JP2007515470A5 - - Google Patents
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- Publication number
- JP2007515470A5 JP2007515470A5 JP2006546389A JP2006546389A JP2007515470A5 JP 2007515470 A5 JP2007515470 A5 JP 2007515470A5 JP 2006546389 A JP2006546389 A JP 2006546389A JP 2006546389 A JP2006546389 A JP 2006546389A JP 2007515470 A5 JP2007515470 A5 JP 2007515470A5
- Authority
- JP
- Japan
- Prior art keywords
- assembly
- component
- net charge
- microvesicle
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007900 aqueous suspension Substances 0.000 claims 12
- -1 polyoxyethylene Polymers 0.000 claims 12
- 239000007789 gas Substances 0.000 claims 11
- 150000003904 phospholipids Chemical class 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 9
- 235000014113 dietary fatty acids Nutrition 0.000 claims 7
- 229930195729 fatty acid Natural products 0.000 claims 7
- 239000000194 fatty acid Substances 0.000 claims 7
- 150000002632 lipids Chemical class 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 239000002243 precursor Substances 0.000 claims 6
- 239000004094 surface-active agent Substances 0.000 claims 6
- 239000000725 suspension Substances 0.000 claims 6
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 4
- 239000004698 Polyethylene Substances 0.000 claims 4
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical class CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 4
- 125000005210 alkyl ammonium group Chemical group 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 239000000693 micelle Substances 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 4
- 229920000573 polyethylene Polymers 0.000 claims 4
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims 4
- 150000003866 tertiary ammonium salts Chemical class 0.000 claims 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 3
- 108010007979 Glycocholic Acid Proteins 0.000 claims 3
- 239000012867 bioactive agent Substances 0.000 claims 3
- 229940099352 cholate Drugs 0.000 claims 3
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 claims 3
- 229940009976 deoxycholate Drugs 0.000 claims 3
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 claims 3
- RFDAIACWWDREDC-FRVQLJSFSA-N glycocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 RFDAIACWWDREDC-FRVQLJSFSA-N 0.000 claims 3
- 150000008103 phosphatidic acids Chemical class 0.000 claims 3
- 150000008106 phosphatidylserines Chemical class 0.000 claims 3
- 239000008365 aqueous carrier Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229940039227 diagnostic agent Drugs 0.000 claims 2
- 239000000032 diagnostic agent Substances 0.000 claims 2
- 239000000839 emulsion Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims 1
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 229920002988 biodegradable polymer Polymers 0.000 claims 1
- 239000004621 biodegradable polymer Substances 0.000 claims 1
- 239000010415 colloidal nanoparticle Substances 0.000 claims 1
- 238000002059 diagnostic imaging Methods 0.000 claims 1
- OGQYPPBGSLZBEG-UHFFFAOYSA-N dimethyl(dioctadecyl)azanium Chemical group CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC OGQYPPBGSLZBEG-UHFFFAOYSA-N 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 229920000831 ionic polymer Polymers 0.000 claims 1
- 239000002563 ionic surfactant Substances 0.000 claims 1
