CA2737038A1 - Amide compounds, compositions and uses thereof - Google Patents

Amide compounds, compositions and uses thereof Download PDF

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Publication number
CA2737038A1
CA2737038A1 CA 2737038 CA2737038A CA2737038A1 CA 2737038 A1 CA2737038 A1 CA 2737038A1 CA 2737038 CA2737038 CA 2737038 CA 2737038 A CA2737038 A CA 2737038A CA 2737038 A1 CA2737038 A1 CA 2737038A1
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Prior art keywords
substituted
unsubstituted
methyl
compound according
alkyl
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CA 2737038
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English (en)
French (fr)
Inventor
Zhi-Liang Wei
Sumithra Gowlugari
Carl Kaub
Zhan Wang
Yeyu Cao
John Kincaid
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Evotec OAI AG
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Evotec OAI AG
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Publication of CA2737038A1 publication Critical patent/CA2737038A1/en
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104058999A (zh) * 2008-02-29 2014-09-24 伊沃泰克股份公司 酰胺化合物、组合物及其应用
KR101422901B1 (ko) 2009-02-13 2014-07-23 시오노기 앤드 컴파니, 리미티드 신규 트라이아진 유도체 및 그것을 함유하는 의약 조성물
CA2754654A1 (en) * 2009-06-22 2010-12-29 F. Hoffmann-La Roche Ag Novel oxazolone and pyrrolidinone-substituted arylamides
EP2604595B1 (en) 2010-08-10 2016-03-16 Shionogi&Co., Ltd. Triazine derivative and pharmaceutical compound that contains same and exhibits analgesic activity
US9550763B2 (en) 2012-02-09 2017-01-24 Shionogi & Co., Ltd. Heterocyclic ring and carbocyclic derivative
TWI637949B (zh) 2013-06-14 2018-10-11 塩野義製藥股份有限公司 胺基三衍生物及含有其等之醫藥組合物
WO2015161011A1 (en) * 2014-04-17 2015-10-22 Merck Sharp & Dohme Corp. Benzamide cgrp receptor antagonists
WO2016084922A1 (ja) * 2014-11-28 2016-06-02 塩野義製薬株式会社 １，２，４－トリアジン誘導体およびその医薬組成物
US10183937B2 (en) 2014-12-09 2019-01-22 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides
AU2015359626B2 (en) 2014-12-09 2020-07-23 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides
WO2016169902A1 (en) 2015-04-23 2016-10-27 F. Hoffmann-La Roche Ag Tetrazole derivatives for use in the treatment of psychiatric disorders
WO2017009274A1 (en) * 2015-07-14 2017-01-19 F. Hoffmann-La Roche Ag 2-phenyl-6-imidazolyl-pyridine-4-carboxamide derivatives and their use as eaat3 inhibitors
WO2017025523A1 (en) * 2015-08-12 2017-02-16 F. Hoffmann-La Roche Ag Pyridine and pyrimidine derivatives
EP3359537B1 (en) * 2015-10-06 2020-03-25 H. Hoffnabb-La Roche Ag Triazole derivatives
JP7068277B2 (ja) 2016-10-14 2022-05-16 エフ．ホフマン－ラ ロシュ アーゲー Ｅａａｔ３阻害剤としてのイミダゾール化合物
WO2018165612A1 (en) 2017-03-10 2018-09-13 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors
US11938114B2 (en) 2017-03-10 2024-03-26 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors
BR112019018691A2 (pt) 2017-03-10 2020-04-07 Rutgers, The State University Of New Jersey derivados de indol como inibidores de bomba de efluxo
WO2018218192A1 (en) 2017-05-26 2018-11-29 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors
WO2019005841A1 (en) * 2017-06-26 2019-01-03 Rutgers, The State University Of New Jersey THERAPEUTIC COMPOUNDS AND METHODS FOR TREATING INFECTION
TWI903299B (zh) 2018-03-08 2025-11-01 美商英塞特公司 作為PI3K-γ抑制劑之胺基吡嗪二醇化合物
