CY1108307T1 - Αντιγονα και εμβολια εντεροκοκκου - Google Patents
Αντιγονα και εμβολια εντεροκοκκουInfo
- Publication number
- CY1108307T1 CY1108307T1 CY20081100934T CY081100934T CY1108307T1 CY 1108307 T1 CY1108307 T1 CY 1108307T1 CY 20081100934 T CY20081100934 T CY 20081100934T CY 081100934 T CY081100934 T CY 081100934T CY 1108307 T1 CY1108307 T1 CY 1108307T1
- Authority
- CY
- Cyprus
- Prior art keywords
- antigen
- carrier
- galactose
- vaccines
- enterprises
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/831—Drug, bio-affecting and body treating compositions involving capsular polysaccharide of bacterium, e.g. polyribosyl ribitol phosphate
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Η πλειονότητα των Ε. faecalis και Ε. faecium απομονώσεων εμπίπτει σε δύο ομάδες και σε τρεις ομάδες αντιστοίχως. Διακριτά αντιγόνα συνδέονται με κάθε μία από τις πέντε ομάδες. Τα Enterococcus αντιγόνα λαμβάνονται εύκολα από στελέχη των Ε. faecalis και Ε. faecium και μπορούν να εκμαιεύσουν παραγωγή προστατευτικών αντισωμάτων. Συνεπώς, τα αντιγόνα είναι χρήσιμα για εμβόλια τα οποία προστατεύουν από μόλυνση με κλινικά σημαντικές (παθογόνους) Enterococcus απομονώσεις. Τα αντιγόνα και τα αντισώματα που παράγονται κατά των αντιγόνων είναι επίσης χρήσιμα σε διαγνωστικές δοκιμασίες.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/949,757 US6756361B1 (en) | 1997-10-14 | 1997-10-14 | Enterococcus antigens and vaccines |
EP98951058A EP1028749B1 (en) | 1997-10-14 | 1998-10-14 | Enterococcus antigens and vaccines |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1108307T1 true CY1108307T1 (el) | 2014-02-12 |
Family
ID=25489514
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081100934T CY1108307T1 (el) | 1997-10-14 | 2008-09-02 | Αντιγονα και εμβολια εντεροκοκκου |
Country Status (14)
Country | Link |
---|---|
US (2) | US6756361B1 (el) |
EP (3) | EP1028749B1 (el) |
JP (2) | JP2001519402A (el) |
AT (1) | ATE397456T1 (el) |
AU (1) | AU754890B2 (el) |
BR (1) | BR9813254A (el) |
CA (1) | CA2306476A1 (el) |
CY (1) | CY1108307T1 (el) |
DE (1) | DE69839587D1 (el) |
DK (1) | DK1028749T3 (el) |
ES (1) | ES2308818T3 (el) |
NZ (1) | NZ504501A (el) |
PT (1) | PT1028749E (el) |
WO (1) | WO1999018996A1 (el) |
Families Citing this family (42)
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US6905670B2 (en) | 1995-03-28 | 2005-06-14 | The General Hospital Corporation | Methods of screening compounds useful for prevention of infection or pathogenicity |
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US6756361B1 (en) * | 1997-10-14 | 2004-06-29 | Nabi | Enterococcus antigens and vaccines |
US7078584B2 (en) | 2000-03-17 | 2006-07-18 | The General Hospital Corporation | Salmonella typhimurium-infected Caenorhabditis elegans for identifying inhibitors of infection |
US7112716B2 (en) | 2000-04-06 | 2006-09-26 | The General Hospital Corporation | Methods for screening and identifying host pathogen defense genes |
US6710403B2 (en) | 2002-07-30 | 2004-03-23 | Fairchild Semiconductor Corporation | Dual trench power MOSFET |
EP2327720A1 (en) * | 2003-05-30 | 2011-06-01 | Intercell AG | Enterococcus antigens |
US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
US20060165716A1 (en) | 2004-07-29 | 2006-07-27 | Telford John L | Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae |
