JP2010500398A5 - - Google Patents
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- Publication number
- JP2010500398A5 JP2010500398A5 JP2009524255A JP2009524255A JP2010500398A5 JP 2010500398 A5 JP2010500398 A5 JP 2010500398A5 JP 2009524255 A JP2009524255 A JP 2009524255A JP 2009524255 A JP2009524255 A JP 2009524255A JP 2010500398 A5 JP2010500398 A5 JP 2010500398A5
- Authority
- JP
- Japan
- Prior art keywords
- vaccine
- bulk
- item
- toxoid
- diphtheria
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 66
- 229960005486 vaccine Drugs 0.000 claims description 34
- 229960003983 diphtheria toxoid Drugs 0.000 claims description 16
- 229960000814 tetanus toxoid Drugs 0.000 claims description 14
- 239000003755 preservative agent Substances 0.000 claims description 12
- 230000002335 preservative effect Effects 0.000 claims description 12
- 239000002671 adjuvant Substances 0.000 claims description 11
- 239000000427 antigen Substances 0.000 claims description 9
- 102000036639 antigens Human genes 0.000 claims description 9
- 108091007433 antigens Proteins 0.000 claims description 9
- 101710154606 Hemagglutinin Proteins 0.000 claims description 8
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims description 8
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims description 8
- 108010081690 Pertussis Toxin Proteins 0.000 claims description 8
- 101710176177 Protein A56 Proteins 0.000 claims description 8
- 239000000185 hemagglutinin Substances 0.000 claims description 8
- 108010021711 pertactin Proteins 0.000 claims description 8
- 241000991587 Enterovirus C Species 0.000 claims description 6
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 4
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 4
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims description 4
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims description 4
- 229910052753 mercury Inorganic materials 0.000 claims description 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 4
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 4
- 229920000053 polysorbate 80 Polymers 0.000 claims description 4
- 229940068968 polysorbate 80 Drugs 0.000 claims description 4
- 206010043376 Tetanus Diseases 0.000 claims description 3
- 206010013023 diphtheria Diseases 0.000 claims description 3
- 241000709701 Human poliovirus 1 Species 0.000 claims description 2
- 241000709704 Human poliovirus 2 Species 0.000 claims description 2
- 241000709727 Human poliovirus 3 Species 0.000 claims description 2
- 101150072453 MEF1 gene Proteins 0.000 claims description 2
- 201000005702 Pertussis Diseases 0.000 claims description 2
- 239000002158 endotoxin Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 238000005119 centrifugation Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0616306.7A GB0616306D0 (en) | 2006-08-16 | 2006-08-16 | Vaccines |
| GB0616306.7 | 2006-08-16 | ||
| PCT/IB2007/003255 WO2008020328A2 (en) | 2006-08-16 | 2007-08-15 | Manufacture of booster vaccines having reduced antigen doses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012200460A Division JP2012236864A (ja) | 2006-08-16 | 2012-09-12 | 低減された抗原用量を有するブースターワクチンの製造 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010500398A JP2010500398A (ja) | 2010-01-07 |
| JP2010500398A5 true JP2010500398A5 (https=) | 2011-09-01 |
| JP5090452B2 JP5090452B2 (ja) | 2012-12-05 |
Family
ID=37081096
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009524255A Expired - Fee Related JP5090452B2 (ja) | 2006-08-16 | 2007-08-15 | 低減された抗原用量を有するブースターワクチンの製造 |
| JP2012200460A Pending JP2012236864A (ja) | 2006-08-16 | 2012-09-12 | 低減された抗原用量を有するブースターワクチンの製造 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012200460A Pending JP2012236864A (ja) | 2006-08-16 | 2012-09-12 | 低減された抗原用量を有するブースターワクチンの製造 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100158940A1 (https=) |
