JP4828423B2 - 抗菌性光力学治療化合物およびその使用方法 - Google Patents
抗菌性光力学治療化合物およびその使用方法 Download PDFInfo
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- JP4828423B2 JP4828423B2 JP2006525379A JP2006525379A JP4828423B2 JP 4828423 B2 JP4828423 B2 JP 4828423B2 JP 2006525379 A JP2006525379 A JP 2006525379A JP 2006525379 A JP2006525379 A JP 2006525379A JP 4828423 B2 JP4828423 B2 JP 4828423B2
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- 230000000844 anti-bacterial effect Effects 0.000 title claims description 9
- 230000001225 therapeutic effect Effects 0.000 title claims description 4
- 238000000034 method Methods 0.000 title description 19
- 150000001875 compounds Chemical class 0.000 title description 9
- OARRHUQTFTUEOS-UHFFFAOYSA-N safranin Chemical compound [Cl-].C=12C=C(N)C(C)=CC2=NC2=CC(C)=C(N)C=C2[N+]=1C1=CC=CC=C1 OARRHUQTFTUEOS-UHFFFAOYSA-N 0.000 claims description 35
- 241000894006 Bacteria Species 0.000 claims description 29
- 239000000203 mixture Substances 0.000 claims description 28
- 238000011282 treatment Methods 0.000 claims description 13
- 238000002428 photodynamic therapy Methods 0.000 claims description 12
- 210000002966 serum Anatomy 0.000 claims description 11
- 239000003504 photosensitizing agent Substances 0.000 claims description 10
- 210000004369 blood Anatomy 0.000 claims description 9
- 239000008280 blood Substances 0.000 claims description 9
- 210000003296 saliva Anatomy 0.000 claims description 8
- 230000002147 killing effect Effects 0.000 claims description 6
- 241000588724 Escherichia coli Species 0.000 claims description 5
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims description 4
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- 230000009885 systemic effect Effects 0.000 claims description 3
- 230000003213 activating effect Effects 0.000 claims description 2
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- 230000002452 interceptive effect Effects 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 239000003642 reactive oxygen metabolite Substances 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims description 2
- 230000000699 topical effect Effects 0.000 claims description 2
- 238000001802 infusion Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000000975 dye Substances 0.000 description 13
- 210000004027 cell Anatomy 0.000 description 10
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 description 7
- 108010013639 Peptidoglycan Proteins 0.000 description 7
- 230000001580 bacterial effect Effects 0.000 description 7
- 239000002953 phosphate buffered saline Substances 0.000 description 7
- 210000001519 tissue Anatomy 0.000 description 7
- 210000002421 cell wall Anatomy 0.000 description 5
- 230000002779 inactivation Effects 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 230000001954 sterilising effect Effects 0.000 description 5
- 241000191967 Staphylococcus aureus Species 0.000 description 4
- 210000000170 cell membrane Anatomy 0.000 description 4
- 210000002381 plasma Anatomy 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 230000000845 anti-microbial effect Effects 0.000 description 3
- 239000006285 cell suspension Substances 0.000 description 3
- 208000002925 dental caries Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 241000251468 Actinopterygii Species 0.000 description 2
- 241000192125 Firmicutes Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 210000005256 gram-negative cell Anatomy 0.000 description 2
- 210000005255 gram-positive cell Anatomy 0.000 description 2
- 230000009931 harmful effect Effects 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000000749 insecticidal effect Effects 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 239000011630 iodine Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 230000001338 necrotic effect Effects 0.000 description 2
- 230000002165 photosensitisation Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 239000001974 tryptic soy broth Substances 0.000 description 2
- 108010050327 trypticase-soy broth Proteins 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000005888 Periodontal Pocket Diseases 0.000 description 1
