JP2008525423A5 - - Google Patents
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- Publication number
- JP2008525423A5 JP2008525423A5 JP2007547709A JP2007547709A JP2008525423A5 JP 2008525423 A5 JP2008525423 A5 JP 2008525423A5 JP 2007547709 A JP2007547709 A JP 2007547709A JP 2007547709 A JP2007547709 A JP 2007547709A JP 2008525423 A5 JP2008525423 A5 JP 2008525423A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- composition according
- composition
- carrier protein
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000014914 Carrier Proteins Human genes 0.000 claims 15
- 108010078791 Carrier Proteins Proteins 0.000 claims 15
- 239000000427 antigen Substances 0.000 claims 11
- 102000036639 antigens Human genes 0.000 claims 11
- 108091007433 antigens Proteins 0.000 claims 11
- 150000001720 carbohydrates Chemical class 0.000 claims 9
- 230000028993 immune response Effects 0.000 claims 4
- 244000052769 pathogen Species 0.000 claims 4
- 101710154606 Hemagglutinin Proteins 0.000 claims 3
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 3
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 3
- 101710176177 Protein A56 Proteins 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000000185 hemagglutinin Substances 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 241000606768 Haemophilus influenzae Species 0.000 claims 2
- 241000700721 Hepatitis B virus Species 0.000 claims 2
- 108010055044 Tetanus Toxin Proteins 0.000 claims 2
- 241000607734 Yersinia <bacteria> Species 0.000 claims 2
- 229940047650 haemophilus influenzae Drugs 0.000 claims 2
- 206010022000 influenza Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
- 229940118376 tetanus toxin Drugs 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000222122 Candida albicans Species 0.000 claims 1
- 201000007336 Cryptococcosis Diseases 0.000 claims 1
- 241000221204 Cryptococcus neoformans Species 0.000 claims 1
- 241000776296 Cryptococcus neoformans var. grubii Species 0.000 claims 1
- 241000194032 Enterococcus faecalis Species 0.000 claims 1
- 241000194031 Enterococcus faecium Species 0.000 claims 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims 1
- 241000709721 Hepatovirus A Species 0.000 claims 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 1
- 241000588748 Klebsiella Species 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 241000186366 Mycobacterium bovis Species 0.000 claims 1
- 241000186362 Mycobacterium leprae Species 0.000 claims 1
- 241000588650 Neisseria meningitidis Species 0.000 claims 1
- 241000223960 Plasmodium falciparum Species 0.000 claims 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 241000193990 Streptococcus sp. 'group B' Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 229940095731 candida albicans Drugs 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 229940032049 enterococcus faecalis Drugs 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229940030998 streptococcus agalactiae Drugs 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0428394.1 | 2004-12-24 | ||
| GBGB0428394.1A GB0428394D0 (en) | 2004-12-24 | 2004-12-24 | Saccharide conjugate vaccines |
| PCT/IB2005/004050 WO2006067632A2 (en) | 2004-12-24 | 2005-12-23 | Saccharide conjugate vaccines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012267162A Division JP2013049717A (ja) | 2004-12-24 | 2012-12-06 | 糖結合体ワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008525423A JP2008525423A (ja) | 2008-07-17 |
| JP2008525423A5 true JP2008525423A5 (https=) | 2009-02-12 |
| JP5737824B2 JP5737824B2 (ja) | 2015-06-17 |
