JP2012502986A5 - - Google Patents
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- Publication number
- JP2012502986A5 JP2012502986A5 JP2011527808A JP2011527808A JP2012502986A5 JP 2012502986 A5 JP2012502986 A5 JP 2012502986A5 JP 2011527808 A JP2011527808 A JP 2011527808A JP 2011527808 A JP2011527808 A JP 2011527808A JP 2012502986 A5 JP2012502986 A5 JP 2012502986A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- methyl
- heterocycloalkyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19258108P | 2008-09-18 | 2008-09-18 | |
| US61/192,581 | 2008-09-18 | ||
| US11822808P | 2008-11-26 | 2008-11-26 | |
| US61/118,228 | 2008-11-26 | ||
| US18091509P | 2009-05-25 | 2009-05-25 | |
| US61/180,915 | 2009-05-25 | ||
| PCT/US2009/005119 WO2010033168A2 (en) | 2008-09-18 | 2009-09-14 | Amide compounds, compositions and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012502986A JP2012502986A (ja) | 2012-02-02 |
| JP2012502986A5 true JP2012502986A5 (enExample) | 2012-08-30 |
| JP5608655B2 JP5608655B2 (ja) | 2014-10-15 |
Family
ID=41328566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011527808A Expired - Fee Related JP5608655B2 (ja) | 2008-09-18 | 2009-09-14 | Ｐ２ｘ３受容体活性のモジュレーター |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20110237578A1 (enExample) |
| EP (1) | EP2346825A2 (enExample) |
| JP (1) | JP5608655B2 (enExample) |
| CA (1) | CA2737038A1 (enExample) |
| WO (1) | WO2010033168A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5539235B2 (ja) * | 2008-02-29 | 2014-07-02 | エボテック・アーゲー | アミド化合物、組成物およびそれらの使用 |
| BRPI1013642A2 (pt) | 2009-02-13 | 2016-04-19 | Shionogi & Co | derivado de triazina e composição farmacêutica compreendendo o mesmo |
| WO2010149541A1 (en) * | 2009-06-22 | 2010-12-29 | F. Hoffmann-La Roche Ag | Novel oxazolone and pyrrolidinone-substituted arylamides |
| RU2565073C2 (ru) | 2010-08-10 | 2015-10-20 | Сионоги Энд Ко., Лтд. | Триазиновое производное и включающая его фармацевтическая композиция, обладающая анальгетической активностью |
| US9550763B2 (en) | 2012-02-09 | 2017-01-24 | Shionogi & Co., Ltd. | Heterocyclic ring and carbocyclic derivative |
| TWI637949B (zh) | 2013-06-14 | 2018-10-11 | 塩野義製藥股份有限公司 | 胺基三衍生物及含有其等之醫藥組合物 |
| WO2015161011A1 (en) * | 2014-04-17 | 2015-10-22 | Merck Sharp & Dohme Corp. | Benzamide cgrp receptor antagonists |
| JPWO2016084922A1 (ja) * | 2014-11-28 | 2017-09-07 | 塩野義製薬株式会社 | １，２，４−トリアジン誘導体およびその医薬組成物 |
| HUE055290T2 (hu) | 2014-12-09 | 2021-11-29 | Bayer Ag | 1,3-Tiazol-2-il-csoporttal szubsztituált benzamid-származékok |
| US10183937B2 (en) | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| CN107207449B (zh) | 2015-04-23 | 2020-11-10 | 豪夫迈·罗氏有限公司 | 用于治疗精神障碍的四唑衍生物 |
| JP6846363B2 (ja) * | 2015-07-14 | 2021-03-24 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ２−フェニル−６−イミダゾリル−ピリジン−４−カルボキサミド誘導体及びそのｅａａｔ３阻害剤としての使用 |
| WO2017025523A1 (en) * | 2015-08-12 | 2017-02-16 | F. Hoffmann-La Roche Ag | Pyridine and pyrimidine derivatives |
| JP6831376B2 (ja) * | 2015-10-06 | 2021-02-17 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | トリアゾール誘導体 |
| CN109563049B (zh) | 2016-10-14 | 2022-11-29 | 豪夫迈·罗氏有限公司 | 作为eaat3抑制剂的咪唑化合物 |
| US11993571B2 (en) | 2017-03-10 | 2024-05-28 | Rutgers, The State University Of New Jersey | Indole derivatives as efflux pump inhibitors |
| WO2018165614A1 (en) | 2017-03-10 | 2018-09-13 | Rutgers, The State University Of New Jersey | Bacterial efflux pump inhibitors |
| WO2018165612A1 (en) | 2017-03-10 | 2018-09-13 | Rutgers, The State University Of New Jersey | Bacterial efflux pump inhibitors |
