JP2007529503A5 - - Google Patents
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- Publication number
- JP2007529503A5 JP2007529503A5 JP2007503444A JP2007503444A JP2007529503A5 JP 2007529503 A5 JP2007529503 A5 JP 2007529503A5 JP 2007503444 A JP2007503444 A JP 2007503444A JP 2007503444 A JP2007503444 A JP 2007503444A JP 2007529503 A5 JP2007529503 A5 JP 2007529503A5
- Authority
- JP
- Japan
- Prior art keywords
- hib
- vaccine
- antigen
- conjugate
- protect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 26
- 102000036639 antigens Human genes 0.000 claims 26
- 108091007433 antigens Proteins 0.000 claims 26
- 229960005486 vaccine Drugs 0.000 claims 22
- 229940001442 combination vaccine Drugs 0.000 claims 13
- 238000000034 method Methods 0.000 claims 13
- 201000005702 Pertussis Diseases 0.000 claims 11
- 206010043376 Tetanus Diseases 0.000 claims 10
- 206010013023 diphtheria Diseases 0.000 claims 10
- 150000001720 carbohydrates Chemical class 0.000 claims 8
- 206010022000 influenza Diseases 0.000 claims 7
- 239000002671 adjuvant Substances 0.000 claims 4
- 241000588747 Klebsiella pneumoniae Species 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- 108010055044 Tetanus Toxin Proteins 0.000 claims 2
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 229940118376 tetanus toxin Drugs 0.000 claims 2
- VJDOAZKNBQCAGE-LMVFSUKVSA-N D-ribitol 5-phosphate Chemical compound OC[C@H](O)[C@H](O)[C@H](O)COP(O)(O)=O VJDOAZKNBQCAGE-LMVFSUKVSA-N 0.000 claims 1
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 1
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 1
- 241000606768 Haemophilus influenzae Species 0.000 claims 1
- 241000700721 Hepatitis B virus Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000000474 Poliomyelitis Diseases 0.000 claims 1
- ZXRRHFSTAFVGOC-UHFFFAOYSA-N [AlH3].[K] Chemical compound [AlH3].[K] ZXRRHFSTAFVGOC-UHFFFAOYSA-N 0.000 claims 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
- 230000005875 antibody response Effects 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 229940045808 haemophilus influenzae type b Drugs 0.000 claims 1
- 239000002596 immunotoxin Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000002482 oligosaccharides Polymers 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0405787.3 | 2004-03-15 | ||
| GBGB0405787.3A GB0405787D0 (en) | 2004-03-15 | 2004-03-15 | Low dose vaccines |
| PCT/IB2005/000927 WO2005089794A2 (en) | 2004-03-15 | 2005-03-14 | Combination vaccines with low dose of hib conjugate |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008056997A Division JP2008150397A (ja) | 2004-03-15 | 2008-03-06 | 低用量のＨｉｂ結合体との組合せワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007529503A JP2007529503A (ja) | 2007-10-25 |
| JP2007529503A5 true JP2007529503A5 (https=) | 2008-04-24 |
| JP4954056B2 JP4954056B2 (ja) | 2012-06-13 |
Family
ID=32117706
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007503444A Expired - Fee Related JP4954056B2 (ja) | 2004-03-15 | 2005-03-14 | 低用量のＨｉｂ結合体との組合せワクチン |
| JP2008056997A Pending JP2008150397A (ja) | 2004-03-15 | 2008-03-06 | 低用量のＨｉｂ結合体との組合せワクチン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008056997A Pending JP2008150397A (ja) | 2004-03-15 | 2008-03-06 | 低用量のＨｉｂ結合体との組合せワクチン |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20090208526A1 (https=) |
| EP (1) | EP1725258B1 (https=) |
| JP (2) | JP4954056B2 (https=) |
| CN (2) | CN102028944B (https=) |
| AT (1) | ATE480257T1 (https=) |
| BR (1) | BRPI0508813B8 (https=) |
| CA (1) | CA2559996C (https=) |
| DE (1) | DE602005023422D1 (https=) |
| DK (1) | DK1725258T3 (https=) |
| GB (1) | GB0405787D0 (https=) |
| RU (1) | RU2435609C2 (https=) |
| SG (1) | SG151253A1 (https=) |
| WO (1) | WO2005089794A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ20024224A3 (cs) * | 2000-06-29 | 2003-05-14 | Glaxosmithkline Biologicals S. A. | Farmaceutický prostředek |
| GB0505518D0 (en) * | 2005-03-17 | 2005-04-27 | Chiron Srl | Combination vaccines with whole cell pertussis antigen |
| PE20110072A1 (es) † | 2005-06-27 | 2011-02-04 | Glaxosmithkline Biolog Sa | Composicion inmunogenica |
| JP5814507B2 (ja) | 2006-09-07 | 2015-11-17 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ワクチン |
| GB0700135D0 (en) * | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Vaccine |
| ES2555786T3 (es) * | 2007-06-04 | 2016-01-08 | Glaxosmithkline Biologicals Sa | Formulación de vacunas contra la meningitis |
