JP2012017342A5 - - Google Patents
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- Publication number
- JP2012017342A5 JP2012017342A5 JP2011228229A JP2011228229A JP2012017342A5 JP 2012017342 A5 JP2012017342 A5 JP 2012017342A5 JP 2011228229 A JP2011228229 A JP 2011228229A JP 2011228229 A JP2011228229 A JP 2011228229A JP 2012017342 A5 JP2012017342 A5 JP 2012017342A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- capsular saccharide
- formula
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 48
- 150000001720 carbohydrates Chemical class 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 231100000699 Bacterial toxin Toxicity 0.000 claims 3
- 241000588650 Neisseria meningitidis Species 0.000 claims 3
- 239000000688 bacterial toxin Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- 206010027202 Meningitis bacterial Diseases 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 230000005875 antibody response Effects 0.000 claims 2
- 201000009904 bacterial meningitis Diseases 0.000 claims 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 108090000623 proteins and genes Chemical group 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 125000006539 C12 alkyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 1
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241000921898 Neisseria meningitidis serogroup A Species 0.000 claims 1
- 125000003172 aldehyde group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 239000012646 vaccine adjuvant Substances 0.000 claims 1
- 229940124931 vaccine adjuvant Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0220198.6 | 2002-08-30 | ||
| GBGB0220198.6A GB0220198D0 (en) | 2002-08-30 | 2002-08-30 | Modified saccharides,conjugates thereof and their manufacture |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004532625A Division JP5268222B2 (ja) | 2002-08-30 | 2003-09-01 | 改変された糖類、それらの結合体、およびそられの製造 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012017342A JP2012017342A (ja) | 2012-01-26 |
| JP2012017342A5 true JP2012017342A5 (https=) | 2013-05-30 |
| JP5314745B2 JP5314745B2 (ja) | 2013-10-16 |
Family
ID=9943241
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004532625A Expired - Fee Related JP5268222B2 (ja) | 2002-08-30 | 2003-09-01 | 改変された糖類、それらの結合体、およびそられの製造 |
| JP2011228229A Expired - Fee Related JP5314745B2 (ja) | 2002-08-30 | 2011-10-17 | 改変された糖類、それらの結合体、およびそられの製造 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004532625A Expired - Fee Related JP5268222B2 (ja) | 2002-08-30 | 2003-09-01 | 改変された糖類、それらの結合体、およびそられの製造 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8895516B2 (https=) |
| EP (1) | EP1534342B1 (https=) |
| JP (2) | JP5268222B2 (https=) |
| CN (2) | CN1688343B (https=) |
| AT (1) | ATE319481T1 (https=) |
| AU (1) | AU2003260921B2 (https=) |
| BR (1) | BR0314089A (https=) |
| CA (1) | CA2497167C (https=) |
| DE (1) | DE60303961T2 (https=) |
| DK (1) | DK1534342T3 (https=) |
| ES (1) | ES2260682T3 (https=) |
| GB (1) | GB0220198D0 (https=) |
| MX (1) | MXPA05002315A (https=) |
| NZ (1) | NZ538703A (https=) |
| RU (2) | RU2005108992A (https=) |
| WO (1) | WO2004019992A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
| ES2461350T3 (es) * | 2003-01-30 | 2014-05-19 | Novartis Ag | Vacunas inyectables contra múltiples serogrupos de meningococos |
| US20070258986A1 (en) * | 2003-11-19 | 2007-11-08 | Govt of the US as represented by the secretary, | Targeted Delivery System for Bioactive Agents |
| ES2533248T3 (es) * | 2005-05-06 | 2015-04-08 | Novartis Ag | Inmunógenos para vacunas contra Meningitidis A |
| PL1973564T3 (pl) | 2005-12-22 | 2017-04-28 | Glaxosmithkline Biologicals S.A. | Szczepionki zawierające koniugaty polisacharydu otoczkowego streptococcus pneumoniae |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| GB0700562D0 (en) * | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| AU2014200640B2 (en) * | 2007-01-11 | 2016-06-16 | Glaxosmithkline Biologicals Sa | Modified saccharides |
| US9475864B2 (en) | 2008-09-05 | 2016-10-25 | University Of Massachusetts | Methods, compositions and vaccines relating to Neisseria meningitidis antibodies |
| BRPI1011753B8 (pt) | 2009-06-22 | 2021-05-25 | Wyeth Llc | conjugados imunogênicos de polissacarídeo capsular de staphylococcus aureus de sorotipos 5 e 8, seu uso e composições que os compreendem |
| HUE036372T2 (hu) | 2009-06-22 | 2018-07-30 | Wyeth Llc | Staphylococcus aureus antigének immunogén készítményei |
| BR112012010223A2 (pt) * | 2009-10-30 | 2016-12-06 | Novartis Ag | purificação de staphylococcus aureus tipo 5 e tipo 8 sacarídeos capsulares |
| KR101594228B1 (ko) | 2010-08-23 | 2016-02-15 | 와이어쓰 엘엘씨 | 네이세리아 메닌기티디스 ｒＬＰ２０８６ 항원의 안정한 제제 |
| NZ607224A (en) | 2010-09-10 | 2014-11-28 | Wyeth Llc | Non-lipidated variants of neisseria meningitidis orf2086 antigens |
