JP2007507487A5 - - Google Patents
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- Publication number
- JP2007507487A5 JP2007507487A5 JP2006530762A JP2006530762A JP2007507487A5 JP 2007507487 A5 JP2007507487 A5 JP 2007507487A5 JP 2006530762 A JP2006530762 A JP 2006530762A JP 2006530762 A JP2006530762 A JP 2006530762A JP 2007507487 A5 JP2007507487 A5 JP 2007507487A5
- Authority
- JP
- Japan
- Prior art keywords
- serogroup
- composition
- conjugated
- capsular saccharide
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 18
- 102000036639 antigens Human genes 0.000 claims 18
- 108091007433 antigens Proteins 0.000 claims 18
- 150000001720 carbohydrates Chemical class 0.000 claims 16
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 230000028993 immune response Effects 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 230000000844 anti-bacterial effect Effects 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 206010022000 influenza Diseases 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims 1
- 241000588650 Neisseria meningitidis Species 0.000 claims 1
- 101710188053 Protein D Proteins 0.000 claims 1
- 101710132893 Resolvase Proteins 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- 230000005875 antibody response Effects 0.000 claims 1
- 229960003983 diphtheria toxoid Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 208000037798 influenza B Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000002772 monosaccharides Chemical group 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Chemical class 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
- 229960000814 tetanus toxoid Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0323102A GB0323102D0 (en) | 2003-10-02 | 2003-10-02 | Liquid vaccines for multiple meningococcal serogroups |
| GB0323102.4 | 2003-10-02 | ||
| GB0412052A GB0412052D0 (en) | 2004-05-28 | 2004-05-28 | Liquid vaccines for multiple meningococcal serogroups |
| GB0412052.3 | 2004-05-28 | ||
| PCT/IB2004/003373 WO2005032583A2 (en) | 2003-10-02 | 2004-10-04 | Liquid vaccines for multiple meningococcal serogroups |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011003484A Division JP5618842B2 (ja) | 2003-10-02 | 2011-01-11 | 複数の髄膜炎菌血清群についての液体ワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007507487A JP2007507487A (ja) | 2007-03-29 |
| JP2007507487A5 true JP2007507487A5 (OSRAM) | 2007-11-22 |
| JP4738339B2 JP4738339B2 (ja) | 2011-08-03 |
Family
ID=34424891
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006530762A Expired - Lifetime JP4738339B2 (ja) | 2003-10-02 | 2004-10-04 | 複数の髄膜炎菌血清群についての液体ワクチン |
| JP2011003484A Expired - Lifetime JP5618842B2 (ja) | 2003-10-02 | 2011-01-11 | 複数の髄膜炎菌血清群についての液体ワクチン |
| JP2014148501A Withdrawn JP2014196362A (ja) | 2003-10-02 | 2014-07-22 | 複数の髄膜炎菌血清群についての液体ワクチン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011003484A Expired - Lifetime JP5618842B2 (ja) | 2003-10-02 | 2011-01-11 | 複数の髄膜炎菌血清群についての液体ワクチン |
| JP2014148501A Withdrawn JP2014196362A (ja) | 2003-10-02 | 2014-07-22 | 複数の髄膜炎菌血清群についての液体ワクチン |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8765135B2 (OSRAM) |
| EP (3) | EP1961426B1 (OSRAM) |
| JP (3) | JP4738339B2 (OSRAM) |
| CN (2) | CN103357002A (OSRAM) |
| AT (1) | ATE506963T1 (OSRAM) |
| AU (2) | AU2004277758A1 (OSRAM) |
| BR (2) | BRPI0415025A (OSRAM) |
| CA (2) | CA2540896C (OSRAM) |
| CY (2) | CY1113522T1 (OSRAM) |
| DE (1) | DE602004032481D1 (OSRAM) |
| DK (2) | DK1670506T3 (OSRAM) |
| ES (1) | ES2397923T3 (OSRAM) |
| NZ (1) | NZ546430A (OSRAM) |
| PL (2) | PL1670506T3 (OSRAM) |
| PT (2) | PT1961426E (OSRAM) |
| RU (2) | RU2378010C2 (OSRAM) |
