JP2008525423A5 - - Google Patents
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- Publication number
- JP2008525423A5 JP2008525423A5 JP2007547709A JP2007547709A JP2008525423A5 JP 2008525423 A5 JP2008525423 A5 JP 2008525423A5 JP 2007547709 A JP2007547709 A JP 2007547709A JP 2007547709 A JP2007547709 A JP 2007547709A JP 2008525423 A5 JP2008525423 A5 JP 2008525423A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- composition according
- composition
- carrier protein
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000014914 Carrier Proteins Human genes 0.000 claims 15
- 108010078791 Carrier Proteins Proteins 0.000 claims 15
- 239000000427 antigen Substances 0.000 claims 11
- 102000036639 antigens Human genes 0.000 claims 11
- 108091007433 antigens Proteins 0.000 claims 11
- 150000001720 carbohydrates Chemical class 0.000 claims 9
- 230000028993 immune response Effects 0.000 claims 4
- 244000052769 pathogen Species 0.000 claims 4
- 101710154606 Hemagglutinin Proteins 0.000 claims 3
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 3
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 3
- 101710176177 Protein A56 Proteins 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000000185 hemagglutinin Substances 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 241000606768 Haemophilus influenzae Species 0.000 claims 2
- 241000700721 Hepatitis B virus Species 0.000 claims 2
- 108010055044 Tetanus Toxin Proteins 0.000 claims 2
- 241000607734 Yersinia <bacteria> Species 0.000 claims 2
- 229940047650 haemophilus influenzae Drugs 0.000 claims 2
- 206010022000 influenza Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
- 229940118376 tetanus toxin Drugs 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000222122 Candida albicans Species 0.000 claims 1
- 201000007336 Cryptococcosis Diseases 0.000 claims 1
- 241000221204 Cryptococcus neoformans Species 0.000 claims 1
- 241000776296 Cryptococcus neoformans var. grubii Species 0.000 claims 1
- 241000194032 Enterococcus faecalis Species 0.000 claims 1
- 241000194031 Enterococcus faecium Species 0.000 claims 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims 1
- 241000709721 Hepatovirus A Species 0.000 claims 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 1
- 241000588748 Klebsiella Species 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 241000186366 Mycobacterium bovis Species 0.000 claims 1
- 241000186362 Mycobacterium leprae Species 0.000 claims 1
- 241000588650 Neisseria meningitidis Species 0.000 claims 1
- 241000223960 Plasmodium falciparum Species 0.000 claims 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 241000193990 Streptococcus sp. 'group B' Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 229940095731 candida albicans Drugs 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 229940032049 enterococcus faecalis Drugs 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229940030998 streptococcus agalactiae Drugs 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0428394.1A GB0428394D0 (en) | 2004-12-24 | 2004-12-24 | Saccharide conjugate vaccines |
| GB0428394.1 | 2004-12-24 | ||
| PCT/IB2005/004050 WO2006067632A2 (en) | 2004-12-24 | 2005-12-23 | Saccharide conjugate vaccines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012267162A Division JP2013049717A (ja) | 2004-12-24 | 2012-12-06 | 糖結合体ワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008525423A JP2008525423A (ja) | 2008-07-17 |
| JP2008525423A5 true JP2008525423A5 (https=) | 2009-02-12 |
| JP5737824B2 JP5737824B2 (ja) | 2015-06-17 |
Family
ID=34130952
