AU2004308756B2 - Gas-filled microvesicle assembly for contrast imaging - Google Patents

Gas-filled microvesicle assembly for contrast imaging Download PDF

Info

Publication number
AU2004308756B2
AU2004308756B2 AU2004308756A AU2004308756A AU2004308756B2 AU 2004308756 B2 AU2004308756 B2 AU 2004308756B2 AU 2004308756 A AU2004308756 A AU 2004308756A AU 2004308756 A AU2004308756 A AU 2004308756A AU 2004308756 B2 AU2004308756 B2 AU 2004308756B2
Authority
AU
Australia
Prior art keywords
assembly
assembly according
gas
suspension
microvesicle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2004308756A
Other languages
English (en)
Other versions
AU2004308756A1 (en
Inventor
Philippe Bussat
Michel Schneider
Anne Senente
Feng Yan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Suisse SA
Original Assignee
Bracco Suisse SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Suisse SA filed Critical Bracco Suisse SA
Publication of AU2004308756A1 publication Critical patent/AU2004308756A1/en
Application granted granted Critical
Publication of AU2004308756B2 publication Critical patent/AU2004308756B2/en
Assigned to BRACCO SUISSE S.A. reassignment BRACCO SUISSE S.A. Request to Amend Deed and Register Assignors: BRACCO RESEARCH SA
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Acoustics & Sound (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Adornments (AREA)
AU2004308756A 2003-12-22 2004-12-21 Gas-filled microvesicle assembly for contrast imaging Ceased AU2004308756B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03029534 2003-12-22
EP03029534.9 2003-12-22
PCT/IB2004/004230 WO2005063305A1 (en) 2003-12-22 2004-12-21 Gas-filled microvesicle assembly for contrast imaging

Publications (2)

Publication Number Publication Date
AU2004308756A1 AU2004308756A1 (en) 2005-07-14
AU2004308756B2 true AU2004308756B2 (en) 2010-06-24

Family

ID=34717195

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004308756A Ceased AU2004308756B2 (en) 2003-12-22 2004-12-21 Gas-filled microvesicle assembly for contrast imaging

Country Status (9)

