|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
ES2445208T3
(es)
|
2002-07-29 |
2014-02-28 |
Rigel Pharmaceuticals, Inc. |
Compuestos de 2,4-pirimidindiamina para uso en métodos para tratar o prevenir enfermedades autoinmunitarias
|
|
BRPI0413018B8
(pt)
|
2003-07-30 |
2021-05-25 |
Rigel Pharmaceuticals Inc |
composto, e, uso de um composto
|
|
BRPI0417345A
(pt)
*
|
2003-12-03 |
2007-03-13 |
Cytopia Res Pty Ltd |
compostos inibidores de quìnase baseados em azola, composições e seus usos
|
|
ATE458730T1
(de)
|
2004-04-13 |
2010-03-15 |
Icagen Inc |
Polycyclische pyrazine als kaliumionenkanal- modulatoren
|
|
US7884109B2
(en)
|
2005-04-05 |
2011-02-08 |
Wyeth Llc |
Purine and imidazopyridine derivatives for immunosuppression
|
|
WO2006133426A2
(en)
|
2005-06-08 |
2006-12-14 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
US20070203161A1
(en)
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
US8076343B2
(en)
*
|
2005-07-26 |
2011-12-13 |
Vertex Pharmaceuticals Incorporated |
Benzimidazoles useful as inhibitors of protein kinases
|
|
TR201802449T4
(tr)
|
2005-10-26 |
2018-03-21 |
Novartis Ag |
Ailesel akdeniz hummasının anti ıl-1beta antikorları ile tedavisi.
|
|
RU2487711C2
(ru)
|
2005-11-21 |
2013-07-20 |
Новартис Аг |
Лечение нейроэндокринных опухолей
|
|
GB0601744D0
(en)
|
2006-01-27 |
2006-03-08 |
Novartis Ag |
Organic compounds
|
|
US7989459B2
(en)
*
|
2006-02-17 |
2011-08-02 |
Pharmacopeia, Llc |
Purinones and 1H-imidazopyridinones as PKC-theta inhibitors
|
|
CA2642229C
(en)
|
2006-02-24 |
2015-05-12 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
US8119643B2
(en)
*
|
2006-03-20 |
2012-02-21 |
Synta Pharmaceuticals Corp. |
Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses
|
|
US8163777B2
(en)
*
|
2006-03-23 |
2012-04-24 |
Synta Pharmaceuticals Corp. |
Benzimidazolyl-pyridine compounds for inflammation and immune-related uses
|
|
TW200837064A
(en)
|
2006-10-04 |
2008-09-16 |
Pharmacopeia Inc |
8-substituted 2-(benzimidazolyl)purine derivatives for immunosuppression
|
|
US7902187B2
(en)
|
2006-10-04 |
2011-03-08 |
Wyeth Llc |
6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
|
|
TW200831104A
(en)
|
2006-10-04 |
2008-08-01 |
Pharmacopeia Inc |
6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
|
|
EP2089369B1
(en)
|
2006-10-19 |
2011-02-02 |
Rigel Pharmaceuticals, Inc. |
2,4 -pyrimidinediamine derivatives as inhibitors of jak kinases for the treatment of autoimmune diseases
|
|
AU2013273769B2
(en)
*
|
2006-11-15 |
2016-05-12 |
Ym Biosciences Australia Pty Ltd |
Inhibitors of Kinase Activity
|
|
DK2848610T3
(da)
*
|
2006-11-15 |
2017-11-06 |
Ym Biosciences Australia Pty |
Hæmmere af kinaseaktivitet
|
|
US20080119496A1
(en)
*
|
2006-11-16 |
2008-05-22 |
Pharmacopeia Drug Discovery, Inc. |
7-Substituted Purine Derivatives for Immunosuppression
|
|
JP2010510211A
(ja)
*
|
2006-11-16 |
2010-04-02 |
ファーマコペイア・リミテッド・ライアビリティ・カンパニー |
