JP2007509034A - エリスロシンに基づく抗菌性光力学治療化合物およびその使用方法 - Google Patents
エリスロシンに基づく抗菌性光力学治療化合物およびその使用方法 Download PDFInfo
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Abstract
【解決手段】ゲル中の光増感剤としてエリスロシンBを含む組成物を生物学的表面上の治療域に導入する段階、該治療域の細菌に該エリスロシンBを結合させるために予定された時間経過させる段階、該治療域に予め選択された波長の照射を当てて、該エリスロシンBを活性化しそしてそれにより光力学反応を誘導して該細菌を殺す段階からなり、そして複雑な媒体が該治療域に存在する病者の治療域の殺菌方法。
【選択図】図4
Description
この研究に使用される生物は、Streptococcus mutans DSM6178(ATCC35668)であった。グラム陽性Streptococcus spec.は、齲歯の発生にともに関係している。
25人のボランティアを5つのグループに分けた。すべてのボランティアに、穏やかなマッサージにより歯上に約2mLのエリスロシンB含有ゲルを適用した。2分間の暴露時間後、口腔を水で濯ぎ、そして歯を、光ファイバーを経る光アプリケーターによって、532nmレーザーCeralas G2(biolitec AG、ドイツ)からの光により照明した。照射時間は約3分間であった。4つの処理されたボランティアグループに関する照明のフルエンス率は、それぞれ約0.05、0.1、0.3および0.5W/cm2であった。ボランティアのコントロールグループは照明されなかった。すべての処理は、口腔からの細菌の除去を避けるために、朝の通常の歯磨き前になされた。第一の処理前そしてすべての処理後、唾液の試料をSalivette(商標)管(Sarstedt Ag and Co.Nuembrecht、ドイツ)により採取し、唾液をSalivette管から取り出し、そしてTYCSBアガー(Streptococcus spec.に関する選択的培地)プレート上にらせんプレーターEddy Jet(iul Instruments、Barcelona、スペイン)を使用して接種した。コロニー形成単位の数(CFU/mL)を、コロニー計数計Countermat Flash(iul Instruments、Barcelona、スペイン)を使用することにより、好気的ワークステーション(Don Whithley Scientific Lim.Shipley、英国)で適切なインキュベーション後数えた。Streptococcus spec.について、唾液中の細菌の数は、歯のプラーク中の細菌の数と一致した。
103 ペプチドグリカン層
105 細胞膜
201 ペプチドグリカンの層
203 細胞膜
205 外側の膜
Claims (22)
- a.ゲル中の光増感剤としてエリスロシンBを含む組成物を生物学的表面上の治療域に導入する段階、
b.該治療域の細菌に該エリスロシンBを結合させるために予定された時間経過させる段階、
c.該治療域に予め選択された波長の照射を当てて、該エリスロシンBを活性化しそしてそれにより光力学反応を誘導して該細菌を殺す段階
からなり、そして複雑な媒体が該治療域に存在することを特徴とする病者の治療域の殺菌方法。 - 該複雑な媒体が唾液である請求項1の殺菌方法。
- 該治療域が、歯および舌背からなる群から選ばれた域上の細菌プラークである請求項1の殺菌方法。
- 該治療域が齲歯である請求項1の殺菌方法。
- 該予め選択された波長が約500nmと約580nmとの間である請求項1の殺菌方法。
- 該予め選択された波長が約530nmである請求項1の殺菌方法。
- 該組成物中の該エリスロシンBの濃度が、該組成物0.5mLあたり1mMより多い請求項1の殺菌方法。
- 該組成物中の該エリスロシンBの濃度が、該組成物0.5mLあたり8mMである請求項1の殺菌方法。
- 該予定された時間が少なくとも1分である請求項1の殺菌方法。
- 該予定された時間が3分と5分との間である請求項9の殺菌方法。
- 該予定された時間が少なくとも5分である請求項9の殺菌方法。
- 該照射を適用する段階が非干渉ランプにより達成される請求項1の殺菌方法。
- 該照射を適用する段階が、照射源に結合される光学伝達系により達成される請求項1の殺菌方法。
- 該光学伝達系が少なくとも1つの光ファイバーである請求項13の殺菌方法。
- 該照射が、非干渉照射および干渉レーザー照射からなる群から選ばれる請求項1の殺菌方法。
- 該照射が、少なくとも約0.05W/cm2のフルエンス率で適用される請求項1の殺菌方法。
- 該フルエンス率が、約0.3W/cm2と約0.5W/cm2との間である請求項16の殺菌方法。
- 該照射の該適用時間が約3分である請求項16の殺菌方法。
- 該治療域が歯および歯肉からなる群から選ばれる請求項1の殺菌方法。
- 該組成物が、ヒドロキシエチルセルロースおよびプロピレングリコールからなる群から選ばれる物質をさらに含む請求項1の殺菌方法。
- エリスロシンBおよび該エリスロシンBを可溶化する成分を含むゲルを含むことを特徴とする生物学的表面の治療のための抗菌性光力学治療組成物。
- ヒドロキシエチルセルロースおよびプロピレングリコールからなる群から選ばれる物質をさらに含む請求項21の抗菌性光力学治療組成物。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US50333903P | 2003-09-16 | 2003-09-16 | |
US60/503,339 | 2003-09-16 | ||
US10/860,297 US20050059731A1 (en) | 2003-09-16 | 2004-06-03 | Erythrosin-based antimicrobial photodynamic therapy compound and its use |
US10/860,297 | 2004-06-03 | ||
PCT/US2004/028726 WO2005032459A2 (en) | 2003-09-16 | 2004-09-03 | Erythrosin-based antimicrobial photodynamic therapy compound and its use |
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US (1) | US20050059731A1 (ja) |
EP (1) | EP1778294A4 (ja) |
JP (1) | JP4943149B2 (ja) |
BR (1) | BRPI0414331B1 (ja) |
MX (1) | MXPA06003033A (ja) |
RU (1) | RU2368375C2 (ja) |
WO (1) | WO2005032459A2 (ja) |
Cited By (5)
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JP2012512857A (ja) * | 2008-12-20 | 2012-06-07 | コンバテック・テクノロジーズ・インコーポレイテッド | 皮膚および創傷における使用のための組成物 |
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Also Published As
Publication number | Publication date |
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BRPI0414331A (pt) | 2006-11-07 |
MXPA06003033A (es) | 2006-12-14 |
RU2006112562A (ru) | 2006-08-10 |
JP4943149B2 (ja) | 2012-05-30 |
BRPI0414331B1 (pt) | 2018-05-29 |
EP1778294A2 (en) | 2007-05-02 |
WO2005032459A3 (en) | 2006-10-12 |
US20050059731A1 (en) | 2005-03-17 |
WO2005032459A2 (en) | 2005-04-14 |
EP1778294A4 (en) | 2010-05-05 |
RU2368375C2 (ru) | 2009-09-27 |
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