A5 JP 2007531758 A5 JP2007531758 A5 JP 2007531758A5 JP 2007506518 A JP2007506518 A JP 2007506518A JP 2007506518 A JP2007506518 A JP 2007506518A JP 2007531758 A5 JP2007531758 A5 JP 2007531758A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- group
- shell
- alkylating agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920002873 Polyethylenimine Polymers 0.000 claims description 8
- 229920000642 polymer Polymers 0.000 claims description 8
- 229940100198 alkylating agent Drugs 0.000 claims description 7
- 239000002168 alkylating agent Substances 0.000 claims description 7
- 150000001412 amines Chemical class 0.000 claims description 6
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 5
- 229920001467 poly(styrenesulfonates) Polymers 0.000 claims description 5
- 239000011591 potassium Substances 0.000 claims description 5
- 229910052700 potassium Inorganic materials 0.000 claims description 5
- -1 quaternary ammonium ions Chemical class 0.000 claims description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 230000029936 alkylation Effects 0.000 claims description 4
- 238000005804 alkylation reaction Methods 0.000 claims description 4
- 229920001002 functional polymer Polymers 0.000 claims description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 4
- 238000005341 cation exchange Methods 0.000 claims description 3
- TYCFGHUTYSLISP-UHFFFAOYSA-N 2-fluoroprop-2-enoic acid Chemical compound OC(=O)C(F)=C TYCFGHUTYSLISP-UHFFFAOYSA-N 0.000 claims description 2
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 2
- 125000002843 carboxylic acid group Chemical group 0.000 claims description 2
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid group Chemical group S(N)(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 claims description 2
- 125000000542 sulfonic acid group Chemical group 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical group S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 239000003814 drug Substances 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims 1
- 206010016803 Fluid overload Diseases 0.000 claims 1
- 208000002682 Hyperkalemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 125000005210 alkyl ammonium group Chemical group 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 230000001195 anabolic effect Effects 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 claims 1
- 229960005084 calcitriol Drugs 0.000 claims 1
- 235000020964 calcitriol Nutrition 0.000 claims 1
- 239000011612 calcitriol Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000028208 end stage renal disease Diseases 0.000 claims 1
- 201000000523 end stage renal failure Diseases 0.000 claims 1
- 150000002334 glycols Chemical class 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000011970 polystyrene sulfonate Substances 0.000 claims 1
- 229960002796 polystyrene sulfonate Drugs 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 239000011324 bead Substances 0.000 description 5
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 4
- 239000011777 magnesium Substances 0.000 description 4
- 229910052749 magnesium Inorganic materials 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000035699 permeability Effects 0.000 description 3
- 229920003155 Eudragit® RL 100 Polymers 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229920003159 Eudragit® RS 100 Polymers 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000011162 core material Substances 0.000 description 1
