JP2008528469A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008528469A5 JP2008528469A5 JP2007551744A JP2007551744A JP2008528469A5 JP 2008528469 A5 JP2008528469 A5 JP 2008528469A5 JP 2007551744 A JP2007551744 A JP 2007551744A JP 2007551744 A JP2007551744 A JP 2007551744A JP 2008528469 A5 JP2008528469 A5 JP 2008528469A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- optionally
- combination according
- hydrogen
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64596305P | 2005-01-21 | 2005-01-21 | |
| PCT/GB2006/000206 WO2006077425A1 (en) | 2005-01-21 | 2006-01-20 | Combinations of pyrazole kinase inhibitors and further antitumor agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008528469A JP2008528469A (ja) | 2008-07-31 |
| JP2008528469A5 true JP2008528469A5 (https=) | 2009-03-12 |
Family
ID=35966985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007551744A Withdrawn JP2008528469A (ja) | 2005-01-21 | 2006-01-20 | ピラゾールキナーゼ阻害剤およびさらなる抗癌剤の組合せ剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20080161355A1 (https=) |
| EP (1) | EP1845975A1 (https=) |
| JP (1) | JP2008528469A (https=) |
| KR (1) | KR20070107707A (https=) |
| CN (1) | CN101146533A (https=) |
| AU (1) | AU2006207322A1 (https=) |
| BR (1) | BRPI0606319A2 (https=) |
| CA (1) | CA2593475A1 (https=) |
| MX (1) | MX2007008809A (https=) |
| RU (1) | RU2007131101A (https=) |
| WO (1) | WO2006077425A1 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2256106T3 (pl) | 2003-07-22 | 2015-08-31 | Astex Therapeutics Ltd | Związki 3,4-pochodne 1h-pirazolu i ich zastosowanie jako kinazy zależne od cyklin (cdk) i modulatory kinazy syntazy glikogenu-3 (gsk-3) |
| TW200533657A (en) | 2004-02-17 | 2005-10-16 | Esteve Labor Dr | Substituted pyrazoline compounds, their preparation and use as medicaments |
| US20080139620A1 (en) * | 2005-01-21 | 2008-06-12 | Astex Therapeutics Limited | Pyrazole Derivatives For The Inhibition Of Cdk's And Gsk's |
| US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
| MX2007008781A (es) * | 2005-01-21 | 2007-09-11 | Astex Therapeutics Ltd | Compuestos farmaceuticos. |
| JP5475234B2 (ja) * | 2005-01-21 | 2014-04-16 | アステックス・セラピューティクス・リミテッド | 医薬化合物 |
| AR054425A1 (es) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
| AR052559A1 (es) * | 2005-01-21 | 2007-03-21 | Astex Therapeutics Ltd | Derivados de pirazol para inhibir cdk's y gsk's |
| US20090036607A1 (en) * | 2005-03-03 | 2009-02-05 | Mitsubishi Rayon Co., Ltd. | Polymer particle, resin composition containing same, and molded body |
| EP1743890A1 (en) | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | 4,5-Dihydro-1H-pyrazole derivatives, their preparation and use as medicaments |
| US7897589B2 (en) | 2005-07-15 | 2011-03-01 | Laboratorios Del Dr. Esteve, S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments |
| EP1743892A1 (en) | 2005-07-15 | 2007-01-17 | Laboratorios del Dr. Esteve S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments |
| EP2027109A1 (en) * | 2006-05-05 | 2009-02-25 | Astex Therapeutics Limited | 4- (2, 6-dichloro-benzoylamino) -1h-pyrazole-s-carboxylic acid (1-methanesulph0nyl-piperidin-4-yl) -amide for the treatment of cancer |
| WO2007129062A1 (en) * | 2006-05-08 | 2007-11-15 | Astex Therapeutics Limited | Pharmaceutical combinations of diazole derivatives for cancer treatment |
| WO2008001101A2 (en) * | 2006-06-29 | 2008-01-03 | Astex Therapeutics Limited | Pharmaceutical combinations |