KR20070104590A (ko) * | 2005-01-10 | 2007-10-26 | 나비 바이오파마슈티컬즈 | 스타필로코쿠스 아우레우스 감염을 치료하는 방법 |
US20110223197A1 (en) | 2005-10-18 | 2011-09-15 | Novartis Vaccines And Diagnostics Inc. | Mucosal and Systemic Immunization with Alphavirus Replicon Particles |
JP5215865B2 (ja) | 2005-11-22 | 2013-06-19 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド | ノロウイルス抗原およびサポウイルス抗原 |
AU2007281934B2 (en) | 2006-01-18 | 2012-11-15 | University Of Chicago | Compositions and methods related to Staphylococcal bacterium proteins |
WO2007109810A2 (en) * | 2006-03-23 | 2007-09-27 | Novartis Ag | Methods for the preparation of imidazole-containing compounds |
CA2646891A1 (en) * | 2006-03-23 | 2007-09-27 | Novartis Ag | Immunopotentiating compounds |
CA2646539A1 (en) | 2006-03-23 | 2007-09-27 | Novartis Ag | Imidazoquinoxaline compounds as immunomodulators |
WO2007141278A2 (en) | 2006-06-06 | 2007-12-13 | Crucell Holland B.V. | Human binding molecules having killing activity against enterococci and staphylococcus aureus and uses thereof |
EP2027155B1 (en) | 2006-06-06 | 2016-01-27 | Crucell Holland B.V. | Human binding molecules having killing activity against staphylococci and uses thereof |
JP5658564B2 (ja) | 2007-08-31 | 2015-01-28 | ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago | ブドウ球菌肺疾患および状態に対する免疫に関連した方法および組成物 |
AU2008299376B2 (en) | 2007-09-12 | 2013-02-28 | Glaxosmithkline Biologicals S.A. | GAS57 mutant antigens and GAS57 antibodies |
KR101773114B1 (ko) | 2007-12-21 | 2017-08-30 | 노파르티스 아게 | 스트렙토라이신 o의 돌연변이 형태 |
BRPI0920041A2 (pt) | 2008-10-06 | 2017-06-27 | Univ Chicago | composições e processos relacionados às proteínas eap, emp e/ou adsa bacterianas |
AU2010204139A1 (en) | 2009-01-12 | 2011-08-11 | Novartis Ag | Cna_B domain antigens in vaccines against gram positive bacteria |
BRPI1010307B1 (pt) | 2009-04-03 | 2021-07-27 | University Of Chicago | Polipeptídeos variantes de proteína a (spa), composição imunogênica compreendendo os mesmos, vacina, método de produção da referida vacina, bem como uso dos referidos polipeptídeos |
ES2596653T3 (es) | 2009-06-16 | 2017-01-11 | Glaxosmithkline Biologicals Sa | Ensayos bactericidas de opsonización y dependientes de anticuerpo mediado por el complemento de alto rendimiento |
US10266585B2 (en) | 2009-08-28 | 2019-04-23 | The Board Of Regents Of The Univerity Of Texas System | Methods of treating brain injury |
RU2559543C2 (ru) * | 2010-01-19 | 2015-08-10 | Универзитетсклиникум Фрайбург | Компоненты энтерококковых клеточных стенок и их антибактериальные применения |
JP2013523818A (ja) | 2010-04-05 | 2013-06-17 | ザ・ユニバーシティー・オブ・シカゴ | 免疫反応のエンハンサーとしてのプロテインA(SpA)抗体に関連する組成物および方法 |
WO2011149564A1 (en) | 2010-05-28 | 2011-12-01 | Tetris Online, Inc. | Interactive hybrid asynchronous computer game infrastructure |
ES2655701T3 (es) | 2010-07-02 | 2018-02-21 | The University Of Chicago | Composiciones y métodos relacionados con variantes de la proteína A (SpA) |
US9095540B2 (en) | 2010-09-09 | 2015-08-04 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens |
CA2817973C (en) | 2010-10-15 | 2019-06-25 | The Board Of Regents Of The University Of Texas System | Antibodies that bind amyloid oligomers |
US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
