JP2007513209A - ポリ（ｎ−ビニルアミド）及びコポリ（ｎ−ビニルアミド）、及び毛細管電気泳動におけるその使用 - Google Patents
ポリ（ｎ−ビニルアミド）及びコポリ（ｎ−ビニルアミド）、及び毛細管電気泳動におけるその使用 Download PDFInfo
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- JP2007513209A JP2007513209A JP2006532979A JP2006532979A JP2007513209A JP 2007513209 A JP2007513209 A JP 2007513209A JP 2006532979 A JP2006532979 A JP 2006532979A JP 2006532979 A JP2006532979 A JP 2006532979A JP 2007513209 A JP2007513209 A JP 2007513209A
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- Prior art keywords
- acrylamide
- methyl
- methacrylamide
- composition
- propyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000005251 capillar electrophoresis Methods 0.000 title abstract description 50
- 229920001577 copolymer Chemical compound 0.000 title abstract description 46
- UYMKPFRHYYNDTL-UHFFFAOYSA-N ethenamine Chemical compound NC=C UYMKPFRHYYNDTL-UHFFFAOYSA-N 0.000 title abstract description 27
- 239000000203 mixture Substances 0.000 claims abstract description 265
- 229920000642 polymer Polymers 0.000 claims abstract description 242
- 239000000178 monomer Substances 0.000 claims abstract description 158
- 238000000034 method Methods 0.000 claims abstract description 53
- 238000000926 separation method Methods 0.000 claims abstract description 39
- 108091033319 polynucleotide Proteins 0.000 claims abstract description 22
- 102000040430 polynucleotide Human genes 0.000 claims abstract description 22
- 239000002157 polynucleotide Substances 0.000 claims abstract description 22
- -1 N-methyl- Chemical compound 0.000 claims description 59
- 230000002401 inhibitory effect Effects 0.000 claims description 41
- 238000007873 sieving Methods 0.000 claims description 36
- 239000000872 buffer Substances 0.000 claims description 31
- 229910052757 nitrogen Inorganic materials 0.000 claims description 28
- 229920002554 vinyl polymer Polymers 0.000 claims description 24
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 22
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims description 22
- PNLUGRYDUHRLOF-UHFFFAOYSA-N n-ethenyl-n-methylacetamide Chemical compound C=CN(C)C(C)=O PNLUGRYDUHRLOF-UHFFFAOYSA-N 0.000 claims description 22
- 150000003839 salts Chemical class 0.000 claims description 22
- ZQXSMRAEXCEDJD-UHFFFAOYSA-N n-ethenylformamide Chemical compound C=CNC=O ZQXSMRAEXCEDJD-UHFFFAOYSA-N 0.000 claims description 20
- 229940088644 n,n-dimethylacrylamide Drugs 0.000 claims description 19
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 18
- DNTMQTKDNSEIFO-UHFFFAOYSA-N n-(hydroxymethyl)-2-methylprop-2-enamide Chemical compound CC(=C)C(=O)NCO DNTMQTKDNSEIFO-UHFFFAOYSA-N 0.000 claims description 18
- WFKDPJRCBCBQNT-UHFFFAOYSA-N n,2-dimethylprop-2-enamide Chemical compound CNC(=O)C(C)=C WFKDPJRCBCBQNT-UHFFFAOYSA-N 0.000 claims description 15
- QALQIBQJEQZNTE-UHFFFAOYSA-N n-(hydroxymethyl)-n,2-dimethylprop-2-enamide Chemical compound OCN(C)C(=O)C(C)=C QALQIBQJEQZNTE-UHFFFAOYSA-N 0.000 claims description 15
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 claims description 14
- 239000004202 carbamide Substances 0.000 claims description 13