| SI (2) | SI1670506T1 (OSRAM) |
| WO (1) | WO2005032583A2 (OSRAM) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070026021A1 (en) * | 1998-05-01 | 2007-02-01 | Chiron S.R.I. | Neisseria meningitidis antigens and compositions |
| DE69937419T2 (de) | 1998-05-01 | 2008-07-24 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Neisseria Meningitidis Antigene und Zusammenstellungen |
| AU761495B2 (en) | 1998-05-29 | 2003-06-05 | Chiron Corporation | Combination meningitidis B/C vaccines |
| US7368261B1 (en) * | 1999-04-30 | 2008-05-06 | Novartis Vaccines And Diagnostics Srl | Conserved Neisserial antigens |
| EP2270174A1 (en) * | 1999-05-19 | 2011-01-05 | Novartis Vaccines and Diagnostics S.r.l. | Combination neisserial compositions |
| PT2275554E (pt) | 1999-10-29 | 2015-06-26 | Novartis Vaccines & Diagnostic | Péptidos antigénicos de neisseria |
| GB9928196D0 (en) * | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| EP2275129A3 (en) * | 2000-01-17 | 2013-11-06 | Novartis Vaccines and Diagnostics S.r.l. | Outer membrane vesicle (OMV) vaccine comprising N. meningitidis serogroup B outer membrane proteins |
| PT1790660E (pt) * | 2000-02-28 | 2012-09-17 | Novartis Vaccines & Diagnostic | Expressão heteróloga de proteínas de neisseria |
| GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
| EP1412381B1 (en) | 2001-07-27 | 2010-06-02 | Novartis Vaccines and Diagnostics S.r.l. | Antibodies against meningococcal adhesin app |
| GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| WO2004014417A2 (en) * | 2002-08-02 | 2004-02-19 | Glaxosmithkline Biologicals Sa | Vaccine compositions comprising l2 and/or l3 immunotype lipooligosaccharides from lgtb- neisseria minigitidis |
| SI2353608T1 (sl) | 2002-10-11 | 2020-12-31 | Glaxosmithkline Biologicals Sa | Polipeptidna cepiva za široko zaščito proti hipervirulentnim meningokoknim linijam |
| GB0227346D0 (en) * | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| CA2540896C (en) * | 2003-10-02 | 2015-06-02 | Chiron Srl | Liquid vaccines for multiple meningococcal serogroups |
| GB0408977D0 (en) * | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| AU2011204789B2 (en) * | 2004-04-22 | 2013-07-11 | Glaxosmithkline Biologicals S.A. | Immunising against meningococcal serogroup Y using proteins |
| GB0413868D0 (en) | 2004-06-21 | 2004-07-21 | Chiron Srl | Dimensional anlaysis of saccharide conjugates |
| GB0419408D0 (en) * | 2004-09-01 | 2004-10-06 | Chiron Srl | 741 chimeric polypeptides |
| GB0505518D0 (en) * | 2005-03-17 | 2005-04-27 | Chiron Srl | Combination vaccines with whole cell pertussis antigen |
| EP2201961B1 (en) * | 2005-06-27 | 2018-01-24 | GlaxoSmithKline Biologicals S.A. | Immunogenic composition |
| AU2012203419B2 (en) * | 2005-06-27 | 2014-06-26 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| US20110008279A1 (en) * | 2005-12-06 | 2011-01-13 | Vega Masignani | Methods and Compositions Relating to Adhesins as Adjuvants |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| CA2688268A1 (en) | 2007-06-04 | 2008-12-11 | Novartis Ag | Formulation of meningitis vaccines |
| CA2702871A1 (en) * | 2007-10-19 | 2009-04-23 | Novartis Ag | Meningococcal vaccine formulations |
| ES2532946T3 (es) * | 2008-02-21 | 2015-04-06 | Novartis Ag | Polipéptidos PUfH meningocócicos |
| EP2297578A2 (en) * | 2008-05-19 | 2011-03-23 | Novartis AG | Vaccine assays |
| US20100105875A1 (en) * | 2008-06-09 | 2010-04-29 | Maria Scarselli | Antibodies against neisserial factor H binding protein |
| GB0816447D0 (en) * | 2008-09-08 | 2008-10-15 | Glaxosmithkline Biolog Sa | Vaccine |