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007547709A Expired - Fee Related JP5737824B2 (ja) | 2004-12-24 | 2005-12-23 | 糖結合体ワクチン |
| JP2012267162A Withdrawn JP2013049717A (ja) | 2004-12-24 | 2012-12-06 | 糖結合体ワクチン |
| JP2015105889A Pending JP2015155464A (ja) | 2004-12-24 | 2015-05-25 | 糖結合体ワクチン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012267162A Withdrawn JP2013049717A (ja) | 2004-12-24 | 2012-12-06 | 糖結合体ワクチン |
| JP2015105889A Pending JP2015155464A (ja) | 2004-12-24 | 2015-05-25 | 糖結合体ワクチン |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20080260773A1 (https=) |
| EP (1) | EP1838345B1 (https=) |
| JP (3) | JP5737824B2 (https=) |
| CN (1) | CN101111261B (https=) |
| AT (1) | ATE492290T1 (https=) |
| AU (1) | AU2005317683B2 (https=) |
| BR (1) | BRPI0519232A2 (https=) |
| CA (1) | CA2594524C (https=) |
| DE (1) | DE602005025531D1 (https=) |
| ES (1) | ES2356670T3 (https=) |
| GB (1) | GB0428394D0 (https=) |
| NZ (2) | NZ593954A (https=) |
| RU (1) | RU2454244C2 (https=) |
| WO (1) | WO2006067632A2 (https=) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0788796B2 (ja) | 1985-09-10 | 1995-09-27 | マツダ株式会社 | エンジンの空燃比制御装置 |
| JPH0788794B2 (ja) | 1985-09-10 | 1995-09-27 | マツダ株式会社 | エンジンの空燃比制御装置 |
| JPH0788797B2 (ja) | 1985-09-10 | 1995-09-27 | マツダ株式会社 | エンジンの空燃比制御装置 |
| JPH0788798B2 (ja) | 1985-09-10 | 1995-09-27 | マツダ株式会社 | エンジンの空燃比制御装置 |
| JPH0788795B2 (ja) | 1985-09-10 | 1995-09-27 | マツダ株式会社 | エンジンの空燃比制御装置 |
| CZ20024224A3 (cs) * | 2000-06-29 | 2003-05-14 | Glaxosmithkline Biologicals S. A. | Farmaceutický prostředek |
| US7527797B1 (en) | 2000-09-01 | 2009-05-05 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Vibrio cholerae 0139 conjugate vaccines |
| CA2881568C (en) * | 2000-10-27 | 2019-09-24 | Novartis Vaccines And Diagnostics, Inc. | Nucleic acids and proteins from streptococcus groups a & b |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| PE20110072A1 (es) * | 2005-06-27 | 2011-02-04 | Glaxosmithkline Biolog Sa | Composicion inmunogenica |
| KR101711903B1 (ko) | 2006-03-17 | 2017-03-03 | 더 거버먼트 오브 더 유나이티드 스테이츠 오브 아메리카 에즈 레프리젠티드 바이 더 세크러테리 오브 더 디파트먼트 오브 헬스 앤드 휴먼 서비시즈 | 복합 다가 면역원성 콘쥬게이트의 제조 방법 |
| EP2066354B1 (en) | 2006-09-29 | 2013-04-17 | Ligocyte Pharmaceuticals, Inc. | Norovirus vaccine formulations |
| GB0622282D0 (en) * | 2006-11-08 | 2006-12-20 | Novartis Ag | Quality control methods |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| GB0700136D0 (en) * | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Process for manufacturing vaccines |
| GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
| CN104740624B (zh) | 2007-09-18 | 2018-04-24 | 武田疫苗股份有限公司 | 赋予针对诺如病毒的保护性免疫应答的疫苗 |
| US20100266636A1 (en) | 2007-09-18 | 2010-10-21 | Ligocyte Pharmaceuticals, Inc. | Method of conferring a protective immune response to norovirus |
| JP2011516597A (ja) * | 2008-04-16 | 2011-05-26 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ワクチン |
| AU2009268937A1 (en) | 2008-06-16 | 2010-01-14 | Aj Park | Compositions for inducing immune responses specific to Globo H and SSEA3 and uses thereof in cancer treatment |
| NO2324113T3 (https=) | 2008-08-08 | 2018-07-28 | ||
| KR101677279B1 (ko) * | 2009-06-16 | 2016-11-29 | 아카데미아 시니카 | 신규한 당지질 애주번트를 갖는 globo h 및 관련 항암 백신 |
| BR112012009014B8 (pt) | 2009-09-30 | 2022-10-04 | Novartis Ag | Processo para preparar conjugado de polissacarídeo capsular de s. aureus tipo 5 ou tipo 8 e molécula de transporte crm197, conjugado e composição imunogênica |
| AU2010300380B2 (en) * | 2009-10-02 | 2016-06-09 | University Of Iowa Research Foundation | Methods of improving vaccine immunogenicity |
| GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
| WO2011123042A1 (en) * | 2010-04-01 | 2011-10-06 | Independent Pharmaceutica Ab | Vaccination procedure and products for use therein |
| CN107913396B (zh) | 2010-08-23 | 2022-03-08 | 惠氏有限责任公司 | 脑膜炎萘瑟氏菌rLP2086抗原的稳定制剂 |
| AU2011300409B2 (en) | 2010-09-10 | 2015-03-26 | Wyeth Llc | Non-lipidated variants of Neisseria meningitidis ORF2086 antigens |
| WO2012054755A1 (en) * | 2010-10-20 | 2012-04-26 | Genocea Biosciences, Inc. | Chlamydia antigens and uses thereof |
| US10059746B2 (en) | 2011-04-04 | 2018-08-28 | University Of Iowa Research Foundation | Methods of improving vaccine immunogenicity |
| CN103648489A (zh) | 2011-05-11 | 2014-03-19 | 儿童医疗中心有限公司 | 多抗原提呈免疫原性组合物及其方法和用途 |
| KR101895768B1 (ko) | 2011-06-01 | 2018-09-07 | 시아먼 유니버시티 | 디프테리아 독소 무독성 돌연변이 씨알엠197 또는 그의 단편을 포함하는 융합 단백질 |
| EP4112074A1 (en) | 2011-07-11 | 2023-01-04 | Takeda Vaccines, Inc. | Parenteral norovirus vaccine formulations |
| MY198910A (en) | 2012-03-09 | 2023-10-02 | Pfizer | Neisseria meningitidis compositions and methods thereof |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| US10722569B2 (en) | 2012-07-05 | 2020-07-28 | Children's Medical Center Corporation | Bacterial biofilm matrix as a platform for protein delivery |
| US9777076B2 (en) | 2012-07-16 | 2017-10-03 | Pfizer Inc. | Saccharides and uses thereof |
| TR201808684T4 (tr) * | 2012-10-02 | 2018-07-23 | Glaxosmithkline Biologicals Sa | Lineer olmayan sakarit konjügatları. |
| US11576958B2 (en) | 2013-02-07 | 2023-02-14 | Children's Medical Center Corporation | Protein antigens that provide protection against pneumococcal colonization and/or disease |
| WO2014136064A2 (en) | 2013-03-08 | 2014-09-12 | Pfizer Inc. | Immunogenic fusion polypeptides |
| RU2662968C2 (ru) | 2013-09-08 | 2018-07-31 | Пфайзер Инк. | Иммуногенная композиция против neisseria meningitidis (варианты) |
| CN104069504B (zh) * | 2014-05-11 | 2019-09-24 | 江苏康泰生物医学技术有限公司 | 一种增强多糖蛋白结合物免疫原性的方法 |
| CN104004085B (zh) * | 2014-05-28 | 2017-01-11 | 山东大学 | 一种结核杆菌lam寡糖缀合物及其制备方法与应用 |
| US9107906B1 (en) | 2014-10-28 | 2015-08-18 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| WO2016132294A1 (en) | 2015-02-19 | 2016-08-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| KR102225282B1 (ko) * | 2015-07-21 | 2021-03-10 | 화이자 인코포레이티드 | 접합된 캡슐형 사카라이드 항원을 포함하는 면역원성 조성물, 그를 포함하는 키트 및 그의 용도 |
| EP3383426A1 (en) | 2015-12-04 | 2018-10-10 | Dana Farber Cancer Institute, Inc. | Vaccination with mica/b alpha 3 domain for the treatment of cancer |
| KR20210068602A (ko) * | 2016-06-02 | 2021-06-09 | 조에티스 서비시즈 엘엘씨 | 감염성 기관지염에 대한 백신 |
| WO2017219004A2 (en) * | 2016-06-17 | 2017-12-21 | Children's Medical Center Corporation | Biofilm matrix-boosted vaccine |
| US11097000B2 (en) * | 2016-10-03 | 2021-08-24 | National Taiwan University | Klebsiella pneumoniae capsule polysaccharide vaccines |
| AU2018215585B2 (en) | 2017-01-31 | 2022-03-17 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| AU2018243910B2 (en) | 2017-03-28 | 2025-04-10 | The Children's Medical Center Corporation | A multiple antigen presenting system (MAPS)-based staphylococcus aureus vaccine, immunogenic composition, and uses thereof |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| WO2018227177A1 (en) * | 2017-06-10 | 2018-12-13 | Inventprise, Llc | Multivalent conjugate vaccines with bivalent or multivalent conjugate polysaccharides that provide improved immunogenicity and avidity |
| MX2019015524A (es) | 2017-06-23 | 2020-09-10 | Univ Maryland | Composiciones inmunogenicas. |