- UUORTJUPDJJXST-UHFFFAOYSA-N n-(2-hydroxyethyl)prop-2-enamide Chemical compound OCCNC(=O)C=C UUORTJUPDJJXST-UHFFFAOYSA-N 0.000 claims description 13
- CCJAYIGMMRQRAO-UHFFFAOYSA-N 2-[4-[(2-hydroxyphenyl)methylideneamino]butyliminomethyl]phenol Chemical compound OC1=CC=CC=C1C=NCCCCN=CC1=CC=CC=C1O CCJAYIGMMRQRAO-UHFFFAOYSA-N 0.000 claims description 12
- FTJXXXSSRCHQKC-UHFFFAOYSA-N n-(2-cyanoethyl)prop-2-enamide Chemical compound C=CC(=O)NCCC#N FTJXXXSSRCHQKC-UHFFFAOYSA-N 0.000 claims description 12
- ULYOZOPEFCQZHH-UHFFFAOYSA-N n-(methoxymethyl)prop-2-enamide Chemical compound COCNC(=O)C=C ULYOZOPEFCQZHH-UHFFFAOYSA-N 0.000 claims description 12
- RUSRUYULUAYXIP-UHFFFAOYSA-N n-acetylprop-2-enamide Chemical compound CC(=O)NC(=O)C=C RUSRUYULUAYXIP-UHFFFAOYSA-N 0.000 claims description 12
- IZKUWTDESDNCCG-UHFFFAOYSA-N n'-acetylprop-2-enehydrazide Chemical compound CC(=O)NNC(=O)C=C IZKUWTDESDNCCG-UHFFFAOYSA-N 0.000 claims description 11
- QRWZCJXEAOZAAW-UHFFFAOYSA-N n,n,2-trimethylprop-2-enamide Chemical compound CN(C)C(=O)C(C)=C QRWZCJXEAOZAAW-UHFFFAOYSA-N 0.000 claims description 11
- BSCJIBOZTKGXQP-UHFFFAOYSA-N n-(2-hydroxyethyl)-2-methylprop-2-enamide Chemical compound CC(=C)C(=O)NCCO BSCJIBOZTKGXQP-UHFFFAOYSA-N 0.000 claims description 11
- YOZHLACIXDCHPV-UHFFFAOYSA-N n-(methoxymethyl)-2-methylprop-2-enamide Chemical compound COCNC(=O)C(C)=C YOZHLACIXDCHPV-UHFFFAOYSA-N 0.000 claims description 11
- OJBZOTFHZFZOIJ-UHFFFAOYSA-N n-acetyl-2-methylprop-2-enamide Chemical compound CC(=O)NC(=O)C(C)=C OJBZOTFHZFZOIJ-UHFFFAOYSA-N 0.000 claims description 11
- YPHQUSNPXDGUHL-UHFFFAOYSA-N n-methylprop-2-enamide Chemical compound CNC(=O)C=C YPHQUSNPXDGUHL-UHFFFAOYSA-N 0.000 claims description 11
- HEOJXQORMIVKQQ-UHFFFAOYSA-N n-(2-cyanoethyl)-2-methylprop-2-enamide Chemical compound CC(=C)C(=O)NCCC#N HEOJXQORMIVKQQ-UHFFFAOYSA-N 0.000 claims description 10
- ADGJZVKOKVENDN-UHFFFAOYSA-N n-(butoxymethyl)-2-methylprop-2-enamide Chemical compound CCCCOCNC(=O)C(C)=C ADGJZVKOKVENDN-UHFFFAOYSA-N 0.000 claims description 10
- VOCDJQSAMZARGX-UHFFFAOYSA-N 1-ethenylpyrrolidine-2,5-dione Chemical compound C=CN1C(=O)CCC1=O VOCDJQSAMZARGX-UHFFFAOYSA-N 0.000 claims description 9
- GROXSGRIVDMIEN-UHFFFAOYSA-N 2-methyl-n-prop-2-enylprop-2-enamide Chemical compound CC(=C)C(=O)NCC=C GROXSGRIVDMIEN-UHFFFAOYSA-N 0.000 claims description 9
- CFZDMXAOSDDDRT-UHFFFAOYSA-N 4-ethenylmorpholine Chemical compound C=CN1CCOCC1 CFZDMXAOSDDDRT-UHFFFAOYSA-N 0.000 claims description 9
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 claims description 9
- BLYOHBPLFYXHQA-UHFFFAOYSA-N n,n-bis(prop-2-enyl)prop-2-enamide Chemical compound C=CCN(CC=C)C(=O)C=C BLYOHBPLFYXHQA-UHFFFAOYSA-N 0.000 claims description 9
- JMCVCHBBHPFWBF-UHFFFAOYSA-N n,n-diethyl-2-methylprop-2-enamide Chemical compound CCN(CC)C(=O)C(C)=C JMCVCHBBHPFWBF-UHFFFAOYSA-N 0.000 claims description 9
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 claims description 9
- RUSMHXACRXXLKQ-UHFFFAOYSA-N n-(2-aminoethyl)-2-methylprop-2-enamide;hydrochloride Chemical compound Cl.CC(=C)C(=O)NCCN RUSMHXACRXXLKQ-UHFFFAOYSA-N 0.000 claims description 9