免疫抑制用7−置換プリン誘導体
|
|
EP2468301A1
(en)
|
2007-05-29 |
2012-06-27 |
Novartis AG |
New indications for anti-IL-1-beta therapy
|
|
EP2167497A2
(en)
|
2007-06-29 |
2010-03-31 |
Sunesis Pharmaceuticals, Inc. |
Heterocyclic compounds useful as raf kinase inhibitors
|
|
AR067354A1
(es)
|
2007-06-29 |
2009-10-07 |
Sunesis Pharmaceuticals Inc |
Compuestos utiles como inhibidores de la raf quinasa
|
|
WO2009037247A1
(en)
*
|
2007-09-17 |
2009-03-26 |
Neurosearch A/S |
Pyrazine derivatives and their use as potassium channel modulators
|
|
CN105367503A
(zh)
|
2007-10-19 |
2016-03-02 |
阿维拉制药公司 |
杂芳基化合物和其用途
|
|
US7989465B2
(en)
*
|
2007-10-19 |
2011-08-02 |
Avila Therapeutics, Inc. |
4,6-disubstituted pyrimidines useful as kinase inhibitors
|
|
WO2009060035A1
(en)
|
2007-11-08 |
2009-05-14 |
Novartis Ag |
Gene expression signatures for chronic/sclerosing allograft nephropathy
|
|
NZ586662A
(en)
*
|
2007-12-19 |
2012-08-31 |
Vertex Pharma |
PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS JANUS KINASE 2 INHIBITORS
|
|
US8268834B2
(en)
|
2008-03-19 |
2012-09-18 |
Novartis Ag |
Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
|
|
SG2014015085A
(en)
|
2008-04-16 |
2014-06-27 |
Portola Pharm Inc |
2,6-diamino-pyrimidin-5-yl-carboxamides as syk or jak kinases inhibitors
|
|
US8138339B2
(en)
|
2008-04-16 |
2012-03-20 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
MX2010011463A
(es)
|
2008-04-16 |
2011-06-03 |
Portola Pharm Inc |
2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak quinasas.
|
|
NZ588830A
(en)
|
2008-04-22 |
2012-11-30 |
Portola Pharm Inc |
Inhibitors of protein kinases
|
|
CA2723358A1
(en)
*
|
2008-05-05 |
2009-11-12 |
Allison B. Reiss |
Method for improving cardiovascular risk profile of cox inhibitors
|
|
EP2288260A4
(en)
|
2008-06-20 |
2013-10-23 |
Genentech Inc |
TRIAZOLOPYRIDINE-JAK HEMMER COMPOUNDS AND METHOD
|
|
BRPI0909945A2
(pt)
|
2008-06-20 |
2015-07-28 |
Genentech Inc |
"composto, composição farmacêutica, método para tratar ou atenuar a gravidade de uma doença ou condição responsiva à inibição da atividade jak2 quinase em um paciente, kit para o tratamento de uma doença ou distúrbio responsivo à inibição da jak quinase"
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
TWI546290B
(zh)
|
2008-06-27 |
2016-08-21 |
賽基艾維洛米斯研究股份有限公司 |
雜芳基化合物及其用途
|
|
US11351168B1
(en)
|
2008-06-27 |
2022-06-07 |
Celgene Car Llc |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
KR101705158B1
(ko)
|
2009-05-05 |
2017-02-09 |
다나-파버 캔서 인스티튜트 인크. |
Egfr 억제제 및 질환 치료방법
|
|
CA2767616A1
(en)
|
2009-07-09 |
2011-01-13 |
The Scripps Research Institute |
Gene expression profiles associated with chronic allograft nephropathy
|
|
TW201111385A
(en)
*
|
2009-08-27 |
2011-04-01 |
Biocryst Pharm Inc |
Heterocyclic compounds as janus kinase inhibitors
|
|
US8791100B2
(en)
|
2010-02-02 |
2014-07-29 |
Novartis Ag |
Aryl benzylamine compounds
|
|
US8247436B2
(en)
|
2010-03-19 |
