JP2012502986A5 - - Google Patents
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- Publication number
- JP2012502986A5 JP2012502986A5 JP2011527808A JP2011527808A JP2012502986A5 JP 2012502986 A5 JP2012502986 A5 JP 2012502986A5 JP 2011527808 A JP2011527808 A JP 2011527808A JP 2011527808 A JP2011527808 A JP 2011527808A JP 2012502986 A5 JP2012502986 A5 JP 2012502986A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- methyl
- heterocycloalkyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19258108P | 2008-09-18 | 2008-09-18 | |
| US61/192,581 | 2008-09-18 | ||
| US11822808P | 2008-11-26 | 2008-11-26 | |
| US61/118,228 | 2008-11-26 | ||
| US18091509P | 2009-05-25 | 2009-05-25 | |
| US61/180,915 | 2009-05-25 | ||
| PCT/US2009/005119 WO2010033168A2 (en) | 2008-09-18 | 2009-09-14 | Amide compounds, compositions and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012502986A JP2012502986A (ja) | 2012-02-02 |
| JP2012502986A5 true JP2012502986A5 (enExample) | 2012-08-30 |
| JP5608655B2 JP5608655B2 (ja) | 2014-10-15 |
Family
ID=41328566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011527808A Expired - Fee Related JP5608655B2 (ja) | 2008-09-18 | 2009-09-14 | Ｐ２ｘ３受容体活性のモジュレーター |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20110237578A1 (enExample) |
| EP (1) | EP2346825A2 (enExample) |
| JP (1) | JP5608655B2 (enExample) |
| CA (1) | CA2737038A1 (enExample) |
| WO (1) | WO2010033168A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101981003B (zh) * | 2008-02-29 | 2014-07-02 | 伊沃泰克股份公司 | 酰胺化合物、组合物及其应用 |
| ES2474490T3 (es) | 2009-02-13 | 2014-07-09 | Shionogi & Co., Ltd. | Derivados de triazina como antagonistas de receptores P2X3 y/o P2X2/3 y composición farmacéutica que los contiene |
| CN102438989B (zh) * | 2009-06-22 | 2015-05-27 | 霍夫曼-拉罗奇有限公司 | 噁唑酮和吡咯烷酮取代的芳基酰胺 |
| PL2604595T3 (pl) | 2010-08-10 | 2016-09-30 | Pochodna triazyny i związek farmaceutyczny, który ją zawiera i wykazuje aktywność przeciwbólową | |
| WO2013118855A1 (ja) | 2012-02-09 | 2013-08-15 | 塩野義製薬株式会社 | 複素環および炭素環誘導体 |
| TWI637949B (zh) | 2013-06-14 | 2018-10-11 | 塩野義製藥股份有限公司 | 胺基三衍生物及含有其等之醫藥組合物 |
| WO2015161011A1 (en) * | 2014-04-17 | 2015-10-22 | Merck Sharp & Dohme Corp. | Benzamide cgrp receptor antagonists |
| WO2016084922A1 (ja) * | 2014-11-28 | 2016-06-02 | 塩野義製薬株式会社 | １，２，４－トリアジン誘導体およびその医薬組成物 |
| US10183937B2 (en) | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| SG10202012274RA (en) | 2014-12-09 | 2021-01-28 | Bayer Ag | 1,3-thiazol-2-yl substituted benzamides |
| JP6518789B2 (ja) | 2015-04-23 | 2019-05-22 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 精神障害の処置において使用するためのテトラゾール誘導体 |
| EP3322699B1 (en) | 2015-07-14 | 2019-05-15 | H. Hoffnabb-La Roche Ag | 2-phenyl-6-imidazolyl-pyridine-4-carboxamide derivatives and their use as eaat3 inhibitors |
| JP6754828B2 (ja) | 2015-08-12 | 2020-09-16 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ピリジン及びピリミジン誘導体 |
| JP6831376B2 (ja) * | 2015-10-06 | 2021-02-17 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | トリアゾール誘導体 |
| WO2018069362A1 (en) | 2016-10-14 | 2018-04-19 | F. Hoffmann-La Roche Ag | Imidazole compounds as eaat3 inhibitors |
| US11938114B2 (en) | 2017-03-10 | 2024-03-26 | Rutgers, The State University Of New Jersey | Bacterial efflux pump inhibitors |
| WO2018165612A1 (en) | 2017-03-10 | 2018-09-13 | Rutgers, The State University Of New Jersey | Bacterial efflux pump inhibitors |
| BR112019018691A2 (pt) | 2017-03-10 | 2020-04-07 | Rutgers, The State University Of New Jersey | derivados de indol como inibidores de bomba de efluxo |