- BQZIOPPACMCUGU-UHFFFAOYSA-N n-(2-aminoethyl)-n-methylprop-2-enamide;hydrochloride Chemical compound Cl.NCCN(C)C(=O)C=C BQZIOPPACMCUGU-UHFFFAOYSA-N 0.000 claims description 9
- VYHUMZYFJVMWRC-UHFFFAOYSA-N n-(2-hydroxyethyl)-n-methylprop-2-enamide Chemical compound OCCN(C)C(=O)C=C VYHUMZYFJVMWRC-UHFFFAOYSA-N 0.000 claims description 9
- SWSFFBPGDIHBJL-UHFFFAOYSA-N n-(2-methoxyethyl)-2-methylprop-2-enamide Chemical compound COCCNC(=O)C(C)=C SWSFFBPGDIHBJL-UHFFFAOYSA-N 0.000 claims description 9
- WOSHDWLEPRMIPR-UHFFFAOYSA-N n-(3-aminopropyl)prop-2-enamide;hydrochloride Chemical compound [Cl-].[NH3+]CCCNC(=O)C=C WOSHDWLEPRMIPR-UHFFFAOYSA-N 0.000 claims description 9
- UTSYWKJYFPPRAP-UHFFFAOYSA-N n-(butoxymethyl)prop-2-enamide Chemical compound CCCCOCNC(=O)C=C UTSYWKJYFPPRAP-UHFFFAOYSA-N 0.000 claims description 9
- YXUAFTLXQLZRJA-UHFFFAOYSA-N n-(cyanomethyl)-n-methylprop-2-enamide Chemical compound N#CCN(C)C(=O)C=C YXUAFTLXQLZRJA-UHFFFAOYSA-N 0.000 claims description 9
- OCXYXUXCRQIICZ-UHFFFAOYSA-N n-(cyanomethyl)prop-2-enamide Chemical compound C=CC(=O)NCC#N OCXYXUXCRQIICZ-UHFFFAOYSA-N 0.000 claims description 9
- AUCNMQYOQYTGPE-UHFFFAOYSA-N n-(hydroxymethyl)-n-methylprop-2-enamide Chemical compound OCN(C)C(=O)C=C AUCNMQYOQYTGPE-UHFFFAOYSA-N 0.000 claims description 9
- RQAKESSLMFZVMC-UHFFFAOYSA-N n-ethenylacetamide Chemical compound CC(=O)NC=C RQAKESSLMFZVMC-UHFFFAOYSA-N 0.000 claims description 9
- FPKZHPVRIDEUIG-UHFFFAOYSA-N n-ethyl-n-propylprop-2-enamide Chemical compound CCCN(CC)C(=O)C=C FPKZHPVRIDEUIG-UHFFFAOYSA-N 0.000 claims description 9
- CNPHCSFIDKZQAK-UHFFFAOYSA-N n-prop-2-enylprop-2-enamide Chemical compound C=CCNC(=O)C=C CNPHCSFIDKZQAK-UHFFFAOYSA-N 0.000 claims description 9
- QQZXAODFGRZKJT-UHFFFAOYSA-N n-tert-butyl-2-methylprop-2-enamide Chemical compound CC(=C)C(=O)NC(C)(C)C QQZXAODFGRZKJT-UHFFFAOYSA-N 0.000 claims description 9
- 229920002401 polyacrylamide Polymers 0.000 claims description 9
- VAYTZRYEBVHVLE-UHFFFAOYSA-N 1,3-dioxol-2-one Chemical compound O=C1OC=CO1 VAYTZRYEBVHVLE-UHFFFAOYSA-N 0.000 claims description 8
- UNMSMHCTGCYBJM-UHFFFAOYSA-N 1-ethenylimidazolidin-2-one Chemical compound C=CN1CCNC1=O UNMSMHCTGCYBJM-UHFFFAOYSA-N 0.000 claims description 8
- YQIGLEFUZMIVHU-UHFFFAOYSA-N 2-methyl-n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C(C)=C YQIGLEFUZMIVHU-UHFFFAOYSA-N 0.000 claims description 8
- VUEZBQJWLDBIDE-UHFFFAOYSA-N 3-ethenyl-1,3-oxazolidin-2-one Chemical compound C=CN1CCOC1=O VUEZBQJWLDBIDE-UHFFFAOYSA-N 0.000 claims description 8
- ZMALNMQOXQXZRO-UHFFFAOYSA-N 4-ethenylmorpholin-3-one Chemical compound C=CN1CCOCC1=O ZMALNMQOXQXZRO-UHFFFAOYSA-N 0.000 claims description 8
- HDYTUPZMASQMOH-UHFFFAOYSA-N 4-ethenylmorpholine-3,5-dione Chemical compound C=CN1C(=O)COCC1=O HDYTUPZMASQMOH-UHFFFAOYSA-N 0.000 claims description 8
- FIOAMJSJHNKQHM-UHFFFAOYSA-N N-(hydroxymethyl)-2-methylbut-2-enamide Chemical compound OCNC(C(=CC)C)=O FIOAMJSJHNKQHM-UHFFFAOYSA-N 0.000 claims description 8
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 8
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical group COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims description 8
