JP2009227680A5 - - Google Patents
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- Publication number
- JP2009227680A5 JP2009227680A5 JP2009119505A JP2009119505A JP2009227680A5 JP 2009227680 A5 JP2009227680 A5 JP 2009227680A5 JP 2009119505 A JP2009119505 A JP 2009119505A JP 2009119505 A JP2009119505 A JP 2009119505A JP 2009227680 A5 JP2009227680 A5 JP 2009227680A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- enterococcal
- carrier
- immunoglobulin
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000427 antigen Substances 0.000 claims 15
- 102000036639 antigens Human genes 0.000 claims 15
- 108091007433 antigens Proteins 0.000 claims 15
- 108060003951 Immunoglobulin Proteins 0.000 claims 5
- 102000018358 immunoglobulin Human genes 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 206010014889 Enterococcal infections Diseases 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 239000002955 immunomodulating agent Substances 0.000 claims 3
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 2
- 229960003983 diphtheria toxoid Drugs 0.000 claims 2
- 239000002158 endotoxin Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 231100000252 nontoxic Toxicity 0.000 claims 2
- 230000003000 nontoxic effect Effects 0.000 claims 2
- 238000005215 recombination Methods 0.000 claims 2
- 230000006798 recombination Effects 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 241000194032 Enterococcus faecalis Species 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- OVRNDRQMDRJTHS-KEWYIRBNSA-N N-acetyl-D-galactosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-KEWYIRBNSA-N 0.000 claims 1
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims 1
- 230000001761 anti-enterococcal effect Effects 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 229930182830 galactose Natural products 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- NVLRFXKSQQPKAD-UHFFFAOYSA-N tricarbon Chemical compound [C]=C=[C] NVLRFXKSQQPKAD-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/949,757 US6756361B1 (en) | 1997-10-14 | 1997-10-14 | Enterococcus antigens and vaccines |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000515628A Division JP2001519402A (ja) | 1997-10-14 | 1998-10-14 | 腸球菌抗原およびワクチン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009227680A JP2009227680A (ja) | 2009-10-08 |
| JP2009227680A5 true JP2009227680A5 (https=) | 2010-08-12 |
Family
ID=25489514
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000515628A Pending JP2001519402A (ja) | 1997-10-14 | 1998-10-14 | 腸球菌抗原およびワクチン |
| JP2009119505A Pending JP2009227680A (ja) | 1997-10-14 | 2009-05-18 | 腸球菌抗原およびワクチン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000515628A Pending JP2001519402A (ja) | 1997-10-14 | 1998-10-14 | 腸球菌抗原およびワクチン |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6756361B1 (https=) |
| EP (3) | EP1028749B1 (https=) |
| JP (2) | JP2001519402A (https=) |
| AT (1) | ATE397456T1 (https=) |
| AU (1) | AU754890B2 (https=) |
| BR (1) | BR9813254A (https=) |
| CA (1) | CA2306476A1 (https=) |
| CY (1) | CY1108307T1 (https=) |
| DE (1) | DE69839587D1 (https=) |
| DK (1) | DK1028749T3 (https=) |
| ES (1) | ES2308818T3 (https=) |
| NZ (1) | NZ504501A (https=) |
| PT (1) | PT1028749E (https=) |
| WO (1) | WO1999018996A1 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6905670B2 (en) | 1995-03-28 | 2005-06-14 | The General Hospital Corporation | Methods of screening compounds useful for prevention of infection or pathogenicity |
| KR100217772B1 (ko) * | 1996-09-03 | 1999-09-01 | 최진호 | 조명기기의 램프 과열방지 장치 및 방법 |
| US6756361B1 (en) * | 1997-10-14 | 2004-06-29 | Nabi | Enterococcus antigens and vaccines |
| US7078584B2 (en) | 2000-03-17 | 2006-07-18 | The General Hospital Corporation | Salmonella typhimurium-infected Caenorhabditis elegans for identifying inhibitors of infection |
| US7112716B2 (en) | 2000-04-06 | 2006-09-26 | The General Hospital Corporation | Methods for screening and identifying host pathogen defense genes |