| US20100330117A1 (en) * | 2008-09-26 | 2010-12-30 | Salubrious Pharmaceutical, Llc | Process for treatment of amyotrophic lateral sclerosis, rheumatoid arthritis, tremors/parkinson's disease, multiple sclerosis, non-viral based cancers, alzheimers's disease, muscular dystrophy, attention deficit disorder, attention deficit hyperactivity disorder, complex regional pain syndrome, diabetes, neuropathic pain, spider arthritis, west nile virus, fibromyalgia, shingles, gout, migraine headaches, senile dementia, post polio syndrome, central virus deafness, asthma, chronic pain of unknown origin and hepatitis c |
| MX2011003277A (es) * | 2008-10-14 | 2012-09-21 | Salubrious Pharmaceuticals LLC | Proceso para el tratamiento de la artritis reumatoide, temblores/enfermedad de parkinson, esclerosis multiple y cancer de tipo no viral. |
| GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
| SMT202000366T1 (it) | 2009-03-24 | 2020-09-10 | Glaxosmithkline Biologicals Sa | Proteina legante fattore h di meningococco come adiuvante |
| CA2803239A1 (en) | 2010-06-25 | 2011-12-29 | Novartis Ag | Combinations of meningococcal factor h binding proteins |
| PL3246044T5 (pl) | 2010-08-23 | 2024-06-17 | Wyeth Llc | Stabilne preparaty antygenów rLP2086 Neisseria meningitidis |
| WO2012031271A1 (en) | 2010-09-04 | 2012-03-08 | Novartis Ag | Bactericidal antibody assays to assess immunogenicity and potency of meningococcal capsular saccharide vaccines |
| US9259462B2 (en) | 2010-09-10 | 2016-02-16 | Glaxosmithkline Biologicals Sa | Developments in meningococcal outer membrane vesicles |
| PE20140173A1 (es) | 2010-09-10 | 2014-02-20 | Wyeth Llc | Variantes no lipidadas de antigenos orf2086 de neisseria meningitidis |
| JP6042455B2 (ja) * | 2012-01-30 | 2016-12-14 | セラム インスティチュート オブ インディア プライベイト リミテッド | 免疫原性組成物の調製方法 |
| JP2015517089A (ja) | 2012-03-08 | 2015-06-18 | ノバルティス アーゲー | タンパク質ベースの髄膜炎菌ワクチンのためのインビトロ有効性アッセイ |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| EP4043029A1 (en) | 2012-03-09 | 2022-08-17 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| JP5698693B2 (ja) * | 2012-03-13 | 2015-04-08 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 髄膜炎菌特異的抗血清に対する血清殺菌アッセイ |
| US10376573B2 (en) | 2012-06-14 | 2019-08-13 | Glaxosmithkline Biologicals Sa | Vaccines for serogroup X meningococcus |
| AU2013295242C1 (en) | 2012-07-27 | 2018-08-09 | Institut National De La Sante Et De La Recherche Medicale | CD147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia |
| US9802987B2 (en) | 2013-03-08 | 2017-10-31 | Pfizer Inc. | Immunogenic fusion polypeptides |
| EP3041502A2 (en) | 2013-09-08 | 2016-07-13 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| EP3229835A1 (en) | 2014-12-09 | 2017-10-18 | Sanofi Pasteur | Compositions comprising n. meningitidis proteins |
| US10888611B2 (en) | 2015-02-19 | 2021-01-12 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| US10374088B2 (en) * | 2015-06-16 | 2019-08-06 | International Business Machines Corporation | Low parasitic capacitance and resistance finFET device |
| CN107709341A (zh) * | 2015-07-28 | 2018-02-16 | Msd韦尔科姆信托希尔曼实验室私人有限公司 | 新的脑膜炎奈瑟氏菌血清组y寡聚体及其合成方法 |
| GB201614687D0 (en) * | 2016-08-31 | 2016-10-12 | Univ Oxford Innovation Ltd | fHbp scaffold |
| PH12019500399B1 (en) | 2016-09-02 | 2024-05-15 | Sanofi Pasteur Inc | Neisseria meningitidis vaccine |
| CA3035320A1 (en) | 2016-09-02 | 2018-03-08 | Glaxosmithkline Biologicals Sa | Vaccines for neisseria gonorrhoeae |
| JP7010961B2 (ja) | 2017-01-31 | 2022-02-10 | ファイザー・インク | 髄膜炎菌組成物およびその方法 |
