CY1110676T1 - ΠΥΡΑΖΟΛΟ[3,4-b]ΠΥΡΙΔΙΝΙΚΕΣ ΕΝΩΣΕΙΣ, ΚΑΙ Η ΧΡΗΣΗ ΤΟΥΣ ΩΣ ΑΝΑΣΤΟΛΕΙΣ ΤΗΣ ΦΩΣΦΟΔΙΕΣΤΕΡΑΣΗΣ - Google Patents

ΠΥΡΑΖΟΛΟ[3,4-b]ΠΥΡΙΔΙΝΙΚΕΣ ΕΝΩΣΕΙΣ, ΚΑΙ Η ΧΡΗΣΗ ΤΟΥΣ ΩΣ ΑΝΑΣΤΟΛΕΙΣ ΤΗΣ ΦΩΣΦΟΔΙΕΣΤΕΡΑΣΗΣ

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Publication number
CY1110676T1
CY1110676T1 CY20101100688T CY101100688T CY1110676T1 CY 1110676 T1 CY1110676 T1 CY 1110676T1 CY 20101100688 T CY20101100688 T CY 20101100688T CY 101100688 T CY101100688 T CY 101100688T CY 1110676 T1 CY1110676 T1 CY 1110676T1
Authority
CY
Cyprus
Prior art keywords
formula
optionally substituted
pyrazolo
sub
hydrogen
Prior art date
Application number
CY20101100688T
Other languages
English (en)
Inventor
David George Allen
Diane Mary Coe
Caroline Mary Cook
Anthony William James Cooper
Michael Dennis Dowle
Christopher David Edlin
Julie Nicole Hamblin
Martin Redpath Johnson
Paul Spencer Jones
Mika Kristian Lindvall
Charlotte Jane Mitchell
Alison Judith Redgrave
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0230165A external-priority patent/GB0230165D0/en
Priority claimed from GB0307998A external-priority patent/GB0307998D0/en
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of CY1110676T1 publication Critical patent/CY1110676T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Η εφεύρεση σχετίζεται με μία ένωση του τύπου (I) ή ένας άλας αυτής: Τύπου (I) όπου: R1 είναι C1- 4αλκύλιο, C1-3φθοραλκύλιο ή -(CH2)2OH˙ R2 είναι ένα άτομο υδρογόνου (Η), μεθύλιο ή C1φθοραλκύλιο˙ R3a είναι ένα άτομο υδρογόνου (Η) ή C1-3αλκύλιο˙ R3 είναι κατ' επιλογή υποκατεστημένο διακλαδισμένο C3-6αλκύλιο, κατ' επιλογή υποκατεστημένο C3-8κυκλοαλκύλιο, κατ' επιλογή υποκατεστημένο μονο-ακόρεστο-C5-7κυκλοαλκενύλιο, κατ' επιλογή υποκατεστημένο φαινύλιο, ή μια κατ' επιλογή υποκατεστημένη ετεροκυκλική ομάδα του υπο-τύπου (aa), ή (bb) ή (cc) στον οποίο n1 και n2 ανεξάρτητα είναι 1 ή 2˙ και Υ είναι Ο, S, SO2, ή NR4˙ και όπου Het είναι του υπο-τύπου (i), ή (ii), ή (iii), ή (iv) ή (ν). Οι ενώσεις είναι αναστολείς της φωσφοδιεστεράσης (PDE), ειδικότερα PDE4 αναστολείς. Επίσης παρέχεται η χρήση μιας ένωσης του τύπου (I), ή ενός φαρμακευτικώς αποδεκτού άλατος αυτής, στην παραγωγή ενός φαρμάκου για την αντιμετώπιση και/ή προφύλαξη μιας φλεγμονώδους και/ή αλλεργικής νόσου σε ένα θηλαστικό όπως ένας άνθρωπος, για παράδειγμα χρόνιας αποφρακτικής πνευμονικής νόσου (COPD), άσθματος, ή αλλεργικής ρινίτιδας.
CY20101100688T 2002-12-23 2010-07-21 ΠΥΡΑΖΟΛΟ[3,4-b]ΠΥΡΙΔΙΝΙΚΕΣ ΕΝΩΣΕΙΣ, ΚΑΙ Η ΧΡΗΣΗ ΤΟΥΣ ΩΣ ΑΝΑΣΤΟΛΕΙΣ ΤΗΣ ΦΩΣΦΟΔΙΕΣΤΕΡΑΣΗΣ CY1110676T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB0230045.7A GB0230045D0 (en) 2002-12-23 2002-12-23 Compounds
GB0230165A GB0230165D0 (en) 2002-12-24 2002-12-24 Compounds
GB0307998A GB0307998D0 (en) 2003-04-07 2003-04-07 Compounds
EP03789413A EP1581532B1 (en) 2002-12-23 2003-12-19 Pyrazolo¬3,4-b pyridine compounds, and their use as phosphodiesterase inhibitors

Publications (1)

Publication Number Publication Date
CY1110676T1 true CY1110676T1 (el) 2015-06-10

Family

ID=32685762

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100688T CY1110676T1 (el) 2002-12-23 2010-07-21 ΠΥΡΑΖΟΛΟ[3,4-b]ΠΥΡΙΔΙΝΙΚΕΣ ΕΝΩΣΕΙΣ, ΚΑΙ Η ΧΡΗΣΗ ΤΟΥΣ ΩΣ ΑΝΑΣΤΟΛΕΙΣ ΤΗΣ ΦΩΣΦΟΔΙΕΣΤΕΡΑΣΗΣ

Country Status (29)

Country Link
US (1) US7528148B2 (el)
EP (1) EP1581532B1 (el)
JP (1) JP4872068B2 (el)
KR (1) KR101088848B1 (el)
CN (1) CN1751042B (el)
AR (1) AR043683A1 (el)
AT (1) ATE466012T1 (el)
AU (2) AU2003293999B2 (el)
BR (1) BR0317645A (el)
CA (1) CA2511340C (el)
CO (1) CO5690642A2 (el)
CY (1) CY1110676T1 (el)
DE (1) DE60332396D1 (el)
DK (1) DK1581532T3 (el)
ES (1) ES2345385T3 (el)
GB (1) GB0230045D0 (el)
HK (1) HK1084384A1 (el)
IL (1) IL169335A0 (el)
IS (1) IS2795B (el)
MA (1) MA27615A1 (el)
MX (1) MXPA05006923A (el)
NO (1) NO332354B1 (el)
NZ (2) NZ540923A (el)
PL (2) PL392790A1 (el)
PT (1) PT1581532E (el)
SI (1) SI1581532T1 (el)
TW (2) TW201004956A (el)
WO (1) WO2004056823A1 (el)
ZA (1) ZA200605901B (el)

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