Country Link
US (1) US9750821B2 (enExample)
EP (1) EP1701745B1 (enExample)
JP (2) JP5513708B2 (enExample)
CN (1) CN100563718C (enExample)
AU (1) AU2004308756B2 (enExample)
CA (1) CA2547024C (enExample)
ES (1) ES2531732T3 (enExample)
NO (1) NO338316B1 (enExample)
WO (1) WO2005063305A1 (enExample)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004210221B2 (en) 2003-02-04 2008-11-20 Bracco Suisse S.A. Ultrasound contrast agents and process for the preparation thereof
EP1696965B1 (en) * 2003-12-22 2014-12-10 Bracco Suisse SA Assembly of gas-filled microvesicle with active component for contrast imaging
CN100563718C (zh) 2003-12-22 2009-12-02 伯拉考开发股份有限公司 用于反差成像的充气微囊组件
JP4837663B2 (ja) 2004-08-18 2011-12-14 ブラッコ・シュイス・ソシエテ・アノニム 造影画像化のためのガス充填微小胞組成物
DE602007006968D1 (de) 2006-09-05 2010-07-15 Bracco Research Sa Gasgefüllte mikrovesikel mit polymer-modifizierten lipiden
WO2009091927A1 (en) * 2008-01-15 2009-07-23 Eugene Tu Ultrasonically active microparticles and method of use
US20090234231A1 (en) * 2008-03-13 2009-09-17 Knight Jon M Imaging Catheter With Integrated Contrast Agent Injector
JP5491511B2 (ja) 2008-10-07 2014-05-14 ブラッコ・シュイス・ソシエテ・アノニム 抗ポリマー抗体およびそれと結合するリポソームまたは微小胞を含むターゲッティング構築物
WO2010054406A1 (en) 2008-11-10 2010-05-14 Alnylam Pharmaceuticals, Inc. Novel lipids and compositions for the delivery of therapeutics
CN101745126B (zh) * 2008-12-10 2012-04-25 温州医学院 一种包载水溶性药物超声造影剂的制备方法
EP2470287A4 (en) 2009-08-28 2015-01-21 Univ Columbia SYSTEMS, METHODS AND DEVICES FOR PRODUCING GAS-FILLED MICROBUBBLES
US9107950B2 (en) 2009-09-15 2015-08-18 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for microbubbles
CN101773675B (zh) * 2010-03-05 2012-05-30 中山大学 一种负载液态氟碳的聚合物纳米超声显像囊泡及其制备方法
US9844504B2 (en) 2010-04-16 2017-12-19 University of Pittsburgh—of the Commonwealth System of Higher Education Custom designed microbubble contrast agents and techniques of ultrasound delivery optimized for gene therapy
TW201208706A (en) 2010-08-17 2012-03-01 Univ Nat Yang Ming Ultrasonically-triggered drug vehicle with magnetic resonance imaging function
WO2012030675A1 (en) * 2010-08-28 2012-03-08 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for plasmid gene transfection using polymer-modified microbubbles
KR102025743B1 (ko) 2011-12-16 2019-09-26 나노비오?스 금속성 및 산화하프늄 소재를 포함하는 나노입자, 이의 제조 및 용도
US10357450B2 (en) 2012-04-06 2019-07-23 Children's Medical Center Corporation Process for forming microbubbles with high oxygen content and uses thereof
US20150087624A1 (en) * 2012-04-24 2015-03-26 Osaka University Method for producing an aqueous dispersion of drug nanoparticles and use thereof
WO2014065513A1 (ko) * 2012-10-25 2014-05-01 서강대학교 산학협력단 약물을 함유한 나노입자가 결합된 초음파 조영제 및 이의 제조방법
EP2934740B1 (en) 2012-12-21 2019-12-11 Bracco Suisse SA Gas-filled microvesicles
EP2968825A4 (en) 2013-03-15 2016-09-07 Childrens Medical Center Gas-filled stabilized particles and methods of use
SG11201509436TA (en) 2013-05-30 2015-12-30 Nanobiotix Pharmaceutical composition, preparation and uses thereof
KR101595795B1 (ko) * 2014-03-19 2016-02-22 (주)아이엠지티 약물을 함유한 나노입자가 결합된 이중-목적 paｔ／초음파 조영제 및 이의 제조방법
CN104337766A (zh) * 2014-10-09 2015-02-11 唐春林 一种地高辛脂质微泡及其制备方法
DK3236934T3 (da) * 2014-11-25 2024-08-19 Curadigm Sas Farmaceutisk sammensætning, fremstilling og anvendelser deraf
MX2017006813A (es) 2014-11-25 2018-01-30 Nanobiotix Composicion farmaceutica, preparacion y usos de la misma.
WO2016083331A1 (en) 2014-11-25 2016-06-02 Nanobiotix Pharmaceutical composition, preparation and uses thereof
JP6836510B2 (ja) 2014-11-25 2021-03-03 キュラディグム・エスアエスＣｕｒａｄｉｇｍ Ｓａｓ 少なくとも２つの異なるナノ粒子と医薬化合物とを組み合わせた医薬組成物、その調製及び使用
AR102780A1 (es) 2014-11-25 2017-03-22 Nanobiotix Composiciones farmacéuticas, su preparación y sus usos
KR102618877B1 (ko) * 2014-12-31 2023-12-28 랜티우스 메디컬 이메징, 인크. 지질-캡슐화된 기체 마이크로스피어 조성물 및 관련 방법
EP3302419A1 (en) 2015-05-28 2018-04-11 Nanobiotix Nanoparticles for use as a therapeutic vaccine
US20190046667A1 (en) * 2016-02-01 2019-02-14 Trust Biosonics Inc. Lipid microbubbles and process of making thereof