- 208000010362 Protozoan Infections Diseases 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- -1 bait Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000003463 hyperproliferative effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 231100000760 phototoxic Toxicity 0.000 description 1
- 239000001044 red dye Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000006150 trypticase soy agar Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
- A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
Description
電磁気的な照射によりコントロール可能でしかも選択的に活性化できる抗菌方法を提供するのが本発明の他の目的である。
グラム陽性およびグラム陰性の細菌の両方を殺すのに有効な方法を提供するのが本発明の他の目的である。
本発明の上記および他の目的、特徴および利点は、図面とともに以下の記述から明らかになるだろう。
〔実施例〕
いくつかの研究は、グラム陽性の細菌(例えば、Staphylococus aureus)が光力学不活性化を特に受けやすいが、一方グラム陰性の細菌(例えば、Escherichia coli、Pseudomonas aeruginosa)が、多くの普通に使用される光増感剤に対して遙かに抵抗性があることを立証している。さらに、本発明者は、さらに複雑な媒体(例えば、血液、血漿、血液の血清、唾液)中のグラム陽性およびグラム陰性の細菌細胞の両者が、また光力学的作用からさらに保護されていることを見いだした。
実験の結果は、図3、4および5に示される。
103 ペプチドグリカン層
105 細胞膜
201 ペプチドグリカンの層
203 細胞膜
Claims (11)
- ヒトの治療域に予め選択された波長の照射を当てることによる光力学治療に用いるための抗菌性組成物であって、
光増感剤としてサフラニンOを含み、
血液の血清、血液および唾液からなる群から選ばれる複雑な媒体を含む該ヒトの治療域に導入されるためのものであり、
該複雑な媒体中の細菌を殺すためのものである、
該予め選択された波長が約500nmと約580nmとの間にある、
ことを特徴とする前記組成物。 - 該予め選択された波長が約530nmである請求項1の組成物。
- 該導入が、全身的な適用、狭い域への適用および局所的な適用からなる群から選ばれる請求項1〜2のいずれか1項の組成物。
- 該全身的な適用が静脈内注入である請求項3の組成物。
- 該狭い域への適用が、非管組織中への狭い域の注入である請求項3の組成物。
- 溶液、クリーム、ゲルおよびローションからなる群から選ばれる形である請求項1〜5のいずれか1項の組成物。
- 該照射の少なくとも約15分前に該治療域に導入されるためのものである請求項1〜6のいずれか1項の組成物。
- 該照射が、非干渉ランプおよび干渉レーザーからなる群から選ばれる照射源によりもたらされる請求項1〜7のいずれか1項の組成物。
- 該照射が、照射源に結合された少なくとも1つの光ファイバーにより達成される請求項1〜8のいずれか1項の組成物。
- 照射によりサフラニンOを活性化して反応性酸素種およびフリーラジカルを生成させるためのものである請求項1〜9のいずれか1項の組成物。
- 細菌がEscherichia coliおよびPseudomonas aeruginosaからなる群から選択される請求項1〜10のいずれか1項の組成物。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49984703P | 2003-09-02 | 2003-09-02 | |
US60/499,847 | 2003-09-02 | ||
US10/860,296 | 2004-06-03 | ||
US10/860,296 US20050049228A1 (en) | 2003-09-02 | 2004-06-03 | Antimicrobial photodynamic therapy compound and method of use |
PCT/US2004/028180 WO2005021094A2 (en) | 2003-09-02 | 2004-08-30 | Antimicrobial photodynamic therapy compound |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2007503917A JP2007503917A (ja) | 2007-03-01 |
JP4828423B2 true JP4828423B2 (ja) | 2011-11-30 |
Family
ID=34221799
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006525379A Active JP4828423B2 (ja) | 2003-09-02 | 2004-08-30 | 抗菌性光力学治療化合物およびその使用方法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US20050049228A1 (ja) |
EP (1) | EP1701726B1 (ja) |
JP (1) | JP4828423B2 (ja) |
BR (1) | BRPI0414069A8 (ja) |
RU (1) | RU2376991C2 (ja) |
WO (1) | WO2005021094A2 (ja) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0515550D0 (en) | 2005-07-29 | 2005-09-07 | Univ Strathclyde | Inactivation of staphylococcus species |
PL1951184T3 (pl) | 2005-11-09 | 2012-06-29 | Valeant Pharmaceuticals Int Inc | Kompozycje do wybielania zębów i sposoby |
US20100266989A1 (en) | 2006-11-09 | 2010-10-21 | Klox Technologies Inc. | Teeth whitening compositions and methods |
WO2009075692A2 (en) | 2007-05-14 | 2009-06-18 | Invista Technologies S.A.R.L. | High efficiency reactor and process |
NZ717641A (en) * | 2008-11-07 | 2017-09-29 | Klox Tech Inc | Combination of an oxidant and a photoactivator for the healing of wounds |
US20120101427A1 (en) * | 2009-04-28 | 2012-04-26 | Gerard Farmer | Novel photosensitizer formulations for oral administration |
EP2459248B1 (en) * | 2009-06-02 | 2019-05-22 | biolitec Unternehmensbeteiligungs II AG | A novel method for microbial depletion in human blood and blood products using antimicrobial photodynamic therapy |
DK2453922T3 (en) | 2009-07-17 | 2018-01-02 | Klox Tech Inc | ANTIBACTERIAL ORAL COMPOSITION |
MX2012008386A (es) * | 2010-01-19 | 2013-01-29 | Biolitec Pharma Marketing Ltd | Pdt antimicrobiana mejorada. |
US20130281913A1 (en) | 2012-04-20 | 2013-10-24 | Klox Technologies Inc. | Biophotonic compositions and methods for providing biophotonic treatment |
US11116841B2 (en) | 2012-04-20 | 2021-09-14 | Klox Technologies Inc. | Biophotonic compositions, kits and methods |