Family
ID=34130952
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007547709A Expired - Fee Related JP5737824B2 (ja) | 2004-12-24 | 2005-12-23 | 糖結合体ワクチン |
| JP2012267162A Withdrawn JP2013049717A (ja) | 2004-12-24 | 2012-12-06 | 糖結合体ワクチン |
| JP2015105889A Pending JP2015155464A (ja) | 2004-12-24 | 2015-05-25 | 糖結合体ワクチン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012267162A Withdrawn JP2013049717A (ja) | 2004-12-24 | 2012-12-06 | 糖結合体ワクチン |
| JP2015105889A Pending JP2015155464A (ja) | 2004-12-24 | 2015-05-25 | 糖結合体ワクチン |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20080260773A1 (https=) |
| EP (1) | EP1838345B1 (https=) |
| JP (3) | JP5737824B2 (https=) |
| CN (1) | CN101111261B (https=) |
| AT (1) | ATE492290T1 (https=) |
| AU (1) | AU2005317683B2 (https=) |
| BR (1) | BRPI0519232A2 (https=) |
| CA (1) | CA2594524C (https=) |
| DE (1) | DE602005025531D1 (https=) |
| ES (1) | ES2356670T3 (https=) |
| GB (1) | GB0428394D0 (https=) |
| NZ (2) | NZ556486A (https=) |
| RU (1) | RU2454244C2 (https=) |
| WO (1) | WO2006067632A2 (https=) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0788796B2 (ja) | 1985-09-10 | 1995-09-27 | マツダ株式会社 | エンジンの空燃比制御装置 |
| JPH0788795B2 (ja) | 1985-09-10 | 1995-09-27 | マツダ株式会社 | エンジンの空燃比制御装置 |
| JPH0788798B2 (ja) | 1985-09-10 | 1995-09-27 | マツダ株式会社 | エンジンの空燃比制御装置 |
| JPH0788794B2 (ja) | 1985-09-10 | 1995-09-27 | マツダ株式会社 | エンジンの空燃比制御装置 |
| JPH0788797B2 (ja) | 1985-09-10 | 1995-09-27 | マツダ株式会社 | エンジンの空燃比制御装置 |
| HU227893B1 (en) * | 2000-06-29 | 2012-05-29 | Glaxosmithkline Biolog Sa | Vaccine compositions |
| AU2000278267A1 (en) * | 2000-09-01 | 2002-03-22 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Vibrio cholerae o139 conjugate vaccines |
| DK1328543T3 (da) * | 2000-10-27 | 2009-11-23 | Novartis Vaccines & Diagnostic | Nukleinsyrer og proteiner fra streptococcus-gruppe A & B |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| US8398983B2 (en) | 2005-06-27 | 2013-03-19 | Glaxosmithkline Biologicals, S.A. | Immunogenic composition |
| AU2007227504B2 (en) | 2006-03-17 | 2013-10-31 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods for preparing complex multivalent immunogenic conjugates |
| SG10202012986SA (en) | 2006-09-29 | 2021-01-28 | Ligocyte Pharmaceuticals Inc | Norovirus vaccine formulations |
| GB0622282D0 (en) * | 2006-11-08 | 2006-12-20 | Novartis Ag | Quality control methods |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| GB0700136D0 (en) * | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Process for manufacturing vaccines |
| GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
| JP2010539192A (ja) | 2007-09-18 | 2010-12-16 | リゴサイト ファーマスーティカルズ，インコーポレイテッド | ノロウイルスに対して防御免疫応答を付与する方法 |
| US20100266636A1 (en) | 2007-09-18 | 2010-10-21 | Ligocyte Pharmaceuticals, Inc. | Method of conferring a protective immune response to norovirus |
| AU2009237648A1 (en) * | 2008-04-16 | 2009-10-22 | Glaxosmithkline Biologicals S.A. | Vaccine |
| CN102065868A (zh) | 2008-06-16 | 2011-05-18 | 中央研究院 | 诱发对于Globo H及SSEA3的特异免疫反应的组合物以及其在癌症治疗中的用途 |
| AU2009279456B2 (en) | 2008-08-08 | 2015-02-05 | Takeda Vaccines, Inc. | Virus-like particles comprising composite capsid amino acid sequences for enhanced cross reactivity |
| CN105535955B (zh) * | 2009-06-16 | 2019-04-23 | 中央研究院 | Globo h及含新颖糖脂质佐剂的相关抗癌疫苗 |
| US8974799B2 (en) | 2009-09-30 | 2015-03-10 | Novartis Ag | Conjugation of Staphylococcus aureus type 5 and type 8 capsular polysaccharides |
| CA2779506A1 (en) * | 2009-10-02 | 2011-04-07 | University Of Iowa Research Foundation | Methods of improving vaccine immunogenicity |
| GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
| WO2011123042A1 (en) * | 2010-04-01 | 2011-10-06 | Independent Pharmaceutica Ab | Vaccination procedure and products for use therein |
| KR101594228B1 (ko) | 2010-08-23 | 2016-02-15 | 와이어쓰 엘엘씨 | 네이세리아 메닌기티디스 ｒＬＰ２０８６ 항원의 안정한 제제 |
| NZ607224A (en) | 2010-09-10 | 2014-11-28 | Wyeth Llc | Non-lipidated variants of neisseria meningitidis orf2086 antigens |
| CA2849391A1 (en) * | 2010-10-20 | 2012-04-26 | Genocea Biosciences, Inc. | Chlamydia antigens and uses thereof |
| CN103826657A (zh) | 2011-04-04 | 2014-05-28 | 衣阿华大学研究基金会 | 改进疫苗免疫原性的方法 |
| CN103648489A (zh) | 2011-05-11 | 2014-03-19 | 儿童医疗中心有限公司 | 多抗原提呈免疫原性组合物及其方法和用途 |
| CN102807621B (zh) | 2011-06-01 | 2016-04-13 | 厦门大学 | 包含白喉毒素无毒突变体crm197或其片段的融合蛋白 |
| CA2841356C (en) | 2011-07-11 | 2022-03-01 | Takeda Vaccines, Inc. | Parenteral norovirus vaccine formulations |
| MX359256B (es) | 2012-03-09 | 2018-09-19 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas. |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| US10722569B2 (en) | 2012-07-05 | 2020-07-28 | Children's Medical Center Corporation | Bacterial biofilm matrix as a platform for protein delivery |
| EP2872535A1 (en) | 2012-07-16 | 2015-05-20 | Pfizer Inc. | Saccharides and uses thereof |
| WO2014053521A2 (en) * | 2012-10-02 | 2014-04-10 | Novartis Ag | Nonlinear saccharide conjugates |
| JP6494527B2 (ja) | 2013-02-07 | 2019-04-03 | ザ チルドレンズ メディカル センター コーポレーション | 肺炎球菌のコロニー形成および／または疾患からの保護を提供するタンパク質抗原 |
| US9802987B2 (en) | 2013-03-08 | 2017-10-31 | Pfizer Inc. | Immunogenic fusion polypeptides |
| RU2662968C2 (ru) | 2013-09-08 | 2018-07-31 | Пфайзер Инк. | Иммуногенная композиция против neisseria meningitidis (варианты) |
| CN104069504B (zh) * | 2014-05-11 | 2019-09-24 | 江苏康泰生物医学技术有限公司 | 一种增强多糖蛋白结合物免疫原性的方法 |
| CN104004085B (zh) * | 2014-05-28 | 2017-01-11 | 山东大学 | 一种结核杆菌lam寡糖缀合物及其制备方法与应用 |
| US9815886B2 (en) | 2014-10-28 | 2017-11-14 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| AU2016221318B2 (en) | 2015-02-19 | 2020-06-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| CN108367063A (zh) * | 2015-07-21 | 2018-08-03 | 辉瑞公司 | 包含缀合的荚膜糖抗原的免疫原性组合物及其试剂盒和用途 |
| KR20180088458A (ko) | 2015-12-04 | 2018-08-03 | 다나-파버 캔서 인스티튜트 인크. | 암의 치료를 위한 mica/b 알파 3 도메인의 백신접종 |
| MX2018014857A (es) * | 2016-06-02 | 2019-03-07 | Zoetis Services Llc | Vacuna contra la bronquitis infecciosa. |
| US11071779B2 (en) | 2016-06-17 | 2021-07-27 | Children's Medical Center Corporation | Biofilm matrix-boosted vaccine |
| US11097000B2 (en) * | 2016-10-03 | 2021-08-24 | National Taiwan University | Klebsiella pneumoniae capsule polysaccharide vaccines |
| AU2018215585B2 (en) | 2017-01-31 | 2022-03-17 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| AU2018243910B2 (en) | 2017-03-28 | 2025-04-10 | The Children's Medical Center Corporation | A multiple antigen presenting system (MAPS)-based staphylococcus aureus vaccine, immunogenic composition, and uses thereof |
| MX2019014829A (es) * | 2017-06-10 | 2020-08-17 | Inventprise Llc | Vacunas de conjugado multivalente con polisacáridos de conjugado bivalente o multivalente que proporcionan inmunogenicidad y avidez mejoradas. |
| US10729763B2 (en) * | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| WO2018237221A1 (en) | 2017-06-23 | 2018-12-27 | Nosocomial Vaccine Corporation | IMMUNOGENIC COMPOSITIONS |
| CN109870581B (zh) * | 2017-12-04 | 2021-05-04 | 厦门万泰凯瑞生物技术有限公司 | 一种定量检测HBsAg的试剂盒及方法 |
| IL281204B2 (en) | 2018-09-12 | 2025-07-01 | Affinivax Inc | Multivalent pneumococcal vaccines |