| CU23652A1 (es) * | 2007-06-29 | 2011-05-27 | Centro Inmunologia Molecular | Composición vacunal homogénea para el tratamiento del cáncer y su método de obtención |
| CN102066401A (zh) | 2008-05-01 | 2011-05-18 | 艾瑞克有限公司 | 蛋白质制品 |
| PE20100365A1 (es) | 2008-10-24 | 2010-05-21 | Panacea Biotec Ltd | Novedosas vacunas de combinacion con tos ferina de celulas enteras y metodo para su elaboracion |
| PE20100366A1 (es) * | 2008-10-24 | 2010-05-21 | Panacea Biotec Ltd | Novedosas composiciones de vacuna con tos ferina acelular asi como el metodo para su elaboracion |
| GB0822633D0 (en) * | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
| WO2011027222A2 (en) | 2009-09-02 | 2011-03-10 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
| CN102655879B (zh) * | 2009-12-16 | 2016-03-09 | 印度血清研究所 | 疫苗组合物 |
| AU2011295853A1 (en) | 2010-09-01 | 2013-04-04 | Irm Llc | Adsorption of immunopotentiators to insoluble metal salts |
| WO2012117377A1 (en) * | 2011-03-02 | 2012-09-07 | Novartis Ag | Combination vaccines with lower doses of antigen and/or adjuvant |
| BR112013027057A2 (pt) | 2011-04-21 | 2020-08-11 | Trustees Of Tufts College | composições e métodos para a estabilização de agentes ativos |
| MX372965B (es) | 2012-03-08 | 2020-04-01 | Glaxosmithkline Biologicals Sa | Formulaciones adyuvadas de vacunas de difteria, tetanos y tos ferina (dtp) de refuerzo. |
| US20150297714A1 (en) * | 2012-10-29 | 2015-10-22 | The Board Of Trustees Of The University Of Arkansas | Novel mucosal adjuvants and delivery systems |
| RU2626532C2 (ru) * | 2015-01-16 | 2017-07-28 | Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации | Комбинированная вакцина для профилактики коклюша, дифтерии, столбняка, гепатита в и инфекции, вызываемой haemophilus influenzae тип в |
| US11027005B2 (en) * | 2016-10-20 | 2021-06-08 | Km Biologics Co., Ltd. | Method for producing Hib conjugate vaccine using PRP with lowered molecular weight |
| CN111032078A (zh) | 2017-07-18 | 2020-04-17 | 血清研究所印度私人有限公司 | 具有改善的稳定性、增强的免疫原性和降低的反应原性的免疫原性组合物及其制备方法 |
| CN110251667A (zh) * | 2018-05-11 | 2019-09-20 | 武汉博沃生物科技有限公司 | 一种免疫组合制剂及其制备方法和应用 |
| EA202190778A1 (ru) | 2018-10-12 | 2021-08-05 | Серум Инститьют Оф Индия Прайват Лтд | Композиция комбинированной вакцины, содержащая уменьшенную дозу инактивированного полиовируса, и способ её получения |
| WO2021176409A1 (en) | 2020-03-05 | 2021-09-10 | Sanofi Healthcare India Private Limited | Preservative combination for vaccine composition |
| CN118903397A (zh) * | 2024-10-12 | 2024-11-08 | 成都迈科康生物科技有限公司 | GloboH六糖、linker化合物、蛋白偶联物及免疫原性组合物在治疗或抑制上皮性肿瘤中的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2734484B1 (fr) * | 1995-05-24 | 1997-06-27 | Pasteur Merieux Serums Vacc | Composition vaccinale liquide et procede de fabrication |
| PL184872B1 (pl) * | 1995-06-23 | 2003-01-31 | Smithkline Beecham Biolog | Kombinowana szczepionkaĆ zestaw do przygotowania kombinowanej szczepionkiĆ sposób wytwarzania kombinowanej szczepionki i jej zastosowanie |
| US20020054884A1 (en) * | 1995-06-23 | 2002-05-09 | Smithkline Beecham Biologicals, Sa | Vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate |
| CZ20024224A3 (cs) | 2000-06-29 | 2003-05-14 | Glaxosmithkline Biologicals S. A. | Farmaceutický prostředek |
-
2004
- 2004-03-15 GB GBGB0405787.3A patent/GB0405787D0/en not_active Ceased
-
2005
- 2005-03-14 RU RU2006136212/15A patent/RU2435609C2/ru not_active IP Right Cessation
- 2005-03-14 AT AT05727218T patent/ATE480257T1/de not_active IP Right Cessation
- 2005-03-14 DE DE602005023422T patent/DE602005023422D1/de not_active Expired - Lifetime
- 2005-03-14 WO PCT/IB2005/000927 patent/WO2005089794A2/en not_active Ceased
- 2005-03-14 DK DK05727218.9T patent/DK1725258T3/da active
- 2005-03-14 JP JP2007503444A patent/JP4954056B2/ja not_active Expired - Fee Related
- 2005-03-14 CN CN2010105870900A patent/CN102028944B/zh not_active Expired - Fee Related
- 2005-03-14 BR BRPI0508813A patent/BRPI0508813B8/pt not_active IP Right Cessation
- 2005-03-14 SG SG200901653-6A patent/SG151253A1/en unknown
- 2005-03-14 US US10/593,007 patent/US20090208526A1/en not_active Abandoned
- 2005-03-14 CN CN2005800152906A patent/CN1968711B/zh not_active Expired - Fee Related
- 2005-03-14 CA CA2559996A patent/CA2559996C/en not_active Expired - Fee Related
- 2005-03-14 EP EP05727218A patent/EP1725258B1/en not_active Expired - Lifetime
-
2008
- 2008-03-06 JP JP2008056997A patent/JP2008150397A/ja active Pending
-
2011
- 2011-09-30 US US13/250,094 patent/US9259460B2/en active Active
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