| WO2018173068A1 (en) * | 2017-03-21 | 2018-09-27 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | A novel synthetic neisseria meningitidis serogroup a oligomer and process for synthesizing thereof |
| JP7231868B2 (ja) | 2019-09-05 | 2023-03-02 | ダイキン工業株式会社 | 組成物およびその製造方法 |
| KR102871663B1 (ko) | 2019-09-27 | 2025-10-16 | 화이자 인코포레이티드 | 네이세리아 메닌기티디스 조성물 및 그의 방법 |
| GB202013262D0 (en) * | 2020-08-25 | 2020-10-07 | Glaxosmithkline Biologicals Sa | Vaccine Composition |
| WO2025077785A1 (zh) * | 2023-10-10 | 2025-04-17 | 康希诺生物股份公司 | 一种抗脑膜炎球菌的免疫组合物及其用途 |
Family Cites Families (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB408978A (en) | 1932-10-22 | 1934-04-19 | Zeiss Carl | Improvements in instruments for measuring parallel coordinates |
| US4057685A (en) | 1972-02-02 | 1977-11-08 | Abbott Laboratories | Chemically modified endotoxin immunizing agent |
| US4356170A (en) | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| US4673574A (en) | 1981-08-31 | 1987-06-16 | Anderson Porter W | Immunogenic conjugates |
| SE8205892D0 (sv) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
| US4459286A (en) | 1983-01-31 | 1984-07-10 | Merck & Co., Inc. | Coupled H. influenzae type B vaccine |
| US4663160A (en) | 1983-03-14 | 1987-05-05 | Miles Laboratories, Inc. | Vaccines for gram-negative bacteria |
| US4761283A (en) | 1983-07-05 | 1988-08-02 | The University Of Rochester | Immunogenic conjugates |
| US6090406A (en) | 1984-04-12 | 2000-07-18 | The Liposome Company, Inc. | Potentiation of immune responses with liposomal adjuvants |
| US5916588A (en) | 1984-04-12 | 1999-06-29 | The Liposome Company, Inc. | Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use |
| US4695624A (en) | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
| US4882317A (en) | 1984-05-10 | 1989-11-21 | Merck & Co., Inc. | Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers and methods of preparing such polysaccharides and conjugataes and of confirming covalency |
| US4808700A (en) | 1984-07-09 | 1989-02-28 | Praxis Biologics, Inc. | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
| IT1187753B (it) | 1985-07-05 | 1987-12-23 | Sclavo Spa | Coniugati glicoproteici ad attivita' immunogenica trivalente |
| US4879213A (en) * | 1986-12-05 | 1989-11-07 | Scripps Clinic And Research Foundation | Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| NL8802046A (nl) | 1988-08-18 | 1990-03-16 | Gen Electric | Polymeermengsel met polyester en alkaansulfonaat, daaruit gevormde voorwerpen. |
| NZ241926A (en) | 1988-08-25 | 1993-08-26 | Liposome Co Inc | Immunisation dosage form comprising a salt of an organic acid derivative of a sterol and an antigen |
| DE3841091A1 (de) | 1988-12-07 | 1990-06-13 | Behringwerke Ag | Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung |
| CA2006700A1 (en) | 1989-01-17 | 1990-07-17 | Antonello Pessi | Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines |
| HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
| AU651949B2 (en) | 1989-07-14 | 1994-08-11 | American Cyanamid Company | Cytokine and hormone carriers for conjugate vaccines |
| IT1237764B (it) | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
| SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
| DE69113564T2 (de) | 1990-08-13 | 1996-05-30 | American Cyanamid Co | Faser-Hemagglutinin von Bordetella pertussis als Träger für konjugierten Impfstoff. |
| US5912336A (en) | 1990-08-23 | 1999-06-15 | University Of North Carolina At Chapel Hill | Isolated nucleic acid molecules encoding transferrin binding proteins from Neisseria gonorrhoeae and Neisseria meningitidis |