JP6231570B2 (ja) | 2012-09-14 | 2017-11-15 | ヴァレアント ファーマシューティカルズ インターナショナル インコーポレイテッドValeant Pharmaceuticals International, Inc. | 歯のホワイトニングのための組成物および方法 |
US20140276354A1 (en) | 2013-03-14 | 2014-09-18 | Klox Technologies Inc. | Biophotonic materials and uses thereof |
AR099941A1 (es) | 2014-04-01 | 2016-08-31 | Klox Tech Inc | Composiciones para relleno de tejido y métodos de uso |
US11272594B2 (en) | 2016-10-31 | 2022-03-08 | Hubbell Incorporated | Multi-array lighting system for providing high intensity narrow spectrum light |
US10232066B2 (en) | 2016-10-31 | 2019-03-19 | Hubbell Incorporated | High intensity narrow spectrum light indicator systems |
US10702617B2 (en) | 2017-10-30 | 2020-07-07 | Hubbell Incorporated | Antimicrobial backlit device |
US11590248B2 (en) | 2017-10-30 | 2023-02-28 | Hubbell Lighting, Inc. | Pulsing high intensity narrow spectrum light |
RU2700407C1 (ru) * | 2018-07-23 | 2019-09-16 | Михаил Тимофеевич Александров | Способ лечения опухолевых и воспалительных заболеваний с применением фотодинамической терапии |
US11388789B2 (en) | 2019-03-18 | 2022-07-12 | Hubbell Lighting, Inc. | Method for controlling operation of a lighting system having high intensity narrow spectrum light sources |
WO2022072615A1 (en) * | 2020-09-30 | 2022-04-07 | Jernigan David A | Method of manipulating phages within the body to attack infectious target cells |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6506791B2 (en) * | 2000-08-09 | 2003-01-14 | Jacksonville State University | Method of treatment of protozoan infections in fish |
WO2003003975A2 (en) * | 2001-06-04 | 2003-01-16 | The General Hospital Corporation | Detection and therapy of vulnerable plaque with photodynamic compounds |
US20030059379A1 (en) * | 2001-09-19 | 2003-03-27 | Andersen Scot N. | Methods for treating periodontal disease |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5798112A (en) * | 1994-12-09 | 1998-08-25 | The United States Of America As Represented By The Secretary Of Agriculture | Phototoxic insecticidal composition and method for controlling insect populations |
US5990199A (en) * | 1995-04-19 | 1999-11-23 | North American Science Associates, Inc. | Indicator ink compositions |
CN1165272C (zh) * | 1997-02-24 | 2004-09-08 | 可乐丽股份有限公司 | 抗微生物的检龋组合物 |
US8187278B2 (en) * | 1998-08-25 | 2012-05-29 | Advanced Photodynamic Technologies, Inc. | Photodynamic cellular and acellular organism eradication utilizing a photosensitive material and benzalkonium chloride |
US6887862B2 (en) * | 2001-05-31 | 2005-05-03 | Miravant Systems, Inc. | Method for improving treatment selectivity and efficacy using intravascular photodynamic therapy |
EP1670540A2 (en) * | 2003-09-05 | 2006-06-21 | The General Hospital Corporation | Photodynamic inactivation of bacterial spores |
-
2004
- 2004-06-03 US US10/860,296 patent/US20050049228A1/en not_active Abandoned
- 2004-08-30 RU RU2006110554/14A patent/RU2376991C2/ru active IP Right Revival
- 2004-08-30 BR BRPI0414069A patent/BRPI0414069A8/pt active Search and Examination
- 2004-08-30 JP JP2006525379A patent/JP4828423B2/ja active Active
- 2004-08-30 EP EP04782618.5A patent/EP1701726B1/en active Active
- 2004-08-30 WO PCT/US2004/028180 patent/WO2005021094A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6506791B2 (en) * | 2000-08-09 | 2003-01-14 | Jacksonville State University | Method of treatment of protozoan infections in fish |
WO2003003975A2 (en) * | 2001-06-04 | 2003-01-16 | The General Hospital Corporation | Detection and therapy of vulnerable plaque with photodynamic compounds |
US20030059379A1 (en) * | 2001-09-19 | 2003-03-27 | Andersen Scot N. | Methods for treating periodontal disease |
Also Published As
Publication number | Publication date |
---|---|
JP2007503917A (ja) | 2007-03-01 |
BRPI0414069A (pt) | 2006-10-24 |
US20050049228A1 (en) | 2005-03-03 |
RU2376991C2 (ru) | 2009-12-27 |
BRPI0414069A8 (pt) | 2016-10-11 |
EP1701726B1 (en) | 2019-01-23 |
EP1701726A2 (en) | 2006-09-20 |
EP1701726A4 (en) | 2007-01-03 |
WO2005021094A2 (en) | 2005-03-10 |
RU2006110554A (ru) | 2006-08-10 |
WO2005021094A3 (en) | 2005-04-28 |
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