JP2007510656A5 - - Google Patents
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- Publication number
- JP2007510656A5 JP2007510656A5 JP2006538425A JP2006538425A JP2007510656A5 JP 2007510656 A5 JP2007510656 A5 JP 2007510656A5 JP 2006538425 A JP2006538425 A JP 2006538425A JP 2006538425 A JP2006538425 A JP 2006538425A JP 2007510656 A5 JP2007510656 A5 JP 2007510656A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- trospium
- release
- trospium chloride
- daily administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 33
- OYYDSUSKLWTMMQ-JKHIJQBDSA-N trospium Chemical compound [N+]12([C@@H]3CC[C@H]2C[C@H](C3)OC(=O)C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CCCC1 OYYDSUSKLWTMMQ-JKHIJQBDSA-N 0.000 claims description 29
- RVCSYOQWLPPAOA-CVPHZBIISA-M [(5s)-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl] 2-hydroxy-2,2-diphenylacetate;chloride Chemical compound [Cl-].[N+]12([C@H]3CCC2CC(C3)OC(=O)C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CCCC1 RVCSYOQWLPPAOA-CVPHZBIISA-M 0.000 claims description 21
- 229960001530 trospium chloride Drugs 0.000 claims description 21
- 229960001491 trospium Drugs 0.000 claims description 20
- 230000003111 delayed effect Effects 0.000 claims description 16
- 238000013270 controlled release Methods 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 6
- 210000002429 large intestine Anatomy 0.000 claims description 6
- 239000008188 pellet Substances 0.000 claims description 6
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims description 5
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 210000003750 lower gastrointestinal tract Anatomy 0.000 claims description 3
- 238000013268 sustained release Methods 0.000 claims 8
- 239000012730 sustained-release form Substances 0.000 claims 8
- 230000036765 blood level Effects 0.000 claims 7
- 239000003826 tablet Substances 0.000 claims 3
- 239000002775 capsule Substances 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 239000008203 oral pharmaceutical composition Substances 0.000 claims 2
- 238000013103 analytical ultracentrifugation Methods 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 239000007942 layered tablet Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- -1 sachets Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 description 8
- 239000003814 drug Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 2
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229920003143 Eudragit® FS 30 D Polymers 0.000 description 1
- 229920003138 Eudragit® L 30 D-55 Polymers 0.000 description 1
- 229920003134 Eudragit® polymer Polymers 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 210000003405 ileum Anatomy 0.000 description 1
- 239000012728 immediate-release (IR) tablet Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- RVCSYOQWLPPAOA-QKYUOBHYSA-M trospium chloride Chemical compound [Cl-].[N+]12([C@@H]3CC[C@H]2C[C@H](C3)OC(=O)C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CCCC1 RVCSYOQWLPPAOA-QKYUOBHYSA-M 0.000 description 1
- 210000002438 upper gastrointestinal tract Anatomy 0.000 description 1
Images
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51719803P | 2003-11-04 | 2003-11-04 | |
| US60/517,198 | 2003-11-04 | ||
| US52396803P | 2003-11-21 | 2003-11-21 | |
| US60/523,968 | 2003-11-21 | ||
| PCT/US2004/036394 WO2005046684A1 (en) | 2003-11-04 | 2004-11-04 | Once daily dosage forms of trospium |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012104795A Division JP5783489B2 (ja) | 2003-11-04 | 2012-05-01 | トロスピウムの1日1回剤形 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007510656A JP2007510656A (ja) | 2007-04-26 |
| JP2007510656A5 true JP2007510656A5 (enExample) | 2014-08-28 |
| JP5610663B2 JP5610663B2 (ja) | 2014-10-22 |
Family
ID=34594857
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006538425A Expired - Fee Related JP5610663B2 (ja) | 2003-11-04 | 2004-11-04 | トロスピウムの1日1回剤形 |
| JP2012104795A Expired - Fee Related JP5783489B2 (ja) | 2003-11-04 | 2012-05-01 | トロスピウムの1日1回剤形 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012104795A Expired - Fee Related JP5783489B2 (ja) | 2003-11-04 | 2012-05-01 | トロスピウムの1日1回剤形 |
Country Status (11)
| Country | Link |
|---|---|
