JP2007523867A5 - - Google Patents

Download PDF

Info

Publication number
JP2007523867A5
JP2007523867A5 JP2006518969A JP2006518969A JP2007523867A5 JP 2007523867 A5 JP2007523867 A5 JP 2007523867A5 JP 2006518969 A JP2006518969 A JP 2006518969A JP 2006518969 A JP2006518969 A JP 2006518969A JP 2007523867 A5 JP2007523867 A5 JP 2007523867A5
Authority
JP
Japan
Prior art keywords
phenyl
alkyl
piperazin
pyridin
trifluoromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2006518969A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007523867A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2004/022326 external-priority patent/WO2005007646A1/en
Publication of JP2007523867A publication Critical patent/JP2007523867A/ja
Publication of JP2007523867A5 publication Critical patent/JP2007523867A5/ja
Withdrawn legal-status Critical Current

Links

JP2006518969A 2003-07-10 2004-07-09 置換複素環式ジアリールアミン類縁体 Withdrawn JP2007523867A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48613303P 2003-07-10 2003-07-10
PCT/US2004/022326 WO2005007646A1 (en) 2003-07-10 2004-07-09 Substituted heterocyclic diarylamine analogues

Publications (2)

Publication Number Publication Date
JP2007523867A JP2007523867A (ja) 2007-08-23
JP2007523867A5 true JP2007523867A5 (enExample) 2007-10-18

Family

ID=34079198

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006518969A Withdrawn JP2007523867A (ja) 2003-07-10 2004-07-09 置換複素環式ジアリールアミン類縁体

Country Status (7)