| CN111163774A (zh) | 2017-05-26 | 2020-05-15 | 罗格斯新泽西州立大学 | 细菌外排泵抑制剂 |
| US11458121B2 (en) | 2017-06-26 | 2022-10-04 | Rutgers, The State University Of New Jersey | Therapeutic compounds and methods to treat infection |
| PE20251292A1 (es) | 2018-03-08 | 2025-05-14 | Incyte Corp | Compuestos diolicos de aminopirazina como inhibidores de pi3k-gamma |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| JP2022512652A (ja) * | 2018-10-10 | 2022-02-07 | べルス・ヘルス・コフ・インコーポレーテッド | Ｐ２ｘ３拮抗薬での皮膚掻痒症の治療 |
| CN111377970B (zh) * | 2018-12-28 | 2022-12-23 | 广东阿格蕾雅光电材料有限公司 | 一种n`n`c`n型四齿铂(ii)配合物的制备及应用 |
| EP3930722A4 (en) | 2019-02-25 | 2022-12-28 | Bellus Health Cough Inc. | TREATMENT WITH P2X3 MODULATORS |
| EP3976179A1 (en) | 2019-05-31 | 2022-04-06 | Chiesi Farmaceutici S.p.A. | Amino quinazoline derivatives as p2x3 inhibitors |
| US20230212169A9 (en) | 2019-05-31 | 2023-07-06 | Chiesi Farmaceutici S.P.A. | Pyridopyrimidines derivatives as p2x3 inhibitors |
| EP4136076A1 (en) * | 2020-04-16 | 2023-02-22 | F. Hoffmann-La Roche AG | Biphenyl derivatives |
| WO2022112493A1 (en) | 2020-11-27 | 2022-06-02 | Chiesi Farmaceutici S.P.A. | Phthalazine derivatives as p2x3 inhibitors |
| CN116601149A (zh) | 2020-11-27 | 2023-08-15 | 奇斯药制品公司 | 作为p2x3抑制剂的氨基喹唑啉衍生物 |
| AU2021386684A1 (en) | 2020-11-27 | 2023-05-25 | Chiesi Farmaceutici S.P.A. | (aza)quinoline 4-amines derivatives as p2x3 inhibitors |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2731469A (en) * | 1953-10-23 | 1956-01-17 | Searle & Co | N-dialkylaminoalkyl derivatives of diarylisonicotinamides |
| JPS6413083A (en) * | 1987-07-07 | 1989-01-17 | Akishiro Nakamura | Streptonigrin derivative and medicinal composition |
| US4916145A (en) * | 1987-07-10 | 1990-04-10 | Hoffmann-La Roche Inc. | Substituted n-[(pyridyl)alkyl]aryl-carboxamide |
| GB9600063D0 (en) | 1996-01-03 | 1996-03-06 | Fujisawa Pharmaceutical Co | Guaridine derivatives |
| US6037324A (en) * | 1996-01-04 | 2000-03-14 | Leukosite, Inc. | Inhibitors of MAdCAM-1-mediated interactions and methods of use therefor |
| WO2002022584A1 (en) | 2000-09-11 | 2002-03-21 | Merck & Co., Inc. | Thrombin inhibitors |
| WO2002070469A2 (en) | 2001-03-05 | 2002-09-12 | Icos Corporation | Selective pde3b inhibitors and use of the same in therapy |
| WO2002094767A2 (en) | 2001-05-18 | 2002-11-28 | Abbott Laboratories | Trisubstituted-n-[(1s)-1,2,3,4-tetrahydro-1-naphthalenyl] benzamides which inhibit p2x3 and p2x2/3 containing receptors |
| US20090286791A1 (en) * | 2001-11-27 | 2009-11-19 | Takeda Pharmaceutical Company Limited | Amide Compounds |
| AR037460A1 (es) | 2001-11-30 | 2004-11-10 | Smithkline Beecham Plc | Compuesto de hidroxietileno, composicion farmaceutica que lo comprende, uso del mismo para la fabricacion de un medicamento y procedimiento para su preparacion |
| CA2484011A1 (en) * | 2002-05-14 | 2003-11-27 | Axys Pharmaceuticals, Inc. | Cysteine protease inhibitors |
| US20060122184A1 (en) * | 2002-12-05 | 2006-06-08 | Axys Pharmaceuticals, Inc. | Cyanomethyl derivatives as cysteine protease inhibitors |
| JP4649413B2 (ja) | 2003-10-03 | 2011-03-09 | メルク・シャープ・エンド・ドーム・コーポレイション | アルツハイマー病の治療用のベンジルエーテル及びベンジルアミノβ−セクレターゼ阻害薬 |
| US20050282824A1 (en) * | 2004-05-07 | 2005-12-22 | Xiaobing Li | Substituted pyrimidines as inhibitors of bacterial type III protein secretion systems |
| JP2007537257A (ja) | 2004-05-13 | 2007-12-20 | メルク エンド カムパニー インコーポレーテッド | アルツハイマー病の治療用ベータセクレターゼ阻害剤として有用なフェニルカルボキサミド化合物 |
| TW200640877A (en) * | 2005-04-28 | 2006-12-01 | Actelion Pharmaceuticals Ltd | Pyrimidine derivatives |