| US6710403B2 (en) | 2002-07-30 | 2004-03-23 | Fairchild Semiconductor Corporation | Dual trench power MOSFET |
| US20080175856A1 (en) | 2003-05-30 | 2008-07-24 | Intercell Ag | Enterococcus Antigens |
| WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
| JP2008508320A (ja) | 2004-07-29 | 2008-03-21 | カイロン コーポレイション | Ｓｔｒｅｐｔｏｃｏｃｃｕｓａｇａｌａｃｔｉａｅのようなグラム陽性細菌に対する免疫原性組成物 |
| WO2006076058A1 (en) * | 2005-01-10 | 2006-07-20 | Nabi Biopharmaceuticals | Method of treating staphylococcus aureus infection |
| CA2626253A1 (en) | 2005-10-18 | 2007-04-26 | Novartis Vaccines And Diagnostics, Inc. | Mucosal and systemic immunizations with alphavirus replicon particles |
| ES2514316T3 (es) | 2005-11-22 | 2014-10-28 | Novartis Vaccines And Diagnostics, Inc. | Partículas similares a virus (VLPs) de Norovirus y Sapovirus |
| AU2007281934B2 (en) | 2006-01-18 | 2012-11-15 | University Of Chicago | Compositions and methods related to Staphylococcal bacterium proteins |
| US8063063B2 (en) * | 2006-03-23 | 2011-11-22 | Novartis Ag | Immunopotentiating compounds |
| ES2536426T3 (es) * | 2006-03-23 | 2015-05-25 | Novartis Ag | Compuestos de imidazoquinoxalina como inmunomoduladores |
| EP2010530A2 (en) * | 2006-03-23 | 2009-01-07 | Novartis AG | Methods for the preparation of imidazole-containing compounds |
| CA2881717C (en) | 2006-06-06 | 2018-06-12 | Cecilia Anna Wilhelmina Geuijen | Human binding molecules having killing activity against staphylococci and uses thereof |
| MX2008014978A (es) | 2006-06-06 | 2008-12-09 | Crucell Holland Bv | Moleculas de union humanas que tienen actividad exterminadora contra enterococos y staphylococcus aureus y usos de las mismas. |
| JP5658564B2 (ja) | 2007-08-31 | 2015-01-28 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | ブドウ球菌肺疾患および状態に対する免疫に関連した方法および組成物 |
| KR101621837B1 (ko) | 2007-09-12 | 2016-05-17 | 노파르티스 아게 | Ｇａｓ57 돌연변이 항원 및 ｇａｓ57 항체 |
| EP2537857B1 (en) | 2007-12-21 | 2017-01-18 | GlaxoSmithKline Biologicals SA | Mutant forms of streptolysin O |
| EP2341929B1 (en) | 2008-10-06 | 2017-01-25 | University Of Chicago | Compositions and methods related to bacterial emp proteins |
| CN103897045A (zh) | 2009-01-12 | 2014-07-02 | 诺华股份有限公司 | 抗革兰氏阳性细菌疫苗中的Cna_B结构域 |
| HUE026855T2 (en) | 2009-04-03 | 2016-07-28 | Univ Chicago | Compositions and methods related to protein a (spa) variants |
| WO2011008400A2 (en) | 2009-06-16 | 2011-01-20 | Novartis Ag | High-throughput complement-mediated antibody-dependent and opsonic bactericidal assays |
| US10266585B2 (en) | 2009-08-28 | 2019-04-23 | The Board Of Regents Of The Univerity Of Texas System | Methods of treating brain injury |
| EP2525800B1 (en) * | 2010-01-19 | 2018-07-04 | Universitätsklinikum Freiburg | Enterococcal cell wall components and antibacterial use thereof |
| EP2555794A4 (en) | 2010-04-05 | 2014-01-15 | Univ Chicago | COMPOSITIONS AND METHODS RELATING TO PROTEIN A (SPA) ANTIBODIES AS IMMUNE REACTION AMPLIFIERS |
| KR20130121699A (ko) | 2010-05-28 | 2013-11-06 | 테트리스 온라인, 인코포레이티드 | 상호작용 혼성 비동기 컴퓨터 게임 기반구조 |
| CA2803298C (en) | 2010-07-02 | 2020-07-14 | The University Of Chicago | Compositions and methods related to protein a (spa) variants |
| EP2614074A1 (en) | 2010-09-09 | 2013-07-17 | The University of Chicago | Methods and compositions involving protective staphylococcal antigens |
| AU2011315920B2 (en) | 2010-10-15 | 2016-04-28 | The Board Of Regents Of The University Of Texas System | Antibodies that bind amyloid oligomers |
| US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
| EP2526951B1 (en) * | 2011-05-27 | 2015-09-30 | Universitätsklinikum Freiburg | Rhamno-polysaccharide from Enterococcus faecium clonal complex 17 and uses thereof |
| BR112014003315A2 (pt) | 2011-08-15 | 2017-03-01 | Univ Chicago | composições e métodos relacionados a anticorpos para a proteína a estafilocócica |
| JP6670106B2 (ja) | 2012-04-26 | 2020-03-18 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | ブドウ球菌コアグラーゼ抗原およびその使用方法 |