2012-08-21 |
Novartis Ag |
Pyridine and pyrazine derivative for the treatment of CF
|
|
BR112012027803A2
(pt)
*
|
2010-04-30 |
2016-08-09 |
Cellzome Ltd |
compostos de pirazol como inibidores de jak
|
|
UA112517C2
(uk)
|
2010-07-06 |
2016-09-26 |
Новартіс Аг |
Тетрагідропіридопіримідинові похідні
|
|
CN105566229A
(zh)
|
2010-08-10 |
2016-05-11 |
西建阿维拉米斯研究公司 |
Btk抑制剂的苯磺酸盐及其用途和制备方法
|
|
US20130317029A1
(en)
|
2010-11-01 |
2013-11-28 |
Portola Pharmaceuticals, Inc. |
Oxypyrimidines as syk modulators
|
|
EP2635285B1
(en)
|
2010-11-01 |
2017-05-03 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
EP2635556B1
(en)
|
2010-11-01 |
2017-06-21 |
Portola Pharmaceuticals, Inc. |
Benzamides and nicotinamides as syk modulators
|
|
US9102625B2
(en)
|
2010-11-01 |
2015-08-11 |
Portola Pharmaceuticals, Inc. |
Nicotinamides as JAK kinase modulators
|
|
MX382354B
(es)
|
2010-11-01 |
2025-03-13 |
Celgene Car Llc |
Compuestos heterocíclicos y usos de los mismos.
|
|
JP5957003B2
(ja)
|
2010-11-10 |
2016-07-27 |
セルジーン アヴィロミクス リサーチ, インコーポレイテッド |
変異体選択的egfr阻害剤およびその使用
|
|
US8889684B2
(en)
*
|
2011-02-02 |
2014-11-18 |
Boehringer Ingelheim International Gmbh |
Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors
|
|
ES2608967T3
(es)
|
2011-03-28 |
2017-04-17 |
Mei Pharma, Inc. |
(Aralquilamino sustituido en alfa y heteroarilalquilamino)pirimidinil y 1,3,5-triazinil benzimidazoles, composiciones farmacéuticas que los contienen, y estos compuestos para usar en el tratamiento de enfermedades proliferativas
|
|
CA2836417A1
(en)
|
2011-05-17 |
2012-11-22 |
Principia Biopharma Inc. |
Azaindole derivatives as tyrosine kinase inhibitors
|
|
CN102267980B
(zh)
*
|
2011-06-04 |
2012-11-21 |
山西大学 |
2,6-二苯并咪唑基吡啶的制备方法
|
|
JP2014518256A
(ja)
|
2011-06-27 |
2014-07-28 |
ノバルティス アーゲー |
テトラヒドロ−ピリド−ピリミジン誘導体の固体形態および塩類
|
|
KR20140058543A
(ko)
|
2011-07-08 |
2014-05-14 |
노파르티스 아게 |
신규 피롤로 피리미딘 유도체
|
|
WO2013057711A1
(en)
|
2011-10-21 |
2013-04-25 |
Novartis Ag |
Quinazoline derivatives as pi3k modulators
|
|
AR088570A1
(es)
|
2011-10-28 |
2014-06-18 |
Celgene Avilomics Res Inc |
Metodos para tratar una enfermedad o trastorno relacionado con la tirosina quinasa de bruton
|
|
CA3094793A1
(en)
|
2011-11-23 |
2013-05-30 |
Portola Pharmaceuticals, Inc. |
Pyrazine kinase inhibitors
|
|
US20140348848A1
(en)
|
2011-12-02 |
2014-11-27 |
Dhananjay Kaul |
Anti-il-1beta (interleukin-1beta) antibody-based prophylactic therapy to prevent complications leading to vaso-occlusion in sickle cell disease
|
|
DK2790705T3
(en)
|
2011-12-15 |
2018-03-12 |
Novartis Ag |
Use of inhibitors of the activity or function of PI3K
|
|
JP5903499B2
(ja)
|
2011-12-22 |
2016-04-13 |
ノバルティス アーゲー |
ジヒドロ−ベンゾ−オキサジンおよびジヒドロ−ピリド−オキサジン誘導体
|
|
WO2013093850A1
(en)
|
2011-12-22 |
2013-06-27 |
Novartis Ag |
Quinoline derivatives
|
|
CA2861010A1
(en)
|
2012-01-13 |
2013-07-18 |
Xiao Xu |
Heterocyclic compounds and uses as anticancer agents
|
|
US9464089B2
(en)
|