| WO2018218192A1 (en) | 2017-05-26 | 2018-11-29 | Rutgers, The State University Of New Jersey | Bacterial efflux pump inhibitors |
| US11458121B2 (en) | 2017-06-26 | 2022-10-04 | Rutgers, The State University Of New Jersey | Therapeutic compounds and methods to treat infection |
| IL277071B2 (en) | 2018-03-08 | 2024-07-01 | Incyte Corp | AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| CA3115939A1 (en) * | 2018-10-10 | 2020-04-16 | Bellus Health Cough Inc. | Treatment of pruritus with p2x3 antagonists |
| CN111377970B (zh) * | 2018-12-28 | 2022-12-23 | 广东阿格蕾雅光电材料有限公司 | 一种n`n`c`n型四齿铂(ii)配合物的制备及应用 |
| JP7578602B2 (ja) | 2019-02-25 | 2024-11-06 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー３）、リミテッド | Ｐ２ｘ３修飾薬での治療 |
| BR112021022099A2 (pt) | 2019-05-31 | 2021-12-28 | Chiesi Farm Spa | Derivados de amino quinazolina como inibidores de p2x3 |
| KR20220016074A (ko) | 2019-05-31 | 2022-02-08 | 키에시 파르마슈티시 엣스. 피. 에이. | P2x3 억제제로서 피리도피리미딘 유도체 |
| JP2023521468A (ja) * | 2020-04-16 | 2023-05-24 | エフ． ホフマン－ラ ロシュ アーゲー | ビフェニル誘導体 |
| CN116601149A (zh) | 2020-11-27 | 2023-08-15 | 奇斯药制品公司 | 作为p2x3抑制剂的氨基喹唑啉衍生物 |
| AU2021386684A1 (en) | 2020-11-27 | 2023-05-25 | Chiesi Farmaceutici S.P.A. | (aza)quinoline 4-amines derivatives as p2x3 inhibitors |
| CA3196335A1 (en) | 2020-11-27 | 2022-06-02 | Chiesi Farmaceutici S.P.A. | Phthalazine derivatives as p2x3 inhibitors |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2731469A (en) * | 1953-10-23 | 1956-01-17 | Searle & Co | N-dialkylaminoalkyl derivatives of diarylisonicotinamides |
| JPS6413083A (en) * | 1987-07-07 | 1989-01-17 | Akishiro Nakamura | Streptonigrin derivative and medicinal composition |
| US4916145A (en) * | 1987-07-10 | 1990-04-10 | Hoffmann-La Roche Inc. | Substituted n-[(pyridyl)alkyl]aryl-carboxamide |
| GB9600063D0 (en) | 1996-01-03 | 1996-03-06 | Fujisawa Pharmaceutical Co | Guaridine derivatives |
| US6037324A (en) * | 1996-01-04 | 2000-03-14 | Leukosite, Inc. | Inhibitors of MAdCAM-1-mediated interactions and methods of use therefor |
| AU2001294557A1 (en) | 2000-09-11 | 2002-03-26 | Merck And Co., Inc. | Thrombin inhibitors |
| AU2002247208A1 (en) | 2001-03-05 | 2002-09-19 | Icos Corporation | Selective pde3b inhibitors and use of the same in therapy |
| DK1392643T3 (da) | 2001-05-18 | 2006-01-30 | Abbott Lab | (1S)-1,2,3,4-tetrahydro-1-naphthalenylbenzamider, der er trisubstituerede ved N, og som inhiberer receptorer indeholdende P2X3 og P2X2/3 |
| TW200304374A (en) * | 2001-11-30 | 2003-10-01 | Smithkline Beecham Plc | Novel compounds |
| US20050288336A1 (en) * | 2002-05-14 | 2005-12-29 | Axys Pharmaceuticals, Inc. | Cysteine protease inhibitors |
| CA2506114A1 (en) * | 2002-12-05 | 2004-06-24 | Axys Pharmaceuticals, Inc. | Cyanomethyl derivatives as cysteine protease inhibitors |
| DE602004014170D1 (de) | 2003-10-03 | 2008-07-10 | Merck & Co Inc | Benzylether- und benzylamino-beta-sekretase-hemmer zur behandlung von alzheimer-krankheit |
| US20050282824A1 (en) * | 2004-05-07 | 2005-12-22 | Xiaobing Li | Substituted pyrimidines as inhibitors of bacterial type III protein secretion systems |
| CA2566053A1 (en) | 2004-05-13 | 2005-12-01 | Merck & Co., Inc. | Phenyl carboxamide compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease |
| TW200640877A (en) * | 2005-04-28 | 2006-12-01 | Actelion Pharmaceuticals Ltd | Pyrimidine derivatives |
| WO2007017510A2 (de) | 2005-08-11 | 2007-02-15 | Boehringer Ingelheim International Gmbh | Isophthalsäurediamide zur behandlung der alzheimer erkrankung |
