JP2007514681A - ビタミンaアセテートの製造方法 - Google Patents
ビタミンaアセテートの製造方法 Download PDFInfo
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- JP2007514681A JP2007514681A JP2006544308A JP2006544308A JP2007514681A JP 2007514681 A JP2007514681 A JP 2007514681A JP 2006544308 A JP2006544308 A JP 2006544308A JP 2006544308 A JP2006544308 A JP 2006544308A JP 2007514681 A JP2007514681 A JP 2007514681A
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- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 title claims abstract description 16
- 229960000342 retinol acetate Drugs 0.000 title claims abstract description 15
- 235000019173 retinyl acetate Nutrition 0.000 title claims abstract description 15
- 239000011770 retinyl acetate Substances 0.000 title claims abstract description 15
- 238000004519 manufacturing process Methods 0.000 title abstract description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 45
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims abstract description 34
- 150000003839 salts Chemical class 0.000 claims abstract description 34
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 claims abstract description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000011877 solvent mixture Substances 0.000 claims abstract description 15
- 238000007239 Wittig reaction Methods 0.000 claims abstract description 10
- 125000001931 aliphatic group Chemical group 0.000 claims abstract description 4
- 150000004945 aromatic hydrocarbons Chemical class 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 claims description 27
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 24
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 16
- 229910021529 ammonia Inorganic materials 0.000 claims description 11
- 230000015572 biosynthetic process Effects 0.000 claims description 11
- 238000003786 synthesis reaction Methods 0.000 claims description 11
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 10
- 229930195733 hydrocarbon Natural products 0.000 claims description 7
- 150000002430 hydrocarbons Chemical class 0.000 claims description 7
- JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 4
- QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 description 21
- 239000011541 reaction mixture Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 7
- 239000002585 base Substances 0.000 description 5
- AFABGHUZZDYHJO-UHFFFAOYSA-N 2-Methylpentane Chemical compound CCCC(C)C AFABGHUZZDYHJO-UHFFFAOYSA-N 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 239000007795 chemical reaction product Substances 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 229920002554 vinyl polymer Polymers 0.000 description 3
- QEGNUYASOUJEHD-UHFFFAOYSA-N 1,1-dimethylcyclohexane Chemical compound CC1(C)CCCCC1 QEGNUYASOUJEHD-UHFFFAOYSA-N 0.000 description 2
- GXDHCNNESPLIKD-UHFFFAOYSA-N 2-methylhexane Chemical compound CCCCC(C)C GXDHCNNESPLIKD-UHFFFAOYSA-N 0.000 description 2
- LAIUFBWHERIJIH-UHFFFAOYSA-N 3-Methylheptane Chemical compound CCCCC(C)CC LAIUFBWHERIJIH-UHFFFAOYSA-N 0.000 description 2
