JP5608655B2 - Ｐ２ｘ３受容体活性のモジュレーター - Google Patents

Ｐ２ｘ３受容体活性のモジュレーター Download PDF

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JP5608655B2
JP5608655B2 JP2011527808A JP2011527808A JP5608655B2 JP 5608655 B2 JP5608655 B2 JP 5608655B2 JP 2011527808 A JP2011527808 A JP 2011527808A JP 2011527808 A JP2011527808 A JP 2011527808A JP 5608655 B2 JP5608655 B2 JP 5608655B2
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JP2012502986A5 (enExample
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チ−リャン ウェイ，
スミスラ ゴウルガリ，
カール カウブ，
チャン ワン，
イェユ カオ，
ジョン キンケイド，
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エヴォテック アーゲー
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Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2715835C (en) * 2008-02-29 2017-03-21 Renovis, Inc. Amide compounds, compositions and uses thereof
KR101422901B1 (ko) 2009-02-13 2014-07-23 시오노기 앤드 컴파니, 리미티드 신규 트라이아진 유도체 및 그것을 함유하는 의약 조성물
ES2593405T3 (es) * 2009-06-22 2016-12-09 F. Hoffmann-La Roche Ag Nuevas arilamidas sustituidas por benzoxazolona
MX346367B (es) 2010-08-10 2017-03-16 Shionogi & Co Ltd * Derivado de triazina y composicion farmaceutica que tiene actividad analgesica que comprende el mismo.
US9550763B2 (en) 2012-02-09 2017-01-24 Shionogi & Co., Ltd. Heterocyclic ring and carbocyclic derivative
TWI637949B (zh) 2013-06-14 2018-10-11 塩野義製藥股份有限公司 胺基三衍生物及含有其等之醫藥組合物
WO2015161011A1 (en) * 2014-04-17 2015-10-22 Merck Sharp & Dohme Corp. Benzamide cgrp receptor antagonists
JPWO2016084922A1 (ja) * 2014-11-28 2017-09-07 塩野義製薬株式会社 １，２，４−トリアジン誘導体およびその医薬組成物
EP3587417B9 (en) 2014-12-09 2022-03-30 Bayer AG 1,3-thiazol-2-yl substituted benzamides
US10183937B2 (en) 2014-12-09 2019-01-22 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides
JP6518789B2 (ja) 2015-04-23 2019-05-22 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 精神障害の処置において使用するためのテトラゾール誘導体
EP3322699B1 (en) 2015-07-14 2019-05-15 H. Hoffnabb-La Roche Ag 2-phenyl-6-imidazolyl-pyridine-4-carboxamide derivatives and their use as eaat3 inhibitors
EP3334727B1 (en) * 2015-08-12 2019-05-15 H. Hoffnabb-La Roche Ag Pyridine and pyrimidine derivatives
JP6831376B2 (ja) * 2015-10-06 2021-02-17 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ トリアゾール誘導体
CN109563049B (zh) 2016-10-14 2022-11-29 豪夫迈·罗氏有限公司 作为eaat3抑制剂的咪唑化合物
US11938114B2 (en) 2017-03-10 2024-03-26 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors
US11180459B2 (en) 2017-03-10 2021-11-23 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors
CA3061238A1 (en) 2017-03-10 2018-09-13 Rutgers, The State University Of New Jersey Indole derivatives as efflux pump inhibitors
CN111163774A (zh) 2017-05-26 2020-05-15 罗格斯新泽西州立大学 细菌外排泵抑制剂
US11458121B2 (en) 2017-06-26 2022-10-04 Rutgers, The State University Of New Jersey Therapeutic compounds and methods to treat infection
BR112020018094A2 (pt) 2018-03-08 2020-12-22 Incyte Corporation Compostos de aminopirazina diol como inibidores de pi3k-¿