- KIHJKWNSLAKEPK-UHFFFAOYSA-N n-(2-methoxyethyl)prop-2-enamide Chemical compound COCCNC(=O)C=C KIHJKWNSLAKEPK-UHFFFAOYSA-N 0.000 claims description 8
- TUYRBJIOKUKUHG-UHFFFAOYSA-N n-(3-aminopropyl)-n-methylprop-2-enamide;hydrochloride Chemical compound Cl.C=CC(=O)N(C)CCCN TUYRBJIOKUKUHG-UHFFFAOYSA-N 0.000 claims description 8
- VWMLWEYHEYQJLO-UHFFFAOYSA-N n-(cyanomethyl)-2-methylprop-2-enamide Chemical class CC(=C)C(=O)NCC#N VWMLWEYHEYQJLO-UHFFFAOYSA-N 0.000 claims description 8
- QUYUHNCWKGUJHO-UHFFFAOYSA-N n-(cyanomethyl)-n,2-dimethylprop-2-enamide Chemical compound N#CCN(C)C(=O)C(C)=C QUYUHNCWKGUJHO-UHFFFAOYSA-N 0.000 claims description 8
- GORGQKRVQGXVEB-UHFFFAOYSA-N n-ethenyl-n-ethylacetamide Chemical compound CCN(C=C)C(C)=O GORGQKRVQGXVEB-UHFFFAOYSA-N 0.000 claims description 8
- DFMIMUDDPBAKFS-UHFFFAOYSA-N n-ethenyl-n-ethylformamide Chemical compound CCN(C=C)C=O DFMIMUDDPBAKFS-UHFFFAOYSA-N 0.000 claims description 8
- OFESGEKAXKKFQT-UHFFFAOYSA-N n-ethenyl-n-methylformamide Chemical compound C=CN(C)C=O OFESGEKAXKKFQT-UHFFFAOYSA-N 0.000 claims description 8
- 150000004702 methyl esters Chemical class 0.000 claims description 7
- OVHHHVAVHBHXAK-UHFFFAOYSA-N n,n-diethylprop-2-enamide Chemical compound CCN(CC)C(=O)C=C OVHHHVAVHBHXAK-UHFFFAOYSA-N 0.000 claims description 7
- YAHBUVWRSTZBAX-UHFFFAOYSA-N n-(2-aminoethyl)prop-2-enamide;hydrochloride Chemical compound Cl.NCCNC(=O)C=C YAHBUVWRSTZBAX-UHFFFAOYSA-N 0.000 claims description 7
- XHIRWEVPYCTARV-UHFFFAOYSA-N n-(3-aminopropyl)-2-methylprop-2-enamide;hydrochloride Chemical compound Cl.CC(=C)C(=O)NCCCN XHIRWEVPYCTARV-UHFFFAOYSA-N 0.000 claims description 7
- OTHWJJNYOTXAES-UHFFFAOYSA-N n-ethenyl-n-propan-2-ylacetamide Chemical compound CC(C)N(C=C)C(C)=O OTHWJJNYOTXAES-UHFFFAOYSA-N 0.000 claims description 7
- BMIGLHLHYIWCCD-UHFFFAOYSA-N n-ethenyl-n-propan-2-ylformamide Chemical compound CC(C)N(C=C)C=O BMIGLHLHYIWCCD-UHFFFAOYSA-N 0.000 claims description 7
- XFHJDMUEHUHAJW-UHFFFAOYSA-N n-tert-butylprop-2-enamide Chemical compound CC(C)(C)NC(=O)C=C XFHJDMUEHUHAJW-UHFFFAOYSA-N 0.000 claims description 7
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 6
- 229920006187 aquazol Polymers 0.000 claims description 6
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 6
- CMMYGCUEJWTBCG-UHFFFAOYSA-N n-(2,2-dimethoxyethyl)prop-2-enamide Chemical compound COC(OC)CNC(=O)C=C CMMYGCUEJWTBCG-UHFFFAOYSA-N 0.000 claims description 6
- ZOTWHNWBICCBPC-UHFFFAOYSA-N n-ethyl-n-methylprop-2-enamide Chemical compound CCN(C)C(=O)C=C ZOTWHNWBICCBPC-UHFFFAOYSA-N 0.000 claims description 6
- QNILTEGFHQSKFF-UHFFFAOYSA-N n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C=C QNILTEGFHQSKFF-UHFFFAOYSA-N 0.000 claims description 6
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims description 6
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 5
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 5
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 5
- 230000005684 electric field Effects 0.000 claims description 5
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 5