IL262647B2 (en) 2016-05-04 2023-03-01 Lantheus Medical Imaging Inc Methods and devices for preparing sharpness factors for ultrasound
US9789210B1 (en) * 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
NO342271B1 (en) * 2016-09-29 2018-04-30 Sintef Tto As A new drug delivery system for treatment of cancer
WO2018160752A1 (en) 2017-02-28 2018-09-07 Children's Medical Center Corporation Stimuli-responsive particles encapsulating a gas and methods of use
JP7227694B2 (ja) * 2017-12-08 2023-02-22 大平 猛 正に帯電したナノバブル分散液
ES2984146T3 (es) 2018-12-21 2024-10-29 Bracco Suisse Sa Microvesículas llenas de gas con ligando
US20200360289A1 (en) * 2019-05-15 2020-11-19 Bracco Suisse Sa Freeze-dried product and gas-filled microvesicles suspension
CA3177232A1 (en) * 2020-06-15 2021-12-23 Bracco Suisse Sa Improvements in ultrasound-mediated therapy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995023615A1 (en) * 1994-03-01 1995-09-08 Holmes, Michael, John Gas-containing microcapsules useful as contrast agents for diagnostic imaging
US5562099A (en) * 1990-10-05 1996-10-08 Massachusetts Institute Of Technology Polymeric microparticles containing agents for imaging
US6331289B1 (en) * 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2647121A (en) * 1951-02-02 1953-07-28 Ruth P Jacoby Diamine-bis-acetamides
US2819718A (en) * 1953-07-16 1958-01-14 Isidore H Goldman Drainage tube
US2844629A (en) * 1956-04-25 1958-07-22 American Home Prod Fatty acid amides and derivatives thereof
US3096560A (en) * 1958-11-21 1963-07-09 William J Liebig Process for synthetic vascular implants
JPS5141663B1 (enExample) * 1966-03-12 1976-11-11
NL143127B (nl) * 1969-02-04 1974-09-16 Rhone Poulenc Sa Versterkingsorgaan voor een defecte hartklep.
US3614955A (en) * 1970-02-09 1971-10-26 Medtronic Inc Standby defibrillator and method of operation
US3614954A (en) * 1970-02-09 1971-10-26 Medtronic Inc Electronic standby defibrillator
US3945052A (en) * 1972-05-01 1976-03-23 Meadox Medicals, Inc. Synthetic vascular graft and method for manufacturing the same
US3805301A (en) * 1972-07-28 1974-04-23 Meadox Medicals Inc Tubular grafts having indicia thereon
US4013507A (en) * 1973-09-18 1977-03-22 California Institute Of Technology Ionene polymers for selectively inhibiting the vitro growth of malignant cells
US3995623A (en) * 1974-12-23 1976-12-07 American Hospital Supply Corporation Multipurpose flow-directed catheter
US4281669A (en) * 1975-05-09 1981-08-04 Macgregor David C Pacemaker electrode with porous system
US4096860A (en) * 1975-10-08 1978-06-27 Mclaughlin William F Dual flow encatheter
CA1069652A (en) * 1976-01-09 1980-01-15 Alain F. Carpentier Supported bioprosthetic heart valve with compliant orifice ring
US4134402A (en) * 1976-02-11 1979-01-16 Mahurkar Sakharam D Double lumen hemodialysis catheter
US4072146A (en) * 1976-09-08 1978-02-07 Howes Randolph M Venous catheter device
US4335723A (en) * 1976-11-26 1982-06-22 The Kendall Company Catheter having inflatable retention means
US4099528A (en) * 1977-02-17 1978-07-11 Sorenson Research Co., Inc. Double lumen cannula
US4140126A (en) * 1977-02-18 1979-02-20 Choudhury M Hasan Method for performing aneurysm repair
US4182833A (en) * 1977-12-07 1980-01-08 Celanese Polymer Specialties Company Cationic epoxide-amine reaction products
US4180068A (en) * 1978-04-13 1979-12-25 Motion Control, Incorporated Bi-directional flow catheter with retractable trocar/valve structure
DE2960875D1 (en) * 1978-04-19 1981-12-10 Ici Plc A method of preparing a tubular product by electrostatic spinning
US4284459A (en) * 1978-07-03 1981-08-18 The Kendall Company Method for making a molded catheter
US4227533A (en) * 1978-11-03 1980-10-14 Bristol-Myers Company Flushable urinary catheter
US4276885A (en) 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4339369A (en) * 1981-04-23 1982-07-13 Celanese Corporation Cationic epoxide-amine reaction products