| JP7535791B2 (ja) | 2018-09-12 | 2024-08-19 | ザ チルドレンズ メディカル センター コーポレーション | 肺炎球菌融合タンパク質ワクチン |
| EP4034157A1 (en) | 2019-09-27 | 2022-08-03 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| US11866463B2 (en) | 2020-02-06 | 2024-01-09 | Longhorn Vaccines And Diagnostics, Llc | Immunogenic compositions to treat and prevent microbial infections |
| WO2022035816A1 (en) | 2020-08-10 | 2022-02-17 | Inventprise, Llc | Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24f |
| CN113150084B (zh) * | 2021-03-23 | 2023-03-21 | 江苏坤力生物制药有限责任公司 | 一种纳米化的冠状病毒抗原及其应用 |
| CN113274489B (zh) * | 2021-04-30 | 2023-08-29 | 山东省药学科学院 | 一种预防真菌感染的几丁质寡糖疫苗及其制备方法 |
| IL326005A (en) | 2021-09-09 | 2026-03-01 | Affinivax Inc | Multivalent pneumococcal vaccines |
| CN114767846B (zh) * | 2022-04-21 | 2025-10-14 | 中国医学科学院医学生物学研究所 | 一种轮状非结构蛋白4在提高重组轮状病毒亚单位疫苗免疫功能中的应用 |
| CN115721711B (zh) * | 2022-10-28 | 2024-01-23 | 普大生物科技(泰州)有限公司 | 一种肺炎球菌荚膜多糖-带状疱疹病毒重组蛋白结合疫苗及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4695624A (en) * | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
| DE69019164T2 (de) * | 1989-12-14 | 1995-09-07 | National Research Council Of Canada, Ottawa, Ontario | Verbessertes meningokokkale polysaccharidkonjugatvakzin. |
| TR199701547T1 (xx) * | 1995-06-07 | 1998-03-21 | Smithkline Beecham Biologicals S.A. | Polisakarit antijen protein e�leni�i i�eren a��. |
| KR19990022680A (ko) * | 1995-06-23 | 1999-03-25 | 장 스테판느 | 폴리사카라이드 항원-담체 단백질 콘쥬게이트 및유리 담체단백질을 포함하는 백신 |
| DE69834808T2 (de) * | 1997-03-27 | 2007-06-06 | Institut Pasteur | Multiple,kohlenhydrathaltige glycopeptid-antigene, daraus entwickelte impfstoffe sowie deren verwendung |
| US7018637B2 (en) * | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
| GB9808932D0 (en) * | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
| OA12590A (en) * | 2001-01-23 | 2006-06-08 | Aventis Pasteur | Multivalent meningococcal polysaccharide-protein conjugate vaccine. |
| GB0107658D0 (en) * | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
-
2004
- 2004-12-24 GB GBGB0428394.1A patent/GB0428394D0/en not_active Ceased
-
2005
- 2005-12-23 CA CA2594524A patent/CA2594524C/en not_active Expired - Fee Related
- 2005-12-23 WO PCT/IB2005/004050 patent/WO2006067632A2/en not_active Ceased
- 2005-12-23 BR BRPI0519232-3A patent/BRPI0519232A2/pt not_active IP Right Cessation
- 2005-12-23 JP JP2007547709A patent/JP5737824B2/ja not_active Expired - Fee Related
- 2005-12-23 CN CN2005800474204A patent/CN101111261B/zh not_active Expired - Fee Related
- 2005-12-23 EP EP05850768A patent/EP1838345B1/en not_active Expired - Lifetime
- 2005-12-23 US US11/793,996 patent/US20080260773A1/en not_active Abandoned
- 2005-12-23 ES ES05850768T patent/ES2356670T3/es not_active Expired - Lifetime
- 2005-12-23 RU RU2007127993/10A patent/RU2454244C2/ru not_active IP Right Cessation
- 2005-12-23 NZ NZ556486A patent/NZ556486A/en not_active IP Right Cessation
- 2005-12-23 DE DE602005025531T patent/DE602005025531D1/de not_active Expired - Lifetime
- 2005-12-23 NZ NZ593954A patent/NZ593954A/xx not_active IP Right Cessation
- 2005-12-23 AU AU2005317683A patent/AU2005317683B2/en not_active Ceased
- 2005-12-23 AT AT05850768T patent/ATE492290T1/de not_active IP Right Cessation
-
2012
- 2012-12-06 JP JP2012267162A patent/JP2013049717A/ja not_active Withdrawn
-
2014
- 2014-08-05 US US14/451,907 patent/US20150165019A1/en not_active Abandoned
-
2015
- 2015-05-25 JP JP2015105889A patent/JP2015155464A/ja active Pending
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