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
BR112021006889A2 (pt) * 2018-10-10 2021-07-13 Bellus Health Cough Inc. método para tratar prurido em um mamífero
CN111377970B (zh) * 2018-12-28 2022-12-23 广东阿格蕾雅光电材料有限公司 一种n`n`c`n型四齿铂(ii)配合物的制备及应用
WO2020174283A1 (en) 2019-02-25 2020-09-03 Bellus Health Cough Inc. Treatment with p2x3 modulators
KR102923602B1 (ko) 2019-05-31 2026-02-06 키에시 파르마슈티시 엣스. 피. 에이. P2x3 억제제로서 피리도피리미딘 유도체
KR102921974B1 (ko) 2019-05-31 2026-02-05 키에시 파르마슈티시 엣스. 피. 에이. P2x3 억제제로서 아미노 퀴나졸린 유도체
CN115397813A (zh) * 2020-04-16 2022-11-25 豪夫迈·罗氏有限公司 联苯衍生物
WO2022112491A1 (en) 2020-11-27 2022-06-02 Chiesi Farmaceutici S.P.A. (aza)quinoline 4-amines derivatives as p2x3 inhibitors
EP4251273B1 (en) 2020-11-27 2025-03-12 Chiesi Farmaceutici S.p.A. Phthalazine derivatives as p2x3 inhibitors
CA3196333A1 (en) 2020-11-27 2022-06-02 Claudio FIORELLI Amino quinazoline derivatives as p2x3 inhibitors

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2731469A (en) * 1953-10-23 1956-01-17 Searle & Co N-dialkylaminoalkyl derivatives of diarylisonicotinamides
JPS6413083A (en) * 1987-07-07 1989-01-17 Akishiro Nakamura Streptonigrin derivative and medicinal composition
US4916145A (en) * 1987-07-10 1990-04-10 Hoffmann-La Roche Inc. Substituted n-[(pyridyl)alkyl]aryl-carboxamide
GB9600063D0 (en) 1996-01-03 1996-03-06 Fujisawa Pharmaceutical Co Guaridine derivatives
US6037324A (en) * 1996-01-04 2000-03-14 Leukosite, Inc. Inhibitors of MAdCAM-1-mediated interactions and methods of use therefor
AU2001294557A1 (en) 2000-09-11 2002-03-26 Merck And Co., Inc. Thrombin inhibitors
AU2002247208A1 (en) 2001-03-05 2002-09-19 Icos Corporation Selective pde3b inhibitors and use of the same in therapy
DE60206164T2 (de) 2001-05-18 2006-06-22 Abbott Laboratories, Abbott Park Trisubstituierte-n-((1s)-1,2,3,4-tetrahydro-1-naphthalenyl) benzamide welche p2x3 und p2x2/3 enthaltende rezeptoren inhibieren
AR037460A1 (es) 2001-11-30 2004-11-10 Smithkline Beecham Plc Compuesto de hidroxietileno, composicion farmaceutica que lo comprende, uso del mismo para la fabricacion de un medicamento y procedimiento para su preparacion
EP1503997A1 (en) * 2002-05-14 2005-02-09 Axys Pharmaceuticals, Inc. Cysteine protease inhibitors
CA2506114A1 (en) * 2002-12-05 2004-06-24 Axys Pharmaceuticals, Inc. Cyanomethyl derivatives as cysteine protease inhibitors
CA2540452A1 (en) 2003-10-03 2005-04-14 Merck & Co., Inc. Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease
WO2005113514A2 (en) * 2004-05-07 2005-12-01 Janssen Pharmaceutica, N.V. Substituted pyrimidines as inhibitors of bacterial type iii protein secretion systems
US7449599B2 (en) 2004-05-13 2008-11-11 Merck + Co Inc. Phenyl carboxamide compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
TW200640877A (en) * 2005-04-28 2006-12-01 Actelion Pharmaceuticals Ltd Pyrimidine derivatives
JP2009504614A (ja) 2005-08-11 2009-02-05 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング アルツハイマー病の治療用化合物
CA2618474A1 (en) * 2005-08-11 2007-02-15 Boehringer Ingelheim International Gmbh Compounds for treating alzheimer's disease
ES2376642T3 (es) * 2005-08-15 2012-03-15 F. Hoffmann-La Roche Ag Derivados de piperidina y de piperazina como antagonistas del p2x3.