- SFRKSDZMZHIISH-UHFFFAOYSA-N 3-ethylhexane Chemical compound CCCC(CC)CC SFRKSDZMZHIISH-UHFFFAOYSA-N 0.000 description 2
- VLJXXKKOSFGPHI-UHFFFAOYSA-N 3-methylhexane Chemical compound CCCC(C)CC VLJXXKKOSFGPHI-UHFFFAOYSA-N 0.000 description 2
- PFEOZHBOMNWTJB-UHFFFAOYSA-N 3-methylpentane Chemical compound CCC(C)CC PFEOZHBOMNWTJB-UHFFFAOYSA-N 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical class [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 2
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- IFTRQJLVEBNKJK-UHFFFAOYSA-N Ethylcyclopentane Chemical compound CCC1CCCC1 IFTRQJLVEBNKJK-UHFFFAOYSA-N 0.000 description 2
- NHTMVDHEPJAVLT-UHFFFAOYSA-N Isooctane Chemical compound CC(C)CC(C)(C)C NHTMVDHEPJAVLT-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- -1 aliphatic alcohols Chemical class 0.000 description 2
- 150000001335 aliphatic alkanes Chemical class 0.000 description 2
- 235000011114 ammonium hydroxide Nutrition 0.000 description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- QWHNJUXXYKPLQM-UHFFFAOYSA-N dimethyl cyclopentane Natural products CC1(C)CCCC1 QWHNJUXXYKPLQM-UHFFFAOYSA-N 0.000 description 2
- JVSWJIKNEAIKJW-UHFFFAOYSA-N dimethyl-hexane Natural products CCCCCC(C)C JVSWJIKNEAIKJW-UHFFFAOYSA-N 0.000 description 2
- 239000012738 dissolution medium Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- GDOPTJXRTPNYNR-UHFFFAOYSA-N methylcyclopentane Chemical compound CC1CCCC1 GDOPTJXRTPNYNR-UHFFFAOYSA-N 0.000 description 2
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- LPDDKAJRWGPGSI-UHFFFAOYSA-N (3-methyl-4-oxobut-2-enyl) acetate Chemical compound CC(=O)OCC=C(C)C=O LPDDKAJRWGPGSI-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 229910000272 alkali metal oxide Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 description 1
- 229910000287 alkaline earth metal oxide Inorganic materials 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 235000019728 animal nutrition Nutrition 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- QVQLCTNNEUAWMS-UHFFFAOYSA-N barium oxide Inorganic materials [Ba]=O QVQLCTNNEUAWMS-UHFFFAOYSA-N 0.000 description 1
- 238000003763 carbonization Methods 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
- C07C403/12—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
60〜80重量%のメタノール、
10〜20重量%の水及び
10〜20重量%の5〜8個の炭素原子を有する脂肪族、脂環式又は芳香族の炭化水素
(ここで、上記範囲内で選択した重量%データは合計100重量%になるべきである)
からなる溶媒混合物中で45〜55℃の温度においてβ-ビニルイオノールから出発する、上記ビタミンAアセテートの製造方法を提供することによって、上記目的が達成されることを見出した。
139.7gのトリフェニルホスフィンを206.8gのメタノール、44.46gの水及び40.68gのヘプタンからなる溶媒混合物中に40℃で攪拌しながら導入した。1時間わたって、72.7gの75%濃度の硫酸を滴下した。次いで 130gの純度92.1%β-ビニルイオノールを2時間にわたって計量添加し、温度を50℃に高め、この混合物を4時間攪拌した。抽出仕上げ処理により、C15塩を純度99.9%(採用したトリフェニルホスフィンに基づく)で得た。
Claims (11)
- 式(I)
で表されるC15塩を与え、そして引き続き、溶媒としての水中で塩基の存在下に、式(IV)
60〜80重量%のメタノール、
10〜20重量%の水及び
10〜20重量%の5〜8個の炭素原子を有する脂肪族、脂環式又は芳香族の炭化水素
(ここで、上記範囲内で選択した重量%データは合計100重量%になるべきである)
からなる溶媒混合物中でβ-ビニルイオノールから出発する、上記ビタミンAアセテートの製造方法。 - ウィッティヒ反応を、採用されるC15塩に基づいて、塩基として2〜2.3当量のアンモニアの存在下に45〜55℃の温度で行う、請求項1に記載の方法。