| EP2049106A2 (en) * | 2006-07-14 | 2009-04-22 | Astex Therapeutics Limited | Pharmaceutical combinations |
| EP2049516A2 (en) * | 2006-07-14 | 2009-04-22 | Astex Therapeutics Limited | Pharmaceutical compounds |
| FR2908409B1 (fr) | 2006-11-10 | 2009-01-09 | Sanofi Aventis Sa | Pyrazoles substituees,compositions les contenant,procede de fabrication et utilisation |
| EP2070916A1 (de) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | 2-Aryl-thiazol-4-carbonsäureamid-Derivate, deren Herstellung und Verwendung als Arzneimittel |
| EP2070925A1 (de) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Neue 2-substituierte Tiazol-4-carbonsäureamid-Derivative deren Herstellung und Verwendung als Arzneimittel |
| EP2070924A1 (de) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Neue 2-Hetarylthiazol-4-carbonsäureamid-Derivative, deren Herstellung und Verwendung als Arzneimittel |
| JP2012504646A (ja) * | 2008-10-01 | 2012-02-23 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 選択的サイクリン依存性キナーゼ4/6阻害剤を用いた化学療法化合物に対する造血系の防護 |
| CN102231983A (zh) * | 2008-10-01 | 2011-11-02 | 北卡罗来纳大学查珀尔希尔分校 | 使用选择性细胞周期蛋白依赖性激酶4/6抑制剂对抗电离辐射的造血防护 |
| US20100144687A1 (en) | 2008-12-05 | 2010-06-10 | Glaser Rebecca L | Pharmaceutical compositions containing testosterone and an aromatase inhibitor |
| EP3406260B1 (en) * | 2009-05-13 | 2020-09-23 | The University of North Carolina at Chapel Hill | Cyclin dependent kinase inhibitors and methods of use |
| FR2947546B1 (fr) * | 2009-07-03 | 2011-07-01 | Sanofi Aventis | Derives de pyrazoles, leur preparation et leur application en therapeutique |
| HUE032571T2 (en) | 2009-10-01 | 2017-09-28 | Janssen Pharmaceutica Nv | Proteasome inhibitors for treating cancer |
| US9452980B2 (en) * | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| EP2640394A4 (en) | 2010-11-17 | 2015-02-25 | Univ North Carolina | PROTECTION OF KIDNEY TISSUE FROM ISCHEMIA BY THE INHIBITION OF PROLEVERATIVE KINASES CDK4 AND CDK6 |
| EP2935248B1 (en) * | 2012-12-21 | 2018-02-28 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| CN103012428A (zh) * | 2013-01-08 | 2013-04-03 | 中国药科大学 | 4-(五元杂环并嘧啶/吡啶取代)氨基-1H-3-吡唑甲酰胺类CDK/Aurora双重抑制剂及其用途 |
| HK1222766A1 (zh) | 2013-03-15 | 2017-07-14 | G1治疗公司 | 高效的抗赘生剂和抗增生剂 |
| DK2968290T3 (da) | 2013-03-15 | 2019-11-25 | G1 Therapeutics Inc | Transient beskyttelse af normale celler under kemoterapi |
| BR112016012141A2 (pt) * | 2014-01-15 | 2017-08-08 | Novartis Ag | "combinações farmacêuticas, uso das mesmas, e embalagem comercial" |
| WO2015161285A1 (en) | 2014-04-17 | 2015-10-22 | G1 Therapeutics, Inc. | Tricyclic lactams for use in the protection of hematopoietic stem and progenitor cells against ionizing radiation |
| WO2016040848A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors |
| WO2016040858A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
| CA2987552A1 (en) | 2015-06-04 | 2016-12-08 | Aurigene Discovery Technologies Limited | Substituted heterocyclyl derivatives as cdk inhibitors |
| US10723705B2 (en) | 2015-08-14 | 2020-07-28 | Incyte Corporation | Heterocyclic compounds and uses thereof |
| WO2017157873A1 (en) | 2016-03-17 | 2017-09-21 | F. Hoffmann-La Roche Ag | 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar |
| CN109803684B (zh) | 2016-08-23 | 2022-08-23 | 卫材 R&D 管理有限公司 | 用于治疗肝细胞癌的组合疗法 |
| US11083722B2 (en) | 2017-03-16 | 2021-08-10 | Eisai R&D Management Co., Ltd. | Combination therapies for the treatment of breast cancer |
| CN107652284B (zh) * | 2017-09-30 | 2020-01-31 | 武汉九州钰民医药科技有限公司 | 用于治疗增殖性疾病的cdk抑制剂 |