2012-01-13 |
2016-10-11 |
Acea Biosciences Inc. |
Heterocyclic compounds and uses thereof
|
|
US9034885B2
(en)
|
2012-01-13 |
2015-05-19 |
Acea Biosciences Inc. |
EGFR modulators and uses thereof
|
|
US9586965B2
(en)
|
2012-01-13 |
2017-03-07 |
Acea Biosciences Inc. |
Pyrrolo[2,3-d]pyrimidine compounds as inhibitors of protein kinases
|
|
PL2825042T3
(pl)
|
2012-03-15 |
2019-02-28 |
Celgene Car Llc |
Sole inhibitora kinazy receptora czynnika wzrostu naskórka
|
|
KR102081042B1
(ko)
|
2012-03-15 |
2020-02-26 |
셀젠 카르 엘엘씨 |
상피 성장 인자 수용체 키나제 억제제의 고체 형태
|
|
WO2014013014A1
(en)
|
2012-07-18 |
2014-01-23 |
Fundació Privada Centre De Regulació Genòmica (Crg) |
Jak inhibitors for activation of epidermal stem cell populations
|
|
CN104704129A
(zh)
|
2012-07-24 |
2015-06-10 |
药品循环公司 |
与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变
|
|
JP2015526520A
(ja)
*
|
2012-08-31 |
2015-09-10 |
プリンシピア バイオファーマ インコーポレイテッド |
Itk阻害剤としてのベンズイミダゾール誘導体
|
|
US9676756B2
(en)
|
2012-10-08 |
2017-06-13 |
Portola Pharmaceuticals, Inc. |
Substituted pyrimidinyl kinase inhibitors
|
|
KR20220143164A
(ko)
|
2012-11-21 |
2022-10-24 |
피티씨 테라퓨틱스, 인크. |
치환된 리버스 피리미딘 bmi-1 저해제
|
|
TW201422625A
(zh)
|
2012-11-26 |
2014-06-16 |
Novartis Ag |
二氫-吡啶并-□衍生物之固體形式
|
|
US9126950B2
(en)
|
2012-12-21 |
2015-09-08 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
EP3007689B1
(en)
|
2013-01-10 |
2018-03-07 |
Pulmokine, Inc. |
Non-selective kinase inhibitors
|
|
MA38287B1
(fr)
|
2013-01-23 |
2018-08-31 |
Astrazeneca Ab |
Nouveaux dérivés aminopyrazine pour le traitement ou la prévention du cancer
|
|
AU2014214846A1
(en)
|
2013-02-08 |
2015-07-23 |
Celgene Avilomics Research, Inc. |
ERK inhibitors and uses thereof
|
|
WO2014128612A1
(en)
|
2013-02-20 |
2014-08-28 |
Novartis Ag |
Quinazolin-4-one derivatives
|
|
NZ715687A
(en)
|
2013-07-11 |
2019-04-26 |
Acea Biosciences Inc |
Pyrimidine derivatives as kinase inhibitors
|
|
UY35675A
(es)
|
2013-07-24 |
2015-02-27 |
Novartis Ag |
Derivados sustituidos de quinazolin-4-ona
|
|
US9492471B2
(en)
|
2013-08-27 |
2016-11-15 |
Celgene Avilomics Research, Inc. |
Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
|
|
AR093580A1
(es)
|
2013-08-30 |
2015-06-10 |
Ptc Therapeutics Inc |
Inhibidores bmi-1 de pirimidina sustituidos
|
|
US9657007B2
(en)
|
2013-09-22 |
2017-05-23 |
Calitor Sciences, Llc |
Substituted aminopyrimidine compounds and methods of use
|
|
US9925184B2
(en)
|
2013-10-11 |
2018-03-27 |
Pulmokine, Inc. |
Spray-dry formulations
|
|
WO2015076800A1
(en)
*
|
2013-11-21 |
2015-05-28 |
Ptc Therapeutics, Inc. |
Substituted pyridine and pyrazine bmi-1 inhibitors
|
|
US9512084B2
(en)
|
2013-11-29 |
2016-12-06 |
Novartis Ag |
Amino pyrimidine derivatives
|
|
US9415049B2
(en)
|
2013-12-20 |
2016-08-16 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
KR20160141856A
(ko)
|
2014-04-24 |
2016-12-09 |
노파르티스 아게 |
포스파티딜이노시톨 3-키나제 억제제로서의 피라진 유도체
|
|
KR20160145780A
(ko)
|