US7838676B2 (en) * 2005-11-21 2010-11-23 Amgen Inc. Beta-secretase modulators and methods of use
CA2652307A1 (en) 2006-04-10 2007-10-18 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
EP2592070B1 (en) * 2006-06-29 2016-08-31 F. Hoffmann-La Roche AG Tetrazole-substituted arylamides
JP2009544616A (ja) * 2006-07-21 2009-12-17 武田薬品工業株式会社 アミド化合物
WO2008023159A1 (en) * 2006-08-24 2008-02-28 Astrazeneca Ab Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders
CL2007002920A1 (es) * 2006-10-13 2008-06-06 Actelion Pharmaceuticals Ltd Compuestos derivados de 2-aminocarbonilpiridina; composicion farmaceutica; y uso para el tratamiento de trastornos vasculares oclusivos.
KR101165936B1 (ko) * 2006-11-09 2012-07-19 에프. 호프만-라 로슈 아게 티아졸 및 옥사졸-치환된 아릴아마이드
WO2008119773A1 (en) 2007-03-30 2008-10-09 Medivir Ab Amide derivatives as inhibitors of aspartyl proteases
ES2553412T3 (es) 2007-10-31 2015-12-09 Merck Sharp & Dohme Corp. Antagonistas del receptor P2X3 para el tratamiento del dolor
EP2215049B1 (en) * 2007-10-31 2019-06-12 Merck Sharp & Dohme Corp. P2x3, receptor antagonists for treatment of pain
US7989454B2 (en) 2007-12-17 2011-08-02 Hoffmann-La Roche Inc. Leukotriene B4 inhibitors
JP5318882B2 (ja) 2007-12-17 2013-10-16 エフ．ホフマン−ラ ロシュ アーゲー 新規なイミダゾール置換アリールアミド
SI2234976T1 (sl) 2007-12-17 2013-07-31 F. Hoffmann-La Roche Ag Novi s pirazolom substituirani arilamidi
ES2542245T3 (es) 2007-12-17 2015-08-03 F. Hoffmann-La Roche Ag Derivados de arilamida sustituido con triazol y su utilización como antagonistas del receptor purinérgico P2x3 y/o P2x2/3
WO2009077371A1 (en) 2007-12-17 2009-06-25 F. Hoffmann-La Roche Ag Tetrazole-substituted arylamide derivatives and their use as p2x3 and/or p2x2/3 purinergic receptor antagonists
EP2358371B1 (en) 2008-10-31 2015-02-11 Merck Sharp & Dohme Corp. P2x3, receptor antagonists for treatment of pain
CA2745290A1 (en) 2008-12-16 2010-06-24 F. Hoffmann-La Roche Ag Thiadiazole-substituted arylamides as p2x3 and p2x2/3 antagonists
AU2010229142A1 (en) 2009-03-23 2011-10-13 Merck Sharp & Dohme Corp. P2X3, receptor antagonists for treatment of pain
WO2010111060A1 (en) 2009-03-23 2010-09-30 Merck Sharp & Dohme Corp. P2x3, receptor antagonists for treatment of pain
WO2010111059A1 (en) 2009-03-23 2010-09-30 Merck Sharp & Dohme Corp. P2x3 receptor antagonists for treatment of pain
EP2445868B1 (en) 2009-06-22 2013-12-18 F.Hoffmann-La Roche Ag Biphenyl amides useful as p2x3 and/or p2x2/3 receptors modulators
CA2754654A1 (en) 2009-06-22 2010-12-29 F. Hoffmann-La Roche Ag Novel oxazolone and pyrrolidinone-substituted arylamides

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