Country Link
US (1) US20070043049A1 (enExample)
EP (1) EP1651636A1 (enExample)
JP (1) JP2007523867A (enExample)
CN (1) CN1820001A (enExample)
AU (1) AU2004257260A1 (enExample)
CA (1) CA2531401A1 (enExample)
WO (1) WO2005007646A1 (enExample)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2307278A1 (en) * 2000-04-28 2001-10-28 University Of British Columbia Use of n-heterocyclic substituted salicylic acids for inhibition of cellular uptake of cystine
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
HRP20050089B1 (hr) 2002-07-29 2015-06-19 Rigel Pharmaceuticals Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti
AU2004257289A1 (en) * 2003-07-16 2005-01-27 Neurogen Corporation Biaryl piperazinyl-pyridine analogues
JP4886511B2 (ja) 2003-07-30 2012-02-29 ライジェル ファーマシューティカルズ, インコーポレイテッド 2,4−ピリミジンジアミン化合物による自己免疫疾患の治療または予防方法
WO2005077938A1 (en) * 2004-02-11 2005-08-25 Amgen Inc. Vanilloid receptor ligands and their use in treatments
JP2008508190A (ja) * 2004-07-19 2008-03-21 ノボ ノルディスク アクティーゼルスカブ 肥満または肥満に関連する疾患および障害の治療におけるカプサイシン受容体の活性の阻害
MY145822A (en) * 2004-08-13 2012-04-30 Neurogen Corp Substituted biaryl piperazinyl-pyridine analogues
AU2005286593A1 (en) 2004-09-23 2006-03-30 Reddy Us Therapeutics, Inc. Novel pyridine compounds, process for their preparation and compositions containing them
DE102005023943A1 (de) 2005-05-20 2006-11-23 Grünenthal GmbH Pentafluorsulfanyl-substituierte Verbindung und deren Verwendung zur Herstellung von Arzneimitteln
US20070203161A1 (en) 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
AU2006254840B2 (en) 2005-06-08 2012-08-02 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the JAK pathway
ES2622493T3 (es) 2006-02-24 2017-07-06 Rigel Pharmaceuticals, Inc. Composiciones y métodos para la inhibición de la ruta de JAK
BRPI0714409A2 (pt) * 2006-07-14 2013-03-12 Novartis Ag derivados de pirimidina como inibidores de alk-5
WO2008057300A2 (en) * 2006-10-27 2008-05-15 Redpoint Bio Corporation Trpvi antagonists and uses thereof
CA2672893C (en) 2006-12-15 2016-02-23 Abraxis Bioscience, Inc. Triazine derivatives and their therapeutical applications
AU2008215948A1 (en) * 2007-02-12 2008-08-21 Merck & Co., Inc. Piperazine derivatives for treatment of AD and related conditions
WO2008121387A1 (en) * 2007-03-30 2008-10-09 University Of Miami Substituted triazine compounds for nerve regeneration
EP2214486A4 (en) * 2007-10-19 2011-03-09 Avila Therapeutics Inc HETEROARYL COMPOUNDS AND ITS USES
US7989465B2 (en) 2007-10-19 2011-08-02 Avila Therapeutics, Inc. 4,6-disubstituted pyrimidines useful as kinase inhibitors
JP2012529517A (ja) 2009-06-09 2012-11-22 アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー ベンジル置換トリアジン誘導体類及びそれらの治療応用
JP2012529519A (ja) 2009-06-09 2012-11-22 アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー スチリル−トリアジン誘導体類及びそれらの治療応用
KR101457027B1 (ko) 2009-06-09 2014-10-31 캘리포니아 캐피탈 에쿼티, 엘엘씨 트리아진 유도체와 이들의 치료적 용도
ES2390326B1 (es) * 2011-04-05 2013-08-14 Universidad Miguel Hernández De Elche Antagonistas de trpv1 y sus usos.
EP2802577B1 (en) 2012-01-13 2017-03-01 Bristol-Myers Squibb Company Triazolyl-substituted pyridyl compounds useful as kinase inhibitors
US9242976B2 (en) 2012-01-13 2016-01-26 Bristol-Myers Squibb Company Thiazolyl- or thiadiazolyl-substituted pyridyl compounds useful as kinase inhibitors
WO2013106612A1 (en) 2012-01-13 2013-07-18 Bristol-Myers Squibb Company Heterocyclic-substituted pyridyl compounds useful as kinase inhibitors
ES2616812T3 (es) 2012-11-08 2017-06-14 Bristol-Myers Squibb Company Compuestos piridilo sustituidos con heterociclo bicíclico útiles como moduladores de quinasa
PE20150953A1 (es) 2012-11-08 2015-06-20 Bristol Myers Squibb Co Compuestos de piridilo sustituidos con heteroarilo utiles como moduladores de cinasa
HUE050761T2 (hu) 2014-01-01 2021-01-28 Medivation Tech Llc Vegyületek és alkalmazási eljárások
TW201609693A (zh) 2014-01-03 2016-03-16 必治妥美雅史谷比公司 雜芳基取代之菸鹼醯胺化合物
AR105113A1 (es) 2015-06-24 2017-09-06 Bristol Myers Squibb Co Compuestos de aminopiridina sustituida con heteroarilo
UY36747A (es) 2015-06-24 2016-12-30 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Compuestos de aminopiridina sustituida con heteroarilo como inhibidores de quinasa y modulantes de irak-4 y composiciones farmacéuticas que los contienen
US10618903B2 (en) 2015-06-24 2020-04-14 Bristol-Myers Squibb Company Heteroaryl substituted aminopyridine compounds
WO2017009751A1 (en) 2015-07-15 2017-01-19 Pfizer Inc. Pyrimidine derivatives
MY200228A (en) 2017-05-11 2023-12-15 Bristol Myers Squibb Co Thienopyridines and benzothiophenes useful as irak4 inhibitors
WO2019119206A1 (en) * 2017-12-18 2019-06-27 Merck Sharp & Dohme Corp. Purine inhibitors of human phosphatidylinositol 3-kinase delta
CN108863949B (zh) * 2018-07-09 2021-01-15 湖南博隽生物医药有限公司 一种用于治疗慢性炎性痛的辣椒素受体拮抗剂及合成方法
WO2021011724A1 (en) 2019-07-18 2021-01-21 Bristol-Myers Squibb Company Tricyclic heteroaryl compounds useful as irak4 inhibitors
WO2021011727A1 (en) 2019-07-18 2021-01-21 Bristol-Myers Squibb Company PYRAZOLO[3,4-d]PYRROLO[1,2-b]PYRIDAZINYL COMPOUNDS USEFUL AS IRAK4 INHIBITORS
JP7573596B2 (ja) 2019-07-23 2024-10-25 ブリストル-マイヤーズ スクイブ カンパニー Irak4阻害剤として有用なチエノピリジニルおよびチアゾロピリジニル化合物
CN114174279B (zh) 2019-08-06 2024-07-02 百时美施贵宝公司 可用作irak4抑制剂的双环杂环化合物
US12570659B2 (en) 2019-08-13 2026-03-10 Bristol-Myers Squibb Company Bicyclic heteroaryl compounds useful as IRAK4 inhibitors
CN113134005B (zh) * 2020-01-16 2022-09-23 中国药科大学 Trpv1通道靶向小分子的应用
CN115335380B (zh) 2020-02-03 2024-08-02 百时美施贵宝公司 可用作irak4抑制剂的三环杂芳基化合物
US12391702B2 (en) 2020-02-03 2025-08-19 Bristol-Myers Squibb Company Benzo[5,6][1,4]dioxino[2,3-b]pyridine compounds useful as IRAK4 inhibitors
DE102022104759A1 (de) 2022-02-28 2023-08-31 SCi Kontor GmbH Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8066701A (en) * 2000-07-20 2002-02-05 Neurogen Corp Capsaicin receptor ligands
WO2002060392A2 (en) * 2001-01-31 2002-08-08 Synaptic Pharmaceutical Corporation Use of gal3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods
AU2002364549B2 (en) * 2001-12-10 2007-11-22 Amgen, Inc Vanilloid receptor ligands and their use in treatments