- MGARLISKINLYPI-UHFFFAOYSA-N n-(2,2-dimethoxyethyl)-2-methylprop-2-enamide Chemical compound COC(OC)CNC(=O)C(C)=C MGARLISKINLYPI-UHFFFAOYSA-N 0.000 claims description 5
- UXGLSABDGQOSET-UHFFFAOYSA-N n-carbamoylprop-2-enamide Chemical compound NC(=O)NC(=O)C=C UXGLSABDGQOSET-UHFFFAOYSA-N 0.000 claims description 5
- JSVQCWVDDBFTKW-UHFFFAOYSA-N n-ethenyl-n-methyldecanamide Chemical compound CCCCCCCCCC(=O)N(C)C=C JSVQCWVDDBFTKW-UHFFFAOYSA-N 0.000 claims description 5
- HQVFKSDWNYVAQD-UHFFFAOYSA-N n-hydroxyprop-2-enamide Chemical compound ONC(=O)C=C HQVFKSDWNYVAQD-UHFFFAOYSA-N 0.000 claims description 5
- QMQNMBYPQFQQPK-UHFFFAOYSA-N n-methoxyprop-2-enamide Chemical compound CONC(=O)C=C QMQNMBYPQFQQPK-UHFFFAOYSA-N 0.000 claims description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 5
- AJUIEYXPANEMOX-UHFFFAOYSA-N (carbamoylamino) prop-2-enoate Chemical compound NC(=O)NOC(=O)C=C AJUIEYXPANEMOX-UHFFFAOYSA-N 0.000 claims description 3
- GUXJXWKCUUWCLX-UHFFFAOYSA-N 2-methyl-2-oxazoline Chemical compound CC1=NCCO1 GUXJXWKCUUWCLX-UHFFFAOYSA-N 0.000 claims description 3
- NGMWKRNPNRTXOQ-UHFFFAOYSA-N 2-methyl-n-(2-morpholin-4-ylethyl)prop-2-enamide Chemical compound CC(=C)C(=O)NCCN1CCOCC1 NGMWKRNPNRTXOQ-UHFFFAOYSA-N 0.000 claims description 3
- PBMWEQHOZPTUQQ-UHFFFAOYSA-N 4-hydroxy-2-methylbut-2-enamide Chemical compound NC(=O)C(C)=CCO PBMWEQHOZPTUQQ-UHFFFAOYSA-N 0.000 claims description 3
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- XWCUDBBUDRNSKP-UHFFFAOYSA-N n-(2-morpholin-4-ylethyl)prop-2-enamide Chemical compound C=CC(=O)NCCN1CCOCC1 XWCUDBBUDRNSKP-UHFFFAOYSA-N 0.000 claims description 3
- IRMNYAOVVDEOKP-UHFFFAOYSA-N n-(3-methoxypropyl)-2-methylprop-2-enamide Chemical compound COCCCNC(=O)C(C)=C IRMNYAOVVDEOKP-UHFFFAOYSA-N 0.000 claims description 3
- RWJGITGQDQSWJG-UHFFFAOYSA-N n-(3-methoxypropyl)prop-2-enamide Chemical compound COCCCNC(=O)C=C RWJGITGQDQSWJG-UHFFFAOYSA-N 0.000 claims description 3
- CNIIWDYLLMUOAJ-UHFFFAOYSA-N n-(4,4-dimethoxybutyl)-2-methylprop-2-enamide Chemical compound COC(OC)CCCNC(=O)C(C)=C CNIIWDYLLMUOAJ-UHFFFAOYSA-N 0.000 claims description 3
- VOPCZDADAYFWNS-UHFFFAOYSA-N n-(4,4-dimethoxybutyl)prop-2-enamide Chemical compound COC(OC)CCCNC(=O)C=C VOPCZDADAYFWNS-UHFFFAOYSA-N 0.000 claims description 3
- KZKMWODWOLPPCG-UHFFFAOYSA-N n-ethenyldecanamide Chemical compound CCCCCCCCCC(=O)NC=C KZKMWODWOLPPCG-UHFFFAOYSA-N 0.000 claims description 3
- 125000006353 oxyethylene group Chemical group 0.000 claims description 3
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- AGPXXDWZLIHETD-UHFFFAOYSA-N n,n-dimethylprop-2-enamide;n,n-di(propan-2-yl)prop-2-enamide Chemical compound CN(C)C(=O)C=C.CC(C)N(C(C)C)C(=O)C=C AGPXXDWZLIHETD-UHFFFAOYSA-N 0.000 claims 1
- 238000004458 analytical method Methods 0.000 abstract description 18
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- 125000000217 alkyl group Chemical group 0.000 description 94
- 125000004404 heteroalkyl group Chemical group 0.000 description 61
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 49
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- 125000003118 aryl group Chemical group 0.000 description 39