| EP (1) | EP2073841B1 (https=) |
| JP (2) | JP5090452B2 (https=) |
| CN (1) | CN101522217B (https=) |
| ES (1) | ES2528665T3 (https=) |
| GB (1) | GB0616306D0 (https=) |
| WO (1) | WO2008020328A2 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0822633D0 (en) * | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
| ES2443952T3 (es) | 2009-09-02 | 2014-02-21 | Novartis Ag | Composiciones inmunógenas que incluyen moduladores de la actividad de TLR |
| ES2458355T3 (es) | 2010-09-01 | 2014-05-05 | Novartis Ag | Adsorción de inmunopotenciadores sobre sales metálicas insolubles |
| WO2012117377A1 (en) | 2011-03-02 | 2012-09-07 | Novartis Ag | Combination vaccines with lower doses of antigen and/or adjuvant |
| CN102526717A (zh) * | 2011-11-25 | 2012-07-04 | 成都康华生物制品有限公司 | 一种吸附无细胞百白破联合疫苗的制备方法 |
| MX372965B (es) | 2012-03-08 | 2020-04-01 | Glaxosmithkline Biologicals Sa | Formulaciones adyuvadas de vacunas de difteria, tetanos y tos ferina (dtp) de refuerzo. |
| CN104159603A (zh) * | 2012-03-08 | 2014-11-19 | 诺华股份有限公司 | 带有tlr4激动剂的联合疫苗 |
| CN103908667A (zh) * | 2014-04-18 | 2014-07-09 | 中国医学科学院医学生物学研究所 | 吸附无细胞百白破-Sabin株脊髓灰质炎联合疫苗及制备方法 |
| CN104707134A (zh) * | 2015-03-27 | 2015-06-17 | 成都欧林生物科技股份有限公司 | 一种无细胞百日破联合疫苗及其制备方法 |
| CN109922828A (zh) * | 2016-10-20 | 2019-06-21 | Km生物医药股份公司 | 使用具有降低了的分子量的PRP的Hib结合疫苗的制造方法 |
| KR102426041B1 (ko) * | 2017-08-01 | 2022-07-29 | 주식회사 녹십자 | 냉동 및 해동 과정을 포함하는 백일해균 유래 단백질 수득 방법 |
| WO2020165920A1 (en) * | 2019-02-12 | 2020-08-20 | Biological E Limited | Multivalent vaccine composition |
| US12233177B2 (en) | 2019-09-16 | 2025-02-25 | Amgen Inc. | Method for external sterilization of drug delivery device |
| CN111053898B (zh) * | 2019-12-26 | 2023-05-16 | 北京科兴中维生物技术有限公司 | 一种疫苗组合物及其应用 |
| CN114748616A (zh) * | 2022-05-23 | 2022-07-15 | 中国医学科学院医学生物学研究所 | 一种成人青少年用无细胞百白破联合疫苗及其制备方法 |
| CN119524117B (zh) * | 2025-01-23 | 2025-09-23 | 康希诺生物股份公司 | 免疫原性组合物、百白破联合疫苗及其制备方法和应用 |
| CN119548620B (zh) * | 2025-01-23 | 2025-09-12 | 康希诺生物股份公司 | 一种用于预防白喉、百日咳和破伤风的免疫原性组合物、疫苗及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5554125A (en) * | 1987-07-08 | 1996-09-10 | Reynolds; David L. | Prefilled vial syringe |
| FI945483A7 (fi) * | 1992-05-23 | 1995-01-20 | Smithkline Beecham Biologicals S A | Hepatiitti B - pinta-antigeenejä ja muita antigeenejä sisältäviä yhdistelmärokotteita |
| US6696065B1 (en) * | 1995-05-04 | 2004-02-24 | Aventis Pastuer Limited | Acellular pertussis vaccines and methods of preparation thereof |
| BRPI9710460B8 (pt) * | 1996-07-02 | 2021-05-25 | Aventis Pasteur | composição imunogênica multi-valente e composição de vacina |
| US20010014331A1 (en) * | 1996-11-07 | 2001-08-16 | Smithkline Beecham Biologicals S.A. | Acellular pertussis vaccine with diphthriae-and tetanus-toxoids |
| GB9623233D0 (en) * | 1996-11-07 | 1997-01-08 | Smithkline Beecham Biolog | Vaccine composition |
| CA2303105A1 (en) * | 1997-09-15 | 1999-03-25 | Pasteur Merieux Msd | Multivalent vaccines |
| EP1004314A1 (fr) * | 1998-11-26 | 2000-05-31 | Pasteur Merieux MSD | Vaccin T.d. Polio rappel pour une population vaccinée ou sensibilisée |
| KR100401423B1 (ko) * | 2001-01-10 | 2003-10-17 | 주식회사 엘지생명과학 | 혼합 백신의 제조 방법 |
-
2006
- 2006-08-16 GB GBGB0616306.7A patent/GB0616306D0/en not_active Ceased
-
2007
- 2007-08-15 EP EP07825522.1A patent/EP2073841B1/en not_active Not-in-force
- 2007-08-15 ES ES07825522.1T patent/ES2528665T3/es active Active
- 2007-08-15 WO PCT/IB2007/003255 patent/WO2008020328A2/en not_active Ceased
- 2007-08-15 US US12/310,188 patent/US20100158940A1/en not_active Abandoned
- 2007-08-15 CN CN200780037461.4A patent/CN101522217B/zh not_active Expired - Fee Related
- 2007-08-15 JP JP2009524255A patent/JP5090452B2/ja not_active Expired - Fee Related
-
2012
- 2012-09-12 JP JP2012200460A patent/JP2012236864A/ja active Pending
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