ATE26584T1 (de) 1983-07-01 1987-05-15 Battelle Memorial Institute In-vivo abbaubares polypeptid und dessen anwendung zur verzoegerten freigabe von medikamenten.
SE463651B (sv) 1983-12-21 1991-01-07 Nycomed As Diagnostikum och kontrastmedel
ATE60340T1 (de) 1984-10-19 1991-02-15 Battelle Memorial Institute Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten.
CH667874A5 (fr) 1985-12-19 1988-11-15 Battelle Memorial Institute Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments.
IE61591B1 (en) 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
US5733572A (en) 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5556610A (en) 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US20080063603A1 (en) 1990-04-02 2008-03-13 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
IN172208B (enExample) * 1990-04-02 1993-05-01 Sint Sa
AU636481B2 (en) 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5487390A (en) 1990-10-05 1996-01-30 Massachusetts Institute Of Technology Gas-filled polymeric microbubbles for ultrasound imaging
JP2974083B2 (ja) 1990-11-26 1999-11-08 株式会社 小松製作所 静油圧―機械式伝動機の制御装置
EP0593627A1 (en) 1991-07-05 1994-04-27 The University Of Rochester Ultrasmall non-aggregated porous particles entrapping gas-bubbles
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
DE4208527A1 (de) * 1992-03-17 1993-09-23 Max Planck Gesellschaft Liposomen mit negativer ueberschussladung
AU4563093A (en) 1992-07-03 1994-01-31 Byk Gulden Lomberg Chemische Fabrik Gmbh Echographic contrast agent composition
US5464696A (en) 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
JP3559849B2 (ja) 1993-07-30 2004-09-02 アイエムシーオーアール ファーマシューティカル カンパニー 超音波技術のための安定化された微小気泡組成物
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
HU225495B1 (en) 1993-12-15 2007-01-29 Bracco Research Sa Gas mixtures useful as ultrasound contrast media
US5876697A (en) 1994-08-04 1999-03-02 Gakko Houjin Toin Gakuen Method for the production of microbubble-type ultrasonic contrast agent using fatty acid surfactants
GB9417941D0 (en) 1994-09-06 1994-10-26 Nycomed Imaging As Improvements in or relating to contrast agents
WO1996009037A1 (en) 1994-09-23 1996-03-28 The Liposome Company, Inc. Method of producing a lyophilized liposome product
US6333021B1 (en) 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
IL116328A (en) 1994-12-16 1999-09-22 Bracco Research Sa Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US5833948A (en) 1995-06-15 1998-11-10 Bracco Research S.A. Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant
NZ331509A (en) 1996-02-19 2000-04-28 Nycomed Imaging As Aqueous dispersions of stabilised gas microbubbles and their use as contrast agents
US6165442A (en) 1996-02-19 2000-12-26 Nycomed Imaging As Thermally stabilized ultrasound contrast agent
ATE237362T1 (de) 1996-02-19 2003-05-15 Amersham Health As Thermostabilisiertes kontrastmittel
DE19781888T1 (de) 1996-07-22 1999-07-01 Seagate Technology Phasendetektor-Schätzeinrichtung
IL128345A (en) 1996-08-02 2003-06-24 Amersham Health As Enhanced contrast agent for ultrasound imaging of the liver
CZ140999A3 (cs) * 1996-10-21 1999-09-15 Nycomed Imaging As Směsný prostředek pro použití jako kontrastní činidlo
WO1998018501A2 (en) 1996-10-28 1998-05-07 Marsden, John, Christopher Improvements in or relating to diagnostic/therapeutic agents
KR20000052830A (ko) 1996-10-28 2000-08-25 조오지 디빈센조, 토브 아스 헬지, 에바 요한손 진단/치료제 또는 그와 관련된 개선
GB9701237D0 (en) 1997-01-22 1997-03-12 Nycomed Imaging As Improvements in or relating to contrast agents
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6245318B1 (en) 1997-05-27 2001-06-12 Mallinckrodt Inc. Selectively binding ultrasound contrast agents
GB9717589D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
JP2001520207A (ja) 1997-10-21 2001-10-30 ニユコメド・イメージング・アクシエセルカペト 微小血管に標的設定された造影剤および血管拡張剤による超音波造影
US20020169138A1 (en) * 1997-10-24 2002-11-14 Southern Research Institute Delivery vehicles for bioactive agents and uses thereof
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
AU753196B2 (en) * 1998-02-09 2002-10-10 Bracco Research S.A. Targeted delivery of biologically active media