- 239000011258 core-shell material Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000012039 electrophile Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000010220 ion permeability Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/813,872 | 2004-03-30 | ||
| US10/814,527 US7854924B2 (en) | 2004-03-30 | 2004-03-30 | Methods and compositions for treatment of ion imbalances |
| US10/813,872 US8282960B2 (en) | 2004-03-30 | 2004-03-30 | Ion binding compositions |
| US10/814,749 | 2004-03-30 | ||
| US10/814,749 US8192758B2 (en) | 2004-03-30 | 2004-03-30 | Ion binding compositions |
| US10/814,527 | 2004-03-30 | ||
| US10/965,274 US7488495B2 (en) | 2004-03-30 | 2004-10-13 | Ion binding polymers and uses thereof |
| US10/965,274 | 2004-10-13 | ||
| PCT/US2005/010747 WO2005097072A1 (en) | 2004-03-30 | 2005-03-30 | Ion binding compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011246755A Division JP5431439B2 (ja) | 2004-03-30 | 2011-11-10 | イオン結合組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007531758A JP2007531758A (ja) | 2007-11-08 |
| JP2007531758A5 true JP2007531758A5 (cg-RX-API-DMAC10.html) | 2012-01-26 |
| JP4964122B2 JP4964122B2 (ja) | 2012-06-27 |
Family
ID=35054544
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007506580A Expired - Lifetime JP4974882B2 (ja) | 2004-03-30 | 2005-03-30 | イオン結合ポリマーとその利用 |
| JP2007506295A Expired - Fee Related JP5000480B2 (ja) | 2004-03-30 | 2005-03-30 | イオンバランス異常の治療の方法および組成物 |
| JP2007506518A Expired - Fee Related JP4964122B2 (ja) | 2004-03-30 | 2005-03-30 | イオン結合組成物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007506580A Expired - Lifetime JP4974882B2 (ja) | 2004-03-30 | 2005-03-30 | イオン結合ポリマーとその利用 |
| JP2007506295A Expired - Fee Related JP5000480B2 (ja) | 2004-03-30 | 2005-03-30 | イオンバランス異常の治療の方法および組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (14) | US7776319B2 (cg-RX-API-DMAC10.html) |
| EP (3) | EP1732516B1 (cg-RX-API-DMAC10.html) |
| JP (3) | JP4974882B2 (cg-RX-API-DMAC10.html) |
| KR (3) | KR101153035B1 (cg-RX-API-DMAC10.html) |
| AU (3) | AU2005228696B2 (cg-RX-API-DMAC10.html) |
| BR (3) | BRPI0509366B8 (cg-RX-API-DMAC10.html) |
| CA (3) | CA2557999C (cg-RX-API-DMAC10.html) |
| DE (1) | DE112005000730B4 (cg-RX-API-DMAC10.html) |
| GB (3) | GB2430624B (cg-RX-API-DMAC10.html) |
| MX (1) | MXPA06011270A (cg-RX-API-DMAC10.html) |
| PL (1) | PL1732523T3 (cg-RX-API-DMAC10.html) |
| WO (3) | WO2005094384A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2792363T3 (da) | 2003-08-26 | 2016-09-26 | Shire Biopharmaceuticals Holdings Ireland Ltd | Farmaceutisk formulering, der omfatter lanthanforbindelser |
| US7381428B2 (en) | 2003-08-26 | 2008-06-03 | Shire International Licensing B.V. | Stabilized lanthanum carbonate compositions |
| KR101153035B1 (ko) * | 2004-03-30 | 2012-06-11 | 리립사, 인크. | 이온 결합 조성물 |
| DE602005019992D1 (de) * | 2004-03-30 | 2010-04-29 | Relypsa Inc | Kaliumbindende polymere und ihre verwendungen |
| CN101321519A (zh) * | 2005-09-30 | 2008-12-10 | 伊立普萨公司 | 制备含有交联壳的核-壳型复合物的方法及其得到的核-壳型复合物 |
| WO2007038801A2 (en) * | 2005-09-30 | 2007-04-05 | Ilypsa, Inc. | Monovalent cation-binding compositions comprising core-shell particles having crosslinked poly-vinylic shells, and methods of use thereof |
| JP2009510126A (ja) | 2005-09-30 | 2009-03-12 | レリプサ， インコーポレイテッド | 哺乳類の胃腸管からカリウムイオンを選択的に除去するための方法および組成物 |