- 式IIIのC15塩の合成を、45〜55℃の温度で行う、請求項1又は2に記載の方法。
- 式IIIのC15塩の合成を、70〜80重量%の濃度を有する硫酸の存在下に行う、請求項1〜3のいずれかに記載の方法。
- a. 式IIIのC15塩の合成を、
64〜72重量%のメタノール
14〜18重量%の水及び
40重量%までの他の炭化水素を含んでいてもよい14〜18重量%のヘプタン
からなる溶媒混合物中で48〜52℃の温度で行い、そして
b. ウィッティヒ反応を、採用されるC15塩に基づいて、塩基として2.1〜2.2当量のアンモニアの存在下に48〜52℃の温度で行う、請求項1〜4のいずれかに記載の方法。 - 式IIIのC15塩の合成を、73〜77重量%の濃度を有する硫酸の存在下に行う、請求項1〜5のいずれかに記載の方法。
- ウィッティヒ反応を、硫酸水素塩(X=HSO4)及びメチル硫酸塩(X=CH3SO4)からなる混合物の形態の式IIIのC15塩を採用して行い、ここで、メチル硫酸塩の割合が0.1〜15%である、請求項1〜6のいずれかに記載の方法。
- メチル硫酸塩の割合が0.1〜5%である、請求項1〜7のいずれかに記載の方法。
- アンモニアを、5〜20重量%の濃度を有する水溶液の形態でウィッティヒ反応に採用する、請求項1〜8のいずれかに記載の方法。
- 半連続的又は完全連続的に行う、請求項1〜9のいずれかに記載の方法。
- C15塩の合成に採用される溶媒混合物を、適切ならば溶媒成分の少なくとも1種の添加により所望の組成を回復した後に、本方法に返送する、請求項1〜10のいずれかに記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10359433A DE10359433A1 (de) | 2003-12-17 | 2003-12-17 | Verfahren zur Herstellung von Vitamin A-Acetat |
PCT/EP2004/014209 WO2005058811A1 (de) | 2003-12-17 | 2004-12-14 | Verfahren zur herstellung von vitamin a- acetat |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2007514681A true JP2007514681A (ja) | 2007-06-07 |
Family
ID=34683506
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006544308A Ceased JP2007514681A (ja) | 2003-12-17 | 2004-12-14 | ビタミンaアセテートの製造方法 |
Country Status (7)
Country | Link |
---|---|
US (2) | US20070082950A1 (ja) |
EP (1) | EP1697317A1 (ja) |
JP (1) | JP2007514681A (ja) |
CN (1) | CN100455558C (ja) |
CA (1) | CA2546307A1 (ja) |
DE (1) | DE10359433A1 (ja) |
WO (1) | WO2005058811A1 (ja) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2130833A1 (en) | 2008-06-05 | 2009-12-09 | DSM IP Assets B.V. | Process for the preparation of zeacarotenes |
CN103288875A (zh) * | 2013-05-24 | 2013-09-11 | 广州巨元生化有限公司 | 一种维生素a磷盐的制备方法 |
CN109517851B (zh) * | 2018-11-29 | 2021-03-02 | 厦门金达威维生素有限公司 | 一种维生素a醋酸酯的合成方法 |
CN109651150B (zh) * | 2018-12-20 | 2022-02-18 | 万华化学集团股份有限公司 | 一种制备维生素a醋酸酯的方法 |
CN111484524B (zh) * | 2019-01-25 | 2022-04-12 | 新发药业有限公司 | 一种维生素a乙酸酯中间体c15及维生素a乙酸酯的制备方法 |
EP3956305A1 (en) * | 2019-04-15 | 2022-02-23 | DSM IP Assets B.V. | Novel enol-acetates(ii) |
JP2022528611A (ja) * | 2019-04-15 | 2022-06-15 | ディーエスエム アイピー アセッツ ビー.ブイ. | 新規なエノールアセテート |
CN111205209B (zh) * | 2020-03-05 | 2021-12-14 | 万华化学集团股份有限公司 | 一种多级连续串联反应萃取制备维生素a醋酸酯的装置及方法 |
CN112876395B (zh) * | 2021-01-15 | 2023-01-13 | 万华化学集团股份有限公司 | 一种维生素a醋酸酯的制备方法 |
WO2022241669A1 (zh) | 2021-05-19 | 2022-11-24 | 万华化学集团股份有限公司 | 一种维生素a醋酸酯的制备方法 |
WO2022241670A1 (zh) | 2021-05-19 | 2022-11-24 | 万华化学集团股份有限公司 | 一种c15膦盐的制备方法 |
CN113201016B (zh) * | 2021-05-19 | 2023-09-19 | 万华化学集团股份有限公司 | 一种c15膦盐的制备方法 |
CN113214126B (zh) * | 2021-05-19 | 2023-07-25 | 万华化学集团股份有限公司 | 一种维生素a醋酸酯的制备方法 |
CN114031534B (zh) * | 2021-11-19 | 2023-09-19 | 万华化学集团股份有限公司 | 一种高稳定性维生素a及其制备方法 |
CN115057886B (zh) * | 2022-06-20 | 2024-05-03 | 万华化学集团股份有限公司 | 一种c15膦盐的制备方法 |
Citations (5)
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---|---|---|---|---|
US3932485A (en) * | 1974-08-28 | 1976-01-13 | Hoffmann-La Roche Inc. | Improved preparation of Wittig salt of vinyl β-ionol |
