JP2012502986A5 - - Google Patents

Download PDF

Info

Publication number
JP2012502986A5
JP2012502986A5 JP2011527808A JP2011527808A JP2012502986A5 JP 2012502986 A5 JP2012502986 A5 JP 2012502986A5 JP 2011527808 A JP2011527808 A JP 2011527808A JP 2011527808 A JP2011527808 A JP 2011527808A JP 2012502986 A5 JP2012502986 A5 JP 2012502986A5
Authority
JP
Japan
Prior art keywords
substituted
unsubstituted
methyl
heterocycloalkyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011527808A
Other languages
English (en)
Japanese (ja)
Other versions
JP5608655B2 (ja
JP2012502986A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/005119 external-priority patent/WO2010033168A2/en
Publication of JP2012502986A publication Critical patent/JP2012502986A/ja
Publication of JP2012502986A5 publication Critical patent/JP2012502986A5/ja
Application granted granted Critical
Publication of JP5608655B2 publication Critical patent/JP5608655B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011527808A 2008-09-18 2009-09-14 P2x3受容体活性のモジュレーター Expired - Fee Related JP5608655B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US19258108P 2008-09-18 2008-09-18
US61/192,581 2008-09-18
US11822808P 2008-11-26 2008-11-26
US61/118,228 2008-11-26
US18091509P 2009-05-25 2009-05-25
US61/180,915 2009-05-25
PCT/US2009/005119 WO2010033168A2 (en) 2008-09-18 2009-09-14 Amide compounds, compositions and uses thereof

Publications (3)

Publication Number Publication Date
JP2012502986A JP2012502986A (ja) 2012-02-02
JP2012502986A5 true JP2012502986A5 (enExample) 2012-08-30
JP5608655B2 JP5608655B2 (ja) 2014-10-15

Family

ID=41328566

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011527808A Expired - Fee Related JP5608655B2 (ja) 2008-09-18 2009-09-14 P2x3受容体活性のモジュレーター

Country Status (5)

Country Link
US (2) US20110237578A1 (enExample)
EP (1) EP2346825A2 (enExample)
JP (1) JP5608655B2 (enExample)
CA (1) CA2737038A1 (enExample)
WO (1) WO2010033168A2 (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009110985A2 (en) * 2008-02-29 2009-09-11 Renovis, Inc. Amide compounds, compositions and uses thereof
KR101422901B1 (ko) 2009-02-13 2014-07-23 시오노기 앤드 컴파니, 리미티드 신규 트라이아진 유도체 및 그것을 함유하는 의약 조성물
CN102438989B (zh) * 2009-06-22 2015-05-27 霍夫曼-拉罗奇有限公司 噁唑酮和吡咯烷酮取代的芳基酰胺
MX346367B (es) 2010-08-10 2017-03-16 Shionogi & Co Ltd * Derivado de triazina y composicion farmaceutica que tiene actividad analgesica que comprende el mismo.
US9550763B2 (en) 2012-02-09 2017-01-24 Shionogi & Co., Ltd. Heterocyclic ring and carbocyclic derivative
TWI637949B (zh) 2013-06-14 2018-10-11 塩野義製藥股份有限公司 胺基三衍生物及含有其等之醫藥組合物
WO2015161011A1 (en) * 2014-04-17 2015-10-22 Merck Sharp & Dohme Corp. Benzamide cgrp receptor antagonists
WO2016084922A1 (ja) * 2014-11-28 2016-06-02 塩野義製薬株式会社 1,2,4-トリアジン誘導体およびその医薬組成物
US10183937B2 (en) 2014-12-09 2019-01-22 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides
CN107207507B (zh) 2014-12-09 2020-11-06 拜耳公司 1,3-噻唑-2-基取代的苯甲酰胺
EP3286182A1 (en) 2015-04-23 2018-02-28 F. Hoffmann-La Roche AG Tetrazole derivatives for use in the treatment of psychiatric disorders
EP3322699B1 (en) 2015-07-14 2019-05-15 H. Hoffnabb-La Roche Ag 2-phenyl-6-imidazolyl-pyridine-4-carboxamide derivatives and their use as eaat3 inhibitors
EP3334727B1 (en) * 2015-08-12 2019-05-15 H. Hoffnabb-La Roche Ag Pyridine and pyrimidine derivatives
JP6831376B2 (ja) * 2015-10-06 2021-02-17 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft トリアゾール誘導体
WO2018069362A1 (en) 2016-10-14 2018-04-19 F. Hoffmann-La Roche Ag Imidazole compounds as eaat3 inhibitors
US11938114B2 (en) 2017-03-10 2024-03-26 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors
WO2018165612A1 (en) 2017-03-10 2018-09-13 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors
IL269210B2 (en) 2017-03-10 2025-05-01 Univ Rutgers Indole derivatives as efflux pump inhibitors
JP7281822B2 (ja) 2017-05-26 2023-05-26 ラトガーズ、ザ ステイト ユニバーシティ オブ ニュージャージー 細菌の排出ポンプ阻害剤
US11458121B2 (en) 2017-06-26 2022-10-04 Rutgers, The State University Of New Jersey Therapeutic compounds and methods to treat infection
LT3762368T (lt) 2018-03-08 2022-06-10 Incyte Corporation Aminopirazindiolio junginiai, kaip pi3k-γ inhibitoriai
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
EP3863640A4 (en) * 2018-10-10 2022-07-06 Bellus Health Cough Inc. TREATMENT OF PRURITIS WITH P2X3 RECEPTOR ANTAGONISTS
CN111377970B (zh) * 2018-12-28 2022-12-23 广东阿格蕾雅光电材料有限公司 一种n`n`c`n型四齿铂(ii)配合物的制备及应用
AU2020228760A1 (en) 2019-02-25 2021-09-23 Glaxosmithkline Intellectual Property (No. 3) Limited Treatment with P2X3 modulators
CN114222741B (zh) 2019-05-31 2025-12-30 奇斯药制品公司 作为p2x3抑制剂的吡啶并嘧啶类衍生物
CA3139019A1 (en) 2019-05-31 2020-12-03 Chiesi Farmaceutici S.P.A. Amino quinazoline derivatives as p2x3 inhibitors
US20230192631A1 (en) * 2020-04-16 2023-06-22 Hoffmann-La Roche Inc. Biphenyl Derivatives
AU2021386405A1 (en) 2020-11-27 2023-05-25 Chiesi Farmaceutici S.P.A. Phthalazine derivatives as p2x3 inhibitors
US20230416233A1 (en) 2020-11-27 2023-12-28 Chiesi Farmaceutici S.P.A. (aza)quinoline 4-amines derivatives as p2x3 inhibitors
MX2023005803A (es) 2020-11-27 2023-05-29 Chiesi Farm Spa Derivados de amino-quinazolina como inhibidores del purinorreceptor 3 p2x (p2x3).