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
JP2022512652A (ja) * 2018-10-10 2022-02-07 べルス・ヘルス・コフ・インコーポレーテッド Ｐ２ｘ３拮抗薬での皮膚掻痒症の治療
CN111377970B (zh) * 2018-12-28 2022-12-23 广东阿格蕾雅光电材料有限公司 一种n`n`c`n型四齿铂(ii)配合物的制备及应用
CN113727716A (zh) 2019-02-25 2021-11-30 贝卢斯医疗咳嗽病公司 采用p2x3调节剂的治疗
CN114222741B (zh) 2019-05-31 2025-12-30 奇斯药制品公司 作为p2x3抑制剂的吡啶并嘧啶类衍生物
PE20220934A1 (es) 2019-05-31 2022-05-31 Chiesi Farm Spa Derivados de aminoquinazolina como inhibidores del purinoreceptor 3 de p2x (p2x3)
US20230192631A1 (en) * 2020-04-16 2023-06-22 Hoffmann-La Roche Inc. Biphenyl Derivatives
AU2021386684A1 (en) 2020-11-27 2023-05-25 Chiesi Farmaceutici S.P.A. (aza)quinoline 4-amines derivatives as p2x3 inhibitors
MX2023005801A (es) 2020-11-27 2023-05-29 Chiesi Farm Spa Derivados de ftalazina como inhibidores de purinoceptor 3 de p2x (p2x3).
ES3026309T3 (en) 2020-11-27 2025-06-11 Chiesi Farm Spa Amino quinazoline derivatives as p2x3 inhibitors

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2731469A (en) * 1953-10-23 1956-01-17 Searle & Co N-dialkylaminoalkyl derivatives of diarylisonicotinamides
JPS6413083A (en) * 1987-07-07 1989-01-17 Akishiro Nakamura Streptonigrin derivative and medicinal composition
US4916145A (en) * 1987-07-10 1990-04-10 Hoffmann-La Roche Inc. Substituted n-[(pyridyl)alkyl]aryl-carboxamide
GB9600063D0 (en) 1996-01-03 1996-03-06 Fujisawa Pharmaceutical Co Guaridine derivatives
US6037324A (en) * 1996-01-04 2000-03-14 Leukosite, Inc. Inhibitors of MAdCAM-1-mediated interactions and methods of use therefor
AU2001294557A1 (en) 2000-09-11 2002-03-26 Merck And Co., Inc. Thrombin inhibitors
AU2002247208A1 (en) 2001-03-05 2002-09-19 Icos Corporation Selective pde3b inhibitors and use of the same in therapy
EP1392643B1 (en) 2001-05-18 2005-09-14 Abbott Laboratories Trisubstituted-n- (1s)-1,2,3,4-tetrahydro-1-naphthalenyl] benzamides which inhibit p2x3 and p2x2/3 containing receptors
AR037460A1 (es) * 2001-11-30 2004-11-10 Smithkline Beecham Plc Compuesto de hidroxietileno, composicion farmaceutica que lo comprende, uso del mismo para la fabricacion de un medicamento y procedimiento para su preparacion
CA2484011A1 (en) * 2002-05-14 2003-11-27 Axys Pharmaceuticals, Inc. Cysteine protease inhibitors
EP1569954A1 (en) * 2002-12-05 2005-09-07 Axys Pharmaceuticals, Inc. Cyanomethyl derivatives as cysteine protease inhibitors
DE602004014170D1 (de) 2003-10-03 2008-07-10 Merck & Co Inc Benzylether- und benzylamino-beta-sekretase-hemmer zur behandlung von alzheimer-krankheit
WO2005113514A2 (en) * 2004-05-07 2005-12-01 Janssen Pharmaceutica, N.V. Substituted pyrimidines as inhibitors of bacterial type iii protein secretion systems
AU2005245376A1 (en) 2004-05-13 2005-12-01 Merck & Co., Inc. Phenyl carboxamide compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's disease
TW200640877A (en) * 2005-04-28 2006-12-01 Actelion Pharmaceuticals Ltd Pyrimidine derivatives