| JP2009504614A (ja) | 2005-08-11 | 2009-02-05 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アルツハイマー病の治療用化合物 |
| EP1917262B1 (en) * | 2005-08-15 | 2011-12-14 | F. Hoffmann-La Roche AG | Piperidine and piperazine derivatives as p2x3 antagonists |
| US7838676B2 (en) * | 2005-11-21 | 2010-11-23 | Amgen Inc. | Beta-secretase modulators and methods of use |
| EP2010529A1 (en) | 2006-04-10 | 2009-01-07 | PainCeptor Pharma Corp. | Compositions and methods for modulating gated ion channels |
| KR101103143B1 (ko) | 2006-06-29 | 2012-01-04 | 에프. 호프만-라 로슈 아게 | 테트라졸-치환된 아릴아마이드 |
| EP2044055A4 (en) * | 2006-07-21 | 2011-03-23 | Takeda Pharmaceutical | amide compounds |
| AU2007287428B2 (en) * | 2006-08-24 | 2011-08-11 | Astrazeneca Ab | Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders |
| AR063258A1 (es) * | 2006-10-13 | 2009-01-14 | Actelion Pharmaceuticals Ltd | Derivados de 2-aminocarbonil-piridina, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento de trastornos vasculares oclusivos. |
| CN101528717B (zh) * | 2006-11-09 | 2013-04-24 | 弗·哈夫曼-拉罗切有限公司 | 噻唑和*唑-取代的芳基酰胺类化合物 |
| WO2008119773A1 (en) | 2007-03-30 | 2008-10-09 | Medivir Ab | Amide derivatives as inhibitors of aspartyl proteases |
| WO2009058299A1 (en) | 2007-10-31 | 2009-05-07 | Merck & Co., Inc. | P2x3 receptor antagonists for treatment of pain |
| EP2215049B1 (en) | 2007-10-31 | 2019-06-12 | Merck Sharp & Dohme Corp. | P2x3, receptor antagonists for treatment of pain |
| ES2517602T3 (es) | 2007-12-17 | 2014-11-03 | F. Hoffmann-La Roche Ag | Derivados arilamida sustituidos con tetrazol y su utilización como antagonistas de receptores purinérgicos P2X3 y/o P2X2/3 |
| US7989454B2 (en) | 2007-12-17 | 2011-08-02 | Hoffmann-La Roche Inc. | Leukotriene B4 inhibitors |
| KR101405746B1 (ko) | 2007-12-17 | 2014-06-10 | 에프. 호프만-라 로슈 아게 | 트리아졸 치환된 아릴아미드 유도체 및 ｐ２ｘ３ 및/또는 ｐ２ｘ２／３ 퓨린성 수용체 길항제로서의 용도 |
| SI2234976T1 (sl) | 2007-12-17 | 2013-07-31 | F. Hoffmann-La Roche Ag | Novi s pirazolom substituirani arilamidi |
| EP2234981B1 (en) | 2007-12-17 | 2016-03-30 | F. Hoffmann-La Roche AG | Novel imidazole-substituted arylamides |
| US8598209B2 (en) * | 2008-10-31 | 2013-12-03 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
| BRPI0922645A2 (pt) | 2008-12-16 | 2019-09-24 | Hoffmann La Roche | "arilamidas tiadiazol substituídas". |
| US9238647B2 (en) | 2009-03-23 | 2016-01-19 | Merck Sharp & Dohme Corp. | P2X3 receptor antagonists for treatment of pain |
| EP2410858B1 (en) | 2009-03-23 | 2016-09-07 | Merck Sharp & Dohme Corp. | P2x3 receptor antagonists for treatment of pain |
| EP2411001B1 (en) | 2009-03-23 | 2018-01-17 | Merck Sharp & Dohme Corp. | P2x3, receptor antagonists for treatment of pain |
| EP2445868B1 (en) | 2009-06-22 | 2013-12-18 | F.Hoffmann-La Roche Ag | Biphenyl amides useful as p2x3 and/or p2x2/3 receptors modulators |
| WO2010149541A1 (en) | 2009-06-22 | 2010-12-29 | F. Hoffmann-La Roche Ag | Novel oxazolone and pyrrolidinone-substituted arylamides |
-
2009
- 2009-09-14 WO PCT/US2009/005119 patent/WO2010033168A2/en not_active Ceased
- 2009-09-14 CA CA 2737038 patent/CA2737038A1/en not_active Abandoned
- 2009-09-14 JP JP2011527808A patent/JP5608655B2/ja not_active Expired - Fee Related
- 2009-09-14 EP EP09736314A patent/EP2346825A2/en not_active Withdrawn
- 2009-09-14 US US13/119,947 patent/US20110237578A1/en not_active Abandoned
-
2014
- 2014-07-09 US US14/327,442 patent/US9133122B2/en not_active Expired - Fee Related
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