2014-04-24 |
2016-12-20 |
노파르티스 아게 |
포스파티딜이노시톨 3-키나제 억제제로서의 아미노 피리딘 유도체
|
|
EP3134397A1
(en)
|
2014-04-24 |
2017-03-01 |
Novartis AG |
Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
|
|
US10443100B2
(en)
|
2014-05-22 |
2019-10-15 |
The Scripps Research Institute |
Gene expression profiles associated with sub-clinical kidney transplant rejection
|
|
US11104951B2
(en)
|
2014-05-22 |
2021-08-31 |
The Scripps Research Institute |
Molecular signatures for distinguishing liver transplant rejections or injuries
|
|
EP3146077A4
(en)
|
2014-05-22 |
2018-05-02 |
The Scripps Research Institute |
Tissue molecular signatures of kidney transplant rejections
|
|
US10005760B2
(en)
|
2014-08-13 |
2018-06-26 |
Celgene Car Llc |
Forms and compositions of an ERK inhibitor
|
|
TWI679205B
(zh)
|
2014-09-02 |
2019-12-11 |
日商日本新藥股份有限公司 |
吡唑并噻唑化合物及醫藥
|
|
GB201518456D0
(en)
*
|
2015-10-19 |
2015-12-02 |
Galapagos Nv |
Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory, autoimmune and/or proliferative diseases
|
|
TWI712604B
(zh)
|
2016-03-01 |
2020-12-11 |
日商日本新藥股份有限公司 |
具jak抑制作用之化合物之結晶
|
|
EA202092441A1
(ru)
|
2016-06-07 |
2021-05-21 |
Джакобио Фармасьютикалс Ко., Лтд. |
Новые гетероциклические производные, применимые в качестве ингибиторов shp2
|
|
WO2018041989A1
(en)
|
2016-09-02 |
2018-03-08 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for diagnosing and treating refractory celiac disease type 2
|
|
RU2763525C2
(ru)
|
2016-10-27 |
2021-12-30 |
Пульмокин, Инк. |
Комбинированная терапия для лечения легочной гипертензии
|
|
KR20240026521A
(ko)
|
2017-03-23 |
2024-02-28 |
자코바이오 파마슈티칼스 컴퍼니 리미티드 |
Shp2 억제제로서 유용한 신규한 헤테로환형 유도체
|
|
AU2017408099A1
(en)
|
2017-04-07 |
2019-11-07 |
ACEA Therapeutics, Inc. |
Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same
|
|
US11304953B2
(en)
|
2017-05-23 |
2022-04-19 |
Mei Pharma, Inc. |
Combination therapy
|
|
KR20200041358A
(ko)
|
2017-08-14 |
2020-04-21 |
메이 파마, 아이엔씨. |
병용 요법
|
|
US10793551B2
(en)
|
2017-10-19 |
2020-10-06 |
Effector Therapeutics Inc. |
Benzimidazole-indole inhibitors of Mnk1 and Mnk2
|
|
JP7837141B2
(ja)
|
2017-10-27 |
2026-03-30 |
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|
|
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(en)
|
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|
|
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|
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|
|
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|
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|
|
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(ja)
|
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|
|
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(en)
|
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|
|
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(pt)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(zh)
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|