| CN100398112C (zh) * | 2006-03-24 | 2008-07-02 | 辽宁诺康生物制药有限责任公司 | 一种治疗血磷酸盐过多症的药物及其制备方法 |
| PL2081551T3 (pl) * | 2006-10-06 | 2013-06-28 | Scil Tech Gmbh | Wytworzenie wysuszonego rekonstytuowanego pęcherzyka do zastosowania farmaceutycznego |
| EP2107072A1 (en) * | 2006-12-26 | 2009-10-07 | Otsuka Pharmaceutical Factory, Inc. | Sodium absorption inhibitor, potassium absorption inhibitor, phosphorus absorption inhibitor and preventive agent, therapeutic agent and food containing the same |
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| CA2827056C (en) | 2011-02-11 | 2020-07-14 | Zs Pharma, Inc | Microporous zirconium silicate for the treatment of hyperkalemia |
| CN110028603A (zh) | 2011-06-27 | 2019-07-19 | 瑞立普萨公司 | 用于将聚合酯转化为聚合酸的方法 |
| CN108276277A (zh) | 2011-06-27 | 2018-07-13 | 瑞立普萨公司 | 丙烯酸酯及衍生物的氟化 |
| US9943637B2 (en) | 2012-06-11 | 2018-04-17 | ZS Pharma, Inc. | Microporous zirconium silicate and its method of production |
| MX2015000381A (es) * | 2012-07-11 | 2015-11-23 | Zs Pharma Inc | Silicato de zirconio microporoso para el tratamiento de la hipercalemia en pacientes hipercalcemicos y composiciones con calcio mejoradas para el tratamiento de la hipercalemia. |
| IN2015DN01369A (cg-RX-API-DMAC10.html) * | 2012-07-19 | 2015-07-03 | Relypsa Inc | |
| EP2882798B1 (en) | 2012-08-09 | 2019-05-08 | Patheon Austria GmbH & Co KG | Process for drying polymeric materials |
| ES3059226T3 (en) | 2012-10-08 | 2026-03-19 | Vifor Int Ltd | Potassium-binding agents for treating hypertension and hyperkalemia |
| HRP20251373T1 (hr) | 2012-10-22 | 2025-12-19 | Zs Pharma, Inc | Mikroporozni cirkonijev silikat za liječenje hiperkalijemije |
| US10695365B2 (en) | 2012-10-22 | 2020-06-30 | ZS Pharma, Inc. | Microporous zirconium silicate for the treatment of hyperkalemia |
| KR102633597B1 (ko) | 2013-06-05 | 2024-02-06 | 트리시다, 인크. | 경구 투여를 위한 양성자-결합 중합체 |
| US10393749B2 (en) * | 2013-12-11 | 2019-08-27 | Shiseido Company, Ltd. | Marker for early diagnosis of kidney failure |
| US9675636B2 (en) * | 2014-01-31 | 2017-06-13 | University Of Kansas | Micelle sequestering polymers |
| JP6468780B2 (ja) * | 2014-09-30 | 2019-02-13 | 積水化成品工業株式会社 | 中空樹脂粒子及びその製造方法 |
| IL322207A (en) | 2014-12-10 | 2025-09-01 | Tricida Inc | Proton-binding polymers for oral administration |
| KR102674230B1 (ko) * | 2014-12-23 | 2024-06-11 | 알데릭스, 인코포레이티드 | 고칼륨혈증의 치료를 위한 조성물 및 방법 |
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| IL262660B2 (en) | 2016-05-06 | 2024-04-01 | Tricida Inc | Compositions for and method of treating acid-base disorders |
| JP2018125951A (ja) * | 2017-01-31 | 2018-08-09 | 日本電産株式会社 | モータ及びそれを備えた送風装置 |
| IL319146A (en) | 2017-11-03 | 2025-04-01 | Tricida Inc | Compositions for and method of treating acid-base disorders |
| JP7365631B2 (ja) * | 2019-09-02 | 2023-10-20 | 国立大学法人福井大学 | ホスホン酸又はホスホン酸エステル構造を有するコア－シェル型高分子微粒子、粒子分散液、成形体及び前記微粒子の製造方法 |
| CN113244339B (zh) * | 2021-06-04 | 2021-09-24 | 南京厚生药业有限公司 | 一种用于高脂血症的考来烯胺散及其制备方法 |
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| US20260043111A1 (en) * | 2022-08-12 | 2026-02-12 | University Of Kansas | Extraction of critical minerals using polyanions |
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2005
- 2005-03-30 KR KR1020067022533A patent/KR101153035B1/ko not_active Expired - Fee Related
- 2005-03-30 DE DE112005000730.8T patent/DE112005000730B4/de not_active Expired - Lifetime
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