US20100168070A1 (en) * 2005-08-11 2010-07-01 Niklas Heine Compounds for the treatment of alzheimer's disease
WO2007017511A2 (de) 2005-08-11 2007-02-15 Boehringer Ingelheim International Gmbh Verbindungen zur behandlung der alzheimer erkrankung
CN101282972A (zh) * 2005-08-15 2008-10-08 弗·哈夫曼-拉罗切有限公司 作为p2x3拮抗剂的哌啶和哌嗪衍生物
US7838676B2 (en) * 2005-11-21 2010-11-23 Amgen Inc. Beta-secretase modulators and methods of use
WO2007115410A1 (en) 2006-04-10 2007-10-18 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
CA2654915C (en) * 2006-06-29 2015-07-28 F.Hoffmann-La Roche Ag Tetrazole-substituted arylamides
EP2044055A4 (en) * 2006-07-21 2011-03-23 Takeda Pharmaceutical amide compounds
CA2660758A1 (en) * 2006-08-24 2008-02-27 Astrazeneca Ab Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders
CL2007002920A1 (es) * 2006-10-13 2008-06-06 Actelion Pharmaceuticals Ltd Compuestos derivados de 2-aminocarbonilpiridina; composicion farmaceutica; y uso para el tratamiento de trastornos vasculares oclusivos.
BRPI0718714B8 (pt) * 2006-11-09 2021-05-25 Hoffmann La Roche arilamidas substituídas por tiazol e oxazol, seu uso e composição farmacêutica que as compreende
WO2008119773A1 (en) 2007-03-30 2008-10-09 Medivir Ab Amide derivatives as inhibitors of aspartyl proteases
JP2011502148A (ja) * 2007-10-31 2011-01-20 メルク・シャープ・エンド・ドーム・コーポレイション 疼痛の治療用としてのｐ２ｘ３受容体アンタゴニスト
US8461185B2 (en) 2007-10-31 2013-06-11 Merck Sharp & Dohme Corp. P2X3 receptor antagonists for treatment of pain
US7989454B2 (en) 2007-12-17 2011-08-02 Hoffmann-La Roche Inc. Leukotriene B4 inhibitors
JP5318882B2 (ja) 2007-12-17 2013-10-16 エフ．ホフマン−ラ ロシュ アーゲー 新規なイミダゾール置換アリールアミド
ES2542245T3 (es) 2007-12-17 2015-08-03 F. Hoffmann-La Roche Ag Derivados de arilamida sustituido con triazol y su utilización como antagonistas del receptor purinérgico P2x3 y/o P2x2/3
PT2234976E (pt) 2007-12-17 2013-07-11 Hoffmann La Roche Novas arilamidas substituídas por pirazol
WO2009077371A1 (en) 2007-12-17 2009-06-25 F. Hoffmann-La Roche Ag Tetrazole-substituted arylamide derivatives and their use as p2x3 and/or p2x2/3 purinergic receptor antagonists
AU2009309019B2 (en) 2008-10-31 2014-11-13 Merck Sharp & Dohme Llc P2X3, receptor antagonists for treatment of pain
MX2011006027A (es) 2008-12-16 2011-06-21 Hoffmann La Roche Arilamidas tiadiazol-sustituidas.
US9238647B2 (en) 2009-03-23 2016-01-19 Merck Sharp & Dohme Corp. P2X3 receptor antagonists for treatment of pain
WO2010111060A1 (en) 2009-03-23 2010-09-30 Merck Sharp & Dohme Corp. P2x3, receptor antagonists for treatment of pain
EP2410858B1 (en) 2009-03-23 2016-09-07 Merck Sharp & Dohme Corp. P2x3 receptor antagonists for treatment of pain
ES2593405T3 (es) 2009-06-22 2016-12-09 F. Hoffmann-La Roche Ag Nuevas arilamidas sustituidas por benzoxazolona
JP5476467B2 (ja) 2009-06-22 2014-04-23 エフ．ホフマン−ラ ロシュ アーゲー 新規なビフェニルピリジンアミドおよびフェニルピリジンアミド

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