PE20091563A1 - Farmacoforos duales - antagonistas muscarinicos de pde4 - Google Patents

Farmacoforos duales - antagonistas muscarinicos de pde4

Info

Publication number
PE20091563A1
PE20091563A1 PE2009000165A PE2009000165A PE20091563A1 PE 20091563 A1 PE20091563 A1 PE 20091563A1 PE 2009000165 A PE2009000165 A PE 2009000165A PE 2009000165 A PE2009000165 A PE 2009000165A PE 20091563 A1 PE20091563 A1 PE 20091563A1
Authority
PE
Peru
Prior art keywords
alkyl
crf
integer
methyl
cycloalkyl
Prior art date
Application number
PE2009000165A
Other languages
English (en)
Inventor
James Francis Callahan
Guoliang Lin
Zehong Wan
Hongxing Yan
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20091563A1 publication Critical patent/PE20091563A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

REFERIDA A DERIVADOS DE PIRAZOLO-PIRIDIN DE FORMULA (I), DONDE LINK REPRESENTA ((CReRe)s3-(CRf=CRf)v1-(CRgRg))s4-X2-((CReRe)t2-(CRf=CRf)v2-(CRgRg))t3; X2 ES ALQUILO C1-C10, UN ANILLO CICLOALQUILO C3-C7, ENTRE OTROS; X1 ES O O N(R4a); R4a ES H O ALQUILO C1-C2; R5a ES H O ALQUILO C1-C2; Z ES C(O), S(O)q, C(O)NH, C(O)O; Z1 ES C(O), S(O)q, HNC(O), OC(O); n ES 1, 2 O 3; q ES 0, 1 O 2; v ES UN ENTERO DE 1 A 5; v1, v2, s3, s4, t2 Y t3 SON UN ENTERO DE 0 A 5; Re, Rf Y Rg SON H O ALQUILO C1-C4; R1 ES ALQUILO C1-C3, CH2-FLUOROALQUILO C1-C2 O CH2CH2OH; R2 ES H, ALQUILO C1-C4, FLUOROALQUILO C1-C2, ENTRE OTROS; R3 ES CICLOALQUILO C4-C7, CICLOALQUENILO C5-C7, ENTRE OTROS; Ar1 Y Ar2 SON FENILO, HETEROARILO MONOCICLICO, ENTRE OTROS; R6 ES NR7R8, UN ANILLO DE 5 A 7 MIEMBROS QUE CONTIENE UNO O DOS NITROGENOS, ENTRE OTROS; R7 ES H O ALQUILO C1-C4; R8 ES (CRd1Rd1)t-NR11R12 O (CRd1Rd1)t1-R14; Rd1 ES H, ALQUILO C1-C4, ENTRE OTROS; R14 ES ALQUILO C1-C4, CICLOALQUILO C3-C6, ENTRE OTROS; t ES UN ENTERO DE 1 A 4; t1 ES UN ENTERO DE 0 A 4; R4 Y R5 SON H, ALQUILO C1-C4, CICLOALQUILO C3-C7-ALQUILO C1-C4, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-{[1,6-DIETIL-4-(TETRAHIDRO-2H-PIRAN-4-ILAMINO)-1H-PIRAZOLO[3,4-b]PIRIDIN-5-IL]METIL}-N'-[(6-FLUORO-3'-{[(3S)-3-METIL-1-PIPERAZINIL]METIL}-3-BIFENILIL)METIL]PROPANODIAMIDA, ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE LA FOSFODIESTERASA DE TIPO IV (PDE4) Y ANTAGONISTAS DE RECEPTORES MUSCARINICOS DE ACETILCOLINA (mAChR)
PE2009000165A 2008-02-06 2009-02-04 Farmacoforos duales - antagonistas muscarinicos de pde4 PE20091563A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2656808P 2008-02-06 2008-02-06

Publications (1)

Publication Number Publication Date
PE20091563A1 true PE20091563A1 (es) 2009-11-05

Family

ID=40935341

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000165A PE20091563A1 (es) 2008-02-06 2009-02-04 Farmacoforos duales - antagonistas muscarinicos de pde4

Country Status (19)