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2731469A (en) * 1953-10-23 1956-01-17 Searle & Co N-dialkylaminoalkyl derivatives of diarylisonicotinamides
JPS6413083A (en) * 1987-07-07 1989-01-17 Akishiro Nakamura Streptonigrin derivative and medicinal composition
US4916145A (en) * 1987-07-10 1990-04-10 Hoffmann-La Roche Inc. Substituted n-[(pyridyl)alkyl]aryl-carboxamide
GB9600063D0 (en) 1996-01-03 1996-03-06 Fujisawa Pharmaceutical Co Guaridine derivatives
US6037324A (en) * 1996-01-04 2000-03-14 Leukosite, Inc. Inhibitors of MAdCAM-1-mediated interactions and methods of use therefor
WO2002022584A1 (en) 2000-09-11 2002-03-21 Merck & Co., Inc. Thrombin inhibitors
WO2002070469A2 (en) 2001-03-05 2002-09-12 Icos Corporation Selective pde3b inhibitors and use of the same in therapy
EP1392643B1 (en) 2001-05-18 2005-09-14 Abbott Laboratories Trisubstituted-n- (1s)-1,2,3,4-tetrahydro-1-naphthalenyl] benzamides which inhibit p2x3 and p2x2/3 containing receptors
WO2008011131A2 (en) * 2006-07-21 2008-01-24 Takeda Pharmaceutical Company Limited Amide compounds
AR037460A1 (es) 2001-11-30 2004-11-10 Smithkline Beecham Plc Compuesto de hidroxietileno, composicion farmaceutica que lo comprende, uso del mismo para la fabricacion de un medicamento y procedimiento para su preparacion
JP2006506326A (ja) * 2002-05-14 2006-02-23 アキシーズ ファーマシューティカルズ インク. システインプロテアーゼ阻害剤
EP1569954A1 (en) * 2002-12-05 2005-09-07 Axys Pharmaceuticals, Inc. Cyanomethyl derivatives as cysteine protease inhibitors
ATE396973T1 (de) 2003-10-03 2008-06-15 Merck & Co Inc Benzylether- und benzylamino-beta-sekretase- hemmer zur behandlung von alzheimer-krankheit
US20050282824A1 (en) * 2004-05-07 2005-12-22 Xiaobing Li Substituted pyrimidines as inhibitors of bacterial type III protein secretion systems
AU2005245376A1 (en) 2004-05-13 2005-12-01 Merck & Co., Inc. Phenyl carboxamide compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's disease
TW200640877A (en) * 2005-04-28 2006-12-01 Actelion Pharmaceuticals Ltd Pyrimidine derivatives
CA2618474A1 (en) 2005-08-11 2007-02-15 Boehringer Ingelheim International Gmbh Compounds for treating alzheimer's disease
WO2007017511A2 (de) 2005-08-11 2007-02-15 Boehringer Ingelheim International Gmbh Verbindungen zur behandlung der alzheimer erkrankung
BRPI0614577A2 (pt) * 2005-08-15 2011-04-05 Hoffmann La Roche derivados de piperidina e piperazina como antagonistas de p2x3
US7838676B2 (en) * 2005-11-21 2010-11-23 Amgen Inc. Beta-secretase modulators and methods of use
EP2010529A1 (en) 2006-04-10 2009-01-07 PainCeptor Pharma Corp. Compositions and methods for modulating gated ion channels
WO2008000645A1 (en) * 2006-06-29 2008-01-03 F. Hoffmann-La Roche Ag Tetrazole-substituted arylamides
AU2007287428B2 (en) * 2006-08-24 2011-08-11 Astrazeneca Ab Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders
AR063258A1 (es) * 2006-10-13 2009-01-14 Actelion Pharmaceuticals Ltd Derivados de 2-aminocarbonil-piridina, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento de trastornos vasculares oclusivos.
ATE517097T1 (de) * 2006-11-09 2011-08-15 Hoffmann La Roche Thiazol- und oxazolsubstituierte arylamide
WO2008119773A1 (en) 2007-03-30 2008-10-09 Medivir Ab Amide derivatives as inhibitors of aspartyl proteases
JP2011502148A (ja) * 2007-10-31 2011-01-20 メルク・シャープ・エンド・ドーム・コーポレイション 疼痛の治療用としてのp2x3受容体アンタゴニスト
AU2008319309B2 (en) 2007-10-31 2012-09-06 Merck Sharp & Dohme Llc P2X3 receptor antagonists for treatment of pain
US7989454B2 (en) 2007-12-17 2011-08-02 Hoffmann-La Roche Inc. Leukotriene B4 inhibitors
WO2009077371A1 (en) 2007-12-17 2009-06-25 F. Hoffmann-La Roche Ag Tetrazole-substituted arylamide derivatives and their use as p2x3 and/or p2x2/3 purinergic receptor antagonists
PL2234976T3 (pl) 2007-12-17 2013-09-30 Hoffmann La Roche Nowe aryloamidy podstawione pirazolem
CA2708791C (en) 2007-12-17 2016-06-21 F. Hoffmann-La Roche Ag Imidazole-substituted arylamides and uses thereof as p2x receptor antagonists
ES2541662T3 (es) 2007-12-17 2015-07-23 F. Hoffmann-La Roche Ag Derivados arilamida sustituidos con triazol y utilización de los mismos como antagonistas de receptores purinérgicos P2X3 y/o P2X2/3
WO2010051188A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. P2x3, receptor antagonists for treatment of pain
CN102245586B (zh) 2008-12-16 2014-07-09 霍夫曼-拉罗奇有限公司 噻二唑取代的芳基酰胺
US8569512B2 (en) 2009-03-23 2013-10-29 Merck Sharp & Dohme Corp. P2X3 receptor antagonists for treatment of pain
EP2410857B1 (en) 2009-03-23 2014-01-29 Merck Sharp & Dohme Corp. P2x3, receptor antagonists for treatment of pain
US8946231B2 (en) 2009-03-23 2015-02-03 Merck Sharp & Dohme Corp. P2X3, receptor antagonists for treatment of pain
CN102438989B (zh) 2009-06-22 2015-05-27 霍夫曼-拉罗奇有限公司 噁唑酮和吡咯烷酮取代的芳基酰胺
ES2450891T3 (es) 2009-06-22 2014-03-25 F. Hoffmann-La Roche Ag Bifenilamidas útiles como moduladores de receptores P2X3 y/o P2X2/3

Similar Documents

Publication Publication Date Title
JP2012502986A5 (enExample)
JP2008534511A5 (enExample)
US10526291B2 (en) Potent dual BRD4-kinase inhibitors as cancer therapeutics
ES2234564T3 (es) Compuestos de tipo amida y su uso en medicina.
CA2787756C (en) Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof
JP2011514894A5 (enExample)
JP5600754B2 (ja) ピラジン誘導体および神経障害の処置におけるそれらの使用
JP5603308B2 (ja) ヘッジホッグ経路調節剤としての化合物および組成物
JP5579704B2 (ja) フェニルおよびベンゾジオキシニル置換インダゾール誘導体
US8906914B2 (en) Ethylene diamine modulators of fatty acid hydrolase
EP1438973A1 (en) Remedies for stress diseases comprising mitochondrial benzodiazepine receptor antagonists
JP2023540661A (ja) CCR8阻害剤を使用してTregsを標的とする方法および組成物
JP2014525425A5 (enExample)
JP2015533782A (ja) スルファモイル−アリールアミド及びb型肝炎の治療のための薬剤としてのその使用
US9988390B2 (en) Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
JP2010524930A5 (enExample)
WO2015054474A1 (en) Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors
CN101537001A (zh) 作为jak-stat3信号通路抑制剂的化合物的应用
JP2004507538A (ja) 二環式複素環化合物、これらの化合物を含む薬剤、それらの使用、及びその生成方法
WO2007139230A1 (ja) 7員環化合物並びにその製造法および医薬用途
JP5509070B2 (ja) 神経変性疾患の治療のためのアリールアミドピリミドン誘導体
CN108368060B (zh) 一类嘧啶类衍生物激酶抑制剂
JPWO2008136377A1 (ja) 二環式複素環化合物
CN1324350A (zh) 苯甲酰哒嗪
WO2005063689A1 (ja) ベンズアミド誘導体