| CN107686477B (zh) * | 2017-09-30 | 2020-01-31 | 武汉九州钰民医药科技有限公司 | 作为cdk4/6抑制剂的新型化合物及其应用 |
| CN115605460A (zh) | 2020-04-29 | 2023-01-13 | 普莱希科公司(Us) | 杂环化合物的合成 |
| US10988479B1 (en) | 2020-06-15 | 2021-04-27 | G1 Therapeutics, Inc. | Morphic forms of trilaciclib and methods of manufacture thereof |
| KR102507397B1 (ko) * | 2020-09-10 | 2023-03-07 | 계명대학교 산학협력단 | 히스톤 탈아세틸화효소 억제 활성을 갖는 신규 화합물 및 이의 용도 |
| CN112755023B (zh) * | 2021-01-22 | 2023-04-25 | 湖南师范大学 | 一种新型表观遗传因子抑制剂2800z在制备肝癌药物中的应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4282361A (en) * | 1978-03-16 | 1981-08-04 | Massachusetts Institute Of Technology | Synthesis for 7-alkylamino-3-methylpyrazolo [4,3-d]pyrimidines |
| US5164196A (en) * | 1987-05-19 | 1992-11-17 | Ventech Research, Inc. | Crotoxin complex as cytotoxic agent |
| US5002755A (en) * | 1988-02-18 | 1991-03-26 | Vanderbilt University | Method of controlling nephrotoxicity of anti-tumor plaintum compounds |
| US5514665A (en) * | 1993-12-30 | 1996-05-07 | University Of British Columbia | Method of preventing or reducing the risk of infection by bacterial pathogens utilizing simple and conjugated dextrans |
| US5502068A (en) * | 1995-01-31 | 1996-03-26 | Synphar Laboratories, Inc. | Cyclopropylpyrroloindole-oligopeptide anticancer agents |
| JP2000504014A (ja) * | 1996-01-30 | 2000-04-04 | メルク エンド カンパニー インコーポレーテッド | ファルネシル―タンパク質転移酵素の阻害剤 |
| US6020357A (en) * | 1996-12-23 | 2000-02-01 | Dupont Pharmaceuticals Company | Nitrogen containing heteroaromatics as factor Xa inhibitors |
| US6306393B1 (en) * | 1997-03-24 | 2001-10-23 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
| US6632815B2 (en) * | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| US20040087798A1 (en) * | 2000-03-14 | 2004-05-06 | Akira Yamada | Novel amide compounds |
| US6455559B1 (en) * | 2001-07-19 | 2002-09-24 | Pharmacia Italia S.P.A. | Phenylacetamido-pyrazole derivatives, process for their preparation and their use as antitumor agents |
| EP1372631A4 (en) * | 2001-02-28 | 2005-07-27 | Brian C Giles | METHOD AND FORMULA FOR ANTITUMOR AND ANTIMETASTATIC EFFECT |
| JPWO2002074298A1 (ja) * | 2001-03-21 | 2004-07-08 | 小野薬品工業株式会社 | Il−6産生阻害剤 |
| US6905669B2 (en) * | 2001-04-24 | 2005-06-14 | Supergen, Inc. | Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase |
| EP1480597A4 (en) * | 2001-05-11 | 2005-02-02 | Burnham Inst | SCREENING, DIAGNOSTIC AND THERAPY PROCEDURES IN CONNECTION WITH RIZ |
| ES2251677T3 (es) * | 2002-01-22 | 2006-05-01 | Warner-Lambert Company Llc | 2-(piridin-2-ilamino)-pirido(2,3-d)pirimidin-7-onas. |
| WO2003075839A2 (en) * | 2002-03-04 | 2003-09-18 | Aton Pharma, Inc. | Methods of inducing terminal differentiation |
| ATE378336T1 (de) * | 2002-09-19 | 2007-11-15 | Schering Corp | Imidazopyridine als hemmstoffe cyclin abhängiger kinasen |
| WO2004039795A2 (en) * | 2002-10-29 | 2004-05-13 | Fujisawa Pharmaceutical Co., Ltd. | Amide compounds for the treatment of hyperlipidemia |
| US7169797B2 (en) * | 2003-02-14 | 2007-01-30 | Abbott Laboratories | Protein-tyrosine phosphatase inhibitors and uses thereof |
| US7320989B2 (en) * | 2003-02-28 | 2008-01-22 | Encysive Pharmaceuticals, Inc. | Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists |
| PL2256106T3 (pl) * | 2003-07-22 | 2015-08-31 | Astex Therapeutics Ltd | Związki 3,4-pochodne 1h-pirazolu i ich zastosowanie jako kinazy zależne od cyklin (cdk) i modulatory kinazy syntazy glikogenu-3 (gsk-3) |
| US20080139620A1 (en) * | 2005-01-21 | 2008-06-12 | Astex Therapeutics Limited | Pyrazole Derivatives For The Inhibition Of Cdk's And Gsk's |