| CN104703622B (zh) | 2012-04-26 | 2017-05-24 | 芝加哥大学 | 与金黄色葡萄球菌疾病期间抵消凝固酶活性的抗体相关的组合物和方法 |
| US9777076B2 (en) | 2012-07-16 | 2017-10-03 | Pfizer Inc. | Saccharides and uses thereof |
| US10125373B2 (en) | 2013-01-22 | 2018-11-13 | Arizona Board Of Regents On Behalf Of Arizona State University | Geminiviral vector for expression of rituximab |
| EP3415160B1 (en) * | 2014-03-04 | 2021-08-18 | Klinikum der Universität München | Polypeptides derived from enterococcus and their use for vaccination and the generation of therapeutic antibodies |
| US11246924B2 (en) | 2016-04-01 | 2022-02-15 | Duke University | Alpha-helical peptide nanofibers as a self-adjuvanting vaccine platform |
| WO2019183500A1 (en) | 2018-03-23 | 2019-09-26 | Hung Chiung Yu | Coccidioides antigens and methods of their use |
| US12514914B2 (en) | 2019-05-14 | 2026-01-06 | The University Of Chicago | Methods and compositions comprising Staphylococcus protein a (SpA) variants |
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| FR2466251B1 (fr) * | 1979-10-03 | 1983-03-18 | Agronomique Inst Nat Rech | Vaccin animal anticolibacillaire, obtention et application |
| US4439422A (en) | 1980-01-02 | 1984-03-27 | Research Corporation | Group B Streptococcus antigens and vaccines |
| US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| US4444879A (en) * | 1981-01-29 | 1984-04-24 | Science Research Center, Inc. | Immunoassay with article having support film and immunological counterpart of analyte |
| JPS5927833A (ja) * | 1982-08-06 | 1984-02-14 | Advance Res & Dev Co Ltd | コレステロール乃至トリグリセリド低下剤 |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| FR2546756B1 (fr) * | 1983-06-03 | 1985-11-29 | Centre Nat Rech Scient | Nouveaux derives immunostimulants, leur preparation et leur application comme medicament |
| US4761283A (en) * | 1983-07-05 | 1988-08-02 | The University Of Rochester | Immunogenic conjugates |
| JPS6028401A (ja) * | 1983-07-27 | 1985-02-13 | Advance Res & Dev Co Ltd | トリグリセリド低下活性多糖類 |
| US4626502A (en) * | 1984-01-27 | 1986-12-02 | Abbott Laboratories | Method for exposing bacterial antigen in bacterial cells assay using same |
| US4695624A (en) | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
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| US5010062A (en) * | 1989-09-25 | 1991-04-23 | Vanderbilt University | Therapeutic agent and method of inhibiting vascularization of tumors |
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| GB9310468D0 (en) * | 1993-05-20 | 1993-07-07 | Oxford Glycosystems Ltd | Sugar complexes |
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-
1997
- 1997-10-14 US US08/949,757 patent/US6756361B1/en not_active Expired - Fee Related
-
1998
- 1998-10-14 WO PCT/US1998/021561 patent/WO1999018996A1/en not_active Ceased
- 1998-10-14 AT AT98951058T patent/ATE397456T1/de active
- 1998-10-14 NZ NZ504501A patent/NZ504501A/en not_active IP Right Cessation
- 1998-10-14 AU AU96949/98A patent/AU754890B2/en not_active Ceased
- 1998-10-14 JP JP2000515628A patent/JP2001519402A/ja active Pending
- 1998-10-14 DK DK98951058T patent/DK1028749T3/da active
- 1998-10-14 CA CA002306476A patent/CA2306476A1/en not_active Abandoned
- 1998-10-14 EP EP98951058A patent/EP1028749B1/en not_active Expired - Lifetime
- 1998-10-14 ES ES98951058T patent/ES2308818T3/es not_active Expired - Lifetime
- 1998-10-14 BR BR9813254-7A patent/BR9813254A/pt not_active IP Right Cessation
- 1998-10-14 DE DE69839587T patent/DE69839587D1/de not_active Expired - Lifetime
- 1998-10-14 EP EP10178313A patent/EP2269635A1/en not_active Withdrawn
- 1998-10-14 PT PT98951058T patent/PT1028749E/pt unknown
- 1998-10-14 EP EP08008590A patent/EP1970073A1/en not_active Withdrawn
-
2004
- 2004-06-28 US US10/876,758 patent/US7291343B2/en not_active Expired - Fee Related
-
2008
- 2008-09-02 CY CY20081100934T patent/CY1108307T1/el unknown
-
2009
- 2009-05-18 JP JP2009119505A patent/JP2009227680A/ja active Pending
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