| US (12) | US7410978B2 (enExample) |
| EP (2) | EP1680110B1 (enExample) |
| JP (2) | JP5610663B2 (enExample) |
| AT (1) | ATE493981T1 (enExample) |
| AU (1) | AU2004289223B2 (enExample) |
| CA (1) | CA2537103C (enExample) |
| DE (1) | DE602004030931D1 (enExample) |
| DK (1) | DK2210605T3 (enExample) |
| ES (1) | ES2359375T3 (enExample) |
| PT (1) | PT2210605T (enExample) |
| WO (1) | WO2005046684A1 (enExample) |
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| EP1973528B1 (en) | 2006-11-17 | 2012-11-07 | Supernus Pharmaceuticals, Inc. | Sustained-release formulations of topiramate |
| WO2008070670A2 (en) * | 2006-12-04 | 2008-06-12 | Supernus Pharmaceuticals, Inc. | Enhanced immediate release formulations of topiramate |
| WO2009130712A2 (en) * | 2008-04-22 | 2009-10-29 | Lupin Limited | Controlled release pharmaceutical compositions of trospium |
| TWI478712B (zh) | 2008-09-30 | 2015-04-01 | Astellas Pharma Inc | 釋控性醫藥組成物 |
| US10265311B2 (en) | 2009-07-22 | 2019-04-23 | PureTech Health LLC | Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation |
| PL3061821T3 (pl) * | 2009-07-22 | 2020-01-31 | PureTech Health LLC | Kompozycje do leczenia zaburzeń łagodzonych przez aktywację receptora muskarynowego |
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| BR112013028755A2 (pt) | 2011-05-10 | 2017-01-31 | Theravida Inc | combinações de solifenacina e estimulantes salivares para o tratamento de bexiga hiperativa |
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| US10751287B2 (en) * | 2013-03-15 | 2020-08-25 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
| CA2936748C (en) | 2014-10-31 | 2017-08-08 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
| CN104739808B (zh) * | 2015-02-13 | 2017-09-22 | 舒泰神(北京)生物制药股份有限公司 | 一种曲司氯铵双释放胶囊及其制备方法 |
| WO2017127073A1 (en) | 2016-01-20 | 2017-07-27 | Theravida, Inc. | Methods and compositions for treating hyperhidrosis |
| JP7096441B2 (ja) | 2018-09-28 | 2022-07-05 | カルナ セラピューティックス,インコーポレイテッド | ムスカリン受容体活性化によって改善される障害を処置するための組成物及び方法 |
| US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
| US12097189B1 (en) | 2024-02-09 | 2024-09-24 | Astellas Pharma Inc. | Pharmaceutical composition for modified release |
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2004
- 2004-11-04 US US10/980,818 patent/US7410978B2/en not_active Expired - Fee Related
- 2004-11-04 DK DK10001664.1T patent/DK2210605T3/en active
- 2004-11-04 AT AT04800569T patent/ATE493981T1/de not_active IP Right Cessation
- 2004-11-04 WO PCT/US2004/036394 patent/WO2005046684A1/en not_active Ceased
- 2004-11-04 DE DE602004030931T patent/DE602004030931D1/de not_active Expired - Lifetime
- 2004-11-04 CA CA002537103A patent/CA2537103C/en not_active Expired - Fee Related
- 2004-11-04 EP EP04800569A patent/EP1680110B1/en not_active Expired - Lifetime
- 2004-11-04 EP EP10001664.1A patent/EP2210605B1/en not_active Expired - Lifetime
- 2004-11-04 JP JP2006538425A patent/JP5610663B2/ja not_active Expired - Fee Related
- 2004-11-04 PT PT100016641T patent/PT2210605T/pt unknown
- 2004-11-04 ES ES04800569T patent/ES2359375T3/es not_active Expired - Lifetime
- 2004-11-04 AU AU2004289223A patent/AU2004289223B2/en not_active Ceased
-
2007
- 2007-08-17 US US11/889,985 patent/US7763635B2/en not_active Expired - Fee Related
- 2007-08-17 US US11/889,964 patent/US7759359B2/en not_active Expired - Fee Related
- 2007-08-17 US US11/889,962 patent/US7781448B2/en not_active Expired - Fee Related
- 2007-08-17 US US11/889,963 patent/US7781449B2/en not_active Expired - Fee Related
-
2010
- 2010-05-12 US US12/778,664 patent/US20100221355A1/en not_active Abandoned
- 2010-05-12 US US12/778,609 patent/US20100221354A1/en not_active Abandoned
- 2010-05-12 US US12/778,568 patent/US20100222375A1/en not_active Abandoned
- 2010-05-12 US US12/778,791 patent/US20100221356A1/en not_active Abandoned
- 2010-05-12 US US12/778,593 patent/US20100221352A1/en not_active Abandoned
- 2010-05-12 US US12/778,604 patent/US20100221353A1/en not_active Abandoned
-
2012
- 2012-05-01 JP JP2012104795A patent/JP5783489B2/ja not_active Expired - Fee Related
- 2012-09-19 US US13/622,804 patent/US20130089607A1/en not_active Abandoned
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