JP5513708B2 - 造影イメージング用の気体封入マイクロベシクル・アセンブリー - Google Patents
造影イメージング用の気体封入マイクロベシクル・アセンブリー Download PDFInfo
- Publication number
- JP5513708B2 JP5513708B2 JP2006546389A JP2006546389A JP5513708B2 JP 5513708 B2 JP5513708 B2 JP 5513708B2 JP 2006546389 A JP2006546389 A JP 2006546389A JP 2006546389 A JP2006546389 A JP 2006546389A JP 5513708 B2 JP5513708 B2 JP 5513708B2
- Authority
- JP
- Japan
- Prior art keywords
- assembly
- gas
- microvesicles
- suspension
- microvesicle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/225—Microparticles, microcapsules
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Acoustics & Sound (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Adornments (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03029534.9 | 2003-12-22 | ||
| EP03029534 | 2003-12-22 | ||
| PCT/IB2004/004230 WO2005063305A1 (en) | 2003-12-22 | 2004-12-21 | Gas-filled microvesicle assembly for contrast imaging |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011237685A Division JP2012051932A (ja) | 2003-12-22 | 2011-10-28 | 造影イメージング用の気体封入マイクロベシクル・アセンブリー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007515470A JP2007515470A (ja) | 2007-06-14 |
| JP2007515470A5 JP2007515470A5 (enExample) | 2007-12-27 |
| JP5513708B2 true JP5513708B2 (ja) | 2014-06-04 |
Family
ID=34717195
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006546389A Expired - Fee Related JP5513708B2 (ja) | 2003-12-22 | 2004-12-21 | 造影イメージング用の気体封入マイクロベシクル・アセンブリー |
| JP2011237685A Pending JP2012051932A (ja) | 2003-12-22 | 2011-10-28 | 造影イメージング用の気体封入マイクロベシクル・アセンブリー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011237685A Pending JP2012051932A (ja) | 2003-12-22 | 2011-10-28 | 造影イメージング用の気体封入マイクロベシクル・アセンブリー |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9750821B2 (enExample) |
| EP (1) | EP1701745B1 (enExample) |
| JP (2) | JP5513708B2 (enExample) |
| CN (1) | CN100563718C (enExample) |
| AU (1) | AU2004308756B2 (enExample) |
| CA (1) | CA2547024C (enExample) |
| ES (1) | ES2531732T3 (enExample) |
| NO (1) | NO338316B1 (enExample) |
| WO (1) | WO2005063305A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004069284A2 (en) | 2003-02-04 | 2004-08-19 | Bracco International B.V. | Ultrasound contrast agents and process for the preparation thereof |
| CN1897978B (zh) * | 2003-12-22 | 2011-11-23 | 博莱科瑞士股份有限公司 | 具有用于反差成像的活性组分的充气微囊组件 |
| JP5513708B2 (ja) | 2003-12-22 | 2014-06-04 | ブラッコ・シュイス・ソシエテ・アノニム | 造影イメージング用の気体封入マイクロベシクル・アセンブリー |
| CN101005858A (zh) | 2004-08-18 | 2007-07-25 | 伯拉考开发股份有限公司 | 用于反差成像的充气微泡组合物 |
| AU2007293888B2 (en) | 2006-09-05 | 2013-05-02 | Bracco Suisse S.A. | Gas-filled microvesicles with polymer-modified lipids |
| WO2009091927A1 (en) * | 2008-01-15 | 2009-07-23 | Eugene Tu | Ultrasonically active microparticles and method of use |
| US20090234231A1 (en) * | 2008-03-13 | 2009-09-17 | Knight Jon M | Imaging Catheter With Integrated Contrast Agent Injector |
| US9192685B2 (en) | 2008-10-07 | 2015-11-24 | Bracco Suisse S.A. | Targeting construct comprising anti-polymer antibody and contrast/therapeutic agents binding to the same |
| EP3757090B1 (en) | 2008-11-10 | 2024-06-12 | Arbutus Biopharma Corporation | Novel lipids and compositions for the delivery of therapeutics |
| CN101745126B (zh) * | 2008-12-10 | 2012-04-25 | 温州医学院 | 一种包载水溶性药物超声造影剂的制备方法 |
| US10058837B2 (en) | 2009-08-28 | 2018-08-28 | The Trustees Of Columbia University In The City Of New York | Systems, methods, and devices for production of gas-filled microbubbles |
| US9107950B2 (en) | 2009-09-15 | 2015-08-18 | The Trustees Of Columbia University In The City Of New York | Systems, methods, and devices for microbubbles |
| CN101773675B (zh) * | 2010-03-05 | 2012-05-30 | 中山大学 | 一种负载液态氟碳的聚合物纳米超声显像囊泡及其制备方法 |
| US9844504B2 (en) | 2010-04-16 | 2017-12-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Custom designed microbubble contrast agents and techniques of ultrasound delivery optimized for gene therapy |
| TW201208706A (en) | 2010-08-17 | 2012-03-01 | Univ Nat Yang Ming | Ultrasonically-triggered drug vehicle with magnetic resonance imaging function |