JPS5315340A (en) * | 1976-07-26 | 1978-02-13 | Hoffmann La Roche | Process for preparing vitaminna acetate |
JPS549248A (en) * | 1977-06-18 | 1979-01-24 | Basf Ag | Production of aqueous solution or microdispersion of polynitrilearylsulfonium salt |
EP0742204A1 (en) * | 1995-05-12 | 1996-11-13 | LABORATORI MAG S.p.A. | Photochemical method for the preparation of 13-cis-retinoic acid |
JP2007514679A (ja) * | 2003-12-17 | 2007-06-07 | ビーエーエスエフ アクチェンゲゼルシャフト | ホスホニウム塩の製造方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3006939A (en) * | 1957-01-17 | 1961-10-31 | Basf Ag | Production of compounds of the betacyclogeranylidene series |
NL124639C (ja) * | 1963-05-24 | |||
DE2729974C3 (de) * | 1977-07-02 | 1981-09-24 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von wäßrigen Lösungen bzw. feinteiligen wäßrigen Dispersionen von Polyenyltriarylphosphoniumsalzen |
US4916250A (en) * | 1988-10-31 | 1990-04-10 | Loyola University Of Chicago | Phosphonate reagent compositions |
TW252974B (ja) * | 1993-03-23 | 1995-08-01 | Takeda Dharm Industry Co Ltd | |
DE19517422A1 (de) * | 1995-05-12 | 1996-11-14 | Basf Ag | Verfahren zur Herstellung von beta-Carotin-Präparaten mit hohem 9(Z)-Gehalt |
DE19734446A1 (de) * | 1997-08-08 | 1999-02-11 | Basf Ag | Verfahren zur Herstellung von Phosphoniumsalzen |
-
2003
- 2003-12-17 DE DE10359433A patent/DE10359433A1/de not_active Withdrawn
-
2004
- 2004-12-14 WO PCT/EP2004/014209 patent/WO2005058811A1/de active Application Filing
- 2004-12-14 EP EP04803835A patent/EP1697317A1/de not_active Withdrawn
- 2004-12-14 JP JP2006544308A patent/JP2007514681A/ja not_active Ceased
- 2004-12-14 CA CA002546307A patent/CA2546307A1/en not_active Abandoned
- 2004-12-14 US US10/580,958 patent/US20070082950A1/en not_active Abandoned
- 2004-12-14 CN CNB2004800376279A patent/CN100455558C/zh not_active Expired - Fee Related
-
2008
- 2008-10-21 US US12/255,460 patent/US20090043121A1/en not_active Abandoned
Patent Citations (5)
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US3932485A (en) * | 1974-08-28 | 1976-01-13 | Hoffmann-La Roche Inc. | Improved preparation of Wittig salt of vinyl β-ionol |
JPS5315340A (en) * | 1976-07-26 | 1978-02-13 | Hoffmann La Roche | Process for preparing vitaminna acetate |
JPS549248A (en) * | 1977-06-18 | 1979-01-24 | Basf Ag | Production of aqueous solution or microdispersion of polynitrilearylsulfonium salt |
EP0742204A1 (en) * | 1995-05-12 | 1996-11-13 | LABORATORI MAG S.p.A. | Photochemical method for the preparation of 13-cis-retinoic acid |
JP2007514679A (ja) * | 2003-12-17 | 2007-06-07 | ビーエーエスエフ アクチェンゲゼルシャフト | ホスホニウム塩の製造方法 |
Also Published As
Publication number | Publication date |
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US20070082950A1 (en) | 2007-04-12 |
EP1697317A1 (de) | 2006-09-06 |
CN100455558C (zh) | 2009-01-28 |
WO2005058811A1 (de) | 2005-06-30 |
CA2546307A1 (en) | 2005-06-30 |
DE10359433A1 (de) | 2005-07-21 |
US20090043121A1 (en) | 2009-02-12 |
CN1894208A (zh) | 2007-01-10 |
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