| JP2009504614A (ja) | 2005-08-11 | 2009-02-05 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アルツハイマー病の治療用化合物 |
| CA2618474A1 (en) * | 2005-08-11 | 2007-02-15 | Boehringer Ingelheim International Gmbh | Compounds for treating alzheimer's disease |
| EP1917262B1 (en) * | 2005-08-15 | 2011-12-14 | F. Hoffmann-La Roche AG | Piperidine and piperazine derivatives as p2x3 antagonists |
| US7838676B2 (en) * | 2005-11-21 | 2010-11-23 | Amgen Inc. | Beta-secretase modulators and methods of use |
| WO2007115409A1 (en) | 2006-04-10 | 2007-10-18 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| EP2038264B1 (en) * | 2006-06-29 | 2016-10-26 | F.Hoffmann-La Roche Ag | Tetrazole-substituted arylamides |
| EP2057140B1 (en) * | 2006-08-24 | 2012-08-08 | AstraZeneca AB | Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders |
| CL2007002920A1 (es) * | 2006-10-13 | 2008-06-06 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 2-aminocarbonilpiridina; composicion farmaceutica; y uso para el tratamiento de trastornos vasculares oclusivos. |
| BRPI0718714B8 (pt) * | 2006-11-09 | 2021-05-25 | Hoffmann La Roche | arilamidas substituídas por tiazol e oxazol, seu uso e composição farmacêutica que as compreende |
| WO2008119773A1 (en) | 2007-03-30 | 2008-10-09 | Medivir Ab | Amide derivatives as inhibitors of aspartyl proteases |
| JP2011502148A (ja) * | 2007-10-31 | 2011-01-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 疼痛の治療用としてのｐ２ｘ３受容体アンタゴニスト |
| US8461185B2 (en) | 2007-10-31 | 2013-06-11 | Merck Sharp & Dohme Corp. | P2X3 receptor antagonists for treatment of pain |
| KR101290385B1 (ko) | 2007-12-17 | 2013-07-29 | 에프. 호프만-라 로슈 아게 | 테트라졸-치환된 아릴아미드 유도체 및 ｐ２ｘ３ 및/또는 ｐ２ｘ２／３ 퓨린성 수용체 길항제로서의 이들의 용도 |
| WO2009077367A1 (en) | 2007-12-17 | 2009-06-25 | F. Hoffmann-La Roche Ag | Novel pyrazole-substituted arylamides |
| US7989454B2 (en) | 2007-12-17 | 2011-08-02 | Hoffmann-La Roche Inc. | Leukotriene B4 inhibitors |
| BR122018070508B8 (pt) | 2007-12-17 | 2021-07-27 | Hoffmann La Roche | derivados de arilamida triazol-substituída e seu uso |
| CA2708791C (en) | 2007-12-17 | 2016-06-21 | F. Hoffmann-La Roche Ag | Imidazole-substituted arylamides and uses thereof as p2x receptor antagonists |
| ES2534199T3 (es) * | 2008-10-31 | 2015-04-20 | Merck Sharp & Dohme Corp. | Antagonistas del receptor P2X3 para el tratamiento del dolor |
| BRPI0922645A2 (pt) | 2008-12-16 | 2019-09-24 | Hoffmann La Roche | "arilamidas tiadiazol substituídas". |
| EP2410858B1 (en) | 2009-03-23 | 2016-09-07 | Merck Sharp & Dohme Corp. | P2x3 receptor antagonists for treatment of pain |
| US9238647B2 (en) | 2009-03-23 | 2016-01-19 | Merck Sharp & Dohme Corp. | P2X3 receptor antagonists for treatment of pain |
| US8569512B2 (en) | 2009-03-23 | 2013-10-29 | Merck Sharp & Dohme Corp. | P2X3 receptor antagonists for treatment of pain |
| CN102438989B (zh) | 2009-06-22 | 2015-05-27 | 霍夫曼-拉罗奇有限公司 | 噁唑酮和吡咯烷酮取代的芳基酰胺 |
| SG177308A1 (en) | 2009-06-22 | 2012-02-28 | Hoffmann La Roche | Novel biphenyl and phenyl-pyridine amides |
-
2009
- 2009-09-14 US US13/119,947 patent/US20110237578A1/en not_active Abandoned
- 2009-09-14 CA CA 2737038 patent/CA2737038A1/en not_active Abandoned
- 2009-09-14 WO PCT/US2009/005119 patent/WO2010033168A2/en not_active Ceased
- 2009-09-14 EP EP09736314A patent/EP2346825A2/en not_active Withdrawn
- 2009-09-14 JP JP2011527808A patent/JP5608655B2/ja not_active Expired - Fee Related
-
2014
- 2014-07-09 US US14/327,442 patent/US9133122B2/en not_active Expired - Fee Related
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