GB9808599D0 (en) 1998-04-22 1998-06-24 Nycomed Imaging As Improvements in or realting to contrast agents
GB9809084D0 (en) 1998-04-28 1998-06-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
FR2782006B1 (fr) 1998-08-07 2002-04-19 Gattefosse Ets Sa Composition a liberation prolongee apte a former une micro-emulsion
JP2000143550A (ja) * 1998-11-10 2000-05-23 Toin Gakuen 超音波造影剤
DE10013850A1 (de) 2000-03-15 2001-09-20 Schering Ag Gasgefüllte Mikrokapseln enthaltend funktionalisiertes Polyalkylcyanacrylat, sowie Verfahren zu deren Herstellung
CA2432474C (en) 2000-12-23 2012-06-26 Dyax Corp. Fibrin binding polypeptides useful inter alia in medical imaging processes
US6793626B2 (en) 2001-01-17 2004-09-21 Fuji Photo Film Co., Ltd. Ultrasonic scatterer, ultrasonic imaging method and ultrasonic imaging apparatus
JP2002212108A (ja) 2001-01-17 2002-07-31 Fuji Photo Film Co Ltd 超音波散乱体
US7179449B2 (en) 2001-01-30 2007-02-20 Barnes-Jewish Hospital Enhanced ultrasound detection with temperature-dependent contrast agents
ES2243350T3 (es) 2001-01-31 2005-12-01 Bracco International B.V. Agente de contraste liofizable que comprende microburbujas de gas.
AU2002317095A1 (en) * 2001-07-03 2003-01-21 Governors Of The University Of Alberta Magnetic nanoparticles for bioseparation application and methods for producing same
JP2005505532A (ja) 2001-08-16 2005-02-24 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー 気体微粒子リポソーム複合体
ES2506142T3 (es) 2002-03-01 2014-10-13 Dyax Corp. Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico
WO2003084574A1 (en) 2002-03-01 2003-10-16 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
CA2489287C (fr) 2002-06-19 2011-04-05 Dimitrios Patsalaridis Dispositif de support ancrable dans le sol
US7459145B2 (en) * 2002-10-25 2008-12-02 Georgia Tech Research Corporation Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring
AU2004210221B2 (en) 2003-02-04 2008-11-20 Bracco Suisse S.A. Ultrasound contrast agents and process for the preparation thereof
AU2004285595A1 (en) 2003-10-31 2005-05-12 Point Biomedical Corporation Reconstitutable microsphere compositions useful as ultrasonic contrast agents
CN100563718C (zh) 2003-12-22 2009-12-02 伯拉考开发股份有限公司 用于反差成像的充气微囊组件
EP1696965B1 (en) 2003-12-22 2014-12-10 Bracco Suisse SA Assembly of gas-filled microvesicle with active component for contrast imaging
CA2554239C (en) 2004-01-20 2015-05-12 Sunnybrook And Women's College Health Sciences Centre High frequency ultrasound imaging using contrast agents
JP4837663B2 (ja) 2004-08-18 2011-12-14 ブラッコ・シュイス・ソシエテ・アノニム 造影画像化のためのガス充填微小胞組成物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5562099A (en) * 1990-10-05 1996-10-08 Massachusetts Institute Of Technology Polymeric microparticles containing agents for imaging
WO1995023615A1 (en) * 1994-03-01 1995-09-08 Holmes, Michael, John Gas-containing microcapsules useful as contrast agents for diagnostic imaging
US6331289B1 (en) * 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors

Also Published As

Publication number Publication date
JP5513708B2 (ja) 2014-06-04
AU2004308756A1 (en) 2005-07-14
JP2012051932A (ja) 2012-03-15
CN1897979A (zh) 2007-01-17
NO338316B1 (no) 2016-08-08
CN100563718C (zh) 2009-12-02
EP1701745B1 (en) 2014-12-10
ES2531732T3 (es) 2015-03-18
CA2547024C (en) 2013-12-17
US9750821B2 (en) 2017-09-05
US20070071685A1 (en) 2007-03-29
NO20063419L (no) 2006-09-21
EP1701745A1 (en) 2006-09-20
JP2007515470A (ja) 2007-06-14
CA2547024A1 (en) 2005-07-14
WO2005063305A1 (en) 2005-07-14

Similar Documents

Publication Publication Date Title
AU2004308756B2 (en) Gas-filled microvesicle assembly for contrast imaging
EP1696965B1 (en) Assembly of gas-filled microvesicle with active component for contrast imaging
EP1590006B1 (en) Ultrasound contrast agents and process for the preparation thereof
CA2662087C (en) Gas-filled microvesicles with polymer-modified lipids
US10010630B2 (en) Gas-filled microvesicles

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired