CA2737038A1 - Amide compounds, compositions and uses thereof - Google Patents

Amide compounds, compositions and uses thereof Download PDF

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Publication number
CA2737038A1
CA2737038A1 CA 2737038 CA2737038A CA2737038A1 CA 2737038 A1 CA2737038 A1 CA 2737038A1 CA 2737038 CA2737038 CA 2737038 CA 2737038 A CA2737038 A CA 2737038A CA 2737038 A1 CA2737038 A1 CA 2737038A1
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Prior art keywords
substituted
unsubstituted
methyl
compound according
alkyl
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CA 2737038
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English (en)
French (fr)
Inventor
Zhi-Liang Wei
Sumithra Gowlugari
Carl Kaub
Zhan Wang
Yeyu Cao
John Kincaid
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Evotec OAI AG
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Evotec OAI AG
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Publication of CA2737038A1 publication Critical patent/CA2737038A1/en
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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