JP2007518690A - 眼疾患治療 - Google Patents
眼疾患治療 Download PDFInfo
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- JP2007518690A JP2007518690A JP2006521975A JP2006521975A JP2007518690A JP 2007518690 A JP2007518690 A JP 2007518690A JP 2006521975 A JP2006521975 A JP 2006521975A JP 2006521975 A JP2006521975 A JP 2006521975A JP 2007518690 A JP2007518690 A JP 2007518690A
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Abstract
【選択図】なし
Description
眼症状を治療し、及び眼の潤滑を高めるための他の組成物、及び方法が望ましい。
本発明のこれら及び他の実施形態は、更に下記の詳細な説明を参照して更に理解されよう。
Claims (40)
- 患者の眼症状の治療方法であって、
組成物の眼内移植工程
を含み、前記組成物は、
徐放性マトリックス、並びに
症状の治療に効果的な量のラパマイシン、アスコマイシン、及びこれらの併用からなる群より選択される薬物
を含むことを特徴とする患者の眼症状の治療方法。 - 免疫反応に関連する症状、加齢性の眼症状、眼の変性状態、眼の水分に関連する症状、角膜手術後の症状、及びこれらの組合せからなる群より選択される症状を治療する請求項1に記載の方法。
- 眼乾燥症、強膜炎、神経炎、乳頭炎、ブドウ膜炎、網膜症、網膜色素変性、黄斑変性、天疱瘡、シェーグレン症候群、ベーチェット症候群、トキソプラスマ症、散弾状脈絡膜症、ヒストプラスマ症、扁平部炎、サルコイドーシス、交感性眼炎、蛇行性脈絡膜症(serpiginous choroidopathy)、びまん性の網膜色素上皮症、原田病、結節性多発動脈炎、及び若年性関節リュウマチからなる群より選択される症状を治療する請求項1に記載の方法。
- 前記組成物は、強膜に移植される請求項1に記載の方法。
- 前記マトリックスは、約3mg〜約5mgの前記薬物を含有する請求項1に記載の方法。
- 患者の眼症状の治療方法であって、
組成物の眼内投与工程
を含み、前記組成物は、
上限約200μgまでの濃度で実質的に無毒性な症状の治療に効果的な薬学的に許容される処方で、ラパマイシン、アスコマイシン、及びこれらの併用からなる群より選択される薬物
を含むことを特徴とする患者の眼症状の治療方法。 - 免疫反応に関連する症状、加齢性の眼症状、眼の変性状態、眼の水分に関連する症状、角膜手術後の症状、及びこれらの組合せからなる群より選択される症状を治療する請求項6に記載の方法。
- 眼乾燥症、強膜炎、神経炎、乳頭炎、ブドウ膜炎、網膜症、網膜色素変性、黄斑変性、天疱瘡、シェーグレン症候群、ベーチェット症候群、トキソプラスマ症、散弾状脈絡膜症、ヒストプラスマ症、扁平部炎、サルコイドーシス、交感性眼炎、蛇行性脈絡膜症(serpiginous choroidopathy)、びまん性の網膜色素上皮症、原田病、結節性多発動脈炎、及び若年性関節リュウマチからなる群より選択される症状を治療する請求項6に記載の方法。
- 前記組成物は、局所適用、眼内注射、及び眼内移植から選択される方法により投与される請求項6に記載の方法。
- 前記組成物は、シクロスポリンA、タクロリムス、及びこれらの併用を更に含む請求項6に記載の方法。
- 患者の眼症状の治療方法であって、
組成物の眼内投与工程
を含み、前記組成物は
症状の治療に効果的な薬学的に許容される処方で本質的にラパマイシン
からなり、前記工程は、約50pg/ml〜約50μg/mlの濃度で局所投与、約1ng/ml〜約200μg/mlの用量で結膜下注射、約1ng/0.1ml〜約200μg/mlの用量で硝子体内注射、又は約20μg/ml〜約200μg/mlの用量で球後注射からなる群より選択される方法により行われることを特徴とする患者の眼症状の治療方法。 - 前記注射は、約50μg/0.1mlの用量で硝子体内注射である請求項11に記載の方法。
- 免疫反応に関連する症状、加齢性の眼症状、眼の変性状態、眼の水分に関連する症状、角膜手術後の症状、及びこれらの組合せからなる群より選択される症状を治療する請求項11に記載の方法。
- 眼乾燥症、強膜炎、神経炎、乳頭炎、ブドウ膜炎、網膜症、網膜色素変性、黄斑変性、天疱瘡、シェーグレン症候群、ベーチェット症候群、トキソプラスマ症、散弾状脈絡膜症、ヒストプラスマ症、扁平部炎、サルコイドーシス、交感性眼炎、蛇行性脈絡膜症(serpiginous choroidopathy)、びまん性の網膜色素上皮症、原田病、結節性多発動脈炎、及び若年性関節リュウマチからなる群より選択される症状を治療する請求項11に記載の方法。
- 眼治療方法であって、
角膜手術後の患者への組成物の眼内投与工程
を含み、前記組成物は、
薬学的に許容される処方、及び患者の術後の眼の水分増加に効果的な量で本質的にラパマイシン
からなることを特徴とする眼治療方法。 - 前記組成物は、局所投与、及び眼内注射からなる群より選択される方法により投与される請求項15に記載の方法。
- 前記組成物は、約1ng/ml〜約200μg/mlの用量で結膜下注射、約1ng/0.1ml〜約200μg/mlの用量で硝子体内注射、又は約20μg/ml〜約200μg/mlの用量で球後注射により投与される請求項15に記載の方法。