| DE69133622D1 (de) | 1990-08-23 | 2009-10-01 | Univ North Carolina | Transferrin bindende Proteine aus Neisseria-Gonorrhoeae und Neisseria-Meningitidis. Ihre Verwendung in einem Impfstoff |
| US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
| FR2682041B1 (fr) | 1991-10-03 | 1994-01-14 | Pasteur Merieux Serums Vaccins | Vaccin contre les infections a neisseria meningitidis. |
| IT1262896B (it) | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
| FI945483A7 (fi) | 1992-05-23 | 1995-01-20 | Smithkline Beecham Biologicals S A | Hepatiitti B - pinta-antigeenejä ja muita antigeenejä sisältäviä yhdistelmärokotteita |
| FR2692592B1 (fr) | 1992-06-19 | 1995-03-31 | Pasteur Merieux Serums Vacc | Fragments d'ADN codant pour les sous-unités du récepteur de la transferrine de Neisseria meningitidis et procédés les exprimant. |
| CA2138997C (en) | 1992-06-25 | 2003-06-03 | Jean-Paul Prieels | Vaccine composition containing adjuvants |
| IL102687A (en) | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
| DE69331495T2 (de) | 1992-08-31 | 2002-10-31 | Baxter Healthcare S.A., Wallisellen | Impfstoffe gegen neisseria meningitidis gruppe c |
| US5425946A (en) | 1992-08-31 | 1995-06-20 | North American Vaccine, Inc. | Vaccines against group C Neisseria meningitidis |
| AU685443B2 (en) | 1993-03-23 | 1998-01-22 | Smithkline Beecham Biologicals (Sa) | Vaccine compositions containing 3-O deacylated monophosphoryl lipid A |
| ES2210262T3 (es) | 1993-09-22 | 2004-07-01 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Procedimiento que permite activar un glucido soluble con la ayuda de nuevos reactivos cianilantes para producir estructuras inmunogenas. |
| GB9326174D0 (en) | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| GB9422096D0 (en) | 1994-11-02 | 1994-12-21 | Biocine Spa | Combined meningitis vaccine |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| FR2734484B1 (fr) | 1995-05-24 | 1997-06-27 | Pasteur Merieux Serums Vacc | Composition vaccinale liquide et procede de fabrication |
| BR9608612A (pt) | 1995-06-07 | 1999-05-04 | Smithkline Beecham Biolog | Vacina compreendendo um conjugado de antígeno de polissacarídeo - proteína portadora e proteína portadora livre |
| EP1082965B1 (en) | 1995-06-23 | 2009-06-10 | GlaxoSmithKline Biologicals S.A. | A vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate |
| GB9513261D0 (en) | 1995-06-29 | 1995-09-06 | Smithkline Beecham Biolog | Vaccines |
| ATE441432T1 (de) | 1997-03-10 | 2009-09-15 | Ottawa Hospital Res Inst | Verwendung von nicht-methyliertem cpg dinukleotid in kombination mit aluminium als adjuvantien |
| US6818222B1 (en) | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
| US6299881B1 (en) | 1997-03-24 | 2001-10-09 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts |
| GB9712347D0 (en) | 1997-06-14 | 1997-08-13 | Smithkline Beecham Biolog | Vaccine |
| GB9713156D0 (en) | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
| EP1279401B1 (en) | 1997-09-05 | 2008-01-09 | GlaxoSmithKline Biologicals S.A. | Oil in water emulsions containing saponins |
| DE69841807D1 (de) | 1997-11-06 | 2010-09-16 | Novartis Vaccines & Diagnostic | Neisseriale antigene |
| GB9725084D0 (en) | 1997-11-28 | 1998-01-28 | Medeva Europ Ltd | Vaccine compositions |
| GB9726398D0 (en) | 1997-12-12 | 1998-02-11 | Isis Innovation | Polypeptide and coding sequences |
| DE69941567D1 (de) | 1998-01-14 | 2009-12-03 | Novartis Vaccines & Diagnostic | Antigene aus neisseria meningitidis |
| CA2320223A1 (en) | 1998-02-12 | 1999-08-19 | American Cyanamid Company | Pneumococcal and meningococcal vaccines formulated with interleukin-12 |
| US7018637B2 (en) * | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