| CN109870581B (zh) * | 2017-12-04 | 2021-05-04 | 厦门万泰凯瑞生物技术有限公司 | 一种定量检测HBsAg的试剂盒及方法 |
| SG11202101973YA (en) | 2018-09-12 | 2021-03-30 | Childrens Medical Ct Corp | Pneumococcal fusion protein vaccines |
| CN112969474A (zh) | 2018-09-12 | 2021-06-15 | 艾芬尼维克斯公司 | 多价肺炎球菌疫苗 |
| WO2021059181A1 (en) | 2019-09-27 | 2021-04-01 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| CA3167081A1 (en) | 2020-02-06 | 2021-08-12 | Luke T. Daum | Immunogenic compositions to treat and prevent microbial infections |
| WO2022035816A1 (en) | 2020-08-10 | 2022-02-17 | Inventprise, Llc | Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24f |
| CN113150084B (zh) * | 2021-03-23 | 2023-03-21 | 江苏坤力生物制药有限责任公司 | 一种纳米化的冠状病毒抗原及其应用 |
| CN113274489B (zh) * | 2021-04-30 | 2023-08-29 | 山东省药学科学院 | 一种预防真菌感染的几丁质寡糖疫苗及其制备方法 |
| MX2024002779A (es) | 2021-09-09 | 2024-06-11 | Affinivax Inc | Vacunas neumocócicas multivalentes. |
| CN114767846B (zh) * | 2022-04-21 | 2025-10-14 | 中国医学科学院医学生物学研究所 | 一种轮状非结构蛋白4在提高重组轮状病毒亚单位疫苗免疫功能中的应用 |
| CN115721711B (zh) * | 2022-10-28 | 2024-01-23 | 普大生物科技(泰州)有限公司 | 一种肺炎球菌荚膜多糖-带状疱疹病毒重组蛋白结合疫苗及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4695624A (en) * | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
| HU9201966D0 (en) * | 1989-12-14 | 1992-10-28 | Ca Nat Research Council | An improved vaccine of meningococcus-polysaccharide conjunction |
| TR199701547T1 (xx) * | 1995-06-07 | 1998-03-21 | Smithkline Beecham Biologicals S.A. | Polisakarit antijen protein e�leni�i i�eren a��. |
| KR19990022680A (ko) * | 1995-06-23 | 1999-03-25 | 장 스테판느 | 폴리사카라이드 항원-담체 단백질 콘쥬게이트 및유리 담체단백질을 포함하는 백신 |
| AU6832398A (en) * | 1997-03-27 | 1998-10-22 | Institut Pasteur | Multiple antigen glycopeptide carbohydrate, vaccine comprising the same and use thereof |
| US7018637B2 (en) * | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
| GB9808932D0 (en) * | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
| SI21352A (sl) * | 2001-01-23 | 2004-06-30 | Aventis Pasteur | Multivalentno meningokokno cepivo iz konjugata polisaharida-proteina |
| GB0107658D0 (en) * | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
-
2004
- 2004-12-24 GB GBGB0428394.1A patent/GB0428394D0/en not_active Ceased
-
2005
- 2005-12-23 JP JP2007547709A patent/JP5737824B2/ja not_active Expired - Fee Related
- 2005-12-23 RU RU2007127993/10A patent/RU2454244C2/ru not_active IP Right Cessation
- 2005-12-23 CN CN2005800474204A patent/CN101111261B/zh not_active Expired - Fee Related
- 2005-12-23 AT AT05850768T patent/ATE492290T1/de not_active IP Right Cessation
- 2005-12-23 CA CA2594524A patent/CA2594524C/en not_active Expired - Fee Related
- 2005-12-23 US US11/793,996 patent/US20080260773A1/en not_active Abandoned
- 2005-12-23 EP EP05850768A patent/EP1838345B1/en not_active Expired - Lifetime
- 2005-12-23 WO PCT/IB2005/004050 patent/WO2006067632A2/en not_active Ceased
- 2005-12-23 AU AU2005317683A patent/AU2005317683B2/en not_active Ceased
- 2005-12-23 NZ NZ593954A patent/NZ593954A/xx not_active IP Right Cessation
- 2005-12-23 NZ NZ556486A patent/NZ556486A/en not_active IP Right Cessation
- 2005-12-23 DE DE602005025531T patent/DE602005025531D1/de not_active Expired - Lifetime
- 2005-12-23 BR BRPI0519232-3A patent/BRPI0519232A2/pt not_active IP Right Cessation
- 2005-12-23 ES ES05850768T patent/ES2356670T3/es not_active Expired - Lifetime
-
2012
- 2012-12-06 JP JP2012267162A patent/JP2013049717A/ja not_active Withdrawn
-
2014
- 2014-08-05 US US14/451,907 patent/US20150165019A1/en not_active Abandoned
-
2015
- 2015-05-25 JP JP2015105889A patent/JP2015155464A/ja active Pending
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