- 150000002772 monosaccharides Chemical class 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Chemical class 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000010409 thin film Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03029534 | 2003-12-22 | ||
| EP03029534.9 | 2003-12-22 | ||
| PCT/IB2004/004230 WO2005063305A1 (en) | 2003-12-22 | 2004-12-21 | Gas-filled microvesicle assembly for contrast imaging |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011237685A Division JP2012051932A (ja) | 2003-12-22 | 2011-10-28 | 造影イメージング用の気体封入マイクロベシクル・アセンブリー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007515470A JP2007515470A (ja) | 2007-06-14 |
| JP2007515470A5 true JP2007515470A5 (enExample) | 2007-12-27 |
| JP5513708B2 JP5513708B2 (ja) | 2014-06-04 |
Family
ID=34717195
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006546389A Expired - Fee Related JP5513708B2 (ja) | 2003-12-22 | 2004-12-21 | 造影イメージング用の気体封入マイクロベシクル・アセンブリー |
| JP2011237685A Pending JP2012051932A (ja) | 2003-12-22 | 2011-10-28 | 造影イメージング用の気体封入マイクロベシクル・アセンブリー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011237685A Pending JP2012051932A (ja) | 2003-12-22 | 2011-10-28 | 造影イメージング用の気体封入マイクロベシクル・アセンブリー |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9750821B2 (enExample) |
| EP (1) | EP1701745B1 (enExample) |
| JP (2) | JP5513708B2 (enExample) |
| CN (1) | CN100563718C (enExample) |
| AU (1) | AU2004308756B2 (enExample) |
| CA (1) | CA2547024C (enExample) |
| ES (1) | ES2531732T3 (enExample) |
| NO (1) | NO338316B1 (enExample) |
| WO (1) | WO2005063305A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004029010D1 (de) | 2003-02-04 | 2010-10-21 | Bracco Suisse Sa | Ultraschall kontrastmittel und verfahren zur erstellung |
| CN1897978B (zh) * | 2003-12-22 | 2011-11-23 | 博莱科瑞士股份有限公司 | 具有用于反差成像的活性组分的充气微囊组件 |
| AU2004308756B2 (en) | 2003-12-22 | 2010-06-24 | Bracco Suisse S.A. | Gas-filled microvesicle assembly for contrast imaging |
| CN101005858A (zh) | 2004-08-18 | 2007-07-25 | 伯拉考开发股份有限公司 | 用于反差成像的充气微泡组合物 |
| JP5420410B2 (ja) | 2006-09-05 | 2014-02-19 | ブラッコ・シュイス・ソシエテ・アノニム | ポリマー修飾脂質を含むガス封入微小胞 |
| US20090180967A1 (en) * | 2008-01-15 | 2009-07-16 | Eugene Tu | Ultrsonically active microparticles and method of use |
| US20090234231A1 (en) * | 2008-03-13 | 2009-09-17 | Knight Jon M | Imaging Catheter With Integrated Contrast Agent Injector |
| JP5491511B2 (ja) | 2008-10-07 | 2014-05-14 | ブラッコ・シュイス・ソシエテ・アノニム | 抗ポリマー抗体およびそれと結合するリポソームまたは微小胞を含むターゲッティング構築物 |
| CN105152939A (zh) | 2008-11-10 | 2015-12-16 | 阿尔尼拉姆医药品有限公司 | 用于递送治疗剂的脂质和组合物 |
| CN101745126B (zh) * | 2008-12-10 | 2012-04-25 | 温州医学院 | 一种包载水溶性药物超声造影剂的制备方法 |
| US10058837B2 (en) | 2009-08-28 | 2018-08-28 | The Trustees Of Columbia University In The City Of New York | Systems, methods, and devices for production of gas-filled microbubbles |
| EP2477550A4 (en) * | 2009-09-15 | 2013-12-04 | Univ Columbia | SYSTEMS, METHODS AND DEVICES FOR MICROBUBBLES |
| CN101773675B (zh) * | 2010-03-05 | 2012-05-30 | 中山大学 | 一种负载液态氟碳的聚合物纳米超声显像囊泡及其制备方法 |
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| US20130216593A1 (en) * | 2010-08-28 | 2013-08-22 | The Trustees Of Columbia University In The City Of New York | Systems, methods, and devices for plasmid gene transfection using polymer-modified microbubbles |
| MX362089B (es) | 2011-12-16 | 2019-01-07 | Nanobiotix | Nanopartículas que comprenden materiales metálicos y óxido de hafnio, preparación y usos de los mismos. |
| US10357450B2 (en) | 2012-04-06 | 2019-07-23 | Children's Medical Center Corporation | Process for forming microbubbles with high oxygen content and uses thereof |