| MX359256B (es) | 2012-03-09 | 2018-09-19 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas. |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| CN102861326A (zh) * | 2012-09-19 | 2013-01-09 | 天津康希诺生物技术有限公司 | 流脑多糖-蛋白质缀合疫苗及制备方法 |
| US9802987B2 (en) | 2013-03-08 | 2017-10-31 | Pfizer Inc. | Immunogenic fusion polypeptides |
| RU2662968C2 (ru) | 2013-09-08 | 2018-07-31 | Пфайзер Инк. | Иммуногенная композиция против neisseria meningitidis (варианты) |
| EP3104886B1 (en) * | 2014-02-14 | 2018-10-17 | Pfizer Inc | Immunogenic glycoprotein conjugates |
| AU2016221318B2 (en) | 2015-02-19 | 2020-06-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| CN107810273B (zh) * | 2015-04-23 | 2022-09-27 | 西纳福克斯股份有限公司 | 用为或衍生自β-(1,4)-N-乙酰半乳糖胺转移酶的糖基转移酶修饰糖蛋白的方法 |
| KR102428253B1 (ko) * | 2016-03-15 | 2022-08-02 | 엠에스디 웰컴 트러스트 힐레맨 랩스 피브이티. 리미티드 | 신규한 다당류-단백질 접합체 및 이의 제조방법 |
| KR102906912B1 (ko) | 2016-09-02 | 2026-01-05 | 사노피 파스퇴르 인크 | 네이세리아 메닌기티디스 백신 |
| AU2018215585B2 (en) | 2017-01-31 | 2022-03-17 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| CA3050120A1 (en) | 2017-02-24 | 2018-08-30 | Merck Sharp & Dohme Corp. | Enhancing immunogenicity of streptococcus pneumoniae polysaccharide-protein conjugates |
| CN111065387B (zh) | 2017-09-07 | 2023-08-25 | 默沙东有限责任公司 | 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途 |
| WO2019050813A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | ANTI-PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC CONJUGATES POLYSACCHARIDE-PROTEIN CARRIER |
| EP3934696A1 (en) * | 2019-03-08 | 2022-01-12 | GlaxoSmithKline Biologicals S.A. | Carbocyclic derivatives and conjugated derivatives thereof, and their use in vaccines |
| EP4034157A1 (en) | 2019-09-27 | 2022-08-03 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2427341A1 (fr) * | 1978-06-02 | 1979-12-28 | Delalande Sa | Nouveaux derives aminoglycosidiques hemisynthetiques, leur procede de preparation et leur application en therapeutique |
| DK0447171T3 (da) * | 1990-03-15 | 1994-12-12 | Tanabe Seiyaku Co | Polysulfat af cyclodextrinderivat og fremgangsmåde til fremstilling deraf |
| EP0737203A1 (en) * | 1993-12-28 | 1996-10-16 | Pfizer Inc. | Steroidal glycosides |
| CA2189356A1 (en) * | 1994-05-02 | 1995-11-09 | Ting Chi Wong | Process for preparation of glycosides of tumor-associated carbohydrate antigens |
| US6472506B1 (en) * | 1997-01-21 | 2002-10-29 | Aventis Pasteur S.A. | Polysaccharide-peptide-conjugates |
| CA2266718C (en) * | 1997-08-08 | 2007-05-22 | Behringwerke Aktiengesellschaft | Polysaccharide conjugates of biomolecules |
| US5929049A (en) * | 1997-08-08 | 1999-07-27 | Dade Behring Marburg Gmbh | Polysaccharide conjugates of biomolecules |
| US5952454A (en) * | 1997-12-12 | 1999-09-14 | The United States Of America As Represented By The Department Of Health And Human Services | Linking compounds useful for coupling carbohydrates to amine-containing carriers |
| PT1777236T (pt) | 2002-03-26 | 2017-02-13 | Glaxosmithkline Biologicals Sa | Sacáridos modificados possuindo estabilidade melhorada em água para utilização como um medicamento |
| GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
-
2002
- 2002-08-30 GB GBGB0220198.6A patent/GB0220198D0/en not_active Ceased
-
2003
- 2003-09-01 JP JP2004532625A patent/JP5268222B2/ja not_active Expired - Fee Related
- 2003-09-01 MX MXPA05002315A patent/MXPA05002315A/es active IP Right Grant
- 2003-09-01 BR BR0314089-0A patent/BR0314089A/pt not_active Application Discontinuation
- 2003-09-01 DK DK03791149T patent/DK1534342T3/da active
- 2003-09-01 EP EP03791149A patent/EP1534342B1/en not_active Expired - Lifetime
- 2003-09-01 NZ NZ538703A patent/NZ538703A/en not_active IP Right Cessation
- 2003-09-01 AT AT03791149T patent/ATE319481T1/de active
- 2003-09-01 CN CN038237245A patent/CN1688343B/zh not_active Expired - Fee Related
- 2003-09-01 RU RU2005108992/04A patent/RU2005108992A/ru unknown
- 2003-09-01 US US10/526,124 patent/US8895516B2/en not_active Expired - Fee Related
- 2003-09-01 WO PCT/IB2003/004194 patent/WO2004019992A1/en not_active Ceased
- 2003-09-01 CA CA2497167A patent/CA2497167C/en not_active Expired - Fee Related
- 2003-09-01 ES ES03791149T patent/ES2260682T3/es not_active Expired - Lifetime
- 2003-09-01 DE DE60303961T patent/DE60303961T2/de not_active Expired - Lifetime
- 2003-09-01 AU AU2003260921A patent/AU2003260921B2/en not_active Ceased
- 2003-09-01 CN CN2010101825535A patent/CN101863998B/zh not_active Expired - Fee Related
-
2008
- 2008-12-19 RU RU2008150551/13A patent/RU2531909C2/ru not_active IP Right Cessation
-
2011
- 2011-10-17 JP JP2011228229A patent/JP5314745B2/ja not_active Expired - Fee Related
-
2014
- 2014-10-23 US US14/521,761 patent/US20150166593A1/en not_active Abandoned
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