| JP5475234B2 (ja) * | 2005-01-21 | 2014-04-16 | アステックス・セラピューティクス・リミテッド | 医薬化合物 |
| AR054425A1 (es) * | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
| AR052559A1 (es) * | 2005-01-21 | 2007-03-21 | Astex Therapeutics Ltd | Derivados de pirazol para inhibir cdk's y gsk's |
| TW200745003A (en) * | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
-
2006
- 2006-01-20 KR KR1020077018887A patent/KR20070107707A/ko not_active Withdrawn
- 2006-01-20 US US11/814,455 patent/US20080161355A1/en not_active Abandoned
- 2006-01-20 JP JP2007551744A patent/JP2008528469A/ja not_active Withdrawn
- 2006-01-20 MX MX2007008809A patent/MX2007008809A/es not_active Application Discontinuation
- 2006-01-20 BR BRPI0606319-5A patent/BRPI0606319A2/pt not_active IP Right Cessation
- 2006-01-20 WO PCT/GB2006/000206 patent/WO2006077425A1/en not_active Ceased
- 2006-01-20 CA CA002593475A patent/CA2593475A1/en not_active Abandoned
- 2006-01-20 EP EP06700799A patent/EP1845975A1/en not_active Withdrawn
- 2006-01-20 CN CNA2006800091875A patent/CN101146533A/zh active Pending
- 2006-01-20 AU AU2006207322A patent/AU2006207322A1/en not_active Abandoned
- 2006-01-20 RU RU2007131101/04A patent/RU2007131101A/ru not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008528469A5 (https=) | ||
| JP2008528468A5 (https=) | ||
| JP7696443B2 (ja) | Egfr変異を有するがんを処置するためのアミノ置換ヘテロ環類 | |
| JP6532878B2 (ja) | 組合せ医薬 | |
| JP2008528471A5 (https=) | ||
| US20230338314A1 (en) | Methods for the treatment of myeloid derived suppressor cells related disorders | |
| RU2020112759A (ru) | Гетероциклические соединения в качестве ингибиторов PAD | |
| RU2007131101A (ru) | Комбинации пиразольных ингибиторов киназы и других средств против злокачественных новообразований | |
| JP2024072291A (ja) | 同種抗体により駆動される慢性移植片対宿主病を処置及び予防する方法 | |
| JP2009536620A5 (https=) | ||
| JP2007517807A5 (https=) | ||
| US9205091B2 (en) | Diazeniumdiolated compounds, pharmaceutical compositions, and method of treating cancer | |
| JP2005526794A5 (ja) | ベンズイミダゾールおよびマイトジェン活性化およびrhoキナーゼ阻害剤としてのその使用 | |
| US20240197729A1 (en) | ALK-5 Inhibitors and Uses Thereof | |
| BRPI0612076A2 (pt) | modulação sinergìstica de flt3 cinase empregando-se moduladores de aminopirimidinas cinase | |
| EP4419094A1 (en) | Compositions and methods for treatment of hyperproliferative, inflammatory, and immunological diseases, and infections | |
| WO2025076109A1 (en) | Use of elesclomol to treat clear-cell ovarian cancers with mutations in arid1a | |
| US20240360135A1 (en) | Imidazo[1,2-b]pyridazinyl compounds and uses thereof | |
| RU2008129623A (ru) | Ингибиторы ccr9 активности | |
| CA3209512A1 (en) | Compositions and methods to improve the therapeutic benefit of suboptimally administered chemical compounds and biological therapies including substituted camptothecins such as irinotecan and topotecan for the treatment of benign and neoplastic hyperproliferative disease conditions, infections, inflammatory and immunological diseases | |
| EA201000882A1 (ru) | Соединение, его применение и фармацевтическая композиция, содержащая это соединение | |
| MA28930B1 (fr) | Derives pyridiniques d'indolin-2-one , leur preparation et leur application en therapeutique | |
| JP6737443B2 (ja) | 治療的処置でのBCRP阻害剤としての使用のための4−アミノ−3−フェニルアミノ−6−フェニルピラゾロ[3,4−d]ピリミジン誘導体 | |
| US20210220331A1 (en) | Inhibitors of ires-mediated protein synthesis | |
| WO2018222975A1 (en) | Methods for the treatment of cancer |