| US20150087624A1 (en) * | 2012-04-24 | 2015-03-26 | Osaka University | Method for producing an aqueous dispersion of drug nanoparticles and use thereof |
| US20150343079A1 (en) * | 2012-10-25 | 2015-12-03 | Sogang University Research Foundation | Ultrasound contrast agent with nanoparticles including drug and method for preparing the same |
| WO2014096165A2 (en) | 2012-12-21 | 2014-06-26 | Bracco Suisse Sa | Gas-filled microvesicles |
| EP2968825A4 (en) | 2013-03-15 | 2016-09-07 | Childrens Medical Center | Gas-filled stabilized particles and methods of use |
| BR112015029853A2 (pt) * | 2013-05-30 | 2017-07-25 | Nanobiotix | uso de uma composição farmacêutica |
| KR101595795B1 (ko) * | 2014-03-19 | 2016-02-22 | (주)아이엠지티 | 약물을 함유한 나노입자가 결합된 이중-목적 paｔ／초음파 조영제 및 이의 제조방법 |
| CN104337766A (zh) * | 2014-10-09 | 2015-02-11 | 唐春林 | 一种地高辛脂质微泡及其制备方法 |
| CA2968473A1 (en) | 2014-11-25 | 2016-06-02 | Nanobiotix | Pharmaceutical composition, preparation and uses thereof |
| LT3223796T (lt) | 2014-11-25 | 2021-10-25 | Curadigm Sas | Farmacinės kompozicijos, jų gamyba ir panaudojimo būdai |
| JP6789960B2 (ja) | 2014-11-25 | 2020-11-25 | キュラディグム・エスアエスＣｕｒａｄｉｇｍ Ｓａｓ | 医薬組成物、その調製及び使用 |
| PL3229843T3 (pl) | 2014-11-25 | 2020-06-29 | Curadigm Sas | Kompozycja farmaceutyczna, wytwarzanie i zastosowanie tej kompozycji |
| PT3229776T (pt) | 2014-11-25 | 2023-08-17 | Curadigm Sas | Composição farmacêutica combinando pelo menos duas nanopartícuas distintas e um composto farmacêutico, preparaçâo e suas utilizações |
| KR102618877B1 (ko) | 2014-12-31 | 2023-12-28 | 랜티우스 메디컬 이메징, 인크. | 지질-캡슐화된 기체 마이크로스피어 조성물 및 관련 방법 |
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| JP2019503403A (ja) * | 2016-02-01 | 2019-02-07 | トラスト バイオソニックス インクＴｒｕｓｔ Ｂｉｏｓｏｎｉｃｓ Ｉｎｃ． | 脂質組成のマイクロバブル及びその製造方法 |
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| WO2018160752A1 (en) | 2017-02-28 | 2018-09-07 | Children's Medical Center Corporation | Stimuli-responsive particles encapsulating a gas and methods of use |
| JP7227694B2 (ja) * | 2017-12-08 | 2023-02-22 | 大平 猛 | 正に帯電したナノバブル分散液 |
| JP7539380B2 (ja) * | 2018-12-21 | 2024-08-23 | ブラッコ・スイス・ソシエテ・アノニム | リガンドを含むガス充填微小胞 |
| US20200360289A1 (en) * | 2019-05-15 | 2020-11-19 | Bracco Suisse Sa | Freeze-dried product and gas-filled microvesicles suspension |
| IL299049A (en) * | 2020-06-15 | 2023-02-01 | Bracco Suisse Sa | Vasospasm inhibitors for use in enhancing the efficacy of combined therapeutic treatment of gas-filled microvesicles and ultrasound for therapy |
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-
2004
- 2004-12-21 AU AU2004308756A patent/AU2004308756B2/en not_active Ceased
- 2004-12-21 CN CNB2004800386196A patent/CN100563718C/zh not_active Expired - Fee Related
- 2004-12-21 EP EP04806409.1A patent/EP1701745B1/en not_active Expired - Lifetime
- 2004-12-21 JP JP2006546389A patent/JP5513708B2/ja not_active Expired - Fee Related
- 2004-12-21 WO PCT/IB2004/004230 patent/WO2005063305A1/en not_active Ceased
- 2004-12-21 CA CA2547024A patent/CA2547024C/en not_active Expired - Fee Related
- 2004-12-21 US US10/584,327 patent/US9750821B2/en not_active Expired - Fee Related
- 2004-12-21 ES ES04806409.1T patent/ES2531732T3/es not_active Expired - Lifetime
-
2006
- 2006-07-24 NO NO20063419A patent/NO338316B1/no not_active IP Right Cessation
-
2011
- 2011-10-28 JP JP2011237685A patent/JP2012051932A/ja active Pending
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