JP2007519619A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007519619A5 JP2007519619A5 JP2006542704A JP2006542704A JP2007519619A5 JP 2007519619 A5 JP2007519619 A5 JP 2007519619A5 JP 2006542704 A JP2006542704 A JP 2006542704A JP 2006542704 A JP2006542704 A JP 2006542704A JP 2007519619 A5 JP2007519619 A5 JP 2007519619A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- group
- phenyl
- propyl
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52634803P | 2003-12-02 | 2003-12-02 | |
| US60/526,348 | 2003-12-02 | ||
| PCT/US2004/040211 WO2005055928A2 (en) | 2003-12-02 | 2004-12-01 | Zn2+ -chelating motif-tethered short -chain fatty acids as a novel class of histone deacetylase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011144993A Division JP5702681B2 (ja) | 2003-12-02 | 2011-06-29 | 新規の種類のヒストン脱アセチル化酵素阻害剤としてのZn2+キレートモチーフ係留短鎖脂肪酸 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007519619A JP2007519619A (ja) | 2007-07-19 |
| JP2007519619A5 true JP2007519619A5 (enExample) | 2011-08-18 |
| JP5107579B2 JP5107579B2 (ja) | 2012-12-26 |
Family
ID=34676611
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006542704A Expired - Fee Related JP5107579B2 (ja) | 2003-12-02 | 2004-12-01 | 新規の種類のヒストン脱アセチル化酵素阻害剤としてのZn2+キレートモチーフ係留短鎖脂肪酸 |
| JP2011144993A Expired - Fee Related JP5702681B2 (ja) | 2003-12-02 | 2011-06-29 | 新規の種類のヒストン脱アセチル化酵素阻害剤としてのZn2+キレートモチーフ係留短鎖脂肪酸 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011144993A Expired - Fee Related JP5702681B2 (ja) | 2003-12-02 | 2011-06-29 | 新規の種類のヒストン脱アセチル化酵素阻害剤としてのZn2+キレートモチーフ係留短鎖脂肪酸 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9115090B2 (enExample) |
| EP (1) | EP1696898B1 (enExample) |
| JP (2) | JP5107579B2 (enExample) |
| AU (1) | AU2004296764B2 (enExample) |
| CA (1) | CA2552279C (enExample) |
| DK (1) | DK1696898T3 (enExample) |
| ES (1) | ES2562778T3 (enExample) |
| HU (1) | HUE028490T2 (enExample) |
| WO (1) | WO2005055928A2 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| JP2006520796A (ja) | 2003-03-17 | 2006-09-14 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼインヒビター |
| AU2004296764B2 (en) | 2003-12-02 | 2011-04-28 | The Ohio State University Research Foundation | Zn2+ -chelating motif-tethered short -chain fatty acids as a novel class of histone deacetylase inhibitors |
| AU2005271841A1 (en) * | 2004-07-12 | 2006-02-16 | Merck & Co., Inc. | Inhibitors of histone deacetylase |
| WO2006066133A2 (en) | 2004-12-16 | 2006-06-22 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7642253B2 (en) | 2005-05-11 | 2010-01-05 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| KR20080032188A (ko) | 2005-07-14 | 2008-04-14 | 다케다 샌디에고, 인코포레이티드 | 히스톤 탈아세틸화 효소 억제제 |
| KR20080086514A (ko) * | 2005-12-19 | 2008-09-25 | 메틸진 인크. | 항진균제의 활성을 증가시키기 위한 히스톤 데아세틸라제억제제 |
| CA2672192A1 (en) * | 2006-12-19 | 2008-06-26 | Methylgene Inc. | Inhibitors of histone deacetylase and prodrugs thereof |
| US8796330B2 (en) | 2006-12-19 | 2014-08-05 | Methylgene Inc. | Inhibitors of histone deacetylase and prodrugs thereof |
| CN101417967A (zh) * | 2007-10-26 | 2009-04-29 | 浙江海正药业股份有限公司 | 组蛋白去乙酰酶抑制剂、其组合物及其应用 |
| CA2735593C (en) | 2008-09-03 | 2017-08-15 | Repligen Corporation | Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors |
| WO2010065446A2 (en) * | 2008-12-01 | 2010-06-10 | The Procter & Gamble Company | Perfume systems |
| GB0903480D0 (en) * | 2009-02-27 | 2009-04-08 | Chroma Therapeutics Ltd | Enzyme Inhibitors |
| WO2010144371A1 (en) * | 2009-06-08 | 2010-12-16 | Gilead Colorado, Inc. | Alkanoylamino benzamide aniline hdac inihibitor compounds |
| WO2011103563A1 (en) * | 2010-02-22 | 2011-08-25 | Arno Therapeutics, Inc | Methods and compositions for inhibiting and preventing the growth of malignant mast cells |
| US8546588B2 (en) * | 2010-02-26 | 2013-10-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US20110212969A1 (en) * | 2010-02-26 | 2011-09-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US20140107166A1 (en) * | 2011-02-14 | 2014-04-17 | Dana-Farber Cancer Institute, Inc. | Histone deacetylase inhibitors and methods of use thereof |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| EP3524324A1 (en) | 2011-02-28 | 2019-08-14 | BioMarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| WO2013041407A1 (en) * | 2011-09-19 | 2013-03-28 | Cellzome Ag | Hydroxamic acids as hdac6 inhibitors |
| EP2763531A4 (en) * | 2011-10-03 | 2015-11-18 | Univ Columbia | NEW MOLECULES FOR THE SELECTIVE INHIBITION OF HISTONDEACETYLASE 6 IN RELATION TO HISTONDEACETYLASE 1 |
| WO2014164784A1 (en) * | 2013-03-12 | 2014-10-09 | Arno Therapeutics | Hdac inhibitor polymorphic forms and methods of use |
| US10029988B2 (en) | 2013-03-15 | 2018-07-24 | Biomarin Pharmaceutical Inc. | HDAC inhibitors |
| KR102091037B1 (ko) | 2013-11-20 | 2020-03-19 | 오하이오 스테이트 이노베이션 파운데이션 | 암-관련 카켁시아를 억제하기 위한 hdac 억제제 |
| CA2933907A1 (en) | 2013-12-23 | 2015-07-02 | The Trustees Of Columbia University In The City Of New York | Selective hdac6 inhibitors |
| US10442788B2 (en) | 2015-04-01 | 2019-10-15 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US10738035B2 (en) | 2015-05-13 | 2020-08-11 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US20180141965A1 (en) * | 2015-05-18 | 2018-05-24 | National And Kapodistrian University Of Athens | Autotaxin inhibitors and uses thereof |
| WO2017011552A1 (en) | 2015-07-13 | 2017-01-19 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| WO2017015451A1 (en) * | 2015-07-22 | 2017-01-26 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| US10301255B2 (en) | 2015-07-22 | 2019-05-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US10022342B2 (en) | 2015-09-02 | 2018-07-17 | Ohio State Innovation Foundation | Methods and compositions for treating multiple myeloma |
| US10280175B2 (en) | 2016-02-02 | 2019-05-07 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| BR112018067964B1 (pt) | 2016-03-07 | 2024-01-16 | Enanta Pharmaceuticals, Inc | Composto, composição farmacêutica que o compreende e uso do referido composto |
| MX2018015315A (es) | 2016-06-10 | 2019-04-25 | Enanta Pharm Inc | Agentes antivirales contra la hepatitis b. |
| WO2018223122A1 (en) * | 2017-06-02 | 2018-12-06 | Ohio State Innovation Foundation | Hdac3-selective inhibitors |
| IL272941B2 (en) | 2017-08-28 | 2023-03-01 | Enanta Pharm Inc | Antiviral agents for viral hepatitis b |
| TW201936192A (zh) | 2017-12-06 | 2019-09-16 | 美商因那塔製藥公司 | B 型肝炎抗病毒試劑 |