- 125000000592 heterocycloalkyl group Chemical group 0.000 description 31
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- 239000003999 initiator Substances 0.000 description 26
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 description 22
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- 238000006116 polymerization reaction Methods 0.000 description 18
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
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- 125000001072 heteroaryl group Chemical group 0.000 description 8
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- YHOSNAAUPKDRMI-UHFFFAOYSA-N n,n-di(propan-2-yl)prop-2-enamide Chemical compound CC(C)N(C(C)C)C(=O)C=C YHOSNAAUPKDRMI-UHFFFAOYSA-N 0.000 description 8
- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 8
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- 125000001544 thienyl group Chemical group 0.000 description 1
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Chemical class OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 229920000428 triblock copolymer Polymers 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical group OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 150000003673 urethanes Chemical class 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F26/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44747—Composition of gel or of carrier mixture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F126/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44752—Controlling the zeta potential, e.g. by wall coatings
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
- C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
- C08F20/52—Amides or imides
- C08F20/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Electrochemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Dispersion Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polyamides (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47151903P | 2003-05-15 | 2003-05-15 | |
| PCT/US2004/014831 WO2004104054A1 (en) | 2003-05-15 | 2004-05-12 | Poly and copoly (n-vinylamide)s and their use in capillary electrophoresis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007513209A true JP2007513209A (ja) | 2007-05-24 |
| JP2007513209A5 JP2007513209A5 (enExample) | 2007-07-05 |
Family
ID=33476854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006532979A Pending JP2007513209A (ja) | 2003-05-15 | 2004-05-12 | ポリ（ｎ−ビニルアミド）及びコポリ（ｎ−ビニルアミド）、及び毛細管電気泳動におけるその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20050025741A1 (enExample) |
| EP (2) | EP1636279B1 (enExample) |
| JP (1) | JP2007513209A (enExample) |
| KR (1) | KR20060124549A (enExample) |
| CN (2) | CN100567339C (enExample) |
| AT (2) | ATE524502T1 (enExample) |
| DE (1) | DE602004019525D1 (enExample) |
| WO (1) | WO2004104054A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021124404A (ja) * | 2020-02-06 | 2021-08-30 | 一丸ファルコス株式会社 | プロテオグリカンの含有量の測定法 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050025741A1 (en) * | 2003-05-15 | 2005-02-03 | Lau Aldrich N.K. | Poly and copoly(N-vinylamide)s and their use in capillary electrophoresis |