| US20130216593A1 (en) * | 2010-08-28 | 2013-08-22 | The Trustees Of Columbia University In The City Of New York | Systems, methods, and devices for plasmid gene transfection using polymer-modified microbubbles |
| CN104093401B (zh) | 2011-12-16 | 2018-06-29 | 纳米生物技术公司 | 包含金属材料和氧化铪材料的纳米粒子、其制备和用途 |
| US10357450B2 (en) | 2012-04-06 | 2019-07-23 | Children's Medical Center Corporation | Process for forming microbubbles with high oxygen content and uses thereof |
| US20150087624A1 (en) * | 2012-04-24 | 2015-03-26 | Osaka University | Method for producing an aqueous dispersion of drug nanoparticles and use thereof |
| EP2913065A4 (en) * | 2012-10-25 | 2016-07-27 | Imgt Co Ltd | ULTRASONIC CONTRASTING AGENTS IN COMBINED MEDICAMENT-BASED NANOPARTICLES AND MANUFACTURING METHOD THEREFOR |
| WO2014096165A2 (en) | 2012-12-21 | 2014-06-26 | Bracco Suisse Sa | Gas-filled microvesicles |
| EP2968825A4 (en) | 2013-03-15 | 2016-09-07 | Childrens Medical Center | Gas-filled stabilized particles and methods of use |
| CN105407878A (zh) * | 2013-05-30 | 2016-03-16 | 纳米生物技术公司 | 药物组合物、制备及其用途 |
| KR101595795B1 (ko) * | 2014-03-19 | 2016-02-22 | (주)아이엠지티 | 약물을 함유한 나노입자가 결합된 이중-목적 pat/초음파 조영제 및 이의 제조방법 |
| CN104337766A (zh) * | 2014-10-09 | 2015-02-11 | 唐春林 | 一种地高辛脂质微泡及其制备方法 |
| MX2017006813A (es) | 2014-11-25 | 2018-01-30 | Nanobiotix | Composicion farmaceutica, preparacion y usos de la misma. |
| DK3229843T3 (da) | 2014-11-25 | 2020-03-09 | Curadigm Sas | Farmaceutisk sammensætning, præparat og anvendelser deraf |
| JP6836510B2 (ja) | 2014-11-25 | 2021-03-03 | キュラディグム・エスアエスCuradigm Sas | 少なくとも2つの異なるナノ粒子と医薬化合物とを組み合わせた医薬組成物、その調製及び使用 |
| US10765632B2 (en) | 2014-11-25 | 2020-09-08 | Curadigm Sas | Methods of improving delivery of compounds for therapy, prophylaxis or diagnosis |
| TW201628610A (zh) | 2014-11-25 | 2016-08-16 | 奈諾生技公司 | 醫藥組合物、其製備及其用途 |
| NZ733010A (en) | 2014-12-31 | 2023-01-27 | Lantheus Medical Imaging Inc | Lipid-encapsulated gas microsphere compositions and related methods |
| EA201792560A1 (ru) | 2015-05-28 | 2018-06-29 | Нанобиотикс | Наночастицы для применения в качестве терапевтической вакцины |
| JP2019503403A (ja) * | 2016-02-01 | 2019-02-07 | トラスト バイオソニックス インクTrust Biosonics Inc. | 脂質組成のマイクロバブル及びその製造方法 |
| BR112018072342A2 (pt) | 2016-05-04 | 2019-02-19 | Lantheus Medical Imaging, Inc. | métodos e dispositivos para preparação de agentes de contraste de ultrassom |
| US9789210B1 (en) | 2016-07-06 | 2017-10-17 | Lantheus Medical Imaging, Inc. | Methods for making ultrasound contrast agents |
| NO342271B1 (en) * | 2016-09-29 | 2018-04-30 | Sintef Tto As | A new drug delivery system for treatment of cancer |
| US11147890B2 (en) | 2017-02-28 | 2021-10-19 | Children's Medical Center Corporation | Stimuli-responsive particles encapsulating a gas and methods of use |
| JP7227694B2 (ja) * | 2017-12-08 | 2023-02-22 | 大平 猛 | 正に帯電したナノバブル分散液 |
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| US20200360289A1 (en) * | 2019-05-15 | 2020-11-19 | Bracco Suisse Sa | Freeze-dried product and gas-filled microvesicles suspension |
| JP2023528745A (ja) * | 2020-06-15 | 2023-07-06 | ブラッコ・スイス・ソシエテ・アノニム | 超音波が介在する治療の改善 |
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- 2004-12-21 CN CNB2004800386196A patent/CN100563718C/zh not_active Expired - Fee Related
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- 2004-12-21 WO PCT/IB2004/004230 patent/WO2005063305A1/en not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2547024A1 (en) | 2005-07-14 |
| US9750821B2 (en) | 2017-09-05 |
| US20070071685A1 (en) | 2007-03-29 |
| CA2547024C (en) | 2013-12-17 |
| AU2004308756B2 (en) | 2010-06-24 |
| WO2005063305A1 (en) | 2005-07-14 |
| EP1701745B1 (en) | 2014-12-10 |
| EP1701745A1 (en) | 2006-09-20 |
| JP2007515470A (ja) | 2007-06-14 |
| JP2012051932A (ja) | 2012-03-15 |
| NO338316B1 (no) | 2016-08-08 |
| ES2531732T3 (es) | 2015-03-18 |
| CN100563718C (zh) | 2009-12-02 |
| CN1897979A (zh) | 2007-01-17 |
| NO20063419L (no) | 2006-09-21 |
| AU2004308756A1 (en) | 2005-07-14 |
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