| TW201927789A (zh) | 2017-12-06 | 2019-07-16 | 美商因那塔製藥公司 | B型肝炎抗病毒試劑 |
| WO2019130346A1 (en) * | 2017-12-27 | 2019-07-04 | K Syed Zameer Ahmed | Novel phenolic compounds from nerium indicum with anti-breast cancer activity |
| US11058678B2 (en) | 2018-01-22 | 2021-07-13 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| WO2019191166A1 (en) | 2018-03-29 | 2019-10-03 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| WO2020061435A1 (en) | 2018-09-21 | 2020-03-26 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| KR102819704B1 (ko) | 2018-11-21 | 2025-06-11 | 이난타 파마슈티칼스, 인코포레이티드 | 항바이러스제로서의 작용화된 헤테로사이클 |
| US11236111B2 (en) | 2019-06-03 | 2022-02-01 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US11760755B2 (en) | 2019-06-04 | 2023-09-19 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US11472808B2 (en) | 2019-06-04 | 2022-10-18 | Enanta Pharmaceuticals, Inc. | Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents |
| US11738019B2 (en) | 2019-07-11 | 2023-08-29 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| WO2021055425A2 (en) | 2019-09-17 | 2021-03-25 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| WO2021188414A1 (en) | 2020-03-16 | 2021-09-23 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
| HRP20251279T1 (hr) | 2020-04-30 | 2025-12-05 | Great Novel Therapeutics Biotech & Medicals Corporation | Inhibitori histon deacetilaze za imunomodulaciju u tumorskom mikrookruženju |
| CN112225737B (zh) * | 2020-12-11 | 2021-04-09 | 北京鑫开元医药科技有限公司 | 具有hdac抑制活性的化合物、制备方法、组合物及用途 |
| CN112516142B (zh) * | 2020-12-11 | 2021-10-15 | 北京华氏精恒医药科技有限公司 | 一种具有hdac抑制活性的药物组合物、制备方法及其用途 |
| CN114539098B (zh) * | 2022-02-26 | 2024-05-24 | 青岛大学 | 一种双功能hdac6抑制剂、合成方法及应用 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5668650A (en) * | 1979-11-07 | 1981-06-09 | Otsuka Pharmaceut Co Ltd | Benzoic acid amide derivative |
| DE3607993A1 (de) | 1986-03-11 | 1987-09-17 | Basf Ag | Verfahren zur herstellung von diaziridinen und produkte daraus |
| NZ219974A (en) * | 1986-04-22 | 1989-08-29 | Goedecke Ag | N-(2'-aminophenyl)-benzamide derivatives, process for their preparation and their use in the control of neoplastic diseases |
| US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5369108A (en) * | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| ATE195530T1 (de) * | 1992-05-20 | 2000-09-15 | Merck & Co Inc | 17-ether und thioether von 4-aza-steroiden |
| CA2135173A1 (en) * | 1992-05-20 | 1993-11-25 | Bruce E. Witzel | Ester derivatives of 4-aza-steroids |
| US5783593A (en) * | 1993-11-04 | 1998-07-21 | Abbott Laboratories | Inhibitors of squalene synthetase and protein farnesyltransferase |
| US5958957A (en) * | 1996-04-19 | 1999-09-28 | Novo Nordisk A/S | Modulators of molecules with phosphotyrosine recognition units |
| IT1283637B1 (it) * | 1996-05-14 | 1998-04-23 | Italfarmaco Spa | Composti ad attivita' antinfiammatoria ed immunosoppressiva |
| JP3354090B2 (ja) | 1996-09-30 | 2002-12-09 | シエーリング アクチエンゲゼルシャフト | 分化誘導剤 |
| US6174905B1 (en) * | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