| US6303114B1 (en) | 1998-03-05 | 2001-10-16 | The Medical College Of Ohio | IL-12 enhancement of immune responses to T-independent antigens |
| KR20010042573A (ko) | 1998-04-09 | 2001-05-25 | 장 스테판느 | 애쥬번트 조성물 |
| DE69937419T2 (de) | 1998-05-01 | 2008-07-24 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Neisseria Meningitidis Antigene und Zusammenstellungen |
| GB9810276D0 (en) | 1998-05-13 | 1998-07-15 | Smithkline Beecham Biolog | Novel compounds |
| AU761495B2 (en) | 1998-05-29 | 2003-06-05 | Chiron Corporation | Combination meningitidis B/C vaccines |
| US6562798B1 (en) | 1998-06-05 | 2003-05-13 | Dynavax Technologies Corp. | Immunostimulatory oligonucleotides with modified bases and methods of use thereof |
| GB9817052D0 (en) | 1998-08-05 | 1998-09-30 | Smithkline Beecham Biolog | Vaccine |
| CN1263510C (zh) | 1998-08-19 | 2006-07-12 | 巴克斯特健康护理股份有限公司 | 多糖－蛋白质缀合物或寡糖－蛋白质缀合物、其制备方法及其应用 |
| MXPA01003557A (es) | 1998-10-09 | 2004-04-05 | Chiron Corp | Secuencias genomicas de neisseria y metodos para su uso. |
| US6146902A (en) | 1998-12-29 | 2000-11-14 | Aventis Pasteur, Inc. | Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions |
| WO2000056359A2 (en) * | 1999-03-19 | 2000-09-28 | Smithkline Beecham Biologicals S.A. | Vaccine against streptococcus pneumoniae |
| FR2791895B1 (fr) | 1999-03-23 | 2001-06-15 | Pasteur Merieux Serums Vacc | Utilisation de trehalose pour stabiliser un vaccin liquide |
| CA2365914A1 (en) | 1999-04-09 | 2000-10-19 | Techlab, Inc. | Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines |
| US7368261B1 (en) | 1999-04-30 | 2008-05-06 | Novartis Vaccines And Diagnostics Srl | Conserved Neisserial antigens |
| WO2001021207A2 (en) | 1999-09-24 | 2001-03-29 | Smithkline Beecham Biologicals S.A. | Use of combination of polyoxyethylene sorbitan ester and octoxynol as adjuvant and its use in vaccines |
| TR200200777T2 (tr) | 1999-09-24 | 2002-09-23 | Smithkline Beecham Biologicals S.A. | Polioksietilen alkil eteri veya esteriyle en az bir iyonik olmayan yüzey aktif maddeli adjuvant. |
| GB9925559D0 (en) | 1999-10-28 | 1999-12-29 | Smithkline Beecham Biolog | Novel method |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| EP1311288A1 (en) | 2000-01-20 | 2003-05-21 | Ottawa Health Research Institute | Immunostimulatory nucleic acids for inducing a th2 immune response |
| PT1790660E (pt) | 2000-02-28 | 2012-09-17 | Novartis Vaccines & Diagnostic | Expressão heteróloga de proteínas de neisseria |
| GB0007432D0 (en) | 2000-03-27 | 2000-05-17 | Microbiological Res Authority | Proteins for use as carriers in conjugate vaccines |
| SI1296715T2 (sl) * | 2000-06-29 | 2016-03-31 | Smithkline Beecham Biologicals S.A. | Multivalentni sestavek cepiva |
| GB0108364D0 (en) | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
| GB0022742D0 (en) | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
| CA2423487C (en) | 2000-09-26 | 2015-12-15 | Hybridon, Inc. | Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes |
| EP2957300B1 (en) * | 2001-01-23 | 2021-07-14 | Sanofi Pasteur Inc. | Multivalent meningococcal polysaccharide-protein conjugate vaccine |
| WO2002091998A2 (en) | 2001-05-11 | 2002-11-21 | Aventis Pasteur, Inc. | Novel meningitis conjugate vaccine |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| EP1409013B1 (en) | 2001-07-26 | 2009-11-18 | Novartis Vaccines and Diagnostics S.r.l. | Vaccines comprising aluminium adjuvants and histidine |
| GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
| EP1412381B1 (en) * | 2001-07-27 | 2010-06-02 | Novartis Vaccines and Diagnostics S.r.l. | Antibodies against meningococcal adhesin app |
| JP4360906B2 (ja) | 2001-09-14 | 2009-11-11 | サイトス バイオテクノロジー アーゲー | ウィルス様粒子によって誘導される免疫応答を高めるための、抗原提示細胞のインビボでの活性化 |
| CA2492826C (en) | 2001-09-14 | 2016-12-13 | Cytos Biotechnology Ag | Encapsulation of unmethylated cpg-containing oligonucleotides into virus-like particles: method of preparation and use |
| US7838015B2 (en) * | 2001-10-03 | 2010-11-23 | Novartis Vaccines And Diagnostics, Inc. | Adjuvanted meningococcus compositions |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| WO2003035836A2 (en) | 2001-10-24 | 2003-05-01 | Hybridon Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends |
| GB0129007D0 (en) * | 2001-12-04 | 2002-01-23 | Chiron Spa | Adjuvanted antigenic meningococcal compositions |
| BR0308768A (pt) | 2002-03-26 | 2005-02-15 | Chiron Srl | Sacarìdeos modificados possuindo estabilidade melhorada em água |
| MXPA04011249A (es) * | 2002-05-14 | 2005-06-06 | Chiron Srl | Vacunas mucosales con adyuvante de quitosano y antigenos meningococicos. |
| GB0302218D0 (en) * | 2003-01-30 | 2003-03-05 | Chiron Sri | Vaccine formulation & Mucosal delivery |
| WO2004014417A2 (en) | 2002-08-02 | 2004-02-19 | Glaxosmithkline Biologicals Sa | Vaccine compositions comprising l2 and/or l3 immunotype lipooligosaccharides from lgtb- neisseria minigitidis |
| SI2353608T1 (sl) * | 2002-10-11 | 2020-12-31 | Glaxosmithkline Biologicals Sa | Polipeptidna cepiva za široko zaščito proti hipervirulentnim meningokoknim linijam |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| PT2172213E (pt) * | 2003-01-30 | 2013-06-03 | Novartis Ag | Vacinas injetáveis contra múltiplos serogrupos meningocócicos |
| WO2004083251A2 (en) | 2003-03-17 | 2004-09-30 | Wyeth Holdings Corporation | Mutant cholera holotoxin as an adjuvant and an antigen carrier protein |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| CA2540896C (en) * | 2003-10-02 | 2015-06-02 | Chiron Srl | Liquid vaccines for multiple meningococcal serogroups |
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- 2004-10-04 CA CA2540896A patent/CA2540896C/en not_active Expired - Lifetime
- 2004-10-04 BR BRPI0415025-2A patent/BRPI0415025A/pt not_active Application Discontinuation
- 2004-10-04 WO PCT/IB2004/003373 patent/WO2005032583A2/en not_active Ceased
- 2004-10-04 US US10/574,424 patent/US8765135B2/en active Active
- 2004-10-04 BR BR122017002991-6A patent/BR122017002991B1/pt active IP Right Grant
- 2004-10-04 JP JP2006530762A patent/JP4738339B2/ja not_active Expired - Lifetime
- 2004-10-04 PT PT08075538T patent/PT1961426E/pt unknown
- 2004-10-04 SI SI200431991T patent/SI1670506T1/sl unknown
- 2004-10-04 NZ NZ546430A patent/NZ546430A/en not_active IP Right Cessation
- 2004-10-04 ES ES04791703T patent/ES2397923T3/es not_active Expired - Lifetime
- 2004-10-04 SI SI200431702T patent/SI1961426T1/sl unknown
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- 2004-10-04 EP EP08075538A patent/EP1961426B1/en not_active Revoked
- 2004-10-04 CA CA2885040A patent/CA2885040C/en not_active Expired - Lifetime
- 2004-10-04 CN CN2013102056030A patent/CN103357002A/zh active Pending
- 2004-10-04 DE DE602004032481T patent/DE602004032481D1/de not_active Expired - Lifetime
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- 2004-10-04 AU AU2004277758A patent/AU2004277758A1/en not_active Abandoned
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- 2004-10-04 AT AT08075538T patent/ATE506963T1/de active
- 2004-10-04 CN CN2013102049520A patent/CN103405761A/zh active Pending
- 2004-10-04 EP EP10180408A patent/EP2277538A1/en not_active Withdrawn
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