WO1998058668A3 - Bordetella pertussis antigens as carriers in vaccinating conjugates and oral vaccines comprising bordetella pertussis fimbriae - Google Patents

Bordetella pertussis antigens as carriers in vaccinating conjugates and oral vaccines comprising bordetella pertussis fimbriae Download PDF

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Publication number
WO1998058668A3
WO1998058668A3 PCT/GB1998/001819 GB9801819W WO9858668A3 WO 1998058668 A3 WO1998058668 A3 WO 1998058668A3 GB 9801819 W GB9801819 W GB 9801819W WO 9858668 A3 WO9858668 A3 WO 9858668A3
Authority
WO
WIPO (PCT)
Prior art keywords
bordetella pertussis
vaccinating
conjugates
carriers
fimbriae
Prior art date
Application number
PCT/GB1998/001819
Other languages
French (fr)
Other versions
WO1998058668A2 (en
Inventor
Graham Henry Farrar
David Hugh Jones
Original Assignee
Microbiological Res Authority
Graham Henry Farrar
David Hugh Jones
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbiological Res Authority, Graham Henry Farrar, David Hugh Jones filed Critical Microbiological Res Authority
Priority to CA002294348A priority Critical patent/CA2294348A1/en
Priority to EP98930917A priority patent/EP1005367A2/en
Priority to AU81194/98A priority patent/AU731216B2/en
Priority to JP50400699A priority patent/JP2002508761A/en
Publication of WO1998058668A2 publication Critical patent/WO1998058668A2/en
Publication of WO1998058668A3 publication Critical patent/WO1998058668A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A vaccinating conjugate comprises an antigen conjugated to a carrier selected from Bordetella pertussis fimbria, pertussis toxin, pertussis toxoid, and pertussis 69kD protein. The conjugate may also comprise a second antigen, different from the first. An oral vaccinating composition comprises Bordetella pertussis fimbria or fimbria-antigen conjugate.
PCT/GB1998/001819 1997-06-20 1998-06-22 Bordetella pertussis antigens as carriers in vaccinating conjugates and oral vaccines comprising bordetella pertussis fimbriae WO1998058668A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002294348A CA2294348A1 (en) 1997-06-20 1998-06-22 Vaccines containing bordetella pertussis antigen
EP98930917A EP1005367A2 (en) 1997-06-20 1998-06-22 Vaccines containing bordetella pertussis antigen
AU81194/98A AU731216B2 (en) 1997-06-20 1998-06-22 Vaccines containing bordetella pertussis antigen
JP50400699A JP2002508761A (en) 1997-06-20 1998-06-22 VODETELLA PERTUSSIS Pili-Containing Vaccination Conjugates and BORDETELLA PERTUSSIS Antigen as Carrier in Oral Vaccines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9713156.9 1997-06-20
GBGB9713156.9A GB9713156D0 (en) 1997-06-20 1997-06-20 Vaccines

Publications (2)

Publication Number Publication Date
WO1998058668A2 WO1998058668A2 (en) 1998-12-30
WO1998058668A3 true WO1998058668A3 (en) 1999-04-15

Family

ID=10814739

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/001819 WO1998058668A2 (en) 1997-06-20 1998-06-22 Bordetella pertussis antigens as carriers in vaccinating conjugates and oral vaccines comprising bordetella pertussis fimbriae

Country Status (6)

Country Link
EP (1) EP1005367A2 (en)
JP (1) JP2002508761A (en)
AU (1) AU731216B2 (en)
CA (1) CA2294348A1 (en)
GB (1) GB9713156D0 (en)
WO (1) WO1998058668A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9358279B2 (en) 2005-06-27 2016-06-07 Glaxosmithkline Biologicals S.A. Immunogenic composition

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