| US5776888A (en) * | 1997-02-07 | 1998-07-07 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6045829A (en) * | 1997-02-13 | 2000-04-04 | Elan Pharma International Limited | Nanocrystalline formulations of human immunodeficiency virus (HIV) protease inhibitors using cellulosic surface stabilizers |
| US6034584A (en) * | 1997-08-06 | 2000-03-07 | Allen-Bradley Company, Llc | Arrangement for mechanically coupling an overload relay to a contactor |
| JP4405602B2 (ja) | 1998-04-16 | 2010-01-27 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | ヒストン脱アセチル化酵素阻害剤 |
| CA2333554A1 (en) * | 1998-06-17 | 1999-12-23 | Chu-Baio Xue | Cyclic hydroxamic acids as metalloproteinase inhibitors |
| US6320078B1 (en) | 1998-07-24 | 2001-11-20 | Mitsui Chemicals, Inc. | Method of producing benzamide derivatives |
| US7658938B2 (en) * | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
| JP2001081031A (ja) | 1999-08-30 | 2001-03-27 | Schering Ag | 溶解性および経口吸収性を改善したベンズアミド誘導体含有製剤 |
| JP2003513912A (ja) * | 1999-11-10 | 2003-04-15 | ワーナー−ランバート・カンパニー | 組合せ化学療法 |
| EP1233958B1 (en) | 1999-11-23 | 2011-06-29 | MethylGene Inc. | Inhibitors of histone deacetylase |
| SK13072002A3 (sk) * | 2000-03-17 | 2003-08-05 | Bristol-Myers Squibb Pharma Company | Deriváty cyklických beta-aminokyselín ako inhibítory matrixových metaloproteáz a TNF-alfa |
| EP1280764B1 (en) | 2000-03-24 | 2010-11-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| PE20020354A1 (es) * | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| ATE310719T1 (de) * | 2000-09-29 | 2005-12-15 | Topotarget Uk Ltd | Carbaminsäurederivate enthaltend eine amidgruppe als hdac-inhibitoren |
| US20020172967A1 (en) * | 2001-02-13 | 2002-11-21 | Gadek Thomas R. | Identification of non-covalent complexes by mass spectrometry |
| JPWO2002074298A1 (ja) | 2001-03-21 | 2004-07-08 | 小野薬品工業株式会社 | Il−6産生阻害剤 |
| ITMI20011733A1 (it) * | 2001-08-07 | 2003-02-07 | Italfarmaco Spa | Derivati dell'acido idrossamico inibitori degli enzimi istone deacetilasi, quali nuovi farmaci antiinfiammatori inibenti la sintesi di citoc |
| JP3681673B2 (ja) | 2001-10-31 | 2005-08-10 | Jfe炉材株式会社 | 高炉樋用不定形耐火物 |
| JP2003137866A (ja) * | 2001-11-01 | 2003-05-14 | Sankyo Co Ltd | フェニレンジアミン誘導体 |
| WO2003070691A1 (en) | 2002-02-21 | 2003-08-28 | Osaka Industrial Promotion Organization | N-hydroxycarboxamide derivative |
| WO2004006867A2 (en) * | 2002-03-15 | 2004-01-22 | Wayne State University | 2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purine antiviral agents |
| US20030225054A1 (en) * | 2002-06-03 | 2003-12-04 | Jingwu Duan | Combined use of tace inhibitors and COX2 inhibitors as anti-inflammatory agents |
| TW200426138A (en) | 2002-12-10 | 2004-12-01 | Hoffmann La Roche | Novel arylene-carboxylic acid (2-amino-phenyl)-amide derivatives, their manufacture and use as pharmaceutical agents |
| ITMI20030025A1 (it) * | 2003-01-10 | 2004-07-11 | Italfarmaco Spa | Derivati dell'acido idrossammico ad attivita' antinfiammatoria. |
| EP1617808A4 (en) * | 2003-04-25 | 2011-11-02 | Penn State Res Found | METHOD AND SYSTEM FOR THE SYSTEMIC DISTRIBUTION OF GROWTH-INHIBITORS OF LIPID-DERIVED BIOACTIVE COMPOUNDS |
| EP1660437B1 (en) * | 2003-08-26 | 2008-10-15 | Amorepacific Corporation | Hydroxamic acid derivatives and the method for preparing thereof |