Country Link
US (1) US8071588B2 (es)
EP (1) EP2247184A4 (es)
JP (1) JP2011511083A (es)
KR (1) KR20100125295A (es)
CN (1) CN101983009A (es)
AR (1) AR070563A1 (es)
AU (1) AU2009212409A1 (es)
BR (1) BRPI0907519A2 (es)
CA (1) CA2714418A1 (es)
CL (1) CL2009000249A1 (es)
CR (1) CR11666A (es)
DO (1) DOP2010000239A (es)
EA (1) EA201070917A1 (es)
IL (1) IL207346A0 (es)
MX (1) MX2010008685A (es)
PE (1) PE20091563A1 (es)
TW (1) TW200946525A (es)
UY (1) UY31636A1 (es)
WO (1) WO2009100167A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY33373A (es) 2010-05-10 2011-12-30 Gilead Sciences Inc ?Compuestos de pirazolopiridina bifuncionales, su uso en terapia y composiciones que los comprenden?.
EP3072943B1 (en) 2015-03-26 2018-05-02 Idemitsu Kosan Co., Ltd. Dibenzofuran/carbazole-substituted benzonitriles
AU2016275764B8 (en) 2015-06-11 2021-03-04 Basilea Pharmaceutica International AG Efflux-pump inhibitors and therapeutic uses thereof
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3833594A (en) * 1971-08-05 1974-09-03 Squibb & Sons Inc Amino derivatives of pyrazolopyridine carboxylic acids and esters
US3925388A (en) * 1971-08-05 1975-12-09 Squibb & Sons Inc 4-Piperazino-{8 3,4-b{9 pyridine-5-carboxylic acids and esters
US3856799A (en) * 1971-08-05 1974-12-24 Squibb & Sons Inc Intermediates for production of amino derivatives of pyrazolopyridine carboxylic acids and esters
BE787249A (fr) * 1971-08-05 1973-02-05 Squibb & Sons Inc Derives amino d'acides pyrazolopyridine carboxyliques, leurs esters et les sels de ces composes, ainsi que leurs procedes de preparation
CA1003419A (en) 1971-11-23 1977-01-11 Theodor Denzel Process for the production of pyrazolo (3,4-b) pyridines
US3840546A (en) * 1972-11-15 1974-10-08 Squibb & Sons Inc Amino derivatives of pyrazolopyridine carboxamides
US3979399A (en) * 1972-11-15 1976-09-07 E. R. Squibb & Sons, Inc. Amino derivatives of pyrazolopyridine carboxamides
US4364948A (en) 1981-09-28 1982-12-21 Ici Americas Inc. Pyrazolo[3,4-b]pyridine compounds
US6326379B1 (en) 1998-09-16 2001-12-04 Bristol-Myers Squibb Co. Fused pyridine inhibitors of cGMP phosphodiesterase
US6670364B2 (en) * 2001-01-31 2003-12-30 Telik, Inc. Antagonists of MCP-1 function and methods of use thereof
TWI236474B (en) 2001-04-03 2005-07-21 Telik Inc Antagonists of MCP-1 function and methods of use thereof
EP1438048A1 (en) * 2001-10-18 2004-07-21 Boehringer Ingelheim Pharmaceuticals Inc. 1,4-disubstituted benzo-fused urea compounds as cytokine inhibitors
EP1499598A1 (en) 2002-04-18 2005-01-26 Ucb, S.A. Chemical compounds with dual activity, processes for their preparation and pharmaceutical compositions
UY27927A1 (es) 2002-08-06 2003-12-31 Glaxo Group Ltd Antagonistas del receptor muscarínico m3 de acetilcolina
CA2497550A1 (en) * 2002-09-16 2004-03-25 Glaxo Group Limited Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors
GB0230045D0 (en) * 2002-12-23 2003-01-29 Glaxo Group Ltd Compounds
EP1613307A4 (en) 2003-04-07 2008-03-12 Glaxo Group Ltd M SB 3 / SB MUSCARIN ACETYLCHOLINE RECEPTOR ANTAGONISTS
PE20050327A1 (es) 2003-07-17 2005-06-08 Glaxo Group Ltd Derivados de 8-azoniabiciclo[3.2.1]octano como antagonistas de los receptores muscarinicos de la acetilcolina
TW200519109A (en) 2003-07-17 2005-06-16 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
AR045914A1 (es) 2003-07-17 2005-11-16 Glaxo Group Ltd Compuesto alcoholico terciario del 8-azoniabiciclo [3.2.1] octano, composicion farmaceutica que lo comprende y su uso para preparar esta ultima
AP2007004238A0 (en) 2003-10-14 2007-12-31 Glaxo Group Ltd Muscarinic acetycholine receptor antagonists
AU2004281167A1 (en) 2003-10-17 2005-04-28 Glaxo Group Limited Muscarinic acetylcholine receptor antagonists field of the invention
AR046225A1 (es) 2003-11-04 2005-11-30 Glaxo Group Ltd Compuesto de 8-azoniabiciclo(3.2.1)octano, composicion farmaceutica para el tratamiento de enfermedades mediadas por receptores de acetilcolina muscarinicos que lo comprende y uso del compuesto para preparar dicha composicion