DK2526951T3 (en) * | 2011-05-27 | 2016-01-04 | Universitätsklinikum Freiburg | Rhamnopolysaccharid from Enterococcus faecium clone 17 complex and uses thereof |
CN103906535B (zh) | 2011-08-15 | 2017-07-14 | 芝加哥大学 | 与葡萄球菌蛋白a的抗体相关的组合物和方法 |
CN104768572B (zh) | 2012-04-26 | 2021-08-24 | 芝加哥大学 | 葡萄球菌凝固酶抗原及其使用方法 |
EP2841101B1 (en) | 2012-04-26 | 2019-08-07 | University Of Chicago | Compositions and methods related to antibodies that neutralize coagulase activity during staphylococcus aureus disease |
WO2014013375A1 (en) | 2012-07-16 | 2014-01-23 | Pfizer Inc. | Saccharides and uses thereof |
US10125373B2 (en) | 2013-01-22 | 2018-11-13 | Arizona Board Of Regents On Behalf Of Arizona State University | Geminiviral vector for expression of rituximab |
EP3415160B1 (en) * | 2014-03-04 | 2021-08-18 | Klinikum der Universität München | Polypeptides derived from enterococcus and their use for vaccination and the generation of therapeutic antibodies |
WO2017173398A1 (en) | 2016-04-01 | 2017-10-05 | Duke University | Alpha-helical peptide nanofibers as a self-adjuvanting vaccine platform |
WO2019183500A1 (en) | 2018-03-23 | 2019-09-26 | Hung Chiung Yu | Coccidioides antigens and methods of their use |
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-
1997
- 1997-10-14 US US08/949,757 patent/US6756361B1/en not_active Expired - Fee Related
-
1998
- 1998-10-14 ES ES98951058T patent/ES2308818T3/es not_active Expired - Lifetime
- 1998-10-14 CA CA002306476A patent/CA2306476A1/en not_active Abandoned
- 1998-10-14 BR BR9813254-7A patent/BR9813254A/pt not_active IP Right Cessation
- 1998-10-14 DE DE69839587T patent/DE69839587D1/de not_active Expired - Lifetime
- 1998-10-14 AU AU96949/98A patent/AU754890B2/en not_active Ceased
- 1998-10-14 JP JP2000515628A patent/JP2001519402A/ja active Pending
- 1998-10-14 DK DK98951058T patent/DK1028749T3/da active
- 1998-10-14 AT AT98951058T patent/ATE397456T1/de active
- 1998-10-14 NZ NZ504501A patent/NZ504501A/en not_active IP Right Cessation
- 1998-10-14 EP EP98951058A patent/EP1028749B1/en not_active Expired - Lifetime
- 1998-10-14 EP EP08008590A patent/EP1970073A1/en not_active Withdrawn
- 1998-10-14 WO PCT/US1998/021561 patent/WO1999018996A1/en active IP Right Grant
- 1998-10-14 PT PT98951058T patent/PT1028749E/pt unknown
- 1998-10-14 EP EP10178313A patent/EP2269635A1/en not_active Withdrawn
-
2004
- 2004-06-28 US US10/876,758 patent/US7291343B2/en not_active Expired - Fee Related
-
2008
- 2008-09-02 CY CY20081100934T patent/CY1108307T1/el unknown
-
2009
- 2009-05-18 JP JP2009119505A patent/JP2009227680A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DK1028749T3 (da) | 2008-09-01 |
DE69839587D1 (de) | 2008-07-17 |
US7291343B2 (en) | 2007-11-06 |
ATE397456T1 (de) | 2008-06-15 |
JP2001519402A (ja) | 2001-10-23 |
PT1028749E (pt) | 2008-09-04 |
EP1028749B1 (en) | 2008-06-04 |
JP2009227680A (ja) | 2009-10-08 |
WO1999018996B1 (en) | 1999-06-03 |
US20050008658A1 (en) | 2005-01-13 |
EP1028749A4 (en) | 2003-03-12 |
US6756361B1 (en) | 2004-06-29 |
WO1999018996A1 (en) | 1999-04-22 |
AU754890B2 (en) | 2002-11-28 |
BR9813254A (pt) | 2001-11-20 |
ES2308818T3 (es) | 2008-12-01 |
NZ504501A (en) | 2003-09-26 |
EP1970073A1 (en) | 2008-09-17 |
EP1028749A1 (en) | 2000-08-23 |
EP2269635A1 (en) | 2011-01-05 |
AU9694998A (en) | 1999-05-03 |
CA2306476A1 (en) | 1999-04-22 |
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