| CN101351260B (zh) * | 2005-11-01 | 2011-12-21 | 西北大学 | 用于微通道分离的基质和动态聚合物体系和组合物 |
| KR20100058499A (ko) * | 2007-08-17 | 2010-06-03 | 하이모 가부시키가이샤 | 전기영동용 프리캐스트 겔, 그 제조방법 및 그 사용방법 |
| KR101475697B1 (ko) | 2009-09-29 | 2015-01-02 | (주) 더바이오 | 모세관 전기영동 기반의 단일쇄 형태변환 다형성 분석용 충진재 및 이를 이용한 모세관 전기영동 기반의 단일쇄 형태변환 다형성 분석법 |
| US9550168B2 (en) | 2012-04-25 | 2017-01-24 | Sandia Corporation | Programmable pH buffers |
| JP6943860B2 (ja) | 2015-12-31 | 2021-10-06 | ユニバーシティ・オブ・ノートル・ダム・デュ・ラック | 電気運動的にポンピングされる界面を介したｅｓｉ−ｍｓ |
| US10416115B2 (en) * | 2016-06-20 | 2019-09-17 | University of Nortre Dame du Lac | System for capillary electrophoresis for peptide and protein analysis |
| WO2018217816A1 (en) | 2017-05-22 | 2018-11-29 | Integenx Inc. | Compositions, methods, kits and devices for molecular analysis |
| CN109580756A (zh) * | 2018-12-03 | 2019-04-05 | 杨翠芳 | 应用于毛细管电泳的组合物 |
| WO2022133439A1 (en) * | 2020-12-17 | 2022-06-23 | Hongene Biotech Corporation | Compositions and kits comprising interpenetrating networks for capillary electrophoresis |
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-
2004
- 2004-05-11 US US10/843,114 patent/US20050025741A1/en not_active Abandoned
- 2004-05-12 KR KR1020057021809A patent/KR20060124549A/ko not_active Abandoned
- 2004-05-12 CN CNB2004800193475A patent/CN100567339C/zh not_active Expired - Fee Related
- 2004-05-12 DE DE602004019525T patent/DE602004019525D1/de not_active Expired - Lifetime
- 2004-05-12 EP EP04751975A patent/EP1636279B1/en not_active Expired - Lifetime
- 2004-05-12 AT AT09000227T patent/ATE524502T1/de not_active IP Right Cessation
- 2004-05-12 EP EP09000227A patent/EP2053067B1/en not_active Expired - Lifetime
- 2004-05-12 JP JP2006532979A patent/JP2007513209A/ja active Pending
- 2004-05-12 AT AT04751975T patent/ATE423147T1/de not_active IP Right Cessation
- 2004-05-12 WO PCT/US2004/014831 patent/WO2004104054A1/en not_active Ceased
- 2004-05-12 CN CN200910207714A patent/CN101724216A/zh active Pending
-
2009
- 2009-11-11 US US12/616,748 patent/US20100051461A1/en not_active Abandoned
-
2014
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2017
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021124404A (ja) * | 2020-02-06 | 2021-08-30 | 一丸ファルコス株式会社 | プロテオグリカンの含有量の測定法 |
| JP7187041B2 (ja) | 2020-02-06 | 2022-12-12 | 一丸ファルコス株式会社 | プロテオグリカンの含有量の測定法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2053067A1 (en) | 2009-04-29 |
| ATE524502T1 (de) | 2011-09-15 |
| EP2053067B1 (en) | 2011-09-14 |
| US20100051461A1 (en) | 2010-03-04 |
| ATE423147T1 (de) | 2009-03-15 |
| EP1636279A1 (en) | 2006-03-22 |
| DE602004019525D1 (de) | 2009-04-02 |
| US20170356877A1 (en) | 2017-12-14 |
| EP1636279B1 (en) | 2009-02-18 |
| US20050025741A1 (en) | 2005-02-03 |
| KR20060124549A (ko) | 2006-12-05 |
| US10551345B2 (en) | 2020-02-04 |
| US9671367B2 (en) | 2017-06-06 |
| WO2004104054A1 (en) | 2004-12-02 |
| CN101724216A (zh) | 2010-06-09 |
| CN1816573A (zh) | 2006-08-09 |
| CN100567339C (zh) | 2009-12-09 |
| US20140209461A1 (en) | 2014-07-31 |
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