UY28645A1 (es) 2003-12-03 2005-06-30 Glaxo Group Ltd Nuevos antagonistas del receptor muscarinico m3 de acetilcolina
PE20050861A1 (es) 2003-12-03 2005-12-10 Glaxo Group Ltd Derivados de sales ciclicas de amonio cuaternario como antagonistas del receptor muscarinico de acetilcolina
AU2004299277A1 (en) * 2003-12-19 2005-06-30 Glaxo Group Limited Pyrazolo (3,4-b) pyridine compounds, and their use as phosphodiesterase inhibitors
TW200534855A (en) 2004-01-13 2005-11-01 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
EP1725236A4 (en) 2004-03-11 2009-05-13 Glaxo Group Ltd NEW M3 MUSCARIN ACETYLCHOLINE RECEPTOR ANTAGONISTS
EP1751089A4 (en) 2004-03-11 2010-03-10 Glaxo Group Ltd NEW M3 MUSCARIN ACETYLCHOLINE RECEPTOR ANTAGONISTS
GB0405933D0 (en) 2004-03-16 2004-04-21 Glaxo Group Ltd Compounds
GB0405937D0 (en) 2004-03-16 2004-04-21 Glaxo Group Ltd Compounds
JP2007529464A (ja) 2004-03-16 2007-10-25 グラクソ　グループ　リミテッド ビラゾロ［３，４−ｂ］ピリジン化合物及びＰＤＥ４阻害剤としてのその使用
EP1725564A4 (en) 2004-03-17 2007-09-12 Glaxo Group Ltd ANTAGONISTS OF THE M3 MUSCARIN ACETYL CHOLIN RECEPTOR
US20070185088A1 (en) 2004-03-17 2007-08-09 Jakob Busch-Petersen M3 muscarinic acetylchoine receptor antagonists
EP1725240A4 (en) 2004-03-17 2009-03-25 Glaxo Group Ltd ANTAGONISTS OF THE ACETYLCHOLINE MUSCARINIC RECEPTOR
JP2007529511A (ja) 2004-03-17 2007-10-25 グラクソ　グループ　リミテッド Ｍ３ムスカリン性アセチルコリン受容体アンタゴニスト
WO2005099706A2 (en) 2004-04-07 2005-10-27 Glaxo Group Limited Muscarinic acetylcholine receptor antagonists
UY28871A1 (es) 2004-04-27 2005-11-30 Glaxo Group Ltd Antagonistas del receptor de acetilcolina muscarinico
WO2005112644A2 (en) 2004-05-13 2005-12-01 Glaxo Group Limited Muscarinic acetylcholine receptor antagonists
WO2005118594A1 (en) 2004-05-28 2005-12-15 Glaxo Group Limited Muscarinic acetylcholine receptor antagonists
EP1765339A4 (en) 2004-06-30 2009-09-02 Glaxo Group Ltd ANTAGONISTS OF MUSCARIN ACETYLCHOLIN RECEPTOR
EP1781104A4 (en) 2004-08-05 2008-05-21 Glaxo Group Ltd ANTAGONISTS OF THE ACETYLCHOLINE MUSCARINIC RECEPTOR
US20090076061A1 (en) 2004-08-06 2009-03-19 Jakob Busch-Petersen Muscarinic acetycholine receptor antagonists
US20090258858A1 (en) 2004-10-29 2009-10-15 Jakob Busch-Petersen Muscarinic acetylcholine receptor antagonists
JP2008520579A (ja) * 2004-11-15 2008-06-19 グラクソ グループ リミテッド 新規ｍ３ムスカリン性アセチルコリン受容体アンタゴニスト
EP1827439A4 (en) 2004-11-15 2009-11-18 Glaxo Group Ltd NEW M3 MUSCARIN ACETYLCHOLINE RECEPTOR ANTAGONISTS
PE20060826A1 (es) 2004-12-06 2006-10-08 Smithkline Beecham Corp Derivado oleofinico de 8-azoniabiciclo[3.2.1]octano y combinacion farmaceutica que lo comprende
PE20061162A1 (es) 2004-12-06 2006-10-14 Smithkline Beecham Corp Compuestos derivados olefinicos de 8-azoniabiciclo[3.2.1]octanos
WO2006065755A2 (en) 2004-12-13 2006-06-22 Glaxo Group Limited Quaternary ammonium salts of fused hetearomatic amines as novel muscarinic acetylcholine receptor antagonists
WO2006065788A2 (en) 2004-12-13 2006-06-22 Glaxo Group Limited Novel muscarinic acetylcholine receptor antagonists
WO2007018514A1 (en) 2005-07-28 2007-02-15 Glaxo Group Limited Novel m3 muscarinic acetylcholine receptor antagonists
WO2007018508A1 (en) 2005-07-28 2007-02-15 Glaxo Group Limited Novel m3 muscarinic acetycholine receptor antagonists
JP2009503101A (ja) 2005-08-02 2009-01-29 グラクソ グループ リミテッド Ｍ３ムスカリン性アセチルコリン受容体アンタゴニスト
US20080275079A1 (en) 2005-08-02 2008-11-06 Glaxo Group Limited M3 Muscarinic Acetylcholine Receptor Antagonists
US7767691B2 (en) 2005-08-18 2010-08-03 Glaxo Group Limited Muscarinic acetylcholine receptor antagonists containing an azoniabiocyclo[2.2.1] heptane ring system
WO2007123953A2 (en) * 2006-04-19 2007-11-01 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
GB0614570D0 (en) * 2006-07-21 2006-08-30 Glaxo Group Ltd Compounds