Similar Documents

Publication Publication Date Title
JP2007523867A5 (enExample)
CN104327084B (zh) Bcr‑abl的小分子豆蔻酸酯抑制剂及其使用方法
JP2007504160A5 (enExample)
JP2005508336A (ja) キナーゼ阻害物質としての3−(アリールアミノ)メチレン−1,3−ジヒドロ−2h−インドール−2−オン類
CA2480356A1 (en) Benzamide derivatives useful as histone deacetylase inhibitors
JP2012502986A5 (enExample)
JP2004508365A5 (enExample)
JP2003525295A5 (enExample)
PT764166E (pt) Antagonistas de factor de libertacao de corticotropina
RU2009101911A (ru) Производные пиридина и пиразина в качестве ингибиторов mnk-киназы
RU2008136553A (ru) Производные бензотиазола в качестве агонистов бета2 адренорецептора
JP2010532312A5 (enExample)
TW200403223A (en) Novel compounds
RU2009148673A (ru) Производные пиразинона и их применение для лечения легочных заболеваний
JP2005508336A5 (enExample)
HRP20100670T1 (hr) Aril-supstituirani pirazol-amid spojevi korisni kao inhibitori kinaze
RU2003105805A (ru) Производные 4-фенилпиридина в качестве антагонистов рецепторов нейрокинина-1
EP1796673A2 (en) Novel pyrimidine compounds, process for their preparation and compositions containing them
JP2009530272A5 (enExample)
BRPI0418074B1 (pt) Derivado de amida, composição farmacêutica, inibidor da tirosina cinase bcr-abl e agentes terapêuticos
RU2015151886A (ru) Ингибиторы киназ
CY1110676T1 (el) ΠΥΡΑΖΟΛΟ[3,4-b]ΠΥΡΙΔΙΝΙΚΕΣ ΕΝΩΣΕΙΣ, ΚΑΙ Η ΧΡΗΣΗ ΤΟΥΣ ΩΣ ΑΝΑΣΤΟΛΕΙΣ ΤΗΣ ΦΩΣΦΟΔΙΕΣΤΕΡΑΣΗΣ
JP2013517283A5 (enExample)
JP2009541268A5 (enExample)
TR201802913T4 (tr) Yeni 4,6-çift ikameli aminopirimidin türevleri.