- 前記組成物は、眼内移植される請求項15に記載の方法。
- 約50pg/ml〜約50μg/mlの濃度で局所投与される請求項15に記載の方法。
- 眼治療方法であって、
角膜手術後の患者への組成物の眼内投与工程
を含み、前記組成物は、
薬学的に許容される処方、及び患者の術後の眼の水分増加に効果的な量で本質的にアスコマイシン
からなることを特徴とする眼治療方法。 - 前記組成物は、局所投与及び眼内注射からなる群より選択される方法により投与される請求項20に記載の方法。
- 前記組成物は、約1ng/ml〜約200μg/mlの用量で結膜下注射、約1ng/0.1ml〜約200μg/mlの用量で硝子体内注射、又は約20μg/ml〜約200μg/mlの用量で球後注射により投与される請求項20に記載の方法。
- 前記組成物は、眼内移植される請求項20に記載の方法。
- 約50pg/ml〜約50μg/mlの濃度で局所投与される請求項20に記載の方法。
- 患者の眼症状の治療方法であって、
患者への薬学的に許容される処方の眼内投与工程
を含み、前記処方は、
実質的に無毒性で眼症状の治療に効果的な上限約200μgまでの量でラパマイシン、アスコマイシン、及びこれらの併用からなる群より選択される薬物、並びに
少なくとも1つの抗生物質
からなることを特徴とする患者の眼症状の治療方法。 - 前記組成物は、局所投与、眼内注射、及び眼内移植からなる群より選択される経路により投与される請求項25に記載の方法。
- 眼症状の治療用組成物であって、
生理学的に許容される眼内処方、及び実質的に無毒性で眼症状の治療に効果的な上限約200μgまでの用量で本質的にラパマイシン
からなることを特徴とする眼症状の治療用組成物。 - 局所投与のために処方される請求項27に記載の組成物。
- 注入可能に処方される請求項27に記載の組成物。
- 眼症状の治療用組成物であって、
生理学的に許容される眼内処方、及び実質的に無毒性で眼症状の治療に効果的な上限約200μgまでの用量で本質的にアスコマイシン
からなることを特徴とする眼症状の治療用組成物。 - 局所投与のために処方される請求項30に記載の組成物。
- 注入可能に処方される請求項30に記載の組成物。
- 眼症状の治療用組成物であって、
生理学的に許容されるマトリックス、並びに
眼内移植のために3mg〜5mgの量でラパマイシン、アスコマイシン、及びこれらの併用からなる群より選択される薬物
を含むことを特徴とする眼症状の治療用組成物。 - 前記マトリックスは、脂質、ポリビニルアルコール、ポリビニルアセテート、ポリカプロラクトン、ポリ(グリコール)酸、ポリ(乳)酸、及びこれらの組合せからなる群より選択される物質を含む請求項33に記載の組成物。
- 前記マトリックスは、前記薬物を徐放する請求項33に記載の組成物。
- 前記マトリックスは、約50μg/日未満、約50pg/日〜約50μg/日、及び約1μg/日〜約5μg/日からなる群より選択される割合で前記薬物を放出する請求項33に記載の組成物。
- 患者の眼症状の治療方法であって、
組成物の眼内投与工程
を含み、前記組成物は、
症状の治療に効果的な薬学的に許容される処方で本質的にアスコマイシン
からなり、前記工程は、約50pg/ml〜約50μg/mlの濃度で局所投与、約1ng/ml〜約200μg/mlの用量で結膜下注射、約1ng/0.1ml〜約200μg/mlの用量で硝子体内注射、又は約20μg/ml〜約200μg/mlの用量で球後注射からなる群より選択される方法により行われることを特徴とする患者の眼症状の治療方法。 - 前記注射は、約50μg/0.1mlの用量で硝子体内注射である請求項37に記載の方法。
- 免疫反応に関連する症状、加齢性の眼症状、眼の変性状態、眼の水分に関連する症状、角膜手術後の症状、及びこれらの組合せからなる群より選択される症状を治療する請求項37に記載の方法。
- 眼乾燥症、強膜炎、神経炎、乳頭炎、ブドウ膜炎、網膜症、網膜色素変性、黄斑変性、天疱瘡、シェーグレン症候群、ベーチェット症候群、トキソプラスマ症、散弾状脈絡膜症、ヒストプラスマ症、扁平部炎、サルコイドーシス、交感性眼炎、蛇行性脈絡膜症(serpiginous choroidopathy)、びまん性の網膜色素上皮症、原田病、結節性多発動脈炎、及び若年性関節リュウマチからなる群より選択される症状を治療する請求項37に記載の方法。
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US10/631,143 US7083802B2 (en) | 2003-07-31 | 2003-07-31 | Treatment of ocular disease |
PCT/US2004/024054 WO2005011813A2 (en) | 2003-07-30 | 2004-07-27 | Treatment of ocular disease |
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US7354574B2 (en) | 2002-11-07 | 2008-04-08 | Advanced Ocular Systems Limited | Treatment of ocular disease |
AR042890A1 (es) | 2003-01-16 | 2005-07-06 | Sucampo Pharmaceuticals Inc | Metodo de tratamiento del ojo seco con una composicion oftalmica que contiene un compuesto macrolido |