Also Published As

Publication number Publication date
JP2011511083A (ja) 2011-04-07
MX2010008685A (es) 2010-08-30
KR20100125295A (ko) 2010-11-30
TW200946525A (en) 2009-11-16
AR070563A1 (es) 2010-04-21
CN101983009A (zh) 2011-03-02
BRPI0907519A2 (pt) 2015-07-28
CA2714418A1 (en) 2009-08-13
EP2247184A4 (en) 2012-07-18
CR11666A (es) 2011-04-28
EA201070917A1 (ru) 2011-02-28
US20090203677A1 (en) 2009-08-13
DOP2010000239A (es) 2011-03-31
UY31636A1 (es) 2009-08-03
WO2009100167A1 (en) 2009-08-13
CL2009000249A1 (es) 2009-09-11
EP2247184A1 (en) 2010-11-10
IL207346A0 (en) 2010-12-30
US8071588B2 (en) 2011-12-06
AU2009212409A1 (en) 2009-08-13

Similar Documents

Publication Publication Date Title
JO2791B1 (en) Acid secretion inhibitor
NO20062633L (no) Pyrazolderivater som proteinkinasemodulatorer
NO20082976L (no) Svovelholdige cykliske ureaderivater, fremstilling derav og farmasoytisk anvendelse derav som kinaseinhibitorer
TW200633991A (en) Chemical compounds
PE20070855A1 (es) Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas
TR200401413T1 (tr) Dibenzilamin bileşikleri ve bunların farmasötik kullanımları
BRPI0014526B8 (pt) compostos cíclicos de seis elementos contendo nitrogênio aromático, composição farmacêutica e uso do mesmo
MEP8409A (en) Fused heterocyclic compound
TW200740820A (en) Fused heterocyclic derivatives and use thereof
DK1755606T4 (da) Quinazolinonderivater, der er anvendelige som vanilloid-antagonister
BR0209334A (pt) Aminas n-aroil cìclicas
EA200870191A1 (ru) Новые производные циклической мочевины, их получение и фармацевтическое применение в качестве ингибиторов киназ
HUP0402313A2 (hu) Szerotonin újrafelvételt gátló fenilpiperazin-származékok, az ezeket tartalmazó gyógyászati készítmények és alkalmazásuk
TR201909709T4 (tr) Fosfordiesteraz inhibitörleri olarak benzodioksol türevleri.
ATE338461T1 (de) Pyrazolpyrimidinfungizide
AR055431A1 (es) Derivados del acido 4-amino-tieno[3,2-c]piridina-7-carboxilico
NO20073811L (no) N-(heteroaryl)-1H-indol-2-karboksamidderivater og deres anvendelse som vanilloid TRPV1 reseptorligander
TW200613297A (en) Pyrazole derivatives
EA200971101A1 (ru) Соединения на основе лантибиотиков, обладающие противомикробной активностью
EA201101566A1 (ru) Производные имидазола и их применение в качестве модуляторов циклинзависимых киназ
UA117151C2 (uk) N-ациліміногетероциклічні сполуки
EA200802052A1 (ru) 2-(пиридин-2-ил)-пиримидины в качестве фунгицидов
PE20070212A1 (es) Heterociclos de 1,4-dihidropiridina-condensados, procesos para preparar los mismos, uso y composiciones que los contienen
HRP20070286T3 (en) Substituted diketopiperazines and their use as oxytocyn antagonists
PE20091563A1 (es) Farmacoforos duales - antagonistas muscarinicos de pde4

Legal Events

Date Code Title Description
FD Application declared void or lapsed