| JP4939941B2 (ja) * | 2003-08-26 | 2012-05-30 | 株式會社アモーレパシフィック | ヒドロキサム酸誘導体及びその製造方法 |
| AU2004296764B2 (en) | 2003-12-02 | 2011-04-28 | The Ohio State University Research Foundation | Zn2+ -chelating motif-tethered short -chain fatty acids as a novel class of histone deacetylase inhibitors |
| ES2401138T3 (es) * | 2004-08-13 | 2013-04-17 | Genentech, Inc. | Inhibidores basados en tiazol de enzimas que usan ATP |
-
2004
- 2004-12-01 AU AU2004296764A patent/AU2004296764B2/en not_active Ceased
- 2004-12-01 JP JP2006542704A patent/JP5107579B2/ja not_active Expired - Fee Related
- 2004-12-01 CA CA 2552279 patent/CA2552279C/en not_active Expired - Lifetime
- 2004-12-01 ES ES04812666.8T patent/ES2562778T3/es not_active Expired - Lifetime
- 2004-12-01 WO PCT/US2004/040211 patent/WO2005055928A2/en not_active Ceased
- 2004-12-01 US US10/597,022 patent/US9115090B2/en active Active
- 2004-12-01 EP EP04812666.8A patent/EP1696898B1/en not_active Expired - Lifetime
- 2004-12-01 DK DK04812666.8T patent/DK1696898T3/en active
- 2004-12-01 HU HUE04812666A patent/HUE028490T2/en unknown
-
2009
- 2009-01-29 US US12/361,626 patent/US8318808B2/en active Active
-
2011
- 2011-06-29 JP JP2011144993A patent/JP5702681B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007519619A5 (enExample) | ||
| KR920021578A (ko) | 포스프노/비아릴 치환된 디펩티드 유도체 | |
| US6927228B2 (en) | Biaromatic compound activators of PPARγ-type receptors | |
| RU2437877C2 (ru) | Новые производные тиофена в качестве агонистов рецептора s1p1/edg1 | |
| CA2458035A1 (en) | Quaternary ammonium salts of omega-aminoalkylamides of r-2-aryl-propionic acids and pharmaceutical compositions containing them | |
| AR048306A1 (es) | Derivados de acidos carboxilicos aromaticos con capacidad moduladora de los niveles de insulina, composiciones farmaceuticas que los contienen y su uso en el tratamiento de trastornos metabolicos que responden a la regulacion de gpr40 | |
| US7589232B2 (en) | Alkynyl aryl carboxamides | |
| RU2011110435A (ru) | Пролекарства метилгидрофумарата, фармацетические композиции с ними и способы применения | |
| KR910004543A (ko) | Acat 억제제 | |
| JP2019503386A5 (enExample) | ||
| RU2008106058A (ru) | Производные пиридазинона в качестве агонистов рецептора тиреоидного гормона | |
| NO20062030L (no) | Derivater av N-heterocyklylmetylbenzamider, fremgangsmate for fremstilling derav og anvendelse av forbindelsene t terapeutiske midler. | |
| CA2446326A1 (en) | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders | |
| CA2396158A1 (en) | Dipeptide nitrile cathepsin k inhibitors | |
| RU99105567A (ru) | Производные пропионовой кислоты и их использование | |
| CA2392570A1 (en) | 4-pyrimidinyl-n-acyl-l-phenylalanines | |
| RU2012129737A (ru) | Замещенные бензамидные производные | |
| RU2383542C2 (ru) | Замещенные гидантоины | |
| JP2004533450A5 (enExample) | ||
| BRPI0711208A2 (pt) | compostos, intermediários para a sìtemse dos compostos, processo, composição farmacêutica, uso de um composto e usos | |
| JP2005533013A5 (enExample) | ||
| RU2009148507A (ru) | Производное тетрагидроизохинолин-1-она или его соль | |
| US7951806B2 (en) | Plasminogen activator inhibitor-1 inhibitor | |
| JP2005522492A5 (enExample) | ||
| JP2003506438A (ja) | 抗菌剤 |