AU2003228126A1 (en) | 2003-05-02 | 2004-11-23 | Arturo Jimenez Bayardo | Method of preparing an aqueous solution of cyclosporin-a and resulting aqueous solution |
US7083802B2 (en) | 2003-07-31 | 2006-08-01 | Advanced Ocular Systems Limited | Treatment of ocular disease |
US7585517B2 (en) | 2003-09-18 | 2009-09-08 | Macusight, Inc. | Transscleral delivery |
US7087237B2 (en) | 2003-09-19 | 2006-08-08 | Advanced Ocular Systems Limited | Ocular solutions |
US7083803B2 (en) | 2003-09-19 | 2006-08-01 | Advanced Ocular Systems Limited | Ocular solutions |
-
2003
- 2003-07-31 US US10/631,143 patent/US7083802B2/en not_active Expired - Fee Related
-
2004
- 2004-07-27 EP EP04779223A patent/EP1675652A2/en not_active Ceased
- 2004-07-27 JP JP2006521975A patent/JP2007518690A/ja active Pending
- 2004-07-27 WO PCT/US2004/024054 patent/WO2005011813A2/en active Search and Examination
- 2004-07-27 CA CA002534214A patent/CA2534214A1/en not_active Abandoned
- 2004-07-27 AU AU2004261187A patent/AU2004261187A1/en not_active Abandoned
-
2006
- 2006-06-09 US US11/450,172 patent/US20060263409A1/en not_active Abandoned
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JP2012025708A (ja) * | 2010-07-27 | 2012-02-09 | Sepa Sigma Inc | 膜透過機構を異にする複数の徐放機構を利用した徐放化局所投与剤 |
WO2014142146A1 (ja) * | 2013-03-13 | 2014-09-18 | 参天製薬株式会社 | マイボーム機能不全の治療剤 |
JP2014198709A (ja) * | 2013-03-13 | 2014-10-23 | 参天製薬株式会社 | マイボーム機能不全の治療剤 |
JP2018065857A (ja) * | 2013-03-13 | 2018-04-26 | 参天製薬株式会社 | マイボーム機能不全の治療剤 |
JP2019108383A (ja) * | 2013-03-13 | 2019-07-04 | 参天製薬株式会社 | マイボーム機能不全の治療剤 |
JP2020203927A (ja) * | 2013-03-13 | 2020-12-24 | 参天製薬株式会社 | マイボーム機能不全の治療剤 |
JP7082162B2 (ja) | 2013-03-13 | 2022-06-07 | 参天製薬株式会社 | マイボーム機能不全の治療剤 |
US11612590B2 (en) | 2013-03-13 | 2023-03-28 | Santen Pharmaceutical Co., Ltd. | Therapeutic agent for meibomian dysfunction |
US11951098B2 (en) | 2013-03-13 | 2024-04-09 | Santen Pharmaceutical Co., Ltd. | Therapeutic agent for meibomian dysfunction |
Also Published As
Publication number | Publication date |
---|---|
US7083802B2 (en) | 2006-08-01 |
AU2004261187A1 (en) | 2005-02-10 |
US20060263409A1 (en) | 2006-11-23 |
CA2534214A1 (en) | 2005-02-10 |
WO2005011813A3 (en) | 2005-04-28 |
US20050025810A1 (en) | 2005-02-03 |
EP1675652A2 (en) | 2006-07-05 |
WO